DE3881024D1 - Verfahren zur herstellung von tetracyclin. - Google Patents

Verfahren zur herstellung von tetracyclin.

Info

Publication number
DE3881024D1
DE3881024D1 DE8888908310T DE3881024T DE3881024D1 DE 3881024 D1 DE3881024 D1 DE 3881024D1 DE 8888908310 T DE8888908310 T DE 8888908310T DE 3881024 T DE3881024 T DE 3881024T DE 3881024 D1 DE3881024 D1 DE 3881024D1
Authority
DE
Germany
Prior art keywords
pct
formula
image
acid addition
date
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888908310T
Other languages
English (en)
Other versions
DE3881024T2 (de
Inventor
Erzsebet Szalay
Gyoergy Lugosi
U Kallay
Zsuzsanna Nad
Istvan Jelinek
Vilmos Simonidesz
Peter Gyori
Lajos Nagy
Marta Lugosi
Singola Ilona Santane
Gabor Besenyi
Laszlo Simandi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of DE3881024D1 publication Critical patent/DE3881024D1/de
Application granted granted Critical
Publication of DE3881024T2 publication Critical patent/DE3881024T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8888908310T 1987-09-18 1988-09-16 Verfahren zur herstellung von tetracyclin. Expired - Fee Related DE3881024T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU874164A HU198173B (en) 1987-09-18 1987-09-18 Process for producing doxycycline
PCT/HU1988/000063 WO1989002429A1 (en) 1987-09-18 1988-09-16 Improved process for the preparation of tetracycline derivatives

Publications (2)

Publication Number Publication Date
DE3881024D1 true DE3881024D1 (de) 1993-06-17
DE3881024T2 DE3881024T2 (de) 1993-08-19

Family

ID=10967162

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888908310T Expired - Fee Related DE3881024T2 (de) 1987-09-18 1988-09-16 Verfahren zur herstellung von tetracyclin.

Country Status (9)

Country Link
US (1) US4960913A (de)
EP (1) EP0331708B1 (de)
JP (1) JPH02501223A (de)
KR (1) KR890701546A (de)
AT (1) ATE89265T1 (de)
DE (1) DE3881024T2 (de)
HU (1) HU198173B (de)
RU (2) RU2057747C1 (de)
WO (1) WO1989002429A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US7919483B2 (en) * 2005-06-24 2011-04-05 Medicis Pharmaceutical Corporation Method for the treatment of acne
US20080242642A1 (en) 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080241235A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7544373B2 (en) * 2007-04-02 2009-06-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8252776B2 (en) 2007-04-02 2012-08-28 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7541347B2 (en) * 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US20080241197A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline dosage forms for the treatment of acne
DE102007034259A1 (de) 2007-07-20 2009-01-22 Otto-Von-Guericke-Universität Magdeburg Medizinische Fakultät Verfahren zur Synthese von A-Ring-aromatisierten Acetyl-Minocyclinen
WO2010017310A1 (en) 2008-08-06 2010-02-11 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
CN102086165B (zh) * 2010-12-29 2013-06-19 开封制药(集团)有限公司 Pd催化剂在生产强力霉素氢化工艺中的应用
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
CA2846083A1 (en) 2011-09-15 2013-03-21 Genentech, Inc. Methods of promoting differentiation
CN105152961B (zh) * 2015-08-31 2017-07-11 河南师范大学 一种强力霉素中间体6‑次甲基土霉素的合成方法
CN109134291B (zh) * 2017-06-19 2021-04-16 河南后羿制药有限公司 一种盐酸多西环素的制备方法和由此方法制备的盐酸多西环素
CN108440329A (zh) * 2018-02-27 2018-08-24 河南师范大学 一种绿色高效合成盐酸多西环素的方法
CN116768748B (zh) * 2023-08-18 2024-01-26 山东国邦药业有限公司 一种美他环素对甲苯磺酸盐的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3444198A (en) * 1967-02-13 1969-05-13 Pfizer & Co C Process for producing alpha-6-deoxytetracyclines
US4066694A (en) * 1971-02-09 1978-01-03 Pfizer Inc. 4-hydroxy-4-dedimethylamino-tetracyclines
US4061676A (en) * 1970-07-03 1977-12-06 Ivan Villax Recovery of doxycycline and products thereof
GB1456369A (en) * 1972-11-30 1976-11-24 Stamicarbon Catalyst preparation
HU167250B (de) * 1973-06-08 1975-09-27
HU168073B (de) * 1973-12-19 1976-02-28
LU76107A1 (de) * 1976-10-29 1978-05-16
US4743699A (en) * 1982-01-19 1988-05-10 Plurichemie Anstalt Homogeneous catalytic system and a process for the preparation of same
PT76061A (en) * 1982-12-30 1983-01-01 Stable homogeneous hydrogenation rhodium catalyst - useful in high yield prodn. of doxycycline by stereospecific hydrogenation
FI67210C (fi) * 1982-05-21 1985-02-11 Suomen Laeaeketehdas Oy Salco Foerfarande foer framstaellning av alfa-6-deoxi-tetracyklin
DK386784A (da) * 1983-08-17 1985-02-18 Hovione Int Ltd Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner
US4902447A (en) * 1988-10-28 1990-02-20 Ranbaxy Laboratories Limited Process for the production of alpha-6-deoxytetracyclines and hydrogenation catalyst useful therein

Also Published As

Publication number Publication date
KR890701546A (ko) 1989-12-20
WO1989002429A1 (en) 1989-03-23
RU1830065C (ru) 1993-07-23
ATE89265T1 (de) 1993-05-15
HU198173B (en) 1989-08-28
RU2057747C1 (ru) 1996-04-10
US4960913A (en) 1990-10-02
EP0331708A1 (de) 1989-09-13
JPH02501223A (ja) 1990-04-26
EP0331708B1 (de) 1993-05-12
DE3881024T2 (de) 1993-08-19

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee