DE3683678D1 - Verfahren zur herstellung von nuetzlichen hochmolekulargewichtssubstanzen durch kultur von vermehrungsfaehigen tierzellen und dazu geeignetes kultursystem. - Google Patents
Verfahren zur herstellung von nuetzlichen hochmolekulargewichtssubstanzen durch kultur von vermehrungsfaehigen tierzellen und dazu geeignetes kultursystem.Info
- Publication number
- DE3683678D1 DE3683678D1 DE8686106201T DE3683678T DE3683678D1 DE 3683678 D1 DE3683678 D1 DE 3683678D1 DE 8686106201 T DE8686106201 T DE 8686106201T DE 3683678 T DE3683678 T DE 3683678T DE 3683678 D1 DE3683678 D1 DE 3683678D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- culture
- molecular weight
- animal cells
- weight substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000126 substance Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP60096770A JPS61257181A (ja) | 1985-05-09 | 1985-05-09 | 動物細胞の培養装置 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3683678D1 true DE3683678D1 (de) | 1992-03-12 |
Family
ID=14173867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686106201T Expired - Lifetime DE3683678D1 (de) | 1985-05-09 | 1986-05-06 | Verfahren zur herstellung von nuetzlichen hochmolekulargewichtssubstanzen durch kultur von vermehrungsfaehigen tierzellen und dazu geeignetes kultursystem. |
Country Status (4)
Country | Link |
---|---|
US (1) | US5447853A (de) |
EP (1) | EP0201086B1 (de) |
JP (1) | JPS61257181A (de) |
DE (1) | DE3683678D1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3641826A1 (de) * | 1986-12-06 | 1988-06-16 | Bayer Ag | Verfahren zur kultivierung von saeugerzellen in einer suspensionskultur, vorrichtung zur durchfuehrung des verfahrens und verwendung bei der herstellung von proteinen |
US4921792A (en) * | 1987-11-27 | 1990-05-01 | Miles Inc. | Continuous cell dispersion, cultivation and substance recovery process |
JP2777385B2 (ja) * | 1988-11-30 | 1998-07-16 | 株式会社日立製作所 | 生物細胞の培養方法,培養システム及び培養装置 |
KR0132666B1 (en) * | 1989-03-14 | 1998-04-14 | Hitachi Kk | Method for controlling cultivation conditions for animal cells |
EP0455757B1 (de) * | 1989-08-04 | 1999-03-31 | GRANDICS, Peter | Integriertes zellkultur-proteinreinigungssystem zur automatisierten herstellung und reinigung von zellkulturprodukten |
JPH0416183A (ja) * | 1990-05-07 | 1992-01-21 | Ngk Insulators Ltd | 動物細胞の培養方法及び装置 |
WO2006026835A1 (en) * | 2004-09-10 | 2006-03-16 | Unisearch Limited | Device and method to prevent culture media degradation |
WO2009023562A2 (en) | 2007-08-09 | 2009-02-19 | Wyeth | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
JP2009072129A (ja) * | 2007-09-21 | 2009-04-09 | Hitachi Plant Technologies Ltd | 生体細胞の分離装置、培養装置及び生体細胞の分離方法 |
WO2012048275A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
JP2014024824A (ja) * | 2012-07-30 | 2014-02-06 | Asahi Kasei Medical Co Ltd | 潅流培養における有用タンパク質を含む培養液の濾過方法 |
WO2016049421A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled feed |
EP3464565A4 (de) | 2016-05-25 | 2020-01-01 | Terumo BCT, Inc. | Zellexpansion |
EP3656842A1 (de) | 2017-03-31 | 2020-05-27 | Terumo BCT, Inc. | Zellexpansion |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
FR3068361B1 (fr) * | 2017-06-30 | 2021-10-15 | Univ Paris Diderot Paris 7 | Systeme fluidique de production de vesicules extracellulaires et procede associe |
CN110241012B (zh) * | 2018-03-09 | 2022-11-01 | 嘉和生物药业有限公司 | 一种生物大分子上游分阶段截留的生产方法、生产模块及在生产中的应用 |
CN110117527A (zh) * | 2019-05-15 | 2019-08-13 | 刘宝全 | 一种干细胞代谢废物的强化排出方法 |
JP7376887B2 (ja) * | 2019-08-20 | 2023-11-09 | Jfeエンジニアリング株式会社 | 動物細胞の増殖促進方法、連続培養方法及び連続培養装置 |
JP7330834B2 (ja) * | 2019-09-20 | 2023-08-22 | 株式会社日立製作所 | 培養方法および培養装置 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51121589A (en) * | 1975-04-14 | 1976-10-23 | Sanraku Inc | Process for separating and producing microbial cells |
US4420398A (en) * | 1981-08-13 | 1983-12-13 | American National Red Cross | Filteration method for cell produced antiviral substances |
CA1258053A (en) * | 1982-12-13 | 1989-08-01 | Halbert Fischel | Blood fractionation system and method |
AU2232383A (en) * | 1982-12-14 | 1984-06-21 | Bio-Response Inc. | Method and apparatus for culture of living cells |
ZA839242B (en) * | 1982-12-15 | 1984-09-26 | Bio Response Inc | A method and system for culturing and treating substances disposed in a flowing culture fluid |
IN161706B (de) * | 1983-10-05 | 1988-01-16 | Solco Basel Ag | |
JPS60102187A (ja) * | 1983-11-07 | 1985-06-06 | Nippon Zenyaku Kogyo Kk | 細胞生産物の連続大量培養法 |
-
1985
- 1985-05-09 JP JP60096770A patent/JPS61257181A/ja active Granted
-
1986
- 1986-05-06 EP EP86106201A patent/EP0201086B1/de not_active Expired - Lifetime
- 1986-05-06 DE DE8686106201T patent/DE3683678D1/de not_active Expired - Lifetime
-
1992
- 1992-04-17 US US07/870,421 patent/US5447853A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH0363348B2 (de) | 1991-09-30 |
EP0201086A2 (de) | 1986-11-12 |
EP0201086A3 (en) | 1988-07-20 |
US5447853A (en) | 1995-09-05 |
EP0201086B1 (de) | 1992-01-29 |
JPS61257181A (ja) | 1986-11-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |