DE3886760D1 - Monoklonale antikörper gegen menschliche interleukin-4 und die sie erzeugenden hybridomen. - Google Patents
Monoklonale antikörper gegen menschliche interleukin-4 und die sie erzeugenden hybridomen.Info
- Publication number
- DE3886760D1 DE3886760D1 DE88910302T DE3886760T DE3886760D1 DE 3886760 D1 DE3886760 D1 DE 3886760D1 DE 88910302 T DE88910302 T DE 88910302T DE 3886760 T DE3886760 T DE 3886760T DE 3886760 D1 DE3886760 D1 DE 3886760D1
- Authority
- DE
- Germany
- Prior art keywords
- hybridomes
- generate
- monoclonal antibodies
- antibodies against
- against human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/247—IL-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/113,623 US5041381A (en) | 1986-07-03 | 1987-10-26 | Monoclonal antibodies against human interleukin-4 and hybridomas producing the same |
PCT/US1988/003631 WO1989003846A2 (en) | 1987-10-26 | 1988-10-21 | Monoclonal antibodies against human interleukin-4 and hybridomas producing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3886760D1 true DE3886760D1 (de) | 1994-02-10 |
DE3886760T2 DE3886760T2 (de) | 1994-09-08 |
Family
ID=22350540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3886760T Expired - Fee Related DE3886760T2 (de) | 1987-10-26 | 1988-10-21 | Monoklonale antikörper gegen menschliche interleukin-4 und die sie erzeugenden hybridomen. |
Country Status (18)
Country | Link |
---|---|
US (1) | US5041381A (de) |
EP (2) | EP0314402A3 (de) |
JP (1) | JPH0698020B2 (de) |
KR (1) | KR930008112B1 (de) |
CN (2) | CN1032816A (de) |
AU (1) | AU611750B2 (de) |
CA (1) | CA1335653C (de) |
DE (1) | DE3886760T2 (de) |
DK (1) | DK169627B1 (de) |
ES (1) | ES2061736T3 (de) |
HK (1) | HK105996A (de) |
IE (1) | IE62491B1 (de) |
IL (1) | IL88145A0 (de) |
MY (1) | MY108526A (de) |
NZ (1) | NZ226692A (de) |
PT (1) | PT88847B (de) |
WO (1) | WO1989003846A2 (de) |
ZA (1) | ZA887987B (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5700915A (en) * | 1985-11-19 | 1997-12-23 | Schering Corporations | Human interleukin immunopurification processes |
HU211059B (en) * | 1988-02-02 | 1995-10-30 | Schering Biotech Corp | Method for producing pharmaceutical compositions usable for reducing immunglobulin e responses, containing human il-4 antibodies |
EP0506855A1 (de) * | 1989-12-15 | 1992-10-07 | Chiron Corporation | Cytokin-antikörper zur behandlung von sepsis |
GB8928501D0 (en) * | 1989-12-18 | 1990-02-21 | Unilever Plc | Reagents |
CA2071908C (en) * | 1989-12-20 | 2002-04-30 | Lata Ramanathan | Antibody antagonists of human interleukin-4 |
US5132109A (en) * | 1990-10-05 | 1992-07-21 | Ludwig Institute For Cancer Research | Method for inhibiting production of ige and method for enhancing production of igg using interleukin 9 and inhibitors thereof |
DE4137333A1 (de) * | 1991-11-13 | 1993-05-19 | W Prof Dr Sebald | Therapeutische mittel, die antagonisten oder partielle agonisten des humanen interleukin 4 sind oder diese enthalten, hil-4-mutantenproteine sowie vefahren zu deren herstellung |
ATE171472T1 (de) * | 1992-02-19 | 1998-10-15 | Schering Corp | Klonierung und expression von humanisierten monoklonalen antikörpern gegen menschliches interleukin-4 |
US5714146A (en) * | 1992-08-26 | 1998-02-03 | Board Of Regents Of The University Of Washington | IL-4 bone therapy |
US5928904A (en) * | 1993-09-07 | 1999-07-27 | Smithkline Beecham Corporation | DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
US5914110A (en) * | 1993-09-07 | 1999-06-22 | Smithkline Beecham Corporation | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
ATE286510T1 (de) * | 1993-09-07 | 2005-01-15 | Smithkline Beecham Corp | In der behandlung von il4 auslösenden krankheiten nützliche rekombinante il4 antikörper |
US20020193575A1 (en) * | 1993-09-07 | 2002-12-19 | Smithkline Beecham P.L.C. | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
US5959085A (en) * | 1993-11-23 | 1999-09-28 | Schering Corporation | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
EP0659766A1 (de) * | 1993-11-23 | 1995-06-28 | Schering-Plough | Menschliche Monoklonalantikörper gegen menschliche Cytokine und Verfahren zur Herstellung dieser Antikörper |
WO1995021942A1 (en) * | 1994-02-15 | 1995-08-17 | T Cell Diagnostics, Inc. | Immunoassay kit comprising universal reagents |
US5597710A (en) * | 1994-03-10 | 1997-01-28 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
US5705154A (en) * | 1995-03-08 | 1998-01-06 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
AUPN481295A0 (en) * | 1995-08-16 | 1995-09-07 | Medvet Science Pty. Ltd. | Agonists of haemopoietic growth factors |
US20020090682A1 (en) * | 1995-10-23 | 2002-07-11 | Tracy Willson | Novel haemopoietin receptor and genetic sequences encoding same |
EP3190126A1 (de) | 2000-05-26 | 2017-07-12 | Immunex Corporation | Verwendung von interleukin-4 rezeptor (il-4r) antikörpern und zusammensetzungen davon |
GB0210535D0 (en) * | 2002-05-08 | 2002-06-19 | Novartis Ag | Organic compounds |
JP2004045384A (ja) * | 2002-05-22 | 2004-02-12 | Matsushita Electric Ind Co Ltd | 免疫学的測定方法、免疫学的測定装置、生体成分測定用トイレ、抗アルブミンモノクローナル抗体、それを産生する細胞株、およびアルブミン検出キット |
US20070104710A1 (en) * | 2002-06-28 | 2007-05-10 | Domants Limited | Ligand that has binding specificity for IL-4 and/or IL-13 |
US20110223168A1 (en) * | 2002-12-27 | 2011-09-15 | Greg Winter | Ligand that has binding specificity for il-4 and/or il-13 |
AR050044A1 (es) * | 2004-08-03 | 2006-09-20 | Novartis Ag | Anticuerpo especifico de il-4 |
US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
GB0807214D0 (en) * | 2008-04-21 | 2008-05-28 | Belfast Health And Social Care | Biomarkers |
GB201210587D0 (en) * | 2012-06-14 | 2012-08-01 | Belfast Health And Social Care Trust | Predictive biomarker |
GB201210571D0 (en) * | 2012-06-14 | 2012-08-01 | Belfast Health And Social Care Trust | Predictive biomarker |
CN103421747B (zh) * | 2013-09-09 | 2015-01-07 | 扬州大学 | 分泌牛il-4单克隆抗体的杂交瘤细胞株、其单克隆抗体及其应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4255329A (en) | 1973-10-02 | 1981-03-10 | Syva Company | Double receptor fluorescent immunoassay |
US4342832A (en) | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
US4431739A (en) * | 1979-11-05 | 1984-02-14 | Genentech, Inc. | Transformant bacterial culture capable of expressing heterologous protein |
US4423147A (en) | 1980-04-11 | 1983-12-27 | Secher David S | Monoclonal antibody to interferon-α |
EP0043342B1 (de) | 1980-06-20 | 1983-12-07 | Battelle Memorial Institute | Verfahren zur Delignifizierung von Holz und anderen Lignocellulosematerialien |
US4486530A (en) | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
US4355023A (en) | 1980-09-30 | 1982-10-19 | The Massachusetts General Hospital | Antibody fragment compositions and process |
US4599308A (en) | 1981-10-06 | 1986-07-08 | Hamer Dean H | Protein from SV40 recombinants |
US4470925A (en) | 1982-05-05 | 1984-09-11 | E. I. Du Pont De Nemours And Company | Immunoglobulin half-molecules and process for producing hybrid antibodies |
US4474493A (en) | 1982-09-09 | 1984-10-02 | Modular Systems, Inc. | Dowel fastener and joints including same |
WO1985001209A1 (en) | 1983-09-15 | 1985-03-28 | University Of Bath | Disinfection of contact lenses |
US4731237A (en) | 1983-11-07 | 1988-03-15 | The Wistar Institute | Immune response to virus induced by anti-idiotype antibodies |
ATE81722T1 (de) | 1984-07-24 | 1992-11-15 | Coselco Mimotopes Pty Ltd | Verfahren zur bestimmung von mimotopen. |
US4562003A (en) | 1984-10-26 | 1985-12-31 | California Biotechnology, Inc. | Monoclonal antibodies against alveolar surfactant protein |
DE3663030D1 (en) | 1985-02-07 | 1989-06-01 | Kowa Co | Monoclonal antibodies to tissue plasminogen activator derived from human normal cells |
WO1986006487A1 (en) | 1985-04-22 | 1986-11-06 | Commonwealth Serum Laboratories Commission | Method for determining mimotopes |
PT83761B (pt) * | 1985-11-19 | 1989-06-30 | Schering Biotech Corp | Metodo para a producao de interleuquina-4 de mamifero |
-
1987
- 1987-10-26 US US07/113,623 patent/US5041381A/en not_active Expired - Lifetime
-
1988
- 1988-10-21 EP EP88309926A patent/EP0314402A3/de active Pending
- 1988-10-21 ES ES88910302T patent/ES2061736T3/es not_active Expired - Lifetime
- 1988-10-21 EP EP88910302A patent/EP0375743B1/de not_active Expired - Lifetime
- 1988-10-21 AU AU27827/89A patent/AU611750B2/en not_active Ceased
- 1988-10-21 JP JP63509356A patent/JPH0698020B2/ja not_active Expired - Lifetime
- 1988-10-21 DE DE3886760T patent/DE3886760T2/de not_active Expired - Fee Related
- 1988-10-21 KR KR1019890701139A patent/KR930008112B1/ko not_active IP Right Cessation
- 1988-10-21 WO PCT/US1988/003631 patent/WO1989003846A2/en active IP Right Grant
- 1988-10-25 ZA ZA887987A patent/ZA887987B/xx unknown
- 1988-10-25 PT PT88847A patent/PT88847B/pt not_active IP Right Cessation
- 1988-10-25 IL IL88145A patent/IL88145A0/xx not_active IP Right Cessation
- 1988-10-25 IE IE321388A patent/IE62491B1/en not_active IP Right Cessation
- 1988-10-25 CA CA000581117A patent/CA1335653C/en not_active Expired - Fee Related
- 1988-10-25 MY MYPI88001210A patent/MY108526A/en unknown
- 1988-10-25 NZ NZ226692A patent/NZ226692A/en unknown
- 1988-10-26 CN CN88107357A patent/CN1032816A/zh active Pending
-
1990
- 1990-04-25 DK DK101890A patent/DK169627B1/da not_active IP Right Cessation
-
1996
- 1996-03-23 CN CN96103790A patent/CN1176391A/zh active Pending
- 1996-06-19 HK HK105996A patent/HK105996A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1989003846A2 (en) | 1989-05-05 |
IL88145A0 (en) | 1989-06-30 |
JPH0698020B2 (ja) | 1994-12-07 |
CA1335653C (en) | 1995-05-23 |
EP0314402A2 (de) | 1989-05-03 |
JPH03503118A (ja) | 1991-07-18 |
DK169627B1 (da) | 1994-12-27 |
EP0375743A1 (de) | 1990-07-04 |
CN1176391A (zh) | 1998-03-18 |
CN1032816A (zh) | 1989-05-10 |
WO1989003846A3 (en) | 1989-05-18 |
ES2061736T3 (es) | 1994-12-16 |
DK101890D0 (da) | 1990-04-25 |
HK105996A (en) | 1996-06-28 |
US5041381A (en) | 1991-08-20 |
AU611750B2 (en) | 1991-06-20 |
IE883213L (en) | 1989-04-26 |
DK101890A (da) | 1990-04-25 |
AU2782789A (en) | 1989-05-23 |
PT88847B (pt) | 1993-01-29 |
DE3886760T2 (de) | 1994-09-08 |
IE62491B1 (en) | 1995-02-08 |
MY108526A (en) | 1996-10-31 |
EP0375743B1 (de) | 1993-12-29 |
KR930008112B1 (ko) | 1993-08-26 |
EP0314402A3 (de) | 1989-06-07 |
KR890701632A (ko) | 1989-12-21 |
ZA887987B (en) | 1990-06-27 |
NZ226692A (en) | 1991-06-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8370 | Indication related to discontinuation of the patent is to be deleted | ||
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: SCHERING CORP., KENILWORTH, N.J., US |
|
8339 | Ceased/non-payment of the annual fee |