DE3855890T2 - Verfahren zur herstellung von imunodiagnose-mitteln - Google Patents

Verfahren zur herstellung von imunodiagnose-mitteln

Info

Publication number
DE3855890T2
DE3855890T2 DE3855890T DE3855890T DE3855890T2 DE 3855890 T2 DE3855890 T2 DE 3855890T2 DE 3855890 T DE3855890 T DE 3855890T DE 3855890 T DE3855890 T DE 3855890T DE 3855890 T2 DE3855890 T2 DE 3855890T2
Authority
DE
Germany
Prior art keywords
antibodies
analyte
panel
mimotopes
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3855890T
Other languages
English (en)
Other versions
DE3855890D1 (de
Inventor
Lawrence Kauvar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telik Inc
Terrapin Technologies Inc
Original Assignee
Telik Inc
Terrapin Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc, Terrapin Technologies Inc filed Critical Telik Inc
Publication of DE3855890D1 publication Critical patent/DE3855890D1/de
Application granted granted Critical
Publication of DE3855890T2 publication Critical patent/DE3855890T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE3855890T 1987-10-13 1988-10-12 Verfahren zur herstellung von imunodiagnose-mitteln Expired - Lifetime DE3855890T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10813087A 1987-10-13 1987-10-13
PCT/US1988/003554 WO1989003430A1 (en) 1987-10-13 1988-10-12 Method to produce immunodiagnostic reagents

Publications (2)

Publication Number Publication Date
DE3855890D1 DE3855890D1 (de) 1997-05-28
DE3855890T2 true DE3855890T2 (de) 1998-02-12

Family

ID=22320487

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3855890T Expired - Lifetime DE3855890T2 (de) 1987-10-13 1988-10-12 Verfahren zur herstellung von imunodiagnose-mitteln

Country Status (11)

Country Link
EP (1) EP0387276B1 (de)
JP (2) JPH07111427B2 (de)
KR (1) KR890701761A (de)
AT (1) ATE152244T1 (de)
AU (1) AU635492B2 (de)
CA (1) CA1340459C (de)
DE (1) DE3855890T2 (de)
HU (1) HUT55143A (de)
IE (1) IE81146B1 (de)
NZ (1) NZ226552A (de)
WO (1) WO1989003430A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599903A (en) * 1992-04-03 1997-02-04 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
US5338659A (en) * 1991-04-02 1994-08-16 Terrapin Technologies, Inc. Method for determining analyte concentration by cross-reactivity profiling
US5340474A (en) * 1988-03-24 1994-08-23 Terrapin Technologies, Inc. Panels of analyte-binding ligands
US5409611A (en) * 1988-03-24 1995-04-25 Terrapin Technoogies, Inc. Method to identify analyte-binding ligands
US5223400A (en) * 1989-06-01 1993-06-29 The Ontario Cancer Institute Immunoassay method for determining the specificity of binding of a monoclonal antibody to an antigen
IT1243281B (it) * 1990-06-12 1994-05-26 Fidia Spa Metodo per la determinazione quantitativa e qualitativa di polipeptidiin liquidi proteici
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
JPH06502723A (ja) * 1990-11-09 1994-03-24 ヴェリジェン，インコーポレーテッド 抗体を検出する分析系の感度及び／又は特異性の決定方法
US5955432A (en) * 1992-04-03 1999-09-21 Terrapin Technologies, Inc. Metabolic effects of certain glutathione analogs
US5733549A (en) * 1992-08-14 1998-03-31 Shino-Test Corporation Peptides including amino acid sequences selected from lipoprotein (a) and apolipoprotein (a), antibodies recognizing these amino acid sequences, and methods of determination using these antibodies
US5356784A (en) * 1993-03-30 1994-10-18 Terrapin Technologies, Inc. Determination of concentration by affinity titration
CA2157929A1 (en) * 1993-03-30 1994-10-13 Lawrence M. Kauvar Determination of concentration by affinity titration and competitive displacement in drug delivery
US5587293A (en) * 1994-01-06 1996-12-24 Terrapin Technologies, Inc. Method to identify binding partners
WO1995018969A1 (en) * 1994-01-06 1995-07-13 Terrapin Technologies, Inc. Surrogates for targets and improved reference panels
US6010861A (en) * 1994-08-03 2000-01-04 Dgi Biotechnologies, Llc Target specific screens and their use for discovering small organic molecular pharmacophores
GB9425582D0 (en) * 1994-12-19 1995-02-15 Iaf Biochem Int Peptides having immunomodulatory activity
JP3421970B2 (ja) 1996-03-01 2003-06-30 ノバルティス アクチエンゲゼルシャフト ペプチド免疫原
AU2002300284B2 (en) * 1997-06-20 2006-01-12 Ciphergen Biosystems, Inc. Retentate chromatography and protein chip arrays with applications in biology and medicine
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US20020029391A1 (en) * 1998-04-15 2002-03-07 Claude Geoffrey Davis Epitope-driven human antibody production and gene expression profiling
EP1086134A2 (de) * 1998-06-13 2001-03-28 AstraZeneca AB Herstellungsverfahren für antikörper die posttranslational modifizierte aminosäuren innerhalb von peptiden binden
AU7103500A (en) * 1999-09-01 2001-03-26 Medalys Corporation High throughput chemical profiling
CN117571882B (zh) * 2024-01-09 2024-04-30 北京豪思生物科技股份有限公司 一种血清中类固醇激素的液相色谱-串联质谱检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
DE3479289D1 (en) * 1983-11-07 1989-09-14 Wistar Inst Immune response to tumours and viruses induced by anti-idiotype antibodies
DE3586772T2 (de) * 1984-07-24 1993-03-04 Coselco Mimotopes Pty Ltd Verfahren zur bestimmung von mimotopen.

Also Published As

Publication number Publication date
WO1989003430A1 (en) 1989-04-20
HUT55143A (en) 1991-04-29
KR890701761A (ko) 1989-12-21
AU2790989A (en) 1989-05-02
EP0387276A4 (en) 1991-01-23
IE81146B1 (en) 2000-05-03
JPH07111427B2 (ja) 1995-11-29
JP2674948B2 (ja) 1997-11-12
AU635492B2 (en) 1993-03-25
DE3855890D1 (de) 1997-05-28
EP0387276B1 (de) 1997-04-23
EP0387276A1 (de) 1990-09-19
HU886713D0 (en) 1991-02-28
JPH0772151A (ja) 1995-03-17
NZ226552A (en) 1991-04-26
IE883094L (en) 1989-04-13
CA1340459C (en) 1999-03-23
ATE152244T1 (de) 1997-05-15
JPH03504638A (ja) 1991-10-09

Similar Documents

Publication Publication Date Title
DE3855890T2 (de) Verfahren zur herstellung von imunodiagnose-mitteln
ATE84879T1 (de) Verfahren zum erreichen einer linearen normkurve in einem sandwich-immunoassay.
ATE48037T1 (de) Verfahren und reagenz zur verwendung zur bestimmung von pivka-ii.
EP0230934A3 (de) Monoklonaler Antikörper, Verfahren zur Messung eines glucosylierten Proteins unter Verwendung von diesem monoklonalen Antikörper, und Kit dafür
DE68921374T2 (de) Monoklonaler Antikörper gegen menschliche Mangan-Superoxiddismutase, Verfahren zu dessen Herstellung, Testreagens, Kit und Testmethode unter Verwendung desselben, Verfahren zur Diagnose von menschlichem Eierstockkrebs und von Herzinfarkt.
DE3884731D1 (de) Monoklonaler Antikörper gegen Methamphetamin, seine Herstellung, Testverfahren und Testsatz für Methamphetamin.
DE69033352T2 (de) Competitives enzym-testverfahren zum nachweis von phosphothioaten
DE69026875T2 (de) Immunobestimmung von menschlichem osteocalcin, reagenz und satz dafür
BR9100924A (pt) Linha de celulas de hibridoma,mutantes,anticorpos,processo para a preparacao de uma linha de celulas de hibridoma,processo para a preparacao de anticorpos,processo e agente para a prova imunologica de metolacloro,derivado de metolacloro e processo para sua preparacao
ES2056919T3 (es) Anticuerpo monoclonal especifico para la fosfolipasa a2 pancreatica humana.
KR890006828A (ko) 효소 분석법
EP0315447A3 (de) Verfahren zur immunologischen Bestimmung von humanem Protein S sowie Reagens und Kit dafür
CA2095735A1 (en) Monoclonal antibodies to hepatitis c virus and method for using same
NO852058L (no) Fremgangsmaate og middel for bestemmelse av atl virus antistoffer.
ATE41242T1 (de) Verfahren zur bestimmung einer immunologisch bindefaehigen substanz.
DK98692A (da) Monoklonalt antistof og fremgangsmaade til fremstilling deraf, hybridoma, som producerer det monoklonale antistof, og proeve for tumorcellefoelsomhed under anvendelse af det monoklonale antistof
EP0248147A3 (de) Verfahren zur Bestimmung der Anwesenheit von Krebszellen
YU164090A (sh) Postopek za dokazovanje analitov
BR8803673A (pt) Hibridoma,mutantes,anticorpo,processos para a preparacao de um hidroma e para a preparacao de um anticorpo,processo para determinacao da existencia de antigeno e kit de teste
SU627379A1 (ru) Способ испытани волокнистых материалов на изгиб
ES8608321A1 (es) Hibridomas productores de anticuerpos monoclonales especifi-cos para la inmunoglobulina e (ige)humana del mieloma ns
DE68917732T2 (de) Immuntestverfahren von chondrocalcin.
EP0213106A3 (de) Verfahren zum Nachweis von Antikörpern und Verfahren zur Herstellung eines Mittels zum Nachweis von Antikörper
IL71508A0 (en) Specific binding assay method and test kit for the determination of haptens,antigens and antibodies
RU96123371A (ru) Способ определения аффиности антител с помощью серологических реакций

Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition