DE3683728D1 - Verfahren zur herstellung von oxiracetam. - Google Patents
Verfahren zur herstellung von oxiracetam.Info
- Publication number
- DE3683728D1 DE3683728D1 DE8686305607T DE3683728T DE3683728D1 DE 3683728 D1 DE3683728 D1 DE 3683728D1 DE 8686305607 T DE8686305607 T DE 8686305607T DE 3683728 T DE3683728 T DE 3683728T DE 3683728 D1 DE3683728 D1 DE 3683728D1
- Authority
- DE
- Germany
- Prior art keywords
- oxiracetam
- producing
- producing oxiracetam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16401985A JPS6226267A (ja) | 1985-07-26 | 1985-07-26 | オキシラセタムの製造法 |
JP2391586A JPS62185069A (ja) | 1986-02-07 | 1986-02-07 | オキシラセタムの製造方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3683728D1 true DE3683728D1 (de) | 1992-03-12 |
Family
ID=26361358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686305607T Expired - Fee Related DE3683728D1 (de) | 1985-07-26 | 1986-07-22 | Verfahren zur herstellung von oxiracetam. |
Country Status (3)
Country | Link |
---|---|
US (1) | US4686296A (de) |
EP (1) | EP0223328B1 (de) |
DE (1) | DE3683728D1 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH680293A5 (de) * | 1990-06-26 | 1992-07-31 | Lonza Ag | |
JP2969616B2 (ja) * | 1994-11-24 | 1999-11-02 | 田辺製薬株式会社 | 4−メルカプトピロリジン化合物の製法 |
CN102070502B (zh) * | 2008-10-13 | 2012-07-25 | 重庆润泽医疗器械有限公司 | 一种(s)-4-羟基-2-氧代-1-吡咯烷乙酰胺的制备方法 |
CN102060744B (zh) * | 2008-10-13 | 2012-08-22 | 重庆润泽医疗器械有限公司 | 一种(s)-4-羟基-2-氧代-1-吡咯烷乙酰胺的制备方法 |
CN101367757B (zh) * | 2008-10-13 | 2012-09-19 | 重庆润泽医疗器械有限公司 | 一种(s)-4-羟基-2-氧代-1-吡咯烷乙酰胺的制备方法 |
CN102101836A (zh) * | 2009-12-16 | 2011-06-22 | 北京润德康医药技术有限公司 | S-奥拉西坦新晶型及其制备方法 |
US9238622B2 (en) | 2010-05-21 | 2016-01-19 | Chongqing Runze Pharmaceutical Co., Ltd. | Crystal form I of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide, preparing method and use thereof |
CN102531989B (zh) * | 2011-08-11 | 2014-02-05 | 重庆润泽医药有限公司 | 一种(s)-奥拉西坦的纯化方法 |
CN102531988A (zh) * | 2011-08-11 | 2012-07-04 | 重庆润泽医疗器械有限公司 | 一种左旋奥拉西坦的纯化方法 |
CN102249977B (zh) * | 2011-08-11 | 2013-06-12 | 重庆润泽医药有限公司 | 4-羟基-2-氧代-1-吡咯烷乙酰胺外消旋体晶型ⅰ及其制备方法 |
CN102432516B (zh) * | 2011-12-14 | 2013-10-09 | 山东阿如拉药物研究开发有限公司 | 奥拉西坦的精制方法 |
CN102452972B (zh) * | 2011-12-28 | 2015-06-17 | 南京优科生物医药有限公司 | 一种制备奥拉西坦化合物的方法 |
CN102627596B (zh) * | 2012-03-16 | 2016-01-27 | 天津景寅医药生物技术发展有限公司 | 一种4-羟基-2-氧代-1-吡咯烷乙酰胺的制备方法 |
CN102718691A (zh) * | 2012-07-20 | 2012-10-10 | 上海现代哈森(商丘)药业有限公司 | 一种吡拉西坦合成新方法 |
CN103342673B (zh) * | 2013-07-31 | 2015-11-18 | 石药集团欧意药业有限公司 | 一种奥拉西坦晶型及其制备方法 |
CN104557655A (zh) * | 2013-10-10 | 2015-04-29 | 重庆医药工业研究院有限责任公司 | 一种奥拉西坦的纯化方法 |
CN103588695B (zh) * | 2013-11-25 | 2015-08-05 | 石药集团欧意药业有限公司 | 一种结晶形式的奥拉西坦化合物及其制备方法 |
CN105820062B (zh) * | 2015-01-04 | 2018-01-30 | 哈尔滨三联药业股份有限公司 | N‑(1‑氧代‑4‑羟基‑2‑丁烯基)氨基乙酰胺化合物及其制备方法和应用 |
CN106511304B (zh) * | 2015-09-11 | 2020-09-08 | 重庆润泽医药有限公司 | 一种稳定的左旋奥拉西坦缓释胶囊及其制备方法 |
CN106890151B (zh) * | 2015-12-17 | 2020-08-11 | 重庆润泽医药有限公司 | 一种稳定的左旋奥拉西坦泡腾片及其制备方法 |
CN105669515B (zh) * | 2016-02-22 | 2018-11-16 | 骆金玲 | 一种奥拉西坦光降解产物及其制备方法和分析检测方法 |
CN107115290B (zh) * | 2016-02-25 | 2020-09-29 | 重庆润泽医药有限公司 | 一种澄清度好的(s)-4-羟基-2氧代-1-吡咯烷乙酰胺注射液及其制备方法 |
CN107115273B (zh) * | 2016-02-25 | 2020-10-09 | 重庆润泽医药有限公司 | 一种稳定性好的左旋奥拉西坦注射剂及其制备方法 |
CN107625748A (zh) * | 2016-07-13 | 2018-01-26 | 重庆润泽医药有限公司 | 一种稳定性好的左旋奥拉西坦缓释胶囊及其制备方法 |
CN107625746A (zh) * | 2016-07-13 | 2018-01-26 | 重庆润泽医药有限公司 | 一种左旋奥拉西坦缓释胶囊及其制备方法 |
CN107625749A (zh) * | 2016-07-13 | 2018-01-26 | 重庆润泽医药有限公司 | 一种(s)‑4‑羟基‑2氧代‑1‑吡咯烷乙酰胺缓释胶囊及其制备方法 |
CN107638412A (zh) * | 2016-07-14 | 2018-01-30 | 重庆润泽医药有限公司 | 一种收率高的左旋奥拉西坦缓释胶囊及其制备方法 |
CN107638414B (zh) * | 2016-07-22 | 2020-08-11 | 重庆润泽医药有限公司 | 一种(s)-4-羟基-2氧代-1-吡咯烷乙酰胺缓释胶囊及其制备方法 |
CN107638413A (zh) * | 2016-07-22 | 2018-01-30 | 重庆润泽医药有限公司 | 一种释放度均匀性好的左旋奥拉西坦缓释胶囊及其制备方法 |
CN107638417A (zh) * | 2016-07-22 | 2018-01-30 | 重庆润泽医药有限公司 | 一种含量均匀性好的左旋奥拉西坦缓释胶囊及其制备方法 |
CN107648203A (zh) * | 2016-07-26 | 2018-02-02 | 重庆润泽医药有限公司 | 一种颗粒流动性好的左旋奥拉西坦缓释胶囊及其制备方法 |
CN107661310A (zh) * | 2016-07-28 | 2018-02-06 | 重庆润泽医药有限公司 | 一种缓释释放的左旋奥拉西坦胶囊及其制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI51098C (fi) | 1975-03-27 | 1976-10-11 | Medipolar Oy | Menetelmä terapeuttisesti arvokkaan 2-okso-1-pyrrolidinyyliasetamidin valmistamiseksi. |
IT1045043B (it) | 1975-08-13 | 1980-04-21 | Isf Spa | Derivati pirrolidinici |
IT1075564B (it) * | 1977-02-11 | 1985-04-22 | Isf Spa | Procedimento per la preparazione di derivati pirrolidinici |
IT1075280B (it) | 1977-02-11 | 1985-04-22 | Isf Spa | Procedimento per la preparazione di derivati pirrolidinici |
IT1141287B (it) * | 1979-06-13 | 1986-10-01 | Nattermann A & Cie | Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono |
JPS6017776B2 (ja) * | 1979-11-07 | 1985-05-07 | 電気化学工業株式会社 | γ−クロロ−β−ヒドロキシ酪酸アルキルエステルの製法 |
DE3030926A1 (de) * | 1980-08-16 | 1982-04-01 | Consortium für elektrochemische Industrie GmbH, 8000 München | Substituierte bernsteinsaeureimide |
JPS5812272B2 (ja) * | 1981-04-28 | 1983-03-07 | 電気化学工業株式会社 | 4−ヒドロキシ−2−ピロリドンの製造法 |
JPS5822034A (ja) * | 1981-08-03 | 1983-02-09 | 高橋 俊吉 | 足跡とか指紋から被疑者の体臭を採取する方法及びその体臭採取器 |
IT1206699B (it) | 1984-02-27 | 1989-04-27 | Isf Spa | Procedimento per preparare derivati di pirrolidone. |
IT1173768B (it) | 1984-04-02 | 1987-06-24 | Isf Spa | Procedimento di preparazione di derivati 1-carbamoilmetilici di 4-idrossi-2-osso-pirrolidina nonche' di intermedi per ottenere tali composti |
-
1986
- 1986-07-22 EP EP86305607A patent/EP0223328B1/de not_active Expired - Lifetime
- 1986-07-22 US US06/889,428 patent/US4686296A/en not_active Expired - Fee Related
- 1986-07-22 DE DE8686305607T patent/DE3683728D1/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US4686296A (en) | 1987-08-11 |
EP0223328B1 (de) | 1992-01-29 |
EP0223328A1 (de) | 1987-05-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |