DE69008428T2 - Leukotrienantagonisten. - Google Patents

Leukotrienantagonisten.

Info

Publication number
DE69008428T2
DE69008428T2 DE69008428T DE69008428T DE69008428T2 DE 69008428 T2 DE69008428 T2 DE 69008428T2 DE 69008428 T DE69008428 T DE 69008428T DE 69008428 T DE69008428 T DE 69008428T DE 69008428 T2 DE69008428 T2 DE 69008428T2
Authority
DE
Germany
Prior art keywords
alkoxy
alkyl
cor3
trifluoromethylthio
tetrazolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69008428T
Other languages
English (en)
Other versions
DE69008428D1 (de
Inventor
James Simpson Frazee
John Gerald Gleason
Ralph Floyd Hall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
SmithKline Beecham Corp
Original Assignee
GlaxoSmithKline LLC
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline LLC, SmithKline Beecham Corp filed Critical GlaxoSmithKline LLC
Application granted granted Critical
Publication of DE69008428D1 publication Critical patent/DE69008428D1/de
Publication of DE69008428T2 publication Critical patent/DE69008428T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/02—Monothiocarboxylic acids
    • C07C327/04—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/08—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
DE69008428T 1989-06-14 1990-06-13 Leukotrienantagonisten. Expired - Fee Related DE69008428T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36604689A 1989-06-14 1989-06-14

Publications (2)

Publication Number Publication Date
DE69008428D1 DE69008428D1 (de) 1994-06-01
DE69008428T2 true DE69008428T2 (de) 1994-11-24

Family

ID=23441449

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69008428T Expired - Fee Related DE69008428T2 (de) 1989-06-14 1990-06-13 Leukotrienantagonisten.

Country Status (14)

Country Link
EP (1) EP0403249B1 (de)
JP (1) JPH0324050A (de)
KR (1) KR910000632A (de)
AT (1) ATE104955T1 (de)
AU (1) AU645253B2 (de)
CA (1) CA2018437A1 (de)
DE (1) DE69008428T2 (de)
DK (1) DK0403249T3 (de)
ES (1) ES2063271T3 (de)
IE (1) IE902141A1 (de)
MX (1) MX21139A (de)
NZ (1) NZ234009A (de)
PT (1) PT94373A (de)
ZA (1) ZA904583B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214201A (en) * 1991-12-12 1993-05-25 Smithkline Beecham Corporation Crystallization of optical isomers of leukotriene antagonists
CA2131787A1 (en) * 1992-03-12 1993-09-16 Masahiko Shikano Antipruritic
ZA939517B (en) * 1992-12-23 1995-01-31 Smithkline Beecham Corp Process

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8700647A1 (es) * 1984-10-11 1986-11-16 Raychem Corp Procedimiento para la preparacion de un compuesto carbonilo aromatico
CA1334200C (en) * 1987-06-24 1995-01-31 James Simpson Frazee Leukotriene antagonists
AU610528B2 (en) * 1987-10-29 1991-05-23 Smithkline Beckman Corporation Leukotriene antagonists
JPH01153658A (ja) * 1987-12-08 1989-06-15 E R Squibb & Sons Inc ヘテロ含有置換基を有するフェニルヒドロキサム酸類
US4954513A (en) * 1988-12-23 1990-09-04 Smithkline Beecham Corporation Leukotriene antagonists

Also Published As

Publication number Publication date
ATE104955T1 (de) 1994-05-15
AU5690290A (en) 1990-12-20
PT94373A (pt) 1991-02-08
IE902141L (en) 1990-12-14
IE902141A1 (en) 1991-01-02
ZA904583B (en) 1992-05-27
MX21139A (es) 1993-12-01
EP0403249B1 (de) 1994-04-27
JPH0324050A (ja) 1991-02-01
KR910000632A (ko) 1991-01-29
EP0403249A1 (de) 1990-12-19
AU645253B2 (en) 1994-01-13
DE69008428D1 (de) 1994-06-01
ES2063271T3 (es) 1995-01-01
NZ234009A (en) 1993-02-25
DK0403249T3 (da) 1994-05-24
CA2018437A1 (en) 1990-12-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee