DE3750655D1 - Verfahren und Vorrichtung zum Abgeben und Auftragen von flüssigen Reagenzien. - Google Patents
Verfahren und Vorrichtung zum Abgeben und Auftragen von flüssigen Reagenzien.Info
- Publication number
- DE3750655D1 DE3750655D1 DE3750655T DE3750655T DE3750655D1 DE 3750655 D1 DE3750655 D1 DE 3750655D1 DE 3750655 T DE3750655 T DE 3750655T DE 3750655 T DE3750655 T DE 3750655T DE 3750655 D1 DE3750655 D1 DE 3750655D1
- Authority
- DE
- Germany
- Prior art keywords
- transducer
- dispensing
- jetting tube
- fluid
- reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 5
- 239000007788 liquid Substances 0.000 title 1
- 239000012530 fluid Substances 0.000 abstract 4
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
- G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
- G01F11/08—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the diaphragm or bellows type
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
- G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
- G01F11/08—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the diaphragm or bellows type
- G01F11/088—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the diaphragm or bellows type using a deformable conduit-like element
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00378—Piezoelectric or ink jet dispensers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00677—Ex-situ synthesis followed by deposition on the substrate
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1041—Ink-jet like dispensers
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Fluid Mechanics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Nanotechnology (AREA)
- Analytical Chemistry (AREA)
- Materials Engineering (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Composite Materials (AREA)
- Crystallography & Structural Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Hydrology & Water Resources (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93147686A | 1986-11-17 | 1986-11-17 |
Publications (3)
Publication Number | Publication Date |
---|---|
DE3750655D1 true DE3750655D1 (de) | 1994-11-17 |
DE3750655T2 DE3750655T2 (de) | 1995-05-11 |
DE3750655T3 DE3750655T3 (de) | 2003-04-24 |
Family
ID=25460832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3750655T Expired - Lifetime DE3750655T3 (de) | 1986-11-17 | 1987-11-16 | Verfahren und Vorrichtung zum Abgeben von flüssigen Reagenzien |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0268237B2 (de) |
JP (1) | JPH076975B2 (de) |
KR (1) | KR880006117A (de) |
AT (1) | ATE112849T1 (de) |
AU (1) | AU603617B2 (de) |
CA (1) | CA1308467C (de) |
DE (1) | DE3750655T3 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
US5700637A (en) * | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
US6054270A (en) * | 1988-05-03 | 2000-04-25 | Oxford Gene Technology Limited | Analying polynucleotide sequences |
US7811751B2 (en) | 1988-05-03 | 2010-10-12 | Oxford Gene Technology Limited | Analysing polynucleotide sequences |
US5275787A (en) * | 1989-10-04 | 1994-01-04 | Canon Kabushiki Kaisha | Apparatus for separating or measuring particles to be examined in a sample fluid |
DE69025370T2 (de) * | 1989-10-04 | 1996-09-12 | Canon Kk | Gerät und Verfahren zur Trennung oder Messung von zu untersuchenden Teilchen in einer Flüssigkeitsprobe |
DE4024545A1 (de) * | 1990-08-02 | 1992-02-06 | Boehringer Mannheim Gmbh | Verfahren und vorrichtung zum dosierten zufuehren einer biochemischen analysefluessigkeit auf ein target |
GB9115053D0 (en) * | 1991-07-12 | 1991-08-28 | Graseby Ionics Ltd | Fluid sampling system |
JPH058128U (ja) * | 1991-07-15 | 1993-02-05 | 帝国ピストンリング株式会社 | 組合せオイルリング |
US5677195A (en) * | 1991-11-22 | 1997-10-14 | Affymax Technologies N.V. | Combinatorial strategies for polymer synthesis |
DE4202850A1 (de) * | 1992-01-31 | 1993-08-05 | Boehringer Mannheim Gmbh | Analysenelement fuer immunoassays |
JPH0610900A (ja) * | 1992-04-27 | 1994-01-21 | Canon Inc | 液体移動方法及び移動装置ならびにこれを利用した測定装置 |
US6092695A (en) * | 1992-05-11 | 2000-07-25 | Cytologix Corporation | Interchangeable liquid dispensing cartridge pump |
US5947167A (en) * | 1992-05-11 | 1999-09-07 | Cytologix Corporation | Dispensing assembly with interchangeable cartridge pumps |
US6180061B1 (en) | 1992-05-11 | 2001-01-30 | Cytologix Corporation | Moving platform slide stainer with heating elements |
US6203759B1 (en) | 1996-05-31 | 2001-03-20 | Packard Instrument Company | Microvolume liquid handling system |
US6537817B1 (en) | 1993-05-31 | 2003-03-25 | Packard Instrument Company | Piezoelectric-drop-on-demand technology |
US6521187B1 (en) | 1996-05-31 | 2003-02-18 | Packard Instrument Company | Dispensing liquid drops onto porous brittle substrates |
DE4331596A1 (de) * | 1993-09-17 | 1995-03-23 | Boehringer Mannheim Gmbh | Verfahren zur quantitativen Analyse von Probenflüssigkeiten |
US6428955B1 (en) | 1995-03-17 | 2002-08-06 | Sequenom, Inc. | DNA diagnostics based on mass spectrometry |
SE9502251D0 (sv) * | 1995-06-21 | 1995-06-21 | Pharmacia Ab | Flow-through sampling cell and use thereof |
JPH0990801A (ja) * | 1995-09-20 | 1997-04-04 | Ricoh Co Ltd | 定着装置における駆動装置 |
US5958342A (en) * | 1996-05-17 | 1999-09-28 | Incyte Pharmaceuticals, Inc. | Jet droplet device |
DE69727422T2 (de) * | 1996-05-31 | 2004-07-01 | Packard Instrument Co., Inc., Downers Grove | Vorrichtung zur Handhabung von Mikroflüssigkeitsmengen |
US6083762A (en) * | 1996-05-31 | 2000-07-04 | Packard Instruments Company | Microvolume liquid handling system |
USRE38281E1 (en) | 1996-07-26 | 2003-10-21 | Biodot, Inc. | Dispensing apparatus having improved dynamic range |
AU4145997A (en) * | 1996-07-26 | 1998-02-20 | Bio-Dot, Inc. | Dispensing apparatus having improved dynamic range |
US5916524A (en) | 1997-07-23 | 1999-06-29 | Bio-Dot, Inc. | Dispensing apparatus having improved dynamic range |
US6875620B1 (en) | 1996-10-31 | 2005-04-05 | Agilent Technologies, Inc. | Tiling process for constructing a chemical array |
EP1457496B1 (de) | 1996-11-06 | 2014-01-15 | Sequenom, Inc. | Immobilisierung mit hoher Dichte von Nukleinsäuren |
US6024925A (en) | 1997-01-23 | 2000-02-15 | Sequenom, Inc. | Systems and methods for preparing low volume analyte array elements |
US5812272A (en) * | 1997-01-30 | 1998-09-22 | Hewlett-Packard Company | Apparatus and method with tiled light source array for integrated assay sensing |
DE19707204A1 (de) | 1997-02-24 | 1998-08-27 | Boehringer Mannheim Gmbh | System zur Herstellung diagnostischer Vielfach-Testelemente |
WO1998045205A2 (en) * | 1997-04-08 | 1998-10-15 | Packard Instrument Company, Inc. | Microvolume liquid handling system |
EP1512975A3 (de) * | 1997-04-08 | 2006-05-24 | Packard Instrument Company, Inc. | Vorrichtung zur Handhabung von Mikroflüssigkeitsmengen |
US6268131B1 (en) | 1997-12-15 | 2001-07-31 | Sequenom, Inc. | Mass spectrometric methods for sequencing nucleic acids |
US6537505B1 (en) | 1998-02-20 | 2003-03-25 | Bio Dot, Inc. | Reagent dispensing valve |
US6183693B1 (en) | 1998-02-27 | 2001-02-06 | Cytologix Corporation | Random access slide stainer with independent slide heating regulation |
US6126268A (en) * | 1998-04-29 | 2000-10-03 | Hewlett-Packard Company | Multi-chamber ink supply |
US6309062B1 (en) | 1998-10-29 | 2001-10-30 | Hewlett-Packard Company | Multi-chamber fluid supply |
JP3801380B2 (ja) * | 1998-04-29 | 2006-07-26 | ヒューレット・パッカード・カンパニー | 多室流体供給源 |
US6723564B2 (en) | 1998-05-07 | 2004-04-20 | Sequenom, Inc. | IR MALDI mass spectrometry of nucleic acids using liquid matrices |
US20020142483A1 (en) | 2000-10-30 | 2002-10-03 | Sequenom, Inc. | Method and apparatus for delivery of submicroliter volumes onto a substrate |
DE10222228A1 (de) | 2002-05-16 | 2003-11-27 | Roche Diagnostics Gmbh | Mikropumpe mit Heizelementen für einen pulsierten Betrieb |
US7541152B2 (en) | 2002-12-24 | 2009-06-02 | Agilent Technologies, Inc. | Integrated light source for diagnostic arrays |
GB2426334A (en) | 2005-05-20 | 2006-11-22 | Orion Diagnostica Oy | Application of a reagent to a matrix material |
WO2009039122A2 (en) | 2007-09-17 | 2009-03-26 | Sequenom, Inc. | Integrated robotic sample transfer device |
EP2662137A1 (de) | 2012-05-08 | 2013-11-13 | Roche Diagniostics GmbH | Ausgabeanordnung |
RU2740022C2 (ru) * | 2016-11-14 | 2020-12-30 | Общество с ограниченной ответственностью научно-исследовательский и проектный институт "ПЕГАЗ" | Самотестирующееся устройство автоматического дозирования реагентов |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1346301A (en) * | 1965-06-04 | 1974-02-06 | Adler Auto Precision Ltd | Methods for mixing and or dispensing liquids and apparatus therefor |
US4339763A (en) * | 1970-06-29 | 1982-07-13 | System Industries, Inc. | Apparatus for recording with writing fluids and drop projection means therefor |
US3857049A (en) * | 1972-06-05 | 1974-12-24 | Gould Inc | Pulsed droplet ejecting system |
IL52322A (en) * | 1976-06-18 | 1980-10-26 | Alfa Laval Ab | Method of making reagent test device and device made accorording to this method |
JPS54155092A (en) * | 1978-05-29 | 1979-12-06 | Central Glass Co Ltd | Automatic titration device |
JPS5647749A (en) * | 1979-09-27 | 1981-04-30 | Mitsubishi Chem Ind Ltd | Automatic titration device |
US4266232A (en) * | 1979-06-29 | 1981-05-05 | International Business Machines Corporation | Voltage modulated drop-on-demand ink jet method and apparatus |
US4449134A (en) * | 1982-04-19 | 1984-05-15 | Xerox Corporation | Composite ink jet drivers |
AU2519184A (en) * | 1983-03-21 | 1984-09-27 | Miles Laboratories Inc. | Microdroplet dispensing apparatus |
-
1987
- 1987-11-13 AU AU81207/87A patent/AU603617B2/en not_active Ceased
- 1987-11-16 AT AT87116861T patent/ATE112849T1/de not_active IP Right Cessation
- 1987-11-16 JP JP62290430A patent/JPH076975B2/ja not_active Expired - Lifetime
- 1987-11-16 EP EP87116861A patent/EP0268237B2/de not_active Expired - Lifetime
- 1987-11-16 CA CA000551937A patent/CA1308467C/en not_active Expired - Fee Related
- 1987-11-16 DE DE3750655T patent/DE3750655T3/de not_active Expired - Lifetime
- 1987-11-17 KR KR870012909A patent/KR880006117A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DE3750655T3 (de) | 2003-04-24 |
EP0268237A3 (en) | 1988-11-30 |
CA1308467C (en) | 1992-10-06 |
EP0268237B1 (de) | 1994-10-12 |
ATE112849T1 (de) | 1994-10-15 |
KR880006117A (ko) | 1988-07-21 |
JPS63139253A (ja) | 1988-06-11 |
EP0268237A2 (de) | 1988-05-25 |
EP0268237B2 (de) | 2002-12-18 |
DE3750655T2 (de) | 1995-05-11 |
AU8120787A (en) | 1988-05-19 |
JPH076975B2 (ja) | 1995-01-30 |
AU603617B2 (en) | 1990-11-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8366 | Restricted maintained after opposition proceedings |