DE3750495D1 - Milbemycin-Derivate mit parasitenabtötender Aktivität, ein Verfahren zu ihrer Herstellung und die sie enthaltenden Zusammensetzungen. - Google Patents

Milbemycin-Derivate mit parasitenabtötender Aktivität, ein Verfahren zu ihrer Herstellung und die sie enthaltenden Zusammensetzungen.

Info

Publication number
DE3750495D1
DE3750495D1 DE3750495T DE3750495T DE3750495D1 DE 3750495 D1 DE3750495 D1 DE 3750495D1 DE 3750495 T DE3750495 T DE 3750495T DE 3750495 T DE3750495 T DE 3750495T DE 3750495 D1 DE3750495 D1 DE 3750495D1
Authority
DE
Germany
Prior art keywords
preparation
compositions containing
milbemycin derivatives
parasiticidal activity
parasiticidal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3750495T
Other languages
English (en)
Other versions
DE3750495T2 (de
Inventor
Rhona Mary Banks
Mark Edward Poulton
Geoffrey Harold Baker
Roderick John Dorgan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868618096A external-priority patent/GB8618096D0/en
Priority claimed from GB868618473A external-priority patent/GB8618473D0/en
Priority claimed from GB868620424A external-priority patent/GB8620424D0/en
Priority claimed from GB868621873A external-priority patent/GB8621873D0/en
Priority claimed from GB868621874A external-priority patent/GB8621874D0/en
Priority claimed from GB868625596A external-priority patent/GB8625596D0/en
Priority claimed from GB878700673A external-priority patent/GB8700673D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of DE3750495D1 publication Critical patent/DE3750495D1/de
Application granted granted Critical
Publication of DE3750495T2 publication Critical patent/DE3750495T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
    • A01N63/28—Streptomyces
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Insects & Arthropods (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE3750495T 1986-07-24 1987-07-24 Milbemycin-Derivate mit parasitenabtötender Aktivität, ein Verfahren zu ihrer Herstellung und die sie enthaltenden Zusammensetzungen. Expired - Fee Related DE3750495T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB868618096A GB8618096D0 (en) 1986-07-24 1986-07-24 Compound
GB868618473A GB8618473D0 (en) 1986-07-29 1986-07-29 Compound
GB868620424A GB8620424D0 (en) 1986-08-22 1986-08-22 Compound
GB868621874A GB8621874D0 (en) 1986-09-11 1986-09-11 Compounds
GB868621873A GB8621873D0 (en) 1986-09-11 1986-09-11 Compounds
GB868625596A GB8625596D0 (en) 1986-10-25 1986-10-25 Compound
GB878700673A GB8700673D0 (en) 1987-01-13 1987-01-13 Compound

Publications (2)

Publication Number Publication Date
DE3750495D1 true DE3750495D1 (de) 1994-10-13
DE3750495T2 DE3750495T2 (de) 1995-02-23

Family

ID=27562754

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3750495T Expired - Fee Related DE3750495T2 (de) 1986-07-24 1987-07-24 Milbemycin-Derivate mit parasitenabtötender Aktivität, ein Verfahren zu ihrer Herstellung und die sie enthaltenden Zusammensetzungen.

Country Status (4)

Country Link
US (2) US5620874A (de)
EP (1) EP0254583B1 (de)
JP (1) JP2587241B2 (de)
DE (1) DE3750495T2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2055695T3 (es) * 1986-09-12 1994-09-01 American Cyanamid Co Derivados 23-desoxi de compuestos ll-f28249.
JPH0672145B2 (ja) * 1986-12-11 1994-09-14 三共株式会社 ミルベマイシン化合物、その製法及び用途
US5212322A (en) * 1986-12-11 1993-05-18 Sankyo Company, Limited Macrolide compounds, their preparation and their use
AR243528A1 (es) * 1986-12-11 1993-08-31 Sankyo Co Procedimiento para preparar compuestos de macrolida y un procedimiento para producir con los mismos una composicion parasiticida.
US4806527A (en) * 1987-03-16 1989-02-21 Merck & Co., Inc. Avermectin derivatives
GB8709327D0 (en) * 1987-04-21 1987-05-28 Beecham Group Plc Compounds
EP0298423A3 (de) * 1987-07-07 1989-10-25 Kumiai Chemical Industry Co., Ltd. KSB-1939-Antibiotikum-Derivate und Verfahren zu ihrer Herstellung sowie diese enthaltenden pestiziden Zusammensetzungen
EP0325462A3 (de) * 1988-01-22 1989-11-02 Beecham Group Plc Milbemycin-Derivate mit anthelmintischer Wirkung
GB8804440D0 (en) * 1988-02-25 1988-03-23 Pfizer Ltd Antiparasitic agents
GB8807280D0 (en) * 1988-03-26 1988-04-27 Pfizer Ltd Antiparasitic agents
JP2849389B2 (ja) * 1988-07-05 1999-01-20 三共株式会社 新規マクロライド化合物
NZ232422A (en) * 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
GB8905605D0 (en) * 1989-03-11 1989-04-26 Beecham Group Plc Novel compounds
GB8917064D0 (en) * 1989-07-26 1989-09-13 Pfizer Ltd Antiparasitic agent
US6514951B1 (en) 1989-12-15 2003-02-04 American Cyanamid Company Pour-on formulations effective for the control of internal and external parasites of homothermic animals
GB9205007D0 (en) * 1992-03-07 1992-04-22 Pfizer Ltd Antiparasitic agents
AU9785698A (en) 1997-10-02 1999-04-27 Microcide Pharmaceuticals, Inc. Fungal efflux pump inhibitors
US6126961A (en) * 1998-04-13 2000-10-03 Kross; Robert D. Composition and method for reducing the colonization of animal intestines by salmonella and other bacterial pathogens
GB9825402D0 (en) 1998-11-19 1999-01-13 Pfizer Ltd Antiparasitic formulations
AU4925100A (en) * 1999-05-26 2000-12-18 Novartis Ag 4-substituted milbemycin derivatives
DK2347654T3 (en) 2001-09-17 2019-04-23 Elanco Us Inc Formulation for the control of lice or ticks in cattle
EP2327410A1 (de) * 2009-10-28 2011-06-01 Consiglio Nazionale Delle Ricerche - Infm Istituto Nazionale Per La Fisica Della Materia Avermectine und Milbemycine zur Behandlung von Flavivirus Infektionen
EP2886640A1 (de) 2013-12-18 2015-06-24 Riga Technical University Trennverfahren für Milbemycin A3 und A4

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4914624A (de) * 1972-06-08 1974-02-08
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4093629A (en) * 1977-04-11 1978-06-06 Merck & Co., Inc. Derivatives of antibiotic substance milbemycin and processes therefor
US4144352A (en) * 1977-12-19 1979-03-13 Merck & Co., Inc. Milbemycin compounds as anthelmintic agents
NZ201681A (en) * 1981-09-03 1985-11-08 Merck & Co Inc Avermectin derivatives and parasiticidal compositions
PT80577B (pt) * 1984-06-05 1987-09-18 American Cyanamid Co Processo para a producao de novos agentes macrolidos ll-f28249 uteis no tratamento de infeccoes helminticas por ectoparasitas artropodes e por acarideos
GB2166436B (en) * 1984-09-14 1989-05-24 Glaxo Group Ltd Antibiotic compounds and their preparation
IL78621A (en) * 1985-04-30 1991-06-30 American Cyanamid Co Mylbemycin analogs,their preparation and pesticidal compositions containing them
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
GB8606123D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Chemical compounds
AR243528A1 (es) * 1986-12-11 1993-08-31 Sankyo Co Procedimiento para preparar compuestos de macrolida y un procedimiento para producir con los mismos una composicion parasiticida.
JP2504501B2 (ja) * 1987-01-09 1996-06-05 三共株式会社 新規マクロライド化合物およびその製造法

Also Published As

Publication number Publication date
US5620874A (en) 1997-04-15
DE3750495T2 (de) 1995-02-23
JPS6357591A (ja) 1988-03-12
US5721271A (en) 1998-02-24
EP0254583A2 (de) 1988-01-27
JP2587241B2 (ja) 1997-03-05
EP0254583A3 (en) 1990-10-31
EP0254583B1 (de) 1994-09-07

Similar Documents

Publication Publication Date Title
DE3750495T2 (de) Milbemycin-Derivate mit parasitenabtötender Aktivität, ein Verfahren zu ihrer Herstellung und die sie enthaltenden Zusammensetzungen.
DE3687980T2 (de) Indolderivate mit einer azabicyclischen seitenkette, verfahren zu ihrer herstellung, zwischenprodukte und pharmazeutische zusammensetzungen.
DE3851280D1 (de) Sulfatierte Hydroxy-Mischether, Verfahren zu ihrer Herstellung und ihre Verwendung.
DE3676396D1 (de) Avermectin- und milbemycin-derivate und verfahren zu ihrer herstellung.
DE19475025I2 (de) Dialkoxypyridine, Verfahren zu ihrer Herstellung, ihre Anwendung und sie enthaltende Arzneimittel.
ATE84040T1 (de) Phenol-substituierte gem-diphosphonat-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel.
DE3582952D1 (de) Dihydropyridin-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE58908176D1 (de) Chinacridon-Pigmente, Verfahren zu ihrer Herstellung und ihre Verwendung.
DE69021444D1 (de) Pteridin-4 (3H)-onen, Verfahren zu ihrer Herstellung und sie enthaltende Medikamente.
DE3782994T2 (de) Erythromycin-a-derivate und verfahren zu ihrer herstellung.
DE386683T1 (de) Xanthinderivate mit bronchodilatorischer aktivitaet, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
DE3675931D1 (de) Thiadiazabicyclononanderivate, verfahren zu ihrer herstellung und herbizide zusammensetzungen.
DE3771376D1 (de) Indol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE3484925D1 (de) Pyrazolochinoline, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen.
DE3576686D1 (de) Chinolinone, verfahren zu ihrer herstellung und die sie enthaltenden pharmazeutischen praeparate.
DE3789466D1 (de) 3,7-Disubstituierte-3-Cephemverbindungen und Verfahren zu ihrer Herstellung.
DE3766299D1 (de) 4-chinolon-3-carbonsaeurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
DE3483308D1 (de) Semicarbazid-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE3687515T2 (de) Oxa-, thia- und diazabicycloalkanderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE58907589D1 (de) Thermoplastische Polypropylen-Polyamid-Formmassen, Verfahren zu ihrer Herstellung und ihre Verwendung.
DE3579602D1 (de) 1h-imidazol-derivate, ein verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DE3481418D1 (de) Substituierte spiropyridinderivate, diese enthaltende pharmazeutische zubereitungen, verfahren zu ihrer herstellung und zubereitungen.
DE3778517D1 (de) 7-brom-beta-carbolin-derivate und verfahren zu ihrer herstellung.
DE3684803D1 (de) Dihydropyridin-alkanolamine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE69017091D1 (de) Cyclomalto-oligosaccharidderivate und Verfahren zu ihrer Herstellung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PFIZER, INC. (N.D.GES.D. STAATES DELAWARE), NEW YO

8339 Ceased/non-payment of the annual fee