DE3864269D1 - Antineoplastische verbindungen. - Google Patents
Antineoplastische verbindungen.Info
- Publication number
- DE3864269D1 DE3864269D1 DE8888300064T DE3864269T DE3864269D1 DE 3864269 D1 DE3864269 D1 DE 3864269D1 DE 8888300064 T DE8888300064 T DE 8888300064T DE 3864269 T DE3864269 T DE 3864269T DE 3864269 D1 DE3864269 D1 DE 3864269D1
- Authority
- DE
- Germany
- Prior art keywords
- och3
- compounds
- substances
- antineoplastic compounds
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000000118 anti-neoplastic effect Effects 0.000 title abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 2
- ZSNYQENLWQYSRK-UHFFFAOYSA-N Combretastatin B1 Natural products OC1=C(O)C(OC)=CC=C1CCC1=CC(OC)=C(OC)C(OC)=C1 ZSNYQENLWQYSRK-UHFFFAOYSA-N 0.000 abstract 1
- SFWXNQDSPCKFAW-UHFFFAOYSA-N Combretastatin B3 Natural products COC1=C(OC)C(OC)=CC(CCC=2C=C(O)C(O)=CC=2)=C1 SFWXNQDSPCKFAW-UHFFFAOYSA-N 0.000 abstract 1
- PBRZRNRAYCSTKB-UHFFFAOYSA-N Combretastatin B4 Natural products COC1=CC(OC)=CC(CCC=2C=C(O)C(O)=CC=2)=C1 PBRZRNRAYCSTKB-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- KTDUNELJBIXZMQ-UHFFFAOYSA-N combretastatin A-3 Natural products COc1ccc(C=C/c2cc(O)c(OC)c(O)c2)cc1OC KTDUNELJBIXZMQ-UHFFFAOYSA-N 0.000 abstract 1
- 229930192183 combretastatin A1 Natural products 0.000 abstract 1
- YUSYSJSHVJULID-UHFFFAOYSA-N combretastatin A1 Z Natural products OC1=C(O)C(OC)=CC=C1C=CC1=CC(OC)=C(OC)C(OC)=C1 YUSYSJSHVJULID-UHFFFAOYSA-N 0.000 abstract 1
- HRRAOGKGGZFKSW-UHFFFAOYSA-N combretastatin A2 Natural products COc1ccc(C=C/c2cc(O)c3OCOc3c2)cc1OC HRRAOGKGGZFKSW-UHFFFAOYSA-N 0.000 abstract 1
- VHHWNDDKJSLBGT-UHFFFAOYSA-N combretastatin B-2 Natural products COc1ccc(CCc2cc(O)c(OC)c(O)c2)cc1OC VHHWNDDKJSLBGT-UHFFFAOYSA-N 0.000 abstract 1
- YUSYSJSHVJULID-WAYWQWQTSA-N combretastatin a-1 Chemical compound OC1=C(O)C(OC)=CC=C1\C=C/C1=CC(OC)=C(OC)C(OC)=C1 YUSYSJSHVJULID-WAYWQWQTSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59087A | 1987-01-06 | 1987-01-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3864269D1 true DE3864269D1 (de) | 1991-09-26 |
Family
ID=21692158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8888300064T Expired - Lifetime DE3864269D1 (de) | 1987-01-06 | 1988-01-06 | Antineoplastische verbindungen. |
Country Status (8)
Country | Link |
---|---|
US (2) | US5409953A (de) |
EP (1) | EP0276051B1 (de) |
JP (1) | JP2558131B2 (de) |
AT (1) | ATE66452T1 (de) |
CA (1) | CA1338645C (de) |
DE (1) | DE3864269D1 (de) |
ES (1) | ES2038747T3 (de) |
GR (1) | GR3003111T3 (de) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1338645C (en) * | 1987-01-06 | 1996-10-15 | George R. Pettit | Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins" |
US4996237A (en) * | 1987-01-06 | 1991-02-26 | Arizona Board Of Regents | Combretastatin A-4 |
EP0334119B1 (de) * | 1988-03-21 | 1993-06-16 | Boehringer Ingelheim Pharmaceuticals Inc. | Verbindungen zur Verhinderung der Biosynthese von der Lipoxygenase abgeleiteten Metaboliten der Arachidonsäure |
GB9106177D0 (en) * | 1991-03-22 | 1991-05-08 | Aston Molecules Ltd | Substituted diphenylethylenes and analogues or derivatives thereof |
US5430062A (en) * | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
IT1256354B (it) * | 1992-08-31 | 1995-12-01 | Francesca Pelizzoni | Derivati della combretastatina ad attivita' anti-tumorale e procedimento per la loro preparazione |
FR2728570B1 (fr) * | 1994-12-23 | 1997-04-11 | Synthelabo | Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique |
US6346510B1 (en) * | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
RU2215525C2 (ru) | 1998-04-03 | 2003-11-10 | Адзиномото Ко., Инк. | Противоопухолевое средство |
US6624197B1 (en) | 1998-05-08 | 2003-09-23 | Calyx Therapeutics, Inc. | Diphenylethylene compounds |
US6331633B1 (en) | 1998-05-08 | 2001-12-18 | Calyx Therapeutics Inc. | Heterocyclic analogs of diphenylethylene compounds |
US7105552B2 (en) | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
US6245814B1 (en) | 1998-05-08 | 2001-06-12 | Calyx Therapeutics, Inc. | Diphenylethylene compounds |
US6448450B1 (en) * | 1998-05-08 | 2002-09-10 | Calyx Therapeutics, Inc. | 1-(3,5-dimethoxyphenyl)-2-(4-hydroxyphenyl)-ethylene for diabetes treatment |
US6538038B1 (en) * | 1999-02-18 | 2003-03-25 | Oxigene, Inc. | Compositions and methods for use in targeting vascular destruction |
EP1810680A3 (de) * | 1999-02-18 | 2008-10-08 | Oxigene, Inc. | Zusammensetzungen und Verfahren zur Verwendung beim Targeting von vaskulärer Zerstörung |
US7407978B2 (en) * | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
US6703020B1 (en) * | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
KR100816572B1 (ko) * | 1999-04-28 | 2008-03-24 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 항-vegf 항체 및 이를 포함하는 약제학적 조성물 |
US7323496B2 (en) * | 1999-11-08 | 2008-01-29 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
US20080108825A1 (en) * | 1999-11-08 | 2008-05-08 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
US6525093B1 (en) * | 1999-11-08 | 2003-02-25 | Calyx Therapeutics Inc. | Compounds to treat diabetes and associated conditions |
US20020002200A1 (en) * | 2000-02-04 | 2002-01-03 | Bishwagit Nag | Novel diphenylethylene compounds |
US20080103302A1 (en) * | 2000-02-04 | 2008-05-01 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
AU4352701A (en) * | 2000-03-10 | 2001-09-24 | Univ Baylor | Tubulin binding ligands and corresponding prodrug constructs |
ES2395097T3 (es) * | 2000-04-27 | 2013-02-08 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona En Nombre De Arizona State University | Profármacos de Combretastatina A1 fosfato y Combretastatina B1 fosfato |
WO2002006279A1 (en) | 2000-07-17 | 2002-01-24 | Oxigene Inc | Efficient method of synthesizing combretastatin a-4 prodrugs |
US7220784B2 (en) * | 2000-12-21 | 2007-05-22 | John Anthony Hadfield | Substituted stilbenes and their reactions |
GB0031263D0 (en) * | 2000-12-21 | 2001-01-31 | Paterson Inst For Cancer Res | Materials and methods for synthesizing stilbenes |
US7037906B1 (en) * | 2000-12-22 | 2006-05-02 | Oxigene, Inc. | Methods for modulating tumor growth and metastasis |
US20050209310A1 (en) * | 2000-12-22 | 2005-09-22 | Chaplin David J | Methods for modulating tumor growth and metastasis |
JP2004523517A (ja) | 2000-12-22 | 2004-08-05 | ブリストル−マイヤーズ スクイブ カンパニー | 腫瘍増殖および転移を調節するための方法 |
US6773702B2 (en) | 2000-12-26 | 2004-08-10 | Oxigene, Inc. | Use of combretastatin A4 and its prodrugs as an immune enhancing therapy |
WO2002102766A2 (en) | 2001-06-15 | 2002-12-27 | Arizona Board Of Regents | Combretastatin a-3 prodrug |
KR20040030042A (ko) * | 2001-07-13 | 2004-04-08 | 옥시젠 인코포레이티드 | 안구 질환을 치료하기 위한 투불린 결합제 투여 조성물 및방법 |
CA2461905A1 (en) * | 2001-09-27 | 2003-04-10 | Board Of Regents, The University Of Texas System | Combined compositions and methods for tumor vasculature coagulation and treatment |
EP1465852A4 (de) * | 2001-12-21 | 2006-04-26 | Univ Arizona | Synthese von combretastatin?a?2?prodrugs |
KR101690826B1 (ko) | 2002-07-15 | 2016-12-28 | 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 | 포스파티딜에탄올아민에 결합하는 펩타이드, 및 바이러스 감염을 치료하는데 있어서 이의 용도 |
US20060100179A1 (en) * | 2002-08-14 | 2006-05-11 | Pero Ronald W | Compositions and methods for use in targeting vascular destruction |
CA2516078C (en) * | 2003-02-28 | 2014-04-29 | Oxigene, Inc. | Catechol compositions and use thereof |
GB0306908D0 (en) * | 2003-03-26 | 2003-04-30 | Angiogene Pharm Ltd | Bioreductively activated stilbene prodrugs |
KR101364762B1 (ko) * | 2005-02-17 | 2014-02-17 | 신타 파마슈티칼스 코프. | 증식성 장애의 치료를 위한 화합물 |
CN1907989B (zh) * | 2005-08-02 | 2011-08-17 | 浙江天皇药业有限公司 | 毛兰素盐及其制备方法和包含其的药物组合物 |
WO2007059118A1 (en) * | 2005-11-14 | 2007-05-24 | Abraxis Bioscience, Inc. | Combretastatin derivatives and related therapeutic methods |
DE112007000790T5 (de) | 2006-03-28 | 2009-04-23 | Council Of Scientific & Industrial Research | Einstufiges mikrowelleninduziertes Verfahren zur Herstellung von substituierten Stilbenen und deren Analoga |
US20090011060A1 (en) * | 2007-07-06 | 2009-01-08 | Peter Koepke | Campsiandra angustifolia extract and methods of extracting and using such extract |
US20090017140A1 (en) * | 2007-07-09 | 2009-01-15 | Peter Koepke | Maytenus abenfolia extract and methods of extracting and using such extract |
US20090035395A1 (en) * | 2007-08-01 | 2009-02-05 | Peter Koepke | Spondias mombin l. extract and methods of extracting and using such extract |
US7879369B2 (en) * | 2007-09-18 | 2011-02-01 | Selvamedica, Llc | Combretum laurifolium Mart. extract and methods of extracting and using such extract |
EA034136B1 (ru) | 2007-11-09 | 2020-01-09 | Перигрин Фармасьютикалз, Инк. | Изолированное антитело, которое связывается с vegf, и его применения |
JP5302328B2 (ja) | 2007-11-21 | 2013-10-02 | オキシジーン, インコーポレイテッド | 造血性新生物を治療するための方法 |
CN101723813A (zh) * | 2008-10-15 | 2010-06-09 | 上海华理生物医药有限公司 | 一种乙氧基二苯乙烷衍生物及其制备方法和用途 |
WO2010113005A2 (en) | 2009-03-27 | 2010-10-07 | Council Of Scientific & Industrial Research | One pot multicomponent synthesis of some novel hydroxy stilbene derivatives with alpha, beta-carbonyl conjugation under microwave irradiation |
CA2839451A1 (en) | 2011-06-27 | 2013-01-03 | The Jackson Laboratory | Methods and compositions for treatment of cancer and autoimmune disease |
WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
WO2014144715A1 (en) | 2013-03-15 | 2014-09-18 | Memorial Sloan-Kettering Cancer Center | Hsp90-targeted cardiac imaging and therapy |
JP6175399B2 (ja) * | 2014-03-31 | 2017-08-02 | 静岡県公立大学法人 | スチルベン類縁化合物を有効成分とする抗炎症剤 |
TW201702218A (zh) | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法 |
WO2016130969A1 (en) | 2015-02-13 | 2016-08-18 | George Robert Pettit | Silstatin compounds |
WO2017031157A1 (en) | 2015-08-18 | 2017-02-23 | Mateon Therapeutics, Inc. | Use of vdas to enhance immunomodulating therapies against tumors |
WO2017197045A1 (en) | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Convergent and enantioselective total synthesis of communesin analogs |
US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
WO2019094709A1 (en) | 2017-11-09 | 2019-05-16 | Pettit George R | Betulastatin compounds |
WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
WO2022182415A1 (en) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
CN113577020B (zh) * | 2021-08-16 | 2022-09-23 | 海南鑫开源医药科技有限公司 | 一种玻璃体腔内注射剂、其制备方法及应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA463336A (en) * | 1950-02-21 | Eli Lilly And Company | Method of producing dialkoxy stilbenes | |
US2496968A (en) * | 1945-10-05 | 1950-02-07 | Burroughs Wellcome Co | Alpha:beta:2:2'-tetramethyl-4:4'-dihydroxystilbene |
US3198840A (en) * | 1960-05-11 | 1965-08-03 | Armour Pharma | Derivatives of diphenyl synthetic estrogens |
US3293307A (en) * | 1963-12-23 | 1966-12-20 | Sun Oil Co | Preparation of substituted ethanes |
GB1046380A (en) * | 1964-07-06 | 1966-10-26 | American Cyanamid Co | New hypocholesteremic compositions |
US3577230A (en) * | 1968-10-18 | 1971-05-04 | Arizona Chem | Process of applying novel algicides |
US3968234A (en) * | 1975-03-05 | 1976-07-06 | The United States Of America As Represented By The Secretary Of Agriculture | Cinnamyl-sesamol derivatives as insect chemosterilants |
DE2658307C2 (de) * | 1976-12-22 | 1979-03-15 | Klinge Pharma Gmbh & Co, 8000 Muenchen | Di-O'-hydroxyphenyD-alkanverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US4326055A (en) * | 1977-12-22 | 1982-04-20 | Hoffmann-La Roche Inc. | Stilbene derivatives |
US4482728A (en) * | 1981-11-05 | 1984-11-13 | The United States Of America As Represented By The Secretary Of Agriculture | Polybutylbenzylphenols and benzyl-3,4-methylenedioxbenzenes in insect population control |
CA1338645C (en) * | 1987-01-06 | 1996-10-15 | George R. Pettit | Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins" |
US4996237A (en) * | 1987-01-06 | 1991-02-26 | Arizona Board Of Regents | Combretastatin A-4 |
EP0278915B1 (de) * | 1987-02-13 | 1991-11-27 | Ciba-Geigy Ag | Diphenyläthylen-Derivate |
GB9106177D0 (en) * | 1991-03-22 | 1991-05-08 | Aston Molecules Ltd | Substituted diphenylethylenes and analogues or derivatives thereof |
-
1987
- 1987-12-17 CA CA000554733A patent/CA1338645C/en not_active Expired - Lifetime
- 1987-12-25 JP JP62327577A patent/JP2558131B2/ja not_active Expired - Lifetime
-
1988
- 1988-01-06 AT AT88300064T patent/ATE66452T1/de not_active IP Right Cessation
- 1988-01-06 DE DE8888300064T patent/DE3864269D1/de not_active Expired - Lifetime
- 1988-01-06 ES ES198888300064T patent/ES2038747T3/es not_active Expired - Lifetime
- 1988-01-06 EP EP88300064A patent/EP0276051B1/de not_active Expired - Lifetime
-
1991
- 1991-11-12 GR GR91401736T patent/GR3003111T3/el unknown
-
1992
- 1992-02-10 US US07/832,998 patent/US5409953A/en not_active Expired - Lifetime
-
1994
- 1994-11-15 US US08/340,156 patent/US5569786A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5409953A (en) | 1995-04-25 |
GR3003111T3 (en) | 1993-02-17 |
ATE66452T1 (de) | 1991-09-15 |
EP0276051A3 (en) | 1988-11-30 |
US5569786A (en) | 1996-10-29 |
CA1338645C (en) | 1996-10-15 |
ES2038747T3 (es) | 1993-08-01 |
JP2558131B2 (ja) | 1996-11-27 |
JPS63233939A (ja) | 1988-09-29 |
EP0276051B1 (de) | 1991-08-21 |
EP0276051A2 (de) | 1988-07-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |