DE3688427T2 - Topische zusammensetzung und verfahren zur anregung des haarwuchses. - Google Patents
Topische zusammensetzung und verfahren zur anregung des haarwuchses.Info
- Publication number
- DE3688427T2 DE3688427T2 DE8686904603T DE3688427T DE3688427T2 DE 3688427 T2 DE3688427 T2 DE 3688427T2 DE 8686904603 T DE8686904603 T DE 8686904603T DE 3688427 T DE3688427 T DE 3688427T DE 3688427 T2 DE3688427 T2 DE 3688427T2
- Authority
- DE
- Germany
- Prior art keywords
- composition
- composition according
- hair growth
- skin
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 238000000034 method Methods 0.000 title claims abstract description 11
- 230000000699 topical effect Effects 0.000 title claims abstract description 8
- 230000003779 hair growth Effects 0.000 title claims description 17
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 56
- 239000002516 radical scavenger Substances 0.000 claims abstract description 19
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 claims abstract description 16
- 230000002280 anti-androgenic effect Effects 0.000 claims abstract description 14
- 239000000051 antiandrogen Substances 0.000 claims abstract description 14
- 239000000839 emulsion Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000003937 drug carrier Substances 0.000 claims abstract description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
- 201000004384 Alopecia Diseases 0.000 claims description 8
- 238000011282 treatment Methods 0.000 claims description 8
- 230000004936 stimulating effect Effects 0.000 claims description 7
- 150000003462 sulfoxides Chemical class 0.000 claims description 7
- 230000003676 hair loss Effects 0.000 claims description 6
- 150000003254 radicals Chemical class 0.000 claims description 6
- 210000004761 scalp Anatomy 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 claims description 5
- 229940022682 acetone Drugs 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 229960003843 cyproterone Drugs 0.000 claims description 4
- 229960000978 cyproterone acetate Drugs 0.000 claims description 4
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 claims description 3
- 229960003473 androstanolone Drugs 0.000 claims description 3
- 239000002537 cosmetic Substances 0.000 claims description 3
- 208000024963 hair loss Diseases 0.000 claims description 3
- 229940091173 hydantoin Drugs 0.000 claims description 3
- 239000002269 analeptic agent Substances 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 239000000344 soap Substances 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 claims 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 claims 1
- 239000003981 vehicle Substances 0.000 abstract description 4
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 abstract description 3
- 229940124563 hair growth stimulant Drugs 0.000 abstract description 3
- 229960003632 minoxidil Drugs 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 abstract 2
- 229960002256 spironolactone Drugs 0.000 abstract 2
- BBNGVMNBBLPZIR-UHFFFAOYSA-N 4h-1$l^{6},2,4-benzothiadiazine 1,1-dioxide Chemical class C1=CC=C2S(=O)(=O)N=CNC2=C1 BBNGVMNBBLPZIR-UHFFFAOYSA-N 0.000 abstract 1
- 239000006071 cream Substances 0.000 description 14
- 210000003491 skin Anatomy 0.000 description 11
- 230000000694 effects Effects 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- -1 6-amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidines Chemical class 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 3
- DUSHUSLJJMDGTE-ZJPMUUANSA-N cyproterone Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DUSHUSLJJMDGTE-ZJPMUUANSA-N 0.000 description 3
- 235000019271 petrolatum Nutrition 0.000 description 3
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- 241001134446 Niveas Species 0.000 description 2
- 239000004264 Petrolatum Substances 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 206010068168 androgenetic alopecia Diseases 0.000 description 2
- 229940003587 aquaphor Drugs 0.000 description 2
- 239000008294 cold cream Substances 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 239000003974 emollient agent Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 210000004209 hair Anatomy 0.000 description 2
- 239000008311 hydrophilic ointment Substances 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000007764 o/w emulsion Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 229940066842 petrolatum Drugs 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- KANINNSSRWMGIP-UHFFFAOYSA-M sodium;butyl 4-hydroxybenzoate;dodecyl sulfate;hexadecan-1-ol;methyl 4-hydroxybenzoate;octadecan-1-ol;propane-1,2-diol;propyl 4-hydroxybenzoate Chemical compound [Na+].CC(O)CO.COC(=O)C1=CC=C(O)C=C1.CCCOC(=O)C1=CC=C(O)C=C1.CCCCOC(=O)C1=CC=C(O)C=C1.CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCCCCCCCO KANINNSSRWMGIP-UHFFFAOYSA-M 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 239000007762 w/o emulsion Substances 0.000 description 2
- MTZBBNMLMNBNJL-UHFFFAOYSA-N xipamide Chemical compound CC1=CC=CC(C)=C1NC(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1O MTZBBNMLMNBNJL-UHFFFAOYSA-N 0.000 description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- 229940095131 (r)- propylene glycol Drugs 0.000 description 1
- CGFWIUHIYQFIIQ-UHFFFAOYSA-N 1-methylsulfinyldecan-2-ol Chemical compound CCCCCCCCC(O)CS(C)=O CGFWIUHIYQFIIQ-UHFFFAOYSA-N 0.000 description 1
- NZJXADCEESMBPW-UHFFFAOYSA-N 1-methylsulfinyldecane Chemical compound CCCCCCCCCCS(C)=O NZJXADCEESMBPW-UHFFFAOYSA-N 0.000 description 1
- CFJOZYXEPAHNRL-UHFFFAOYSA-N 1-methylsulfinyldodecan-2-ol Chemical compound CCCCCCCCCCC(O)CS(C)=O CFJOZYXEPAHNRL-UHFFFAOYSA-N 0.000 description 1
- CJPDBKNETSCHCH-UHFFFAOYSA-N 1-methylsulfinyldodecane Chemical compound CCCCCCCCCCCCS(C)=O CJPDBKNETSCHCH-UHFFFAOYSA-N 0.000 description 1
- QXHDZSXNJUJQAY-UHFFFAOYSA-N 1-methylsulfinylhexane Chemical compound CCCCCCS(C)=O QXHDZSXNJUJQAY-UHFFFAOYSA-N 0.000 description 1
- NXYISNOFXSBTFH-UHFFFAOYSA-N 1-methylsulfinyltetradecan-2-ol Chemical compound CCCCCCCCCCCCC(O)CS(C)=O NXYISNOFXSBTFH-UHFFFAOYSA-N 0.000 description 1
- KRUABTDBQQLWLS-UHFFFAOYSA-N 1-methylsulfinyltetradecane Chemical compound CCCCCCCCCCCCCCS(C)=O KRUABTDBQQLWLS-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 208000004631 alopecia areata Diseases 0.000 description 1
- 102000001307 androgen receptors Human genes 0.000 description 1
- 108010080146 androgen receptors Proteins 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- 150000003230 pyrimidines Chemical class 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75713185A | 1985-07-18 | 1985-07-18 | |
| US85805086A | 1986-04-30 | 1986-04-30 | |
| PCT/US1986/001393 WO1987000427A1 (en) | 1985-07-18 | 1986-07-03 | Topical composition and method for stimulating hair growth |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3688427D1 DE3688427D1 (enExample) | 1993-06-17 |
| DE3688427T2 true DE3688427T2 (de) | 1993-08-26 |
Family
ID=27116334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8686904603T Expired - Fee Related DE3688427T2 (de) | 1985-07-18 | 1986-07-03 | Topische zusammensetzung und verfahren zur anregung des haarwuchses. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0232311B1 (enExample) |
| AT (1) | ATE89159T1 (enExample) |
| AU (1) | AU6131686A (enExample) |
| DE (1) | DE3688427T2 (enExample) |
| WO (1) | WO1987000427A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5723502A (en) * | 1985-07-18 | 1998-03-03 | Proctor; Peter H. | Topical spin trap composition and method |
| US5352442A (en) * | 1985-07-18 | 1994-10-04 | Proctor Peter H | Topical tempo |
| US5728714A (en) * | 1985-07-18 | 1998-03-17 | Proctor; Peter H. | Method for treating hair loss using tempo |
| US5714510A (en) * | 1985-07-18 | 1998-02-03 | Proctor; Peter H. | Topical proxyl composition and method |
| US5472687A (en) * | 1985-07-18 | 1995-12-05 | Proctor; Peter H. | Topical pyridine N-oxides |
| US6150405A (en) * | 1985-07-18 | 2000-11-21 | Proctor; Peter H. | Hair loss treatment with ascorbates |
| US5716947A (en) * | 1985-07-18 | 1998-02-10 | Proctor; Peter H. | Topical doxyl composition and method |
| US5714482A (en) * | 1985-07-18 | 1998-02-03 | Proctor; Peter H. | Topical spin labels and method |
| US5470876A (en) * | 1985-07-18 | 1995-11-28 | Proctor; Peter H. | Topical sod for treating hair loss |
| GB8606368D0 (en) * | 1986-03-14 | 1986-04-23 | Unilever Plc | Skin treatment composition |
| GB8630720D0 (en) * | 1986-12-23 | 1987-02-04 | Unilever Plc | Cosmetic compositions |
| JPS6456610A (en) * | 1987-05-15 | 1989-03-03 | Hooruden Jiyon | Hair recovery accelerator composition |
| DE3915133C2 (de) * | 1987-11-13 | 2003-04-03 | Christoph Luderschmidt | Haarwuchsmittel |
| DE68917946T2 (de) * | 1988-01-29 | 1995-01-05 | Peter H Proctor | Haarwachstumanregung mit Nitroxyd und anderen Radikalen. |
| FR2641184B1 (fr) * | 1988-12-30 | 1991-04-05 | Oreal | Composition pour induire et stimuler la croissance des cheveux et/ou freiner leur chute, a base de derives de pyrimidine et de filtres solaires |
| CA2085605C (en) * | 1990-08-10 | 2003-03-11 | Arthur Robert Diani | Stimulation of hair growth with potassium channel openers and 5alpha-reductase inhibitors |
| WO1992009259A1 (en) * | 1990-11-29 | 1992-06-11 | The Upjohn Company | Stimulation of hair growth with potassium channel openers and an androgen receptor blocker |
| DE4213314A1 (de) * | 1992-04-23 | 1993-10-28 | Ingeborg Zingraf | Haarwasser und Haarbehandlungsverfahren zur Verringerung des Haarausfalls und Förderung des Haarwachstums bei androgenetischem Haarausfall |
| US5538945A (en) * | 1994-06-17 | 1996-07-23 | Procyte Corporation | Stimulation of hair growth by peptide copper complexes |
| GB2314019B (en) * | 1996-06-10 | 2000-03-15 | Bio Scient Ltd | The use of L-Lysine in the treatment of hair loss |
| AU3596900A (en) * | 1999-02-19 | 2000-09-04 | Marcus R. Jones | Method and composition for promoting hair growth |
| US7435757B2 (en) | 2004-07-02 | 2008-10-14 | Schering Ag | 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1 |
| WO2008032227A2 (en) | 2006-09-11 | 2008-03-20 | Biomas, Ltd. | Topical formulations of tellurium-containing compounds |
| US20120245205A1 (en) | 2009-07-29 | 2012-09-27 | Delong Mitchell A | Compositions and methods for inhibiting hair growth |
| CN113398248B (zh) * | 2021-07-27 | 2023-08-15 | 上海交通大学医学院附属第九人民医院 | 一种改善皮瓣血运的外用药及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3551554A (en) * | 1968-08-16 | 1970-12-29 | Crown Zellerbach Corp | Enhancing tissue penetration of physiologically active agents with dmso |
| US3896238A (en) * | 1972-04-05 | 1975-07-22 | Procter & Gamble | Dermatological compositions |
| GB1570524A (en) * | 1976-03-11 | 1980-07-02 | Unilever Ltd | Cosmetic |
| US4139619A (en) * | 1976-05-24 | 1979-02-13 | The Upjohn Company | 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth |
| DE2942666A1 (de) * | 1979-10-23 | 1981-05-07 | Wella Ag, 6100 Darmstadt | Kosmetisches mittel zur behandlung der haare und der kopfhaut |
-
1986
- 1986-07-03 AT AT86904603T patent/ATE89159T1/de not_active IP Right Cessation
- 1986-07-03 EP EP86904603A patent/EP0232311B1/en not_active Expired - Lifetime
- 1986-07-03 DE DE8686904603T patent/DE3688427T2/de not_active Expired - Fee Related
- 1986-07-03 WO PCT/US1986/001393 patent/WO1987000427A1/en not_active Ceased
- 1986-07-03 AU AU61316/86A patent/AU6131686A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE89159T1 (de) | 1993-05-15 |
| EP0232311B1 (en) | 1993-05-12 |
| DE3688427D1 (enExample) | 1993-06-17 |
| EP0232311A4 (en) | 1988-02-15 |
| WO1987000427A1 (en) | 1987-01-29 |
| AU6131686A (en) | 1987-02-10 |
| EP0232311A1 (en) | 1987-08-19 |
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