DE3672868D1 - Behandlung von auf einer festen phase adsorbierten biologischen und pharmazeutischen produkten mit viren und pyrogenen inaktivierenden agenzien. - Google Patents
Behandlung von auf einer festen phase adsorbierten biologischen und pharmazeutischen produkten mit viren und pyrogenen inaktivierenden agenzien.Info
- Publication number
- DE3672868D1 DE3672868D1 DE8686104849T DE3672868T DE3672868D1 DE 3672868 D1 DE3672868 D1 DE 3672868D1 DE 8686104849 T DE8686104849 T DE 8686104849T DE 3672868 T DE3672868 T DE 3672868T DE 3672868 D1 DE3672868 D1 DE 3672868D1
- Authority
- DE
- Germany
- Prior art keywords
- pyrogens
- biological
- viruses
- treatment
- pharmaceutical products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 title abstract 3
- 230000000415 inactivating effect Effects 0.000 title abstract 3
- 239000002510 pyrogen Substances 0.000 title abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 229940127557 pharmaceutical product Drugs 0.000 title abstract 2
- 239000007787 solid Substances 0.000 title 1
- 239000007790 solid phase Substances 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0094—Gaseous substances
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20261—Methods of inactivation or attenuation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
- Y10S435/815—Enzyme separation or purification by sorption
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/722,561 US4673733A (en) | 1985-04-11 | 1985-04-11 | Treatment of biological and pharmaceutical products adsorbed on a solid phase with virus and pyrogen inactivating agents |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3672868D1 true DE3672868D1 (de) | 1990-08-30 |
Family
ID=24902372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686104849T Expired - Fee Related DE3672868D1 (de) | 1985-04-11 | 1986-04-09 | Behandlung von auf einer festen phase adsorbierten biologischen und pharmazeutischen produkten mit viren und pyrogenen inaktivierenden agenzien. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4673733A (de) |
EP (1) | EP0197554B1 (de) |
JP (1) | JPS61275210A (de) |
AT (1) | ATE54828T1 (de) |
AU (1) | AU580402B2 (de) |
CA (1) | CA1262682A (de) |
DE (1) | DE3672868D1 (de) |
DK (1) | DK161786A (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ212523A (en) * | 1985-06-24 | 1989-01-06 | Univ Massey | Mobile phase for purification of proteins by high performance liquid chromatography |
US4758657A (en) * | 1985-07-11 | 1988-07-19 | Armour Pharmaceutical Company | Method of purifying Factor VIII:C |
US4749783A (en) * | 1986-07-11 | 1988-06-07 | Miles Laboratories, Inc. | Viral inactivation and purification of active proteins |
DE3704550A1 (de) * | 1987-02-13 | 1988-08-25 | Behringwerke Ag | Verfahren zur inaktivierung huellhaltiger viren in mittels einer zelle in vitro hergestellten protein-praeparationen |
DE3707987A1 (de) * | 1987-03-12 | 1988-09-22 | Behringwerke Ag | Inaktivierung von human immunodeficiency virus (hiv) in proteinhaltigen loesungen durch phenole |
CA1339946C (en) * | 1987-03-31 | 1998-07-07 | Michael J. Griffith | Ultrapurification process for polypeptides |
US4876241A (en) * | 1987-05-22 | 1989-10-24 | Armour Pharmaceutical Company | Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants |
ES2087156T3 (es) * | 1989-06-15 | 1996-07-16 | Rorer Int Overseas | Metodos para la inactivacion de virus en composiciones farmaceuticas contaminadas por virus. |
AU6428390A (en) * | 1989-08-16 | 1991-04-03 | Rorer International (Overseas) Inc. | Treatment of immobilized matrices with antimicrobial agents to remove pyrogen-producing organisms and pyrogens |
US5202246A (en) * | 1989-08-16 | 1993-04-13 | Armour Pharmaceutical Company | Treatment of immobilized matrices for preparation of pharmaceutical and biological products with anti-microbial agents to remove pyrogen-producing organisms and pyrogens |
AT402891B (de) * | 1991-06-20 | 1997-09-25 | Immuno Ag | Verfahren zur herstellung eines inaktivierten blutproduktes |
ATE151880T1 (de) * | 1991-06-26 | 1997-05-15 | Perseptive Biosystems Inc | Verfahren und vorrichtung zum nachweis von kontaminationsspuren |
AT398079B (de) * | 1991-11-04 | 1994-09-26 | Immuno Ag | Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung |
DE4142908C2 (de) * | 1991-12-24 | 1994-02-10 | Octapharma Ag Glarus | Verfahren zur Herstellung eines virusinaktivierten Prothrombinkomplex-Konzentrats (PPSB) |
AT399818B (de) * | 1992-04-24 | 1995-07-25 | Immuno Ag | Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation |
JP3133338B2 (ja) * | 1992-12-16 | 2001-02-05 | イムノ・アクチエンゲゼルシャフト | ウイルス的に安全な生物学的組成物の調製方法 |
DE4302163A1 (de) * | 1993-01-27 | 1994-07-28 | Thomae Gmbh Dr K | Verfahren zur Reinigung von Proteinen und Peptiden |
DE4320294A1 (de) * | 1993-06-18 | 1994-12-22 | Immuno Ag | Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen |
GB9407886D0 (en) * | 1994-04-21 | 1994-06-15 | Ici Plc | Purification process |
DE19544297A1 (de) * | 1995-11-28 | 1997-06-05 | Behringwerke Ag | Verfahren zur Entfernung von aromatischen Verbindungen aus produkthaltigen Lösungen |
US5659017A (en) * | 1995-11-07 | 1997-08-19 | Alpha Therapeutic Corporation | Anion exchange process for the purification of Factor VIII |
IT1285551B1 (it) * | 1996-01-30 | 1998-06-18 | Paolo Giovannetti | Composizione e procedimento per la sterilizzazione di substrati di coltura |
US5786458A (en) * | 1996-06-28 | 1998-07-28 | Bayer Corporation | Selective stabilization of protein during viral inactivation |
AT405939B (de) * | 1997-02-24 | 1999-12-27 | Immuno Ag | Verfahren zur inaktivierung von lipidumhüllten viren |
DE59800935D1 (en) | 1997-04-08 | 2001-08-02 | Baxter Ag | Immuntolerante prothrombinkomplex-präparation |
AT405608B (de) * | 1997-04-08 | 1999-10-25 | Immuno Ag | Verfahren zur inaktivierung von pathogenen, insbesondere von viren, in einem biologischen material |
FR2772381B1 (fr) * | 1997-12-15 | 2001-06-08 | Lab Francais Du Fractionnement | Procede de preparation par filtration d'une solution de facteur viii securisee viralement |
US6585890B2 (en) * | 2000-02-04 | 2003-07-01 | Applied Research Associates, Inc. | Process for producing sterile water for injection from potable water |
GB0027047D0 (en) * | 2000-11-06 | 2000-12-20 | Ici Plc | Process for reducing the concentration of undesired compounds in a composition |
JP2002267642A (ja) * | 2001-03-13 | 2002-09-18 | Tosoh Corp | アルカリ土類金属イオン測定用イオンクロマトグラフィー溶離液およびそれを用いたアルカリ土類金属イオン分析方法 |
ES2318145T3 (es) | 2002-02-19 | 2009-05-01 | Resolution Chemicals Limited | Esterilizacion de esteroides por medio de disolventes. |
US7122149B2 (en) * | 2002-07-12 | 2006-10-17 | Applied Research Associates, Inc. | Apparatus and method for continuous depyrogenation and production of sterile water for injection |
RU2520817C2 (ru) * | 2006-01-25 | 2014-06-27 | Октафарма Аг | Очистка и применение фактора, способствующего заживлению ран |
US9328326B2 (en) * | 2006-08-10 | 2016-05-03 | Merck Patent Gmbh | Method for isolating cells |
DE102010046817A1 (de) * | 2010-09-28 | 2012-03-29 | Sartorius Stedim Biotech Gmbh | Verfahren zur Abtrennung von Viren aus einem Kontaminanten enthaltenden flüssigen Medium |
DE202015100806U1 (de) | 2015-02-19 | 2015-04-15 | Paul Schaffrath | Vorrichtung zur Inaktivierung von Krankheitserregern in Flüssigkeiten |
JP6584803B2 (ja) * | 2015-03-19 | 2019-10-02 | 国立大学法人滋賀医科大学 | 汎用性エンドトキシンフリー化処理方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1767389A1 (de) * | 1968-05-06 | 1971-09-02 | Bayer Ag | Verfahren zur Abtrennung von Pyrogenen aus Rohpraeparaten von L-Asparaginase |
US4035316A (en) * | 1975-11-24 | 1977-07-12 | California Institute Of Technology | Cell specific, variable density, polymer microspheres |
JPS53113080A (en) * | 1977-03-10 | 1978-10-03 | Sumitomo Chem Co Ltd | Purification of urokinase |
US4305870A (en) * | 1979-01-31 | 1981-12-15 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Intravenous plasma derivatives and their production |
US4321363A (en) * | 1980-02-21 | 1982-03-23 | Nippon Soda Company Limited | Adsorbent for urokinase containing agarose |
US4411795A (en) * | 1980-03-10 | 1983-10-25 | Baxter Travenol Laboratories, Inc. | Particle adsorption |
US4412985A (en) * | 1980-10-06 | 1983-11-01 | Edward Shanbrom | Depyrogenation process |
US4315919A (en) * | 1980-10-06 | 1982-02-16 | Edward Shanbrom | Depyrogenation process |
US4380511A (en) * | 1981-08-12 | 1983-04-19 | Miles Laboratories, Inc. | Purification of bovine thrombin |
US4511556A (en) * | 1982-06-10 | 1985-04-16 | The United States Of America As Represented By The Department Of Health And Human Services | Inactivation of a lipid virus |
CA1208551A (en) * | 1982-12-27 | 1986-07-29 | Ricardo H. Landaburu | Solvent treatment of plasma protein products |
JPS6156133A (ja) * | 1984-08-24 | 1986-03-20 | Chemo Sero Therapeut Res Inst | 発熱物質の除去方法 |
-
1985
- 1985-04-11 US US06/722,561 patent/US4673733A/en not_active Expired - Lifetime
-
1986
- 1986-04-09 AU AU55960/86A patent/AU580402B2/en not_active Expired - Fee Related
- 1986-04-09 CA CA000506180A patent/CA1262682A/en not_active Expired
- 1986-04-09 DE DE8686104849T patent/DE3672868D1/de not_active Expired - Fee Related
- 1986-04-09 EP EP86104849A patent/EP0197554B1/de not_active Expired - Lifetime
- 1986-04-09 AT AT86104849T patent/ATE54828T1/de not_active IP Right Cessation
- 1986-04-10 DK DK161786A patent/DK161786A/da not_active IP Right Cessation
- 1986-04-11 JP JP61082425A patent/JPS61275210A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
US4673733A (en) | 1987-06-16 |
CA1262682C (en) | 1989-11-07 |
CA1262682A (en) | 1989-11-07 |
DK161786A (da) | 1986-10-12 |
ATE54828T1 (de) | 1990-08-15 |
EP0197554A3 (en) | 1987-03-25 |
AU5596086A (en) | 1986-11-06 |
JPH0578532B2 (de) | 1993-10-29 |
EP0197554B1 (de) | 1990-07-25 |
EP0197554A2 (de) | 1986-10-15 |
AU580402B2 (en) | 1989-01-12 |
DK161786D0 (da) | 1986-04-10 |
JPS61275210A (ja) | 1986-12-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |