DE3878994D1 - Kovalente kupplung von antikoagulantien und dergleichen an biomaterialien. - Google Patents

Kovalente kupplung von antikoagulantien und dergleichen an biomaterialien.

Info

Publication number
DE3878994D1
DE3878994D1 DE8888201177T DE3878994T DE3878994D1 DE 3878994 D1 DE3878994 D1 DE 3878994D1 DE 8888201177 T DE8888201177 T DE 8888201177T DE 3878994 T DE3878994 T DE 3878994T DE 3878994 D1 DE3878994 D1 DE 3878994D1
Authority
DE
Germany
Prior art keywords
coagulants
biomaterials
covalent coupling
covalent
coupling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888201177T
Other languages
English (en)
Other versions
DE3878994T2 (de
Inventor
Jan Feijen
Gerard Engbers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cordis Europa NV
Original Assignee
Cordis Europa NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cordis Europa NV filed Critical Cordis Europa NV
Publication of DE3878994D1 publication Critical patent/DE3878994D1/de
Application granted granted Critical
Publication of DE3878994T2 publication Critical patent/DE3878994T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0047—Enzymes, e.g. urokinase, streptokinase

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
DE8888201177T 1987-06-09 1988-06-08 Kovalente kupplung von antikoagulantien und dergleichen an biomaterialien. Expired - Lifetime DE3878994T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8701337A NL8701337A (nl) 1987-06-09 1987-06-09 Substraat voorzien van een bloedcompatibel oppervlak, verkregen door koppeling aan het oppervlak van een fysiologisch aktieve stof met remmende invloed op de vorming van bloedstolsels en/of in staat om gevormde bloedstolsels af te breken, alsmede werkwijze ter vervaardiging van het substraat.

Publications (2)

Publication Number Publication Date
DE3878994D1 true DE3878994D1 (de) 1993-04-15
DE3878994T2 DE3878994T2 (de) 1993-06-17

Family

ID=19850115

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888201177T Expired - Lifetime DE3878994T2 (de) 1987-06-09 1988-06-08 Kovalente kupplung von antikoagulantien und dergleichen an biomaterialien.

Country Status (6)

Country Link
US (1) US5061750A (de)
EP (1) EP0294905B1 (de)
JP (1) JPH02131769A (de)
CA (1) CA1302896C (de)
DE (1) DE3878994T2 (de)
NL (1) NL8701337A (de)

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US5126140A (en) * 1988-08-03 1992-06-30 New England Deaconess Hospital Corporation Thrombomodulin-coated bicompatible substance
JP2874029B2 (ja) * 1989-06-21 1999-03-24 テルモ株式会社 医療用材料およびその製造方法ならびにそれを用いた医療用器具
NL194941C (nl) * 1990-02-15 2003-08-04 Cordis Corp Werkwijze voor het aanbrengen van een fysiologisch actieve verbinding op een substraatoppervlak.
GB9009570D0 (en) * 1990-04-27 1990-06-20 Biocompatibles Ltd Antithrombogenic polymers
NL9001387A (nl) * 1990-06-19 1992-01-16 Holland Biomaterials Group B V Werkwijze ter modificering van de eigenschappen van een substraatoppervlak door kovalente koppeling van een verbinding aan het oppervlak alsmede membraan gemodificeerd volgens de werkwijze.
US5612034A (en) * 1990-10-03 1997-03-18 Redcell, Inc. Super-globuling for in vivo extended lifetimes
EP0484057A3 (en) * 1990-11-02 1993-04-21 The Dow Chemical Company Antithrombogenic surfaces, their preparation, and materials therefore
DE69125828T2 (de) * 1991-05-21 1997-07-31 Hewlett Packard Gmbh Verfahren zur Vorbehandlung der Oberfläche eines medizinischen Artikels
SE470006B (sv) * 1991-09-26 1993-10-25 Corline Systems Ab Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet
JP3093375B2 (ja) * 1991-11-01 2000-10-03 株式会社東海メディカルプロダクツ 抗血栓性物質の固定化方法
US5217743A (en) * 1992-02-07 1993-06-08 Paradigm Biotechnologies Partnership Biomaterials of enhanced biocompatibility
US5376692A (en) * 1992-05-15 1994-12-27 Purdue Research Foundation Method of binding using irradiation and product with albumin bound to biomaterials
US5344455A (en) * 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
US5350800A (en) * 1993-01-19 1994-09-27 Medtronic, Inc. Method for improving the biocompatibility of solid surfaces
DK1155689T3 (da) 1993-07-19 2006-11-20 Angiotech Pharm Inc Antiangiogene stents og fremgangsmåder til fremstilling heraf
DE4334272C2 (de) * 1993-10-07 1996-07-18 Stemberger Axel Dr Beschichtung für Biomaterial und seine Verwendung
US5759205A (en) * 1994-01-21 1998-06-02 Brown University Research Foundation Negatively charged polymeric electret implant
US5507804A (en) * 1994-11-16 1996-04-16 Alcon Laboratories, Inc. Cross-linked polyethylene oxide coatings to improve the biocompatibility of implantable medical devices
US5700559A (en) * 1994-12-16 1997-12-23 Advanced Surface Technology Durable hydrophilic surface coatings
US5532311A (en) * 1995-02-01 1996-07-02 Minnesota Mining And Manufacturing Company Process for modifying surfaces
US6179817B1 (en) 1995-02-22 2001-01-30 Boston Scientific Corporation Hybrid coating for medical devices
US5869127A (en) * 1995-02-22 1999-02-09 Boston Scientific Corporation Method of providing a substrate with a bio-active/biocompatible coating
US6558798B2 (en) 1995-02-22 2003-05-06 Scimed Life Systems, Inc. Hydrophilic coating and substrates coated therewith having enhanced durability and lubricity
US5583213A (en) * 1995-05-12 1996-12-10 Minnesota Mining And Manufacturing Company Process to activate sulfated polysaccharides
US6562781B1 (en) 1995-11-30 2003-05-13 Hamilton Civic Hospitals Research Development Inc. Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US6491965B1 (en) * 1995-11-30 2002-12-10 Hamilton Civic Hospitals Research Development, Inc. Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US7045585B2 (en) * 1995-11-30 2006-05-16 Hamilton Civic Hospital Research Development Inc. Methods of coating a device using anti-thrombin heparin
EP0780419A1 (de) * 1995-12-22 1997-06-25 Holland Biomaterials Group B.V. Polymere mit multifunktionalen Stellen und deren Verwendungen
US6150472A (en) * 1995-12-22 2000-11-21 Holland Biomaterials Group B.V. Multi-functional site containing polymers, and applications thereof
US5811151A (en) * 1996-05-31 1998-09-22 Medtronic, Inc. Method of modifying the surface of a medical device
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
FR2758394B1 (fr) * 1997-01-14 1999-03-19 Hospal Ind Moyens pour la bio-epuration specifique d'un fluide biologique
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US6146771A (en) * 1997-07-01 2000-11-14 Terumo Cardiovascular Systems Corporation Process for modifying surfaces using the reaction product of a water-insoluble polymer and a polyalkylene imine
US6197289B1 (en) 1997-07-01 2001-03-06 Terumo Cardiovascular Systems Corporation Removal of biologically active agents
US6136950A (en) * 1997-09-23 2000-10-24 Mbt Holding Ag Highly efficient cement dispersants
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US6429266B2 (en) * 1998-06-30 2002-08-06 University Of South Alabama Thermal grafts of polyamides with pendant carboxylic acid groups, methods for producing the same, compositions containing the same, and methods of using the same
US6120847A (en) * 1999-01-08 2000-09-19 Scimed Life Systems, Inc. Surface treatment method for stent coating
US6419692B1 (en) 1999-02-03 2002-07-16 Scimed Life Systems, Inc. Surface protection method for stents and balloon catheters for drug delivery
US6156373A (en) * 1999-05-03 2000-12-05 Scimed Life Systems, Inc. Medical device coating methods and devices
US6258121B1 (en) 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US7300662B2 (en) 2000-05-12 2007-11-27 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
US8236048B2 (en) 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
US6776796B2 (en) 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
US20020111590A1 (en) 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
ES2275737T3 (es) 2000-09-29 2007-06-16 Cordis Corporation Dispositivos medicos revestidos.
US7261735B2 (en) 2001-05-07 2007-08-28 Cordis Corporation Local drug delivery devices and methods for maintaining the drug coatings thereon
AU2001294634B2 (en) 2000-10-16 2006-07-06 Innovational Holdings, Llc Expandable medical device for delivery of beneficial agent
US7771468B2 (en) 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
US7195640B2 (en) 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US20030065377A1 (en) * 2001-09-28 2003-04-03 Davila Luis A. Coated medical devices
US7108701B2 (en) 2001-09-28 2006-09-19 Ethicon, Inc. Drug releasing anastomosis devices and methods for treating anastomotic sites
US7097850B2 (en) 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
US7491768B2 (en) 2002-06-25 2009-02-17 Woong-Sig Moon Polymer resin formulation having anti-microbial or anti-coagulability and preparation method thereof
DE10237572A1 (de) * 2002-08-13 2004-02-26 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Stent mit polymerer Beschichtung
DE10329296B4 (de) * 2003-06-24 2007-07-12 Leibniz-Institut Für Polymerforschung Dresden E.V. Beschichtungssystem für Biomaterialien
DE10330900B4 (de) * 2003-07-01 2006-09-14 Leibniz-Institut Für Polymerforschung Dresden E.V. Biomaterial mit einem modularen Beschichtungssystem zur Anwendung in Medizinprodukten mit direktem Blutkontakt
US11839698B2 (en) 2014-03-13 2023-12-12 W. L. Gore & Associates, Inc. Drug composition and coating

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3826678A (en) * 1972-06-06 1974-07-30 Atomic Energy Commission Method for preparation of biocompatible and biofunctional materials and product thereof
GB1583008A (en) * 1977-10-19 1981-01-21 Unitika Ltd Process for preparing antithrombogenic ploymeric material
JPS5664788A (en) * 1979-10-27 1981-06-02 Unitika Ltd Method for imparting enzyme activity to solid surface
EP0046828B1 (de) * 1980-09-01 1985-12-04 Teijin Limited Heparin-Derivat, seine Herstellung und Verfahren zur Herstellung biomedizinischer Gegenstände mit antithrombogenen Eigenschaften
DE3109141A1 (de) * 1981-03-11 1982-09-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München Antithrombogene ausruestung von matrix-oberflaechen
NL188622C (nl) * 1981-12-15 1992-08-17 Cordis Europ Werkwijze ter verbetering van de bloedcompatibiliteit van een materiaaloppervlak door bekleding daarvan met een heparine of heparine-analoga en een eiwit houdende film, alsmede voorwerp, omvattende een oppervlak met verbeterde bloedcompatibiliteit verkregen onder toepassing van een op het oppervlak aangebrachte heparine of heparine-analoga en een eiwit houdende film.
US4521564A (en) * 1984-02-10 1985-06-04 Warner-Lambert Company Covalent bonded antithrombogenic polyurethane material
CH665954A5 (fr) * 1985-07-08 1988-06-30 Battelle Memorial Institute Substrat dont la surface presente une activite antithrombogenique.

Also Published As

Publication number Publication date
EP0294905B1 (de) 1993-03-10
JPH02131769A (ja) 1990-05-21
US5061750A (en) 1991-10-29
CA1302896C (en) 1992-06-09
DE3878994T2 (de) 1993-06-17
EP0294905A1 (de) 1988-12-14
NL8701337A (nl) 1989-01-02

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Legal Events

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8364 No opposition during term of opposition