DE3683678D1 - Verfahren zur herstellung von nuetzlichen hochmolekulargewichtssubstanzen durch kultur von vermehrungsfaehigen tierzellen und dazu geeignetes kultursystem. - Google Patents

Verfahren zur herstellung von nuetzlichen hochmolekulargewichtssubstanzen durch kultur von vermehrungsfaehigen tierzellen und dazu geeignetes kultursystem.

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Publication number
DE3683678D1
DE3683678D1 DE8686106201T DE3683678T DE3683678D1 DE 3683678 D1 DE3683678 D1 DE 3683678D1 DE 8686106201 T DE8686106201 T DE 8686106201T DE 3683678 T DE3683678 T DE 3683678T DE 3683678 D1 DE3683678 D1 DE 3683678D1
Authority
DE
Germany
Prior art keywords
production
culture
molecular weight
animal cells
weight substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686106201T
Other languages
English (en)
Inventor
Michiyuki Tokashiki
Kimihiko Hamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of DE3683678D1 publication Critical patent/DE3683678D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE8686106201T 1985-05-09 1986-05-06 Verfahren zur herstellung von nuetzlichen hochmolekulargewichtssubstanzen durch kultur von vermehrungsfaehigen tierzellen und dazu geeignetes kultursystem. Expired - Lifetime DE3683678D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60096770A JPS61257181A (ja) 1985-05-09 1985-05-09 動物細胞の培養装置

Publications (1)

Publication Number Publication Date
DE3683678D1 true DE3683678D1 (de) 1992-03-12

Family

ID=14173867

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686106201T Expired - Lifetime DE3683678D1 (de) 1985-05-09 1986-05-06 Verfahren zur herstellung von nuetzlichen hochmolekulargewichtssubstanzen durch kultur von vermehrungsfaehigen tierzellen und dazu geeignetes kultursystem.

Country Status (4)

Country Link
US (1) US5447853A (de)
EP (1) EP0201086B1 (de)
JP (1) JPS61257181A (de)
DE (1) DE3683678D1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3641826A1 (de) * 1986-12-06 1988-06-16 Bayer Ag Verfahren zur kultivierung von saeugerzellen in einer suspensionskultur, vorrichtung zur durchfuehrung des verfahrens und verwendung bei der herstellung von proteinen
US4921792A (en) * 1987-11-27 1990-05-01 Miles Inc. Continuous cell dispersion, cultivation and substance recovery process
JP2777385B2 (ja) * 1988-11-30 1998-07-16 株式会社日立製作所 生物細胞の培養方法，培養システム及び培養装置
KR0132666B1 (en) * 1989-03-14 1998-04-14 Hitachi Kk Method for controlling cultivation conditions for animal cells
EP0455757B1 (de) * 1989-08-04 1999-03-31 GRANDICS, Peter Integriertes zellkultur-proteinreinigungssystem zur automatisierten herstellung und reinigung von zellkulturprodukten
JPH0416183A (ja) * 1990-05-07 1992-01-21 Ngk Insulators Ltd 動物細胞の培養方法及び装置
WO2006026835A1 (en) * 2004-09-10 2006-03-16 Unisearch Limited Device and method to prevent culture media degradation
WO2009023562A2 (en) 2007-08-09 2009-02-19 Wyeth Use of perfusion to enhance production of fed-batch cell culture in bioreactors
JP2009072129A (ja) * 2007-09-21 2009-04-09 Hitachi Plant Technologies Ltd 生体細胞の分離装置、培養装置及び生体細胞の分離方法
WO2012048275A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
JP2014024824A (ja) * 2012-07-30 2014-02-06 Asahi Kasei Medical Co Ltd 潅流培養における有用タンパク質を含む培養液の濾過方法
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
EP3464565A4 (de) 2016-05-25 2020-01-01 Terumo BCT, Inc. Zellexpansion
EP3656842A1 (de) 2017-03-31 2020-05-27 Terumo BCT, Inc. Zellexpansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
FR3068361B1 (fr) * 2017-06-30 2021-10-15 Univ Paris Diderot Paris 7 Systeme fluidique de production de vesicules extracellulaires et procede associe
CN110241012B (zh) * 2018-03-09 2022-11-01 嘉和生物药业有限公司 一种生物大分子上游分阶段截留的生产方法、生产模块及在生产中的应用
CN110117527A (zh) * 2019-05-15 2019-08-13 刘宝全 一种干细胞代谢废物的强化排出方法
JP7376887B2 (ja) * 2019-08-20 2023-11-09 Ｊｆｅエンジニアリング株式会社 動物細胞の増殖促進方法、連続培養方法及び連続培養装置
JP7330834B2 (ja) * 2019-09-20 2023-08-22 株式会社日立製作所 培養方法および培養装置

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51121589A (en) * 1975-04-14 1976-10-23 Sanraku Inc Process for separating and producing microbial cells
US4420398A (en) * 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
CA1258053A (en) * 1982-12-13 1989-08-01 Halbert Fischel Blood fractionation system and method
AU2232383A (en) * 1982-12-14 1984-06-21 Bio-Response Inc. Method and apparatus for culture of living cells
ZA839242B (en) * 1982-12-15 1984-09-26 Bio Response Inc A method and system for culturing and treating substances disposed in a flowing culture fluid
IN161706B (de) * 1983-10-05 1988-01-16 Solco Basel Ag
JPS60102187A (ja) * 1983-11-07 1985-06-06 Nippon Zenyaku Kogyo Kk 細胞生産物の連続大量培養法

Also Published As

Publication number Publication date
JPH0363348B2 (de) 1991-09-30
EP0201086A2 (de) 1986-11-12
EP0201086A3 (en) 1988-07-20
US5447853A (en) 1995-09-05
EP0201086B1 (de) 1992-01-29
JPS61257181A (ja) 1986-11-14

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