DE3887353D1 - Behandlungsverfahren für magen-darm-krankheiten. - Google Patents

Behandlungsverfahren für magen-darm-krankheiten.

Info

Publication number
DE3887353D1
DE3887353D1 DE88908644T DE3887353T DE3887353D1 DE 3887353 D1 DE3887353 D1 DE 3887353D1 DE 88908644 T DE88908644 T DE 88908644T DE 3887353 T DE3887353 T DE 3887353T DE 3887353 D1 DE3887353 D1 DE 3887353D1
Authority
DE
Germany
Prior art keywords
stomach
diseases
treatment procedure
procedure
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE88908644T
Other languages
English (en)
Other versions
DE3887353T2 (de
Inventor
Thomas Julius Borody
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EXOMED AUSTRALIA Pty Ltd
Capability Services Pty Ltd
Gastro Services Pty Ltd
Ostapat Pty Ltd
Original Assignee
EXOMED AUSTRALIA Pty Ltd
Capability Services Pty Ltd
Gastro Services Pty Ltd
Ostapat Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EXOMED AUSTRALIA Pty Ltd, Capability Services Pty Ltd, Gastro Services Pty Ltd, Ostapat Pty Ltd filed Critical EXOMED AUSTRALIA Pty Ltd
Publication of DE3887353D1 publication Critical patent/DE3887353D1/de
Application granted granted Critical
Publication of DE3887353T2 publication Critical patent/DE3887353T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/245Bismuth; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE88908644T 1987-10-12 1988-09-29 Behandlungsverfahren für magen-darm-krankheiten. Expired - Lifetime DE3887353T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AUPI483887 1987-10-12
AUPI598587 1987-12-18
AUPI751388 1988-03-30
PCT/AU1988/000379 WO1989003219A1 (en) 1987-10-12 1988-09-29 Improved method for treatment of gastrointestinal disorders

Publications (2)

Publication Number Publication Date
DE3887353D1 true DE3887353D1 (de) 1994-03-03
DE3887353T2 DE3887353T2 (de) 1994-05-05

Family

ID=27157393

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88908644T Expired - Lifetime DE3887353T2 (de) 1987-10-12 1988-09-29 Behandlungsverfahren für magen-darm-krankheiten.

Country Status (7)

Country Link
US (2) US5196205A (de)
EP (1) EP0439453B1 (de)
JP (1) JP2733849B2 (de)
CA (1) CA1330759C (de)
DE (1) DE3887353T2 (de)
NZ (1) NZ226437A (de)
WO (1) WO1989003219A1 (de)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU45590A (sh) * 1990-03-07 1992-07-20 PLIVA FARMACEVTSKA, KEMIJSKA, PREHRAMBENA I KOZMETIČKA INDUSTRIJA s.p.o. Novi kompleksi odnosno helati antibiotika s dvovalentnim i/ili trovalentnim metalima i postupci za njihovo dobijanje
GB9010039D0 (en) * 1990-05-03 1990-06-27 Reckitt & Colmann Prod Ltd Medicament preparation
DE69117955T2 (de) * 1990-07-20 1996-09-19 Tillotts Pharma Ag, Ziefen Produkte und verfahren zur behandlung des verdauungskanals
GB9018603D0 (en) * 1990-08-24 1990-10-10 Smith Kline French Lab Compositions
JPH06509340A (ja) * 1991-07-24 1994-10-20 ザ、プロクター、エンド、ギャンブル、カンパニー 抗菌治療方法及び組成物
GB9120131D0 (en) * 1991-09-20 1991-11-06 Glaxo Group Ltd Medicaments
JPH06298611A (ja) * 1993-04-16 1994-10-25 Nippon Chemiphar Co Ltd 抗菌剤
US5478819A (en) * 1993-06-23 1995-12-26 Simo Tarpila Phospholipid composition and use thereof
US5549911A (en) * 1994-01-14 1996-08-27 Laboratoires Des Produits Ethiques Ethypharm Galenic form of 5-nitromidazole derivatives which is effective for the treatment of parasitoses and infections of the entire gastrointestinal tract
TW420610B (en) * 1994-04-07 2001-02-01 Pfizer A pharmaceutical composition for treating a H. pylori infection or gastric or duodenal ulcers
US6902738B2 (en) * 1994-05-02 2005-06-07 Josman Laboratories, Inc. Topical oral dosage forms containing bismuth compounds
US6426085B1 (en) 1994-05-02 2002-07-30 Josman Laboratories Inc. Use of bismuth-containing compounds in topical oral dosage forms for the treatment of halitosis
US5834002A (en) 1994-05-02 1998-11-10 Josman Laboratories, Inc. Chewing gum containing colloidal bismuth subcitrate
DE69620582T2 (de) * 1995-01-26 2002-11-07 Nycomed Imaging As Verwendung von WISMUTVERBINDUNGEN zur Herstellung eines Arzneimittels zur Behandlung von Magenverstimmungen, die durch Helicobacter pylori verursacht werden
GB9501560D0 (en) * 1995-01-26 1995-03-15 Nycomed Imaging As Contrast agents
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
US6379651B1 (en) * 1995-02-07 2002-04-30 Josman Laboratories Oral-topical dosage forms for delivering antibacterials/antibiotics to oral cavity to eradicate H. pylori as a concomitant treatment for peptic ulcers and other gastro-intestinal diseases
AU4596796A (en) * 1995-02-07 1996-08-27 Narayan Krishnarao Athanikar Concomitant treatment with bismuth and antibacterials
US6372784B1 (en) 1995-02-07 2002-04-16 Josman Laboratories, Inc. Bismuth-containing compounds in topical dosage forms for treatment of corneal and dermal wounds
CN1068519C (zh) * 1995-02-14 2001-07-18 中国医学科学院仲瘤医院 一种治疗上消化道溃疡并有效抑制其复发的药物组合物
WO1996035436A1 (en) * 1995-05-09 1996-11-14 The Procter & Gamble Company Compositions comprising bismuth and one or more antimicrobials, for the treatment and prevention of gastrointestinal disorders
JP3767831B2 (ja) * 1995-06-14 2006-04-19 木村 健 ヘリコバクター・ピロリ除菌用組成物
US6132768A (en) * 1995-07-05 2000-10-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Oral pharmaceutical composition with delayed release of active ingredient for reversible proton pump inhibitors
EP0879035B1 (de) * 1995-08-24 2006-06-14 Josman Laboratories, Inc. Bismut enthaltende arzneimittel in topischen darreichungsformen
US5981522A (en) * 1995-09-01 1999-11-09 Kaneka Corporation Treatment of disease caused by infection of Helicobacter
US5744168A (en) * 1995-12-07 1998-04-28 The Procter & Gamble Company Methods and compositions for the prevention and treatment of gastrointestinal disorders
US6051604A (en) * 1995-12-07 2000-04-18 The Proctor & Gamble Company Methods and compositions for the prevention and treatment of gastrointestinal disorders
US5702729A (en) * 1995-12-07 1997-12-30 The Procter & Gamble Company Methods for the prevention and treatment of gastrointestinal disorders caused or mediated by algae or cyanobacteria
US5900410A (en) * 1996-08-27 1999-05-04 Hartmann; John F. Monotherapy of peptic ulcers and gastritis
DE19709897A1 (de) * 1997-03-11 1998-09-17 Hoechst Ag Wismutsalze von Antibiotika der Moenomycin-Gruppe, Verfahren zu ihrer Herstellung, ihre Verwendung und solche Salze enthaltende Arzneimittel
EP0980204A4 (de) * 1997-04-01 2005-06-15 Merieux Oravax 76 kDA, 32 kDa UND 50 kDa HELICOBACTER POLYPEPTIDE UND KORRESPONDIERENDE POLYNUCLEOTID-MOLEKÜLE
US20030124141A1 (en) * 1997-04-01 2003-07-03 Rainer Haas Helicobacter polypeptides and corresponding polynucleotide molecules
US20020026035A1 (en) * 1997-04-01 2002-02-28 Harold Kleanthous Helicobacter ghpo 1360 and ghpo 750 polypeptides and corresponding polynucleotide molecules
US20030158396A1 (en) * 1997-07-29 2003-08-21 Harold Kleanthous Identification of polynucleotides encoding novel helicobacter polypeptides in the helicobacter genome
IT1296980B1 (it) * 1997-12-17 1999-08-03 Istituto Pirri S R L Capsula doppia come forma farmaceutica per la somministrazione di principi attivi in terapie multiple
EP1120100B1 (de) * 1998-10-05 2005-08-17 Kabushiki Kaisha Yakult Honsha Antibakterielle mittel und ein herstellungsverfahren dafür
AU772188B2 (en) 1998-11-17 2004-04-08 Nitromed, Inc. Nitrosated and nitrosylated H2 receptor antagonist compounds, compositions and methods of use
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6677321B1 (en) * 1999-12-09 2004-01-13 Bruce Levin Methods and compositions for treatment of inflammatory disease
US7329412B2 (en) * 2000-12-22 2008-02-12 The Trustees Of Columbia University In The City Of New York Antimicrobial medical devices containing chlorhexidine free base and salt
US6582719B2 (en) 2001-02-02 2003-06-24 The Trustees Of Columbia University In The City Of New York Combinations of antiseptic and antibiotic agents that inhibit the development of resistant microorganisms
US20050192547A1 (en) * 2002-01-31 2005-09-01 Modak Shanta M. Combinations of antiseptic and antibiotic agents containing medical devices
AUPS088702A0 (en) 2002-03-04 2002-03-28 Borody, Thomas Julius Electrolyte purgative
US7670612B2 (en) 2002-04-10 2010-03-02 Innercap Technologies, Inc. Multi-phase, multi-compartment capsular delivery apparatus and methods for using same
EP1552833B1 (de) 2002-10-16 2016-12-28 Takeda Pharmaceutical Company Limited Herstellung eines amorphen, optisch aktiven Isomers von Lansoprazol
PL2361620T3 (pl) 2004-02-06 2016-12-30 Zastosowanie aminosalicylanów w zespole jelita drażliwego z dominującą postacią biegunkową
JP5009152B2 (ja) * 2004-05-28 2012-08-22 サリックス ファーマシューティカルズ, インコーポレイテッド 放射線誘発性腸炎の予防、処置、および回復
US8461187B2 (en) 2004-06-16 2013-06-11 Takeda Pharmaceuticals U.S.A., Inc. Multiple PPI dosage form
US8921344B2 (en) * 2006-11-03 2014-12-30 Salix Pharmaceuticals, Inc. Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives
US7452872B2 (en) * 2005-08-24 2008-11-18 Salix Pharmaceuticals, Inc. Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives
EP2529729A1 (de) * 2005-08-24 2012-12-05 Salix Pharmaceuticals, Inc. Balsazidformulierungen und Herstellung davon
CN100393359C (zh) * 2005-12-13 2008-06-11 济南百诺医药科技开发有限公司 根除幽门螺旋杆菌的多单元组合物
US9981069B2 (en) 2007-06-20 2018-05-29 The Trustees Of Columbia University In The City Of New York Bio-film resistant surfaces
JP5629581B2 (ja) 2007-10-12 2014-11-19 タケダ ファーマシューティカルズ ユー.エス.エー. インコーポレイティド 食物の摂取から独立した消化器疾患の治療方法
TWI463998B (zh) * 2009-12-31 2014-12-11 Synmosa Biopharma Corp Amoxicillin and clomycin have a high absorption rate of pharmaceutical ingredients
SI3564357T1 (sl) 2010-02-01 2022-09-30 Rebiotix, Inc. Bakterioterapija Clostridium Difficile colitisa
MX358142B (es) 2010-04-26 2018-08-06 Salix Pharmaceuticals Ltd Formulaciones y usos del derivado del ácido 2 - hidroxi -5 - fenilazobenzóico para el tratamiento de varones.
CA2821196C (en) 2010-12-13 2022-11-22 Thomas Julius Borody Gastric and colonic formulations and methods for making and using them
US20120232040A1 (en) * 2011-03-07 2012-09-13 Yen-Hsu Chen Medication for clinical extensively-drug resistant acinetobacter baumannii
EP2601947A1 (de) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Kombinationspräparat mit fester Dosierung zur Behandlung von Erkrankungen einhergehend mit Helicobacter pylori
TR201904884T4 (tr) 2012-07-27 2019-05-21 Redhill Biopharma Ltd Koloni̇k boşaltmada kullanima yöneli̇k formülasyonlar ve formülasyonlarin üreti̇m yöntemleri̇
US8906668B2 (en) 2012-11-23 2014-12-09 Seres Health, Inc. Synergistic bacterial compositions and methods of production and use thereof
EP2951283A4 (de) 2013-02-04 2017-01-25 Seres Therapeutics, Inc. Zusammensetzungen und verfahren
KR102222273B1 (ko) 2013-02-04 2021-03-08 세레스 테라퓨틱스, 인코포레이티드 조성물 및 방법
AU2014232370B2 (en) 2013-03-15 2018-11-01 Seres Therapeutics, Inc. Network-based microbial compositions and methods
US9694039B2 (en) 2013-06-05 2017-07-04 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US9511100B2 (en) 2013-06-05 2016-12-06 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US10383901B2 (en) 2013-06-05 2019-08-20 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
KR102093537B1 (ko) 2013-06-05 2020-04-23 리바이오틱스, 인코퍼레이티드 미생물상 복원 요법(mrt), 조성물 및 제조방법
US9782445B2 (en) 2013-06-05 2017-10-10 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US9511099B2 (en) 2013-06-05 2016-12-06 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
KR102379658B1 (ko) 2013-11-25 2022-03-28 세레스 테라퓨틱스, 인코포레이티드 상승적 박테리아 조성물 및 그것의 생산 방법 및 용도
US9956282B2 (en) 2013-12-16 2018-05-01 Seres Therapeutics, Inc. Bacterial compositions and methods of use thereof for treatment of immune system disorders
BR112017026586B1 (pt) 2015-06-09 2021-11-03 Rebiotix, Inc. Composições de terapia de restauração de microbiota (mrt) e métodos de fabricação
US10828340B2 (en) 2015-06-09 2020-11-10 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
US10799539B2 (en) 2015-06-09 2020-10-13 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
US10905726B2 (en) 2015-06-09 2021-02-02 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
EP3668527A1 (de) 2017-08-14 2020-06-24 Seres Therapeutics, Inc. Zusammensetzungen und verfahren zur behandlung von cholestase

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4084168A (en) * 1968-07-18 1970-01-22 Masti-Kure Products Co. Inc Antibiotic compositions for enhanced efficacy containing zirconium
FR2053002A1 (en) * 1969-06-21 1971-04-16 Clin Midy Bismuth slats of alpha methiminobenzyl - penicillin
DE1963496A1 (de) * 1969-12-18 1971-06-24 Hans Voigt Chemisch Pharmazeut Pharmazeutisches Praeparat zur Behandlung von Magen-Darm-Erkrankungen
CH638975A5 (fr) * 1979-07-27 1983-10-31 Prebuilt Ets Composition medicamenteuse pour le traitement des ulceres gastro-duodenaux.
US4535081A (en) * 1979-11-23 1985-08-13 Pfizer Inc. Antiallergic and antiulcer 1-oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides and intermediates therefor
EP0222834A4 (de) * 1985-04-18 1989-10-04 Borody Thomas J Behandlung von nichtulcerativer dyspepsia mit wismutsalzen.
DE3686362T2 (de) * 1985-06-13 1993-02-11 Marshall Barry James Verfahren zur behandlung von magen-darmstoerungen.
EP0462631B1 (de) * 1985-06-13 1996-03-20 Barry James Dr. Marshall Verfahren und Zusammensetzungen zur Behandlung von gastrointestinalen Störungen
EP0264883A3 (de) * 1986-10-21 1990-04-04 Banyu Pharmaceutical Co., Ltd. Substituierte Pyridinderivate
US4935406A (en) * 1988-09-20 1990-06-19 Marion Laboratories, Inc. Use of bismuth (phosph/sulf)ated saccharides against Camplyobacter-associated gastrointestinal disorders

Also Published As

Publication number Publication date
JPH03503404A (ja) 1991-08-01
US5476669A (en) 1995-12-19
EP0439453A1 (de) 1991-08-07
JP2733849B2 (ja) 1998-03-30
EP0439453B1 (de) 1994-01-19
WO1989003219A1 (en) 1989-04-20
DE3887353T2 (de) 1994-05-05
US5196205A (en) 1993-03-23
EP0439453A4 (de) 1991-02-15
NZ226437A (en) 1991-03-26
CA1330759C (en) 1994-07-19

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