DE3751764D1 - Verfahren zur Herstellung von N1,N4-Diethylspermin - Google Patents

Verfahren zur Herstellung von N1,N4-Diethylspermin

Info

Publication number
DE3751764D1
DE3751764D1 DE3751764T DE3751764T DE3751764D1 DE 3751764 D1 DE3751764 D1 DE 3751764D1 DE 3751764 T DE3751764 T DE 3751764T DE 3751764 T DE3751764 T DE 3751764T DE 3751764 D1 DE3751764 D1 DE 3751764D1
Authority
DE
Germany
Prior art keywords
general formula
stands
chem
pharmaceutically acceptable
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3751764T
Other languages
English (en)
Other versions
DE3751764T2 (de
Inventor
Raymond J Bergeron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
Original Assignee
University of Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida filed Critical University of Florida
Publication of DE3751764D1 publication Critical patent/DE3751764D1/de
Application granted granted Critical
Publication of DE3751764T2 publication Critical patent/DE3751764T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
    • C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE3751764T 1986-12-02 1987-12-01 Verfahren zur Herstellung von N1,N4-Diethylspermin Expired - Fee Related DE3751764T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93683586A 1986-12-02 1986-12-02

Publications (2)

Publication Number Publication Date
DE3751764D1 true DE3751764D1 (de) 1996-05-02
DE3751764T2 DE3751764T2 (de) 1996-10-31

Family

ID=25469139

Family Applications (2)

Application Number Title Priority Date Filing Date
DE87310591T Expired - Fee Related DE3786896T2 (de) 1986-12-02 1987-12-01 Verwendung eines Spermin-Derivats mit anti-neoplastischer Wirkung zur Herstellung pharmazeutischer Zusammensetzungen.
DE3751764T Expired - Fee Related DE3751764T2 (de) 1986-12-02 1987-12-01 Verfahren zur Herstellung von N1,N4-Diethylspermin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE87310591T Expired - Fee Related DE3786896T2 (de) 1986-12-02 1987-12-01 Verwendung eines Spermin-Derivats mit anti-neoplastischer Wirkung zur Herstellung pharmazeutischer Zusammensetzungen.

Country Status (6)

Country Link
EP (2) EP0536853B1 (de)
JP (1) JPH0653661B2 (de)
AT (1) ATE136021T1 (de)
CA (1) CA1305425C (de)
DE (2) DE3786896T2 (de)
ES (2) ES2059398T3 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091576A (en) * 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5753714A (en) * 1987-02-03 1998-05-19 Merrell Pharmaceuticals Inc. Polyamine derivatives
ZA887410B (en) * 1987-10-08 1989-06-28 Merrell Dow Pharma Polyamine derivatives as antineoplastic agents
US5654484A (en) * 1987-10-08 1997-08-05 Merrell Pharmaceuticals Inc. Polyamine derivatives as antineoplastic agents
ATE120447T1 (de) * 1989-01-10 1995-04-15 Merrell Dow Pharma Polyamin-derivate als antineoplastische mittel.
US5561136A (en) * 1990-12-13 1996-10-01 Merrell Pharmaceuticals Inc. Method of treating cancer by conjunctive therapy with N,N'-bis[ethylamino)propyl]-1,7-heptanediamine and a cytotoxic agent
GB9105489D0 (en) * 1991-03-15 1991-05-01 Johnson Matthey Plc Improvements in chemical compounds
FR2714052B1 (fr) * 1993-12-22 1996-02-02 Synthelabo Préparation de polyamines substituées sur les deux azotes terminaux.
CA2155095A1 (en) * 1993-12-27 1995-07-06 Jorg Frei Unsaturate amino compounds for use as anticancer and antiprotozoic agent
JP3979664B2 (ja) * 1995-03-15 2007-09-19 ノバルティス・アクチエンゲゼルシャフト プトレッシン、スペルミジンおよびスペルミンなどの細胞内の内因性ポリアミンレベルを低下させるピペリジニル−２−アルキル置換直鎖ポリアミン、およびその細胞増殖に対する影響
WO1998017624A1 (en) * 1996-10-18 1998-04-30 Wisconsin Alumni Research Foundation Conformationally restricted polyamines and their use as antineoplastic agents
US5889061A (en) * 1997-10-15 1999-03-30 Wisconsin Alumni Research Foundation Conformationally restricted polyamines
US7045550B2 (en) 2001-08-07 2006-05-16 Wisconsin Alumni Research Foundation Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
WO2016007821A2 (en) * 2014-07-11 2016-01-14 Genzyme Corporation Main chain polyamines
WO2018059214A1 (zh) * 2016-09-29 2018-04-05 广州君赫生物科技有限公司 影响saicar合成的化合物及应用
SG11201908662XA (en) * 2017-04-20 2019-11-28 Geneheal Biotechnology Co Ltd Applications of spermine and its derivative in preparation of antitumor drug
AU2018253689B2 (en) 2017-04-20 2020-07-23 Geneheal Biotechnology Co., Ltd. Applications of spermidine and its derivative

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS606348B2 (ja) * 1976-03-31 1985-02-18 三菱化学株式会社 新規ポリアミン類
JPS5998015A (ja) * 1982-11-27 1984-06-06 Microbial Chem Res Found 免疫賦活剤

Also Published As

Publication number Publication date
ES2059398T3 (es) 1994-11-16
EP0270349B1 (de) 1993-08-04
JPS63211225A (ja) 1988-09-02
EP0536853B1 (de) 1996-03-27
DE3786896T2 (de) 1993-12-23
DE3786896D1 (de) 1993-09-09
EP0536853A2 (de) 1993-04-14
EP0536853A3 (en) 1993-05-12
ES2088091T3 (es) 1996-08-01
CA1305425C (en) 1992-07-21
DE3751764T2 (de) 1996-10-31
JPH0653661B2 (ja) 1994-07-20
EP0270349A2 (de) 1988-06-08
EP0270349A3 (en) 1990-09-12
ATE136021T1 (de) 1996-04-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee