DE3782073T2 - Synthetische atriale peptide. - Google Patents
Synthetische atriale peptide.Info
- Publication number
- DE3782073T2 DE3782073T2 DE8787870038T DE3782073T DE3782073T2 DE 3782073 T2 DE3782073 T2 DE 3782073T2 DE 8787870038 T DE8787870038 T DE 8787870038T DE 3782073 T DE3782073 T DE 3782073T DE 3782073 T2 DE3782073 T2 DE 3782073T2
- Authority
- DE
- Germany
- Prior art keywords
- atrial peptides
- synthetic atrial
- ser
- synthetic
- peptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000001746 atrial effect Effects 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 102000002723 Atrial Natriuretic Factor Human genes 0.000 abstract 1
- 101800001288 Atrial natriuretic factor Proteins 0.000 abstract 1
- XZKQVQKUZMAADP-IMJSIDKUSA-N Ser-Ser Chemical group OC[C@H](N)C(=O)N[C@@H](CO)C(O)=O XZKQVQKUZMAADP-IMJSIDKUSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 108010082685 antiarrhythmic peptide Proteins 0.000 abstract 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
- NSQLIUXCMFBZME-MPVJKSABSA-N carperitide Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 NSQLIUXCMFBZME-MPVJKSABSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000001452 natriuretic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
- C07K14/582—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/844,906 US4716147A (en) | 1986-03-27 | 1986-03-27 | Synthetic airial peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3782073D1 DE3782073D1 (en) | 1992-11-12 |
| DE3782073T2 true DE3782073T2 (de) | 1993-05-06 |
Family
ID=25293931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8787870038T Expired - Fee Related DE3782073T2 (de) | 1986-03-27 | 1987-03-26 | Synthetische atriale peptide. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4716147A (de) |
| EP (1) | EP0239558B1 (de) |
| JP (1) | JPS62240699A (de) |
| AT (1) | ATE81345T1 (de) |
| AU (1) | AU595592B2 (de) |
| DE (1) | DE3782073T2 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5212286A (en) * | 1984-04-19 | 1993-05-18 | Scios Nova Inc. | Atrial natriuretic/vasodilator peptide compounds |
| US5057603A (en) * | 1986-01-31 | 1991-10-15 | Merck & Co., Inc. | Peptides having ANF activity |
| EP0246795A3 (de) * | 1986-05-20 | 1990-04-04 | Advanced Peptide Development Limited | Synthetische natriuretische Peptide |
| US5565606A (en) * | 1986-10-21 | 1996-10-15 | Hoechst Aktiengesellschaft | Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method |
| DE3723551A1 (de) * | 1987-07-16 | 1989-01-26 | Hoechst Ag | Peptide mit vasorelaxierender, natriuretischer und diuretischer wirkung, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
| DK531986D0 (da) * | 1986-11-07 | 1986-11-07 | Novo Industri As | Peptider |
| US4859736A (en) * | 1987-03-30 | 1989-08-22 | Ciba-Geigy Corporation | Synthetic polystyrene resin and its use in solid phase peptide synthesis |
| US4816443A (en) * | 1987-05-19 | 1989-03-28 | Merck & Co., Inc. | Piptides having ANF activity |
| DE3881467T2 (de) * | 1987-10-09 | 1993-10-21 | Takeda Chemical Industries Ltd | Vasokonstriktor-Peptid. |
| US5262521A (en) * | 1991-06-07 | 1993-11-16 | Sri International | Isolated atrial peptide-degrading enzyme and novel compounds useful as inhibitors thereof |
| US5665704A (en) * | 1993-11-12 | 1997-09-09 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
| US6525022B1 (en) | 1993-11-12 | 2003-02-25 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
| US5846932A (en) * | 1993-11-12 | 1998-12-08 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
| EP2004633A4 (de) * | 2006-03-30 | 2009-08-26 | Palatin Technologies Inc | Lineare natriuretische peptidkonstrukte |
| US8580746B2 (en) | 2006-03-30 | 2013-11-12 | Palatin Technologies, Inc. | Amide linkage cyclic natriuretic peptide constructs |
| AU2007233116B2 (en) | 2006-03-30 | 2013-05-09 | Palatin Technologies, Inc. | Cyclic natriuretic peptide constructs |
| US8436140B2 (en) * | 2008-06-02 | 2013-05-07 | Washington University | Natriuretic peptide-mediated imaging of atherosclerotic plaque |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4496544A (en) * | 1983-11-10 | 1985-01-29 | Washington University | Atrial Peptides |
| US4508712A (en) * | 1984-01-10 | 1985-04-02 | Washington University | Atrial peptide |
| US4952561A (en) * | 1984-02-07 | 1990-08-28 | Merck & Co., Inc. | Cardiac atrial peptides |
| JPH0672157B2 (ja) * | 1984-08-29 | 1994-09-14 | 味の素株式会社 | 新規ペプチド |
-
1986
- 1986-03-27 US US06/844,906 patent/US4716147A/en not_active Expired - Fee Related
-
1987
- 1987-03-26 AU AU70660/87A patent/AU595592B2/en not_active Ceased
- 1987-03-26 AT AT87870038T patent/ATE81345T1/de not_active IP Right Cessation
- 1987-03-26 DE DE8787870038T patent/DE3782073T2/de not_active Expired - Fee Related
- 1987-03-26 JP JP62072973A patent/JPS62240699A/ja active Pending
- 1987-03-26 EP EP87870038A patent/EP0239558B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0239558A2 (de) | 1987-09-30 |
| EP0239558B1 (de) | 1992-10-07 |
| AU7066087A (en) | 1987-10-01 |
| EP0239558A3 (en) | 1990-01-03 |
| DE3782073D1 (en) | 1992-11-12 |
| ATE81345T1 (de) | 1992-10-15 |
| AU595592B2 (en) | 1990-04-05 |
| US4716147A (en) | 1987-12-29 |
| JPS62240699A (ja) | 1987-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |