DE3850931D1 - Heterobifunktionelle Kupplungsmittel. - Google Patents

Heterobifunktionelle Kupplungsmittel.

Info

Publication number
DE3850931D1
DE3850931D1 DE3850931T DE3850931T DE3850931D1 DE 3850931 D1 DE3850931 D1 DE 3850931D1 DE 3850931 T DE3850931 T DE 3850931T DE 3850931 T DE3850931 T DE 3850931T DE 3850931 D1 DE3850931 D1 DE 3850931D1
Authority
DE
Germany
Prior art keywords
coupling agents
proteins
heterobifunctional coupling
heterobifunctional
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3850931T
Other languages
English (en)
Other versions
DE3850931T2 (de
Inventor
Christopher Bieniarz
Grady Barnes
Christopher Joseph Welch
Carol A Schlesinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/246,971 external-priority patent/US4994385A/en
Priority claimed from US07/254,288 external-priority patent/US5002883A/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE3850931D1 publication Critical patent/DE3850931D1/de
Application granted granted Critical
Publication of DE3850931T2 publication Critical patent/DE3850931T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE3850931T 1987-10-30 1988-10-27 Heterobifunktionelle Kupplungsmittel. Expired - Fee Related DE3850931T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11493087A 1987-10-30 1987-10-30
US07/246,971 US4994385A (en) 1987-10-30 1988-09-22 Heterobifunctional coupling agents
US07/254,288 US5002883A (en) 1987-10-30 1988-10-11 Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents

Publications (2)

Publication Number Publication Date
DE3850931D1 true DE3850931D1 (de) 1994-09-08
DE3850931T2 DE3850931T2 (de) 1994-12-01

Family

ID=27381577

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3850931T Expired - Fee Related DE3850931T2 (de) 1987-10-30 1988-10-27 Heterobifunktionelle Kupplungsmittel.

Country Status (7)

Country Link
EP (1) EP0314127B1 (de)
JP (1) JP2964407B2 (de)
AT (1) ATE109464T1 (de)
AU (1) AU626809B2 (de)
CA (1) CA1340387C (de)
DE (1) DE3850931T2 (de)
ES (1) ES2060636T3 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066490A (en) * 1988-06-01 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Protein crosslinking reagents cleavable within acidified intracellular vesicles
US5104815A (en) 1988-10-11 1992-04-14 Abbott Laboratories Assay for cobalamins
JP3124018B2 (ja) * 1989-05-02 2001-01-15 アボット・ラボラトリーズ 結合アッセイ用固相の調製方法
GB8927365D0 (en) * 1989-12-04 1990-01-31 Ici Plc Reagent
US5091542A (en) * 1990-03-09 1992-02-25 Hybritech Incorporated Tris-maleimido compounds as intermediates in trifunctional antibody synthesis
KR930702683A (ko) * 1990-10-22 1993-09-09 챨스 엠. 브록 항체 등에 효소 등을 커플링시키기 위한 동종이작용성 제제
DE4033714C3 (de) * 1990-10-24 1995-09-07 Brahms Diagnostica Gmbh Neues Hapten-Analytikum basierend auf dem Prinzip einer Antigen-Antikörper-Reaktion
US5258507A (en) * 1990-11-08 1993-11-02 Amoco Corporation Labeling reagents useful for the chemical attachment of nitrophenyl derivative ligands to DNA probes
DE69133095T2 (de) 1990-11-20 2003-03-27 Dade Behring Marburg Gmbh Cyclosporin-Immunoassay
JP3093383B2 (ja) * 1990-11-30 2000-10-03 塩野義製薬株式会社 抗体標識のための放射性ヨウ素化合物
US5294536A (en) * 1992-04-23 1994-03-15 Pb Diagnostic Systems, Inc. Conjugates
IL107715A0 (en) * 1992-11-25 1994-02-27 Baxter Int Water soluble non-immunogenic polyamide cross-linking agents
US5283344A (en) * 1993-03-10 1994-02-01 Abbott Laboratories Coupling method using selective amination of maleimide
JPH08509064A (ja) * 1993-09-22 1996-09-24 デイド、インターナショナル、インコーポレイテッド 化学的に架橋したタンパクの固相支持体上の固定化
DE4435728A1 (de) * 1994-01-19 1995-07-20 Boehringer Mannheim Gmbh Biotinsilan-Verbindungen und diese Verbindungen enthaltende Bindematrix
US5919758A (en) * 1994-03-22 1999-07-06 Beth Israel Deaconess Medical Center Modified polypeptides with altered biological activity
ES2170937T3 (es) * 1996-01-26 2002-08-16 Roche Diagnostics Corp Agentes de reticulacion bis-maleimido.
US5763196A (en) * 1996-01-26 1998-06-09 Boehringer Mannheim Corporation Assays using cross-linked polypeptide fragments of β-galactosidase
US7220842B2 (en) 2004-04-05 2007-05-22 Dade Behring Inc. Immunoassays for buprenorphine and norbuprenorphine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201770A (en) * 1973-05-07 1980-05-06 The Ohio State University Antigenic modification of polypeptides
US4536391A (en) * 1982-11-17 1985-08-20 Otsuka Pharmaceutical Co. Process for preparing urokinase complex
JPS59176675A (ja) * 1983-03-26 1984-10-06 Eiken Kagaku Kk 酵素免疫測定用試薬
JPS60146154A (ja) * 1984-01-11 1985-08-01 Eisai Co Ltd オステオカルシン関連誘導体
JP2507982B2 (ja) * 1984-04-10 1996-06-19 武田薬品工業株式会社 ヒト癌胎児性抗原反応性モノクロ―ナル抗体の製造法
EP0158291A3 (de) * 1984-04-10 1988-07-27 Takeda Chemical Industries, Ltd. Verfahren zur Reinigung von karzinoembryonischem Antigen und Verfahren zur Herstellung eines monoklonalen Antikörpers, der mit karzinoembryonischem Antigen reagiert
US4659839A (en) * 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments

Also Published As

Publication number Publication date
EP0314127B1 (de) 1994-08-03
EP0314127A3 (en) 1990-10-31
DE3850931T2 (de) 1994-12-01
ATE109464T1 (de) 1994-08-15
JP2964407B2 (ja) 1999-10-18
ES2060636T3 (es) 1994-12-01
AU2441188A (en) 1989-07-13
EP0314127A2 (de) 1989-05-03
CA1340387C (en) 1999-02-09
JPH01201158A (ja) 1989-08-14
AU626809B2 (en) 1992-08-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee