ES2069892T3 - Complejos de ciclopentadienilcarbonilo-99mtc, procedimiento para su preparacion asi como su utilizacion en el diagnostico. - Google Patents

Complejos de ciclopentadienilcarbonilo-99mtc, procedimiento para su preparacion asi como su utilizacion en el diagnostico.

Info

Publication number
ES2069892T3
ES2069892T3 ES91910279T ES91910279T ES2069892T3 ES 2069892 T3 ES2069892 T3 ES 2069892T3 ES 91910279 T ES91910279 T ES 91910279T ES 91910279 T ES91910279 T ES 91910279T ES 2069892 T3 ES2069892 T3 ES 2069892T3
Authority
ES
Spain
Prior art keywords
complexes
pct
diagnosis
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91910279T
Other languages
English (en)
Inventor
Martin Wenzel
Paul-Eberhardt Schulze
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Institut fuer Diagnostikforschung GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut fuer Diagnostikforschung GmbH filed Critical Institut fuer Diagnostikforschung GmbH
Application granted granted Critical
Publication of ES2069892T3 publication Critical patent/ES2069892T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0487—Metallocenes, i.e. complexes based on a radioactive metal complexed by two cyclopentadienyl anions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

LA INVENCION CONCIERNE A COMPLEJOS 99MTC DE CICLOPENTADIENILCARBONILO DE LA FORMULA GENERAL (I), EN DONDE XR PUEDE TENER DIVERSOS SIGNIFICADOS. ESTOS NUEVOS COMPLEJOS DEL TECNECIO 99M SE PUEDEN APLICAR EN EL SECTOR DEL DIAGNOSTICO MEDICO. ADEMAS, LA INVENCION CONCIERNE A UN PROCEDIMIENTO PARA LA OBTENCION DE LOS COMPLEJOS DE LA INVENCION.
ES91910279T 1990-06-01 1991-05-31 Complejos de ciclopentadienilcarbonilo-99mtc, procedimiento para su preparacion asi como su utilizacion en el diagnostico. Expired - Lifetime ES2069892T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4018172 1990-06-01
DE4028867 1990-09-08

Publications (1)

Publication Number Publication Date
ES2069892T3 true ES2069892T3 (es) 1995-05-16

Family

ID=25893909

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91910279T Expired - Lifetime ES2069892T3 (es) 1990-06-01 1991-05-31 Complejos de ciclopentadienilcarbonilo-99mtc, procedimiento para su preparacion asi como su utilizacion en el diagnostico.

Country Status (10)

Country Link
US (1) US5538712A (es)
EP (1) EP0532566B1 (es)
JP (1) JPH06501450A (es)
AT (1) ATE119539T1 (es)
CA (1) CA2084315A1 (es)
DE (1) DE59104905D1 (es)
DK (1) DK0532566T3 (es)
ES (1) ES2069892T3 (es)
GR (1) GR3015362T3 (es)
WO (1) WO1991018908A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808091A (en) * 1991-10-29 1998-09-15 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia localizing moiety
US6359120B1 (en) 1991-10-29 2002-03-19 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia-localizing moiety
DE4313670A1 (de) * 1993-04-22 1994-10-27 Diagnostikforschung Inst Radioaktive Metallocen-carbonsäuren und deren Homologe zur Proteinmarkierung
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
US5700446A (en) * 1996-06-13 1997-12-23 Neuro Imaging Technologies, Llc Synthesis of ferrocenyl phenyltropane analogs and their radio-transformation to technetium neuroprobes for mapping monoamine reuptake sites
RU2125017C1 (ru) * 1997-07-02 1999-01-20 Научно-производственное объединение "Радиевый институт им.В.Г.Хлопина" Способ получения водорастворимых карбонильных комплексов короткоживущих технеция (1) и рения (1)
EP1233968A2 (en) * 1999-12-03 2002-08-28 Yale University Transition metal-cyclopentadienyl-tropane conjugates
EP1490114A1 (en) * 2002-04-01 2004-12-29 Biostream, Inc. Pendant fatty acid imaging agents
JP2008512360A (ja) * 2004-09-07 2008-04-24 トライアンフ，オペレーティング アズ ア ジョイント ヴェンチャー バイ ザ ガバナーズ オブ ザ ユニバーシティ オブ アルバータ，ザ ユニバーシティ オブ ブリティッシュ コロンビア，カールトン 放射性同位体でラベル化された糖−金属錯体の合成方法
CA2593256A1 (en) * 2005-01-05 2006-07-13 Board Of Regents, The University Of Texas System Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
CN101654465B (zh) * 2009-09-11 2012-10-03 兰州大学 一种羰基锝标记的2-硝基咪唑配合物及其制备方法与用途
CN102311459B (zh) * 2011-06-03 2014-06-25 北京师范大学 新型锝-99m标记的高级脂肪酸衍生物
CN103435655B (zh) * 2013-08-06 2016-04-06 北京师范大学 结合σ1受体的三羰基环戊二烯类配体化合物、其制备方法及应用
CN103772440B (zh) * 2014-01-10 2017-02-15 北京师范大学 一种锝‑99m标记的高级脂肪酸衍生物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3028404A (en) * 1958-11-03 1962-04-03 Ethyl Corp Manufacture of cyclopentadienyl metal carbonyl compounds
DE2246460A1 (de) * 1972-09-21 1974-04-04 Schering Ag Metallocene und metallocen-derivate mit radioaktivem zentralatom
DE3218859A1 (de) * 1982-05-15 1983-11-17 Wenzel, Martin, Prof. Dr., 1000 Berlin Amin-derivate des ruthenocens und ferrocens als radiopharmaka
DE3244886A1 (de) * 1982-12-01 1984-06-07 Byk-Mallinckrodt Cil B.V., Petten Metallocen-derivate der aminosaeuren glycin und alanin mit radioaktivem zentralatom als radiopharmaka.
DE3523262A1 (de) * 1984-12-12 1987-01-08 Martin Prof Dr Wenzel Metallocen-derivate fuer die diagnostik des gehirns und anderer organe
DE3445782A1 (de) * 1984-12-12 1986-06-12 Martin Prof. Dr. 1000 Berlin Wenzel Metallocen-derivate zur gehirn- und lungendiagnostik
US4765971A (en) * 1985-05-31 1988-08-23 Mallinckrodt, Inc. Technetium (Tc-99m)-arene complexes useful in myocardial imaging
AU1966188A (en) * 1987-08-07 1989-03-09 Mallinckrodt, Inc. Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound

Also Published As

Publication number Publication date
WO1991018908A1 (de) 1991-12-12
CA2084315A1 (en) 1991-12-02
ATE119539T1 (de) 1995-03-15
US5538712A (en) 1996-07-23
EP0532566B1 (de) 1995-03-08
GR3015362T3 (en) 1995-06-30
DK0532566T3 (da) 1995-07-31
EP0532566A1 (de) 1993-03-24
JPH06501450A (ja) 1994-02-17
DE59104905D1 (de) 1995-04-13

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