DE3887338D1 - Superaktive menschliche insulin-analoge. - Google Patents

Superaktive menschliche insulin-analoge.

Info

Publication number
DE3887338D1
DE3887338D1 DE88906597T DE3887338T DE3887338D1 DE 3887338 D1 DE3887338 D1 DE 3887338D1 DE 88906597 T DE88906597 T DE 88906597T DE 3887338 T DE3887338 T DE 3887338T DE 3887338 D1 DE3887338 D1 DE 3887338D1
Authority
DE
Germany
Prior art keywords
human insulin
insulin analogs
superactive
superactive human
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88906597T
Other languages
English (en)
Other versions
DE3887338T2 (de
Inventor
Panayotis Katsoyannis
Gerald Schwartz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icahn School of Medicine at Mount Sinai
Original Assignee
Mount Sinai School of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mount Sinai School of Medicine filed Critical Mount Sinai School of Medicine
Application granted granted Critical
Publication of DE3887338D1 publication Critical patent/DE3887338D1/de
Publication of DE3887338T2 publication Critical patent/DE3887338T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE88906597T 1987-07-17 1988-07-07 Superaktive menschliche insulin-analoge. Expired - Fee Related DE3887338T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/074,558 US4992418A (en) 1987-07-17 1987-07-17 Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
PCT/US1988/002289 WO1989000580A1 (en) 1987-07-17 1988-07-07 Superactive human insulin analogues

Publications (2)

Publication Number Publication Date
DE3887338D1 true DE3887338D1 (de) 1994-03-03
DE3887338T2 DE3887338T2 (de) 1994-05-05

Family

ID=22120214

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88906597T Expired - Fee Related DE3887338T2 (de) 1987-07-17 1988-07-07 Superaktive menschliche insulin-analoge.

Country Status (10)

Country Link
US (1) US4992418A (de)
EP (1) EP0382732B1 (de)
JP (1) JP2729498B2 (de)
KR (1) KR970009353B1 (de)
AU (1) AU616131B2 (de)
DE (1) DE3887338T2 (de)
DK (1) DK13990D0 (de)
FI (1) FI98731C (de)
HU (1) HU205145B (de)
WO (1) WO1989000580A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE101620T1 (de) * 1988-06-23 1994-03-15 Hoechst Ag Mini-proinsulin, seine herstellung und verwendung.
WO1992020367A1 (en) * 1991-05-24 1992-11-26 Amylin Pharmaceuticals, Inc. Treatment of anorexia and related states
CA2071382A1 (en) * 1991-06-21 1992-12-22 David N. Brems Insulin analogs
TW224471B (de) * 1991-11-26 1994-06-01 Lilly Co Eli
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
WO2002101074A2 (en) * 2001-06-08 2002-12-19 Boehringer Ingelheim Pharmaceuticals, Inc. Nucleic acid constructs useful for glucose regulated production of human insulin in somatic cell lines
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US7396936B1 (en) 2004-11-09 2008-07-08 Kemia, Inc. Modulators of calcitonin and amylin receptor activity
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
EP2074140B8 (de) 2006-10-04 2015-10-28 Case Western Reserve University Fibrillationsresistentes insulin und insulinanaloga
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
US8354435B2 (en) 2008-09-08 2013-01-15 The Board Of Trustees Of The Leland Stanford Junior University Modulators of aldehyde dehydrogenase activity and methods of use thereof
JP2012506856A (ja) 2008-10-28 2012-03-22 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ アルデヒドデヒドロゲナーゼのモジュレーターおよびその使用方法
WO2012149106A1 (en) 2011-04-29 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
EP2771026A4 (de) * 2011-10-27 2015-08-05 Univ Case Western Reserve Ultrakonzentrierte und schnell wirkende insulinanalogformulierungen
EP2970124B1 (de) 2013-03-14 2019-05-22 The Board of Trustees of the Leland Stanford Junior University Mitochondriale aldehyd-dehydrogenase-2-modulatoren und verfahren zur verwendung davon

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3420810A (en) * 1966-10-25 1969-01-07 Atomic Energy Commission Process for joining the a and b chains of insulin
DE2252157C3 (de) * 1972-10-25 1976-03-18 Hoechst Ag Zwischenprodukte zur herstellung von insulin, insulin-analogen und -derivaten und verfahren zur herstellung von insulin, insulin analogen und derivaten
DE2253327A1 (de) * 1972-10-31 1974-05-09 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
DD153829A1 (de) * 1979-08-09 1982-02-03 Guenter Losse Verfahren zur herstellung neuartiger hybridinsuline mit insulinaehnlicher wirkung
US4421685A (en) * 1980-03-27 1983-12-20 Eli Lilly And Company Process for producing an insulin
US4430266A (en) * 1980-11-28 1984-02-07 Eli Lilly And Company Process for producing an insulin precursor
DOP1982004086A (es) * 1981-08-27 1988-03-22 Lilly Co Eli Formula farmaceutica que comprende insulina humana y proinsulina humana
US4652548A (en) * 1981-08-27 1987-03-24 Eli Lilly And Company Pharmaceutical formulations comprising human insulin, human C-peptide, and human proinsulin
US4459226A (en) * 1982-02-26 1984-07-10 Eli Lilly And Company Process for recovering insulin
ATE37983T1 (de) * 1982-04-22 1988-11-15 Ici Plc Mittel mit verzoegerter freigabe.
US4569792A (en) * 1984-06-14 1986-02-11 Eli Lilly And Company Anti-diabetic compounds
US4569791A (en) * 1984-06-14 1986-02-11 Eli Lilly And Company Anti-diabetic compounds
US4581165A (en) * 1984-06-14 1986-04-08 Eli Lilly And Company Anti-diabetic compounds
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation

Also Published As

Publication number Publication date
KR920700227A (ko) 1992-02-19
AU2126988A (en) 1989-02-13
WO1989000580A1 (en) 1989-01-26
US4992418A (en) 1991-02-12
KR970009353B1 (ko) 1997-06-10
DK13990A (da) 1990-01-17
AU616131B2 (en) 1991-10-17
JP2729498B2 (ja) 1998-03-18
FI98731B (fi) 1997-04-30
HUT54178A (en) 1991-01-28
EP0382732A1 (de) 1990-08-22
HU205145B (en) 1992-03-30
DE3887338T2 (de) 1994-05-05
EP0382732B1 (de) 1994-01-19
JPH02504274A (ja) 1990-12-06
DK13990D0 (da) 1990-01-17
FI900249A0 (fi) 1990-01-16
FI98731C (fi) 1997-08-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee