DE3869969D1 - Versuchsmethode unter verwendung von partikeln mit assoziiertem, fluoreszierendem stoff. - Google Patents

Versuchsmethode unter verwendung von partikeln mit assoziiertem, fluoreszierendem stoff.

Info

Publication number
DE3869969D1
DE3869969D1 DE8888300033T DE3869969T DE3869969D1 DE 3869969 D1 DE3869969 D1 DE 3869969D1 DE 8888300033 T DE8888300033 T DE 8888300033T DE 3869969 T DE3869969 T DE 3869969T DE 3869969 D1 DE3869969 D1 DE 3869969D1
Authority
DE
Germany
Prior art keywords
particles
test method
fluorescent substance
associated fluorescent
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888300033T
Other languages
English (en)
Inventor
John Pease
Litai Weng
Hrair Kirakossian
Edwin F Ullman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of DE3869969D1 publication Critical patent/DE3869969D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/007—Squaraine dyes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809—Multifield plates or multicontainer arrays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/821—Chemistry: analytical and immunological testing involving complement factors or complement systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/823—Immunogenic carrier or carrier per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE8888300033T 1987-01-07 1988-01-05 Versuchsmethode unter verwendung von partikeln mit assoziiertem, fluoreszierendem stoff. Expired - Lifetime DE3869969D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/000,925 US4891324A (en) 1987-01-07 1987-01-07 Particle with luminescer for assays

Publications (1)

Publication Number Publication Date
DE3869969D1 true DE3869969D1 (de) 1992-05-21

Family

ID=21693584

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888300033T Expired - Lifetime DE3869969D1 (de) 1987-01-07 1988-01-05 Versuchsmethode unter verwendung von partikeln mit assoziiertem, fluoreszierendem stoff.

Country Status (6)

Country Link
US (1) US4891324A (de)
EP (1) EP0275139B1 (de)
JP (1) JP2653807B2 (de)
CA (1) CA1312822C (de)
DE (1) DE3869969D1 (de)
ES (1) ES2036667T3 (de)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5026905A (en) * 1984-08-28 1991-06-25 Syntex (U.S.A.) Inc. Fluorescent dyes
US5145774A (en) * 1984-08-28 1992-09-08 Syntex (U.S.A.) Inc. Fluorescent dyes
US5306731A (en) * 1985-06-14 1994-04-26 Massachusetts Eye And Ear Infirmary Method and products for treating the eye
US6013531A (en) * 1987-10-26 2000-01-11 Dade International Inc. Method to use fluorescent magnetic polymer particles as markers in an immunoassay
US5252459A (en) * 1988-09-23 1993-10-12 Abbott Laboratories Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles
US6352862B1 (en) * 1989-02-17 2002-03-05 Unilever Patent Holdings B.V. Analytical test device for imuno assays and methods of using same
CA2056435A1 (en) * 1989-05-15 1990-11-16 Thomas D. Madden Accumulation of drugs into liposomes by a proton gradient
CA2046894C (en) * 1989-12-14 1999-10-19 Dade International Inc. Magnetically responsive fluorescent polymer particles and application thereof
US5078994A (en) * 1990-04-12 1992-01-07 Eastman Kodak Company Microgel drug delivery system
US5639620A (en) * 1990-10-31 1997-06-17 Coulter Corporation Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same
DE4041080A1 (de) * 1990-12-21 1992-06-25 Behringwerke Ag Verfahren zur bestimmung eines analyten
FI88545C (fi) * 1991-03-12 1993-05-25 Jouko Kankare Bestaemningsmetod
US5171450A (en) * 1991-03-20 1992-12-15 Nalco Chemical Company Monitoring and dosage control of tagged polymers in cooling water systems
IL101945A (en) * 1991-05-22 1998-02-08 Behringwerke Ag Methods for determining an analyte using induced luminescence, and kits therefor
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US6251581B1 (en) 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5578498A (en) 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US5248590A (en) * 1991-07-22 1993-09-28 Becton, Dickinson And Company Surface modified liposomes
US5248772A (en) * 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
US6002000A (en) * 1992-07-20 1999-12-14 Dade Behring Marburg Gmbh Chemiluminescent compounds and methods of use
CA2140661A1 (en) * 1992-07-20 1994-02-03 Sharat Singh Novel chemiluminescent compounds and methods of use
ES2113547T3 (es) * 1992-07-31 1998-05-01 Behringwerke Ag Matrices quimioluminiscentes fotoactivables.
US5279940A (en) * 1992-08-03 1994-01-18 Eastman Kodak Company Chemiluminescent composition containing cationic surfactants or polymers and 4'-hydroxyacetanilide, test kits and their use in analytical methods
WO1994009368A1 (en) * 1992-10-15 1994-04-28 Coulter Corporation Particles having gelatin-aminodextran coatings of and processes for making same
CA2170873A1 (en) * 1993-09-03 1995-03-09 Dariush Davalian Fluorescent oxygen channeling immunoassays
US5585249A (en) * 1994-10-03 1996-12-17 Board Of Trustees Operating Michigan State University Polyhydroxybutyrate and polyphosphate membranes with channels
US5580749A (en) * 1994-10-21 1996-12-03 Georgia Tech Research Corporation Internal reference for chemically modified spheres
US6251691B1 (en) 1996-04-25 2001-06-26 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
DE19621312A1 (de) * 1996-05-28 1997-12-04 Bayer Ag Maskierung der Hintergrundfluoreszenz und Signalverstärkung bei der optischen Analyse biologisch medizinischer Assays
ES2156610T3 (es) * 1996-12-18 2001-07-01 Stiftung Fur Diagnostische For Particulas sinteticas como reactivos de aglutinacion.
GB9716476D0 (en) * 1997-08-04 1997-10-08 Amersham Int Plc Dye intermediate and method
US6365346B1 (en) 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
WO1999042838A1 (en) 1998-02-18 1999-08-26 Dade Behring Inc. Chemiluminescent compositions for use in detection of multiple analytes
US6254830B1 (en) * 1999-11-05 2001-07-03 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Magnetic focusing immunosensor for the detection of pathogens
US6703248B1 (en) 1999-12-15 2004-03-09 Dade Behring Marburg Gmbh Particles for diagnostic and therapeutic use
US7179660B1 (en) 2000-03-06 2007-02-20 Dade Behring Marburg Gmbh Carriers coated with polysaccharides, their preparation and use
JP4744778B2 (ja) * 2000-06-21 2011-08-10 バイオアレイ ソルーションズ リミテッド 特定のランダム粒子アレイを適用した複数の被検体分子の分析方法
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
CN1152055C (zh) * 2001-03-20 2004-06-02 清华大学 磁性微球的表面包覆和基团功能化修饰方法及所得微球及其应用
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
KR20040068122A (ko) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US7402397B2 (en) 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20040229294A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US6764819B2 (en) * 2002-07-16 2004-07-20 Emp Biotech Gmbh Method for chemiluminescent detection
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US7927796B2 (en) * 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
AU2004276761B2 (en) * 2003-09-22 2009-12-24 Bioarray Solutions, Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
US7402399B2 (en) * 2003-10-14 2008-07-22 Monogram Biosciences, Inc. Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy
US7582488B2 (en) * 2003-10-28 2009-09-01 Bio Array Solutions Ltd. Gel-shell beads with adsorbed or bound biomolecules
US7563569B2 (en) * 2003-10-28 2009-07-21 Michael Seul Optimization of gene expression analysis using immobilized capture probes
WO2005045059A2 (en) * 2003-10-28 2005-05-19 Bioarray Solutions Ltd. Allele assignment and probe selection in multiplexed assays of polymorphic targets
CN1882703B (zh) 2003-10-29 2011-07-06 佰尔瑞溶液有限公司 通过断裂双链脱氧核糖核酸进行多元核酸分析
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US20070045902A1 (en) 2004-07-13 2007-03-01 Brauker James H Analyte sensor
US8170803B2 (en) 2004-07-13 2012-05-01 Dexcom, Inc. Transcutaneous analyte sensor
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US20060204999A1 (en) * 2005-03-14 2006-09-14 Stephen Macevicz Detecting molecular complexes
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US20060281104A1 (en) * 2005-06-13 2006-12-14 Macevicz Stephen C Leuco dye particles and uses thereof
US20100034748A1 (en) * 2008-08-07 2010-02-11 Guizhi Li Molecular imaging probes based on loaded reactive nano-scale latex
US20080181965A1 (en) * 2006-04-10 2008-07-31 Leon Jeffrey W Loaded latex optical molecular imaging probes
US7799534B2 (en) 2006-05-09 2010-09-21 Beckman Coulter, Inc. Nonseparation assay methods
US7732153B2 (en) 2006-05-09 2010-06-08 Beckman Coulter, Inc. Nonseparation assay methods
WO2008023489A1 (fr) * 2006-08-21 2008-02-28 National Institute Of Advanced Industrial Science And Technology Composé dérivé de l'acide squarique, réactif de détection d'une protéine comprenant le composé et procédé de détection d'une protéine utilisant le réactif
US8906354B2 (en) 2007-02-28 2014-12-09 Bruker Biospin Corporation Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes
WO2009062027A1 (en) * 2007-11-07 2009-05-14 Beckman Coulter, Inc. Nonseparation assay methods using peroxide generating enzymes
CN105001666B (zh) * 2015-07-20 2016-10-05 福州大学 一种非对称近红外方酸染料及其制备方法与应用
TW202104874A (zh) * 2019-05-29 2021-02-01 學校法人早稻田大學 檢測生體分子用的溫度響應性螢光粒子
CN111296426B (zh) * 2020-03-31 2021-09-24 大连理工大学 以非磷脂类脂质体作为载体的纳米农药剂型的制备方法及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3850578A (en) * 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
US4529561A (en) * 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
US4193983A (en) * 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
US4576912A (en) * 1978-11-30 1986-03-18 Technicon Instruments Corporation Fluoroimmunoassaying
US4372745A (en) * 1979-12-19 1983-02-08 Electro-Nucleonics, Inc. Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer
NL8000173A (nl) * 1980-01-11 1981-08-03 Akzo Nv Toepassing van in water dispergeerbare, hydrofobe kleurstoffen als label in immunochemische testen.
US4483921A (en) * 1981-01-12 1984-11-20 Collaborative Research, Inc. Immunoassay with antigen or antibody labeled liposomes sequestering enzyme
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4483929A (en) * 1982-05-03 1984-11-20 Liposome Technology Incorporated Liposomes with glycolipid-linked antibodies
US4485054A (en) * 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US4628037A (en) * 1983-05-12 1986-12-09 Advanced Magnetics, Inc. Binding assays employing magnetic particles
US4605630A (en) * 1983-07-27 1986-08-12 Cooper Lipotech Inc. Large-liposome agglutination reagent and method
US4748129A (en) * 1984-08-28 1988-05-31 Snytex (U.S.A.) Inc. Assay method employing fluorescent cell incorporative dye
FI844027A (fi) * 1984-10-12 1986-04-13 Labsystems Oy Immunologiskt bestaemningsfoerfarande.
US4698263A (en) * 1985-05-23 1987-10-06 Becton Dickinson And Company Sac having a marker linked thereto
US4806488A (en) * 1985-09-06 1989-02-21 Syntex (U.S.A.) Inc. Ligand-receptor assays employing squarate dye compositions

Also Published As

Publication number Publication date
JPS63191065A (ja) 1988-08-08
ES2036667T3 (es) 1993-06-01
CA1312822C (en) 1993-01-19
EP0275139A3 (en) 1988-08-03
EP0275139A2 (de) 1988-07-20
EP0275139B1 (de) 1992-04-15
US4891324A (en) 1990-01-02
JP2653807B2 (ja) 1997-09-17

Similar Documents

Publication Publication Date Title
DE3869969D1 (de) Versuchsmethode unter verwendung von partikeln mit assoziiertem, fluoreszierendem stoff.
DE3481890D1 (de) Fingerabdruckentwicklungsverfahren unter verwendung von cyanakrylaten.
DE3884641D1 (de) Aufzeichnungsflüssigkeit und Aufzeichnungsverfahren unter Verwendung derselben.
DE3575363D1 (de) Halbleiter mit flachen, hyperabrupt dotierten gebieten und verfahren zu ihrer herstellung unter verwendung ionenimplantierter stoerstoffe.
DE3775359D1 (de) Pruefung von photodioden mit elektronenstrahlen.
DE69019009D1 (de) Zellkulturverfahren.
DE3789876T2 (de) Knochenplatte mit konischen Löchern.
DE3853014T2 (de) Apparat zur Prüfung von Einkäufen.
DE3883522D1 (de) Verfahren zum diagnostizieren von blutpfropfen mit fibrin-bindenden proteinen.
DE68908685T2 (de) Verfahren zur verwendung chemilumineszierender 1,2-dioxetane.
NO871830D0 (no) Komposittelektroder, framgangsmaate for framstilling av disse samt apparat der elektrodene benyttes.
DE68919565T2 (de) Immuntestverfahren unter Verwendung magnetischer Markerteilchen.
DE3686100T2 (de) Apparat zur pruefung von objekten.
DE3850592T2 (de) Apparat zur Vorbereitung von Briefen.
DE68909385T2 (de) Apparat zur Herstellung von Perlen.
NO885836D0 (no) Kvantitativ metode for bestemmelse av 1,4-dihydronikotinamid-adenin-dinukleotid i opploesning.
DE3878282D1 (de) Fotomechanischer apparat unter verwendung von fotoelektrischer abtastung.
DE3788105T2 (de) Apparat zur Durchführung von Marktforschung mit Hilfe von Zweiwegkommunikation.
DE69020985D1 (de) Apparat zur Trennung von Lösungen.
DK512088D0 (da) Cell screening, apparatus and methods
DE3750072T2 (de) Informations-Übertragungseinrichtung unter Verwendung von Elektronenstrahlen.
DE3850513T2 (de) Apparat zur Verarbeitung von Briefen.
DE3685815D1 (de) Verfahren zur identifizierung von mit polymethin gefaerbten lymphocytsubpopulationen und zusammensetzungen davon.
DE68922879D1 (de) Fluoreszenzimmunoassaymethode unter Verwendung von mit Fluoreszenzlöschern verknüpften Pseudoantigenen.
DE68914094D1 (de) Immunoanalyseverfahren.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: BARZ, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 80803 MUENCHEN