DE3874021T2 - Leukotrien-antagonisten. - Google Patents

Leukotrien-antagonisten.

Info

Publication number
DE3874021T2
DE3874021T2 DE8888305185T DE3874021T DE3874021T2 DE 3874021 T2 DE3874021 T2 DE 3874021T2 DE 8888305185 T DE8888305185 T DE 8888305185T DE 3874021 T DE3874021 T DE 3874021T DE 3874021 T2 DE3874021 T2 DE 3874021T2
Authority
DE
Germany
Prior art keywords
alkyl
alkoxy
cor3
furanyl
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888305185T
Other languages
English (en)
Other versions
DE3874021D1 (de
Inventor
John Gerald Gleason
Ralph Floyd Hall
Irene Nijole Uzinskas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
SmithKline Beecham Corp
Original Assignee
GlaxoSmithKline LLC
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline LLC, SmithKline Beecham Corp filed Critical GlaxoSmithKline LLC
Application granted granted Critical
Publication of DE3874021D1 publication Critical patent/DE3874021D1/de
Publication of DE3874021T2 publication Critical patent/DE3874021T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Furan Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
DE8888305185T 1987-06-24 1988-06-07 Leukotrien-antagonisten. Expired - Fee Related DE3874021T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6659287A 1987-06-24 1987-06-24

Publications (2)

Publication Number Publication Date
DE3874021D1 DE3874021D1 (de) 1992-10-01
DE3874021T2 true DE3874021T2 (de) 1993-02-11

Family

ID=22070480

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888305185T Expired - Fee Related DE3874021T2 (de) 1987-06-24 1988-06-07 Leukotrien-antagonisten.

Country Status (11)

Country Link
US (1) US5135938A (de)
EP (1) EP0296731B1 (de)
JP (1) JP2677382B2 (de)
AT (1) ATE79873T1 (de)
AU (1) AU1759488A (de)
DE (1) DE3874021T2 (de)
DK (1) DK327188A (de)
ES (1) ES2051850T3 (de)
GR (1) GR3006224T3 (de)
PT (1) PT87616B (de)
ZA (1) ZA884239B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254571A (en) * 1988-04-21 1993-10-19 Smith Kline & French Laboratories Ltd. Chemical compounds
CA2083610A1 (en) * 1990-06-06 1991-12-07 John G. Gleason Leukotriene antagonists
WO2018234267A1 (de) * 2017-06-19 2018-12-27 Sika Technology Ag Latenter härter und härtbare polyurethanzusammensetzung

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868369A (en) 1972-11-14 1975-02-25 Smithkline Corp 3-heterocyclicthiomethylcephalosporins
US3989694A (en) 1974-12-27 1976-11-02 Smithkline Corporation 7-Acyl-3-(substituted triazolyl thiomethyl)cephalosporins
US4286089A (en) 1974-12-27 1981-08-25 Smithkline Corporation 7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins
US4048311A (en) 1976-01-08 1977-09-13 Smithkline Corporation 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)cephalosporins
US4220644A (en) 1976-05-03 1980-09-02 Smithkline Corporation 7-Acylamino-3-(substituted tetrazolyl thiomethyl) cephalosporins
IL69691A (en) * 1982-09-23 1988-01-31 Merck Frosst Canada Inc Leukotriene antagonists,their preparation and pharmaceutical compositions containing them
US4661505A (en) * 1982-11-03 1987-04-28 Eli Lilly And Company Leukotriene antagonists
JPS59161366A (ja) * 1983-03-04 1984-09-12 Zenichi Yoshida チアジアゾリノン類
GR81524B (de) * 1983-07-18 1984-12-11 Lilly Co Eli
US5105017A (en) * 1983-07-18 1992-04-14 Eli Lilly And Company Leukotriene antagonist intermediates
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
GB8432144D0 (en) * 1984-12-20 1985-01-30 Lilly Industries Ltd Organic compounds
GB8502258D0 (en) * 1985-01-30 1985-02-27 Lilly Industries Ltd Organic compounds
EP0217519B1 (de) * 1985-08-31 1992-02-05 FISONS plc 5-gliedrige heterocyclische Angiotensin-Umwandlungsenzym-Inhibitoren
GB8530222D0 (en) * 1985-12-07 1986-01-15 Lilly Industries Ltd Organic compounds

Also Published As

Publication number Publication date
AU1759488A (en) 1989-01-05
EP0296731B1 (de) 1992-08-26
PT87616B (pt) 1992-09-30
JP2677382B2 (ja) 1997-11-17
ES2051850T3 (es) 1994-07-01
PT87616A (pt) 1988-06-01
ZA884239B (en) 1989-06-28
ATE79873T1 (de) 1992-09-15
US5135938A (en) 1992-08-04
DE3874021D1 (de) 1992-10-01
JPS6426571A (en) 1989-01-27
EP0296731A1 (de) 1988-12-28
GR3006224T3 (de) 1993-06-21
DK327188A (da) 1988-12-25
DK327188D0 (da) 1988-06-15

Similar Documents

Publication Publication Date Title
HRP20030665B1 (en) Xanthine derivative, production and use thereof as a medicament
IE792524L (en) Azabicycloalkyl derivatives.
DK633088D0 (da) Hidtil ukendte forbindelser
ES480850A1 (es) Procedimiento para preparar hidantoinas.
SE0201937D0 (sv) Therapeutic agents
DE3865373D1 (de) Leukotrienantagonisten.
ATE79873T1 (de) Leukotrien-antagonisten.
DK709088D0 (da) Hidtil ukendte forbindelser
DK663588D0 (da) Hidtil ukendte forbindelser
DK37580A (da) 4,5-dihydro-4-oxofuran-2-carboxylsyrederivater samt deres fremstilling og anvendelse
RS49829B (sr) Postupak i intermedijeri za proizvodnju piridin-2,3-dikarboksilat jedinjenja
DE3688161T2 (de) Gegebenenfalls etherifizierte oder esterifizierte in Stellung 2 substituierte 4-OH-Chinolincarbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung, ihre Anwendung als Arzneimittel und diese enthaltende Zubereitungen.
DE69008428T2 (de) Leukotrienantagonisten.
DE3783279D1 (de) Substituierte furazane.
FI930383A (fi) Foerfarande och mellanprodukt foer framstaellning av 2-hydroxi-3-sulfido-3-fenylpropansyror
JPS53127444A (en) Oxime substd. phenylacetic acid derivtives and their preparation
TH1331B (th) สารn-(1-กลุ่มแทนที่-4,5-ไดไฮโดร-1h-พิราโซล-4-อิล) เบนซะไมด์

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee