SG11201908662XA - Applications of spermine and its derivative in preparation of antitumor drug - Google Patents
Applications of spermine and its derivative in preparation of antitumor drugInfo
- Publication number
- SG11201908662XA SG11201908662XA SG11201908662XA SG11201908662XA SG 11201908662X A SG11201908662X A SG 11201908662XA SG 11201908662X A SG11201908662X A SG 11201908662XA SG 11201908662X A SG11201908662X A SG 11201908662XA
- Authority
- SG
- Singapore
- Prior art keywords
- spermine
- derivative
- applications
- preparation
- antitumor drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57415—Specifically defined cancers of breast
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/9015—Ligases (6)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710261440 | 2017-04-20 | ||
| PCT/CN2018/075427 WO2018192293A1 (en) | 2017-04-20 | 2018-02-06 | Applications of spermine and its derivative in preparation of antitumor drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201908662XA true SG11201908662XA (en) | 2019-11-28 |
Family
ID=63856309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201908662X SG11201908662XA (en) | 2017-04-20 | 2018-02-06 | Applications of spermine and its derivative in preparation of antitumor drug |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11684593B2 (en) |
| EP (1) | EP3613416B1 (en) |
| JP (1) | JP6810814B2 (en) |
| KR (1) | KR20190122242A (en) |
| CN (1) | CN110494131B (en) |
| AU (1) | AU2018253671B2 (en) |
| CA (1) | CA3057206C (en) |
| NZ (1) | NZ757708A (en) |
| SG (1) | SG11201908662XA (en) |
| WO (1) | WO2018192293A1 (en) |
| ZA (1) | ZA201906237B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018059216A1 (en) | 2016-09-29 | 2018-04-05 | 广州君赫生物科技有限公司 | Compounds reducing saicar synthase activity, and applications |
| KR20190122242A (en) | 2017-04-20 | 2019-10-29 | 진힐 바이오테크놀로지 컴퍼니 리미티드 | Application of spermine and its derivatives in the preparation of anti-tumor drugs |
| EP3613731A4 (en) * | 2017-04-20 | 2021-01-13 | Geneheal Biotechnology Co., Ltd. | Applications of spermidine and its derivative |
| WO2020147471A1 (en) * | 2019-01-17 | 2020-07-23 | 广州君赫生物科技有限公司 | New use of aspartic acid |
| WO2023017262A1 (en) * | 2021-08-11 | 2023-02-16 | Cambridge Enterprise Limited | Use of polyamines in the treatment of brain tumours |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1305425C (en) * | 1986-12-02 | 1992-07-21 | Raymond J. Bergeron | Anti-neoplastic spermine derivative |
| US4952585A (en) | 1988-12-15 | 1990-08-28 | Merrell Dow Pharmaceuticals Inc. | Castanospermine esters in the inhibition of tumor metastasis |
| US5541230A (en) * | 1993-11-05 | 1996-07-30 | Us Health | Therapeutic polyamines |
| WO1997011691A1 (en) * | 1995-09-29 | 1997-04-03 | Children's Medical Center Corporation | Treatment of human prostate cancer with spermine |
| US8198334B2 (en) * | 1997-10-27 | 2012-06-12 | Pathologica Llc | Methods for modulating macrophage proliferation in ocular disease using polyamine analogs |
| MXPA00009705A (en) | 1998-04-03 | 2003-07-14 | Univ Manitoba | The use of polyamines in the treatment of dermatological symptoms. |
| CA2318004A1 (en) | 1999-09-15 | 2001-03-15 | Oridigm Corporation | Novel polyamine analogues as therapeutic and diagnostic agents |
| ES2187288B1 (en) | 2001-09-24 | 2004-09-16 | Garbil Pharma Investigacion Chile Ltda | AMINAS AS ANTI-ALCOHOLISM AGENTS. |
| US20050002943A1 (en) | 2001-10-31 | 2005-01-06 | Oberdan Leo | Amp-kinase agonists or adenosine pro-drugs as immuno-stimulating agents |
| ITMI20031570A1 (en) | 2003-07-31 | 2005-02-01 | Giuliani Spa | COMPOSITION FOR DIETARY, PHARMACEUTICAL OR COSMETIC USE |
| CN101205555A (en) | 2006-12-18 | 2008-06-25 | 中国疾病预防控制中心寄生虫病预防控制所 | Schistosoma japonicum resistant medicine action target, medicine sifting method and lead compounds |
| CN101037423A (en) * | 2007-04-16 | 2007-09-19 | 河南大学 | High spermidine conjugates, preparation and application thereof |
| WO2009151569A2 (en) | 2008-06-09 | 2009-12-17 | Combinatorx, Incorporated | Beta adrenergic receptor agonists for the treatment of b-cell proliferative disorders |
| US9708255B2 (en) | 2009-08-18 | 2017-07-18 | Robert A. Casero | (bis)urea and (bis)thiourea compounds as epigenic modulators of lysine-specific demethylase 1 and methods of treating disorders |
| CN103748091A (en) | 2011-06-29 | 2014-04-23 | 由俄勒冈州高等教育委员会代表的波特兰州立大学 | Analyte detection using near-infrared fluorophores |
| FR2980709B1 (en) | 2011-09-29 | 2013-10-25 | Nutrialys Medical Nutrition Sa | COMPOSITIONS CONTAINING SPERMINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
| WO2014067038A1 (en) | 2012-10-29 | 2014-05-08 | 广州百赫医疗信息科技有限公司 | Target point, preparation and method for treating human adsl deficiency |
| US20150290160A1 (en) | 2012-11-14 | 2015-10-15 | Biomark Technologies Inc. | Spermidine/Spermine N1-Acetyltransferase Substrates As Anti-Cancer Drug Compounds |
| EP2950820A4 (en) | 2013-01-30 | 2016-08-03 | Biomark Technologies Inc | Spermidine/spermine n1-acetyltransferase antibodies as anti-cancer drug compounds |
| US20160369281A1 (en) | 2015-06-16 | 2016-12-22 | Geneheal Biotechnology Co., Ltd. | Target point, preparation and method for treating human ADSL deficiency |
| CN106399380A (en) | 2016-09-13 | 2017-02-15 | 上海云舜生物技术有限公司 | Compound containing anti-PD (Program Death)-1 gene and poly-spermidine and application of compound to treatment of tumors |
| JP6870077B2 (en) | 2016-09-29 | 2021-05-12 | 広州君赫生物科技有限公司 | New use of spermine and its derivatives |
| WO2018059216A1 (en) | 2016-09-29 | 2018-04-05 | 广州君赫生物科技有限公司 | Compounds reducing saicar synthase activity, and applications |
| KR20190122242A (en) | 2017-04-20 | 2019-10-29 | 진힐 바이오테크놀로지 컴퍼니 리미티드 | Application of spermine and its derivatives in the preparation of anti-tumor drugs |
-
2018
- 2018-02-06 KR KR1020197028417A patent/KR20190122242A/en not_active IP Right Cessation
- 2018-02-06 EP EP18787222.1A patent/EP3613416B1/en active Active
- 2018-02-06 CN CN201880019008.9A patent/CN110494131B/en active Active
- 2018-02-06 AU AU2018253671A patent/AU2018253671B2/en active Active
- 2018-02-06 SG SG11201908662X patent/SG11201908662XA/en unknown
- 2018-02-06 NZ NZ757708A patent/NZ757708A/en unknown
- 2018-02-06 WO PCT/CN2018/075427 patent/WO2018192293A1/en unknown
- 2018-02-06 CA CA3057206A patent/CA3057206C/en active Active
- 2018-02-06 JP JP2019551698A patent/JP6810814B2/en active Active
- 2018-02-06 US US16/497,305 patent/US11684593B2/en active Active
-
2019
- 2019-09-20 ZA ZA2019/06237A patent/ZA201906237B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3613416B1 (en) | 2021-12-15 |
| NZ757708A (en) | 2022-01-28 |
| JP6810814B2 (en) | 2021-01-06 |
| EP3613416A4 (en) | 2020-10-21 |
| KR20190122242A (en) | 2019-10-29 |
| WO2018192293A1 (en) | 2018-10-25 |
| US20200330402A1 (en) | 2020-10-22 |
| AU2018253671B2 (en) | 2020-08-20 |
| EP3613416A1 (en) | 2020-02-26 |
| AU2018253671A1 (en) | 2019-10-10 |
| CA3057206A1 (en) | 2018-10-25 |
| CA3057206C (en) | 2022-11-01 |
| CN110494131B (en) | 2022-11-08 |
| CN110494131A (en) | 2019-11-22 |
| US11684593B2 (en) | 2023-06-27 |
| JP2020511500A (en) | 2020-04-16 |
| ZA201906237B (en) | 2021-04-28 |
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