DE3650403T3 - Polyphosphonat enthaltende Packung zur Behandlung von Osteoporose. - Google Patents

Polyphosphonat enthaltende Packung zur Behandlung von Osteoporose. Download PDF

Info

Publication number
DE3650403T3
DE3650403T3 DE3650403T DE3650403T DE3650403T3 DE 3650403 T3 DE3650403 T3 DE 3650403T3 DE 3650403 T DE3650403 T DE 3650403T DE 3650403 T DE3650403 T DE 3650403T DE 3650403 T3 DE3650403 T3 DE 3650403T3
Authority
DE
Germany
Prior art keywords
treatment
polyphosphonate
osteoporosis
containing pack
pack
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3650403T
Other languages
English (en)
Other versions
DE3650403D1 (de
DE3650403T2 (de
Inventor
Lawrence Flora
Benjamin Franklin Floyd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24983007&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3650403(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of DE3650403D1 publication Critical patent/DE3650403D1/de
Application granted granted Critical
Publication of DE3650403T2 publication Critical patent/DE3650403T2/de
Anticipated expiration legal-status Critical
Publication of DE3650403T3 publication Critical patent/DE3650403T3/de
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Removal Of Specific Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
DE3650403T 1985-06-06 1986-06-04 Polyphosphonat enthaltende Packung zur Behandlung von Osteoporose. Expired - Lifetime DE3650403T3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/741,976 US4761406A (en) 1985-06-06 1985-06-06 Regimen for treating osteoporosis

Publications (3)

Publication Number Publication Date
DE3650403D1 DE3650403D1 (de) 1995-11-02
DE3650403T2 DE3650403T2 (de) 1996-03-28
DE3650403T3 true DE3650403T3 (de) 2006-06-14

Family

ID=24983007

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3650403T Expired - Lifetime DE3650403T3 (de) 1985-06-06 1986-06-04 Polyphosphonat enthaltende Packung zur Behandlung von Osteoporose.

Country Status (13)

Country Link
US (1) US4761406A (de)
EP (1) EP0210728B2 (de)
JP (1) JP2509185B2 (de)
AT (1) ATE128356T1 (de)
AU (1) AU603766B2 (de)
CA (2) CA1338376E (de)
DE (1) DE3650403T3 (de)
DK (1) DK174584B1 (de)
FI (1) FI862407A (de)
GB (1) GB2177001B (de)
HK (1) HK104292A (de)
PH (1) PH23686A (de)
ZA (1) ZA864149B (de)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2039237T3 (es) * 1986-04-24 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. Procedimiento para preparar nuevos compuestos de acido difosfonico.
EP0272208B1 (de) * 1986-11-21 1991-06-12 Ciba-Geigy Ag Aromatisch substituierte Azacyclo-alkylalkandiphosphonsäuren
DE3640938A1 (de) * 1986-11-29 1988-06-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel
US5190930A (en) * 1987-12-11 1993-03-02 Ciba-Geigy Corporation Araliphatylaminoalkanediphosphonic acids
US5110807A (en) * 1988-12-01 1992-05-05 Ciba-Geigy Corporation Araliphatylaminoalkanediphosphonic acids
US7452359B1 (en) * 1988-06-13 2008-11-18 Warsaw Orthopedic, Inc. Apparatus for inserting spinal implants
WO1990009179A1 (en) * 1989-02-16 1990-08-23 University Of Georgia Research Foundation, Inc. Treatment of tibial dyschondroplasia
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5139786A (en) * 1989-07-07 1992-08-18 Ciba-Geigy Corporation Topical formulations
MX21452A (es) * 1989-07-07 1994-01-31 Ciba Geigy Ag Preparaciones farmaceuticas que se administran en forma topica.
US5356887A (en) * 1990-01-31 1994-10-18 Merck & Co., Inc. Pharmaceutical compositions containing insoluble calcium salts of amino-hydroxybutylidene bisphoshonic acids
US5204334A (en) * 1990-10-18 1993-04-20 Ciba-Geigy Corporation Benzoheterocyclylalkylaminoalkanediphosphonic acids, compositions thereof, and use thereof in the treatment of calcium metabolism disorders
ES2069424T3 (es) 1991-02-26 1995-05-01 Procter & Gamble Pharma Metodos para el tratamiento de la osteoporosis.
TW207543B (de) * 1991-08-27 1993-06-11 Ciba Geigy Ag
CA2124792C (en) * 1991-12-17 2000-07-04 Ann D. Geddes Methods for the treatment of osteoporosis using bisphosphonates and parathyroid hormone
US5382658A (en) * 1992-04-03 1995-01-17 Allelix Biopharmaceuticals Inc. Stability-enhanced variants of parathyroid hormone
DK0648120T3 (da) * 1992-06-30 1998-01-19 Procter & Gamble Pharma Anvendelse af phosphonater til behandling af osteoporose
US5409911A (en) * 1992-09-11 1995-04-25 Merck & Co., Inc. Prostaglandin analog for treating osteoporosis
US5366965A (en) * 1993-01-29 1994-11-22 Boehringer Mannheim Gmbh Regimen for treatment or prophylaxis of osteoporosis
US5449819A (en) * 1994-06-06 1995-09-12 Merck & Co., Inc. Process for removing waste pox, alendronate and its by products
FR2727629A1 (fr) * 1994-12-06 1996-06-07 Sanofi Sa Trousse pour cycle de traitement de l'osteoporose
KR19980702210A (ko) * 1995-02-17 1998-07-15 폴락 돈나 엘 비척추골 골절의 위험률을 감소시키는 방법
US20010051616A1 (en) * 1995-02-17 2001-12-13 David B. Karpf Method of lessening the risk of vertebral fractures
WO1996039107A1 (en) 1995-06-06 1996-12-12 Merck & Co., Inc. Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices
US20010031244A1 (en) * 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
US6432932B1 (en) 1997-07-22 2002-08-13 Merck & Co., Inc. Method for inhibiting bone resorption
US5994329A (en) 1997-07-22 1999-11-30 Merck & Co., Inc. Method for inhibiting bone resorption
IT1303672B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
JP4486256B2 (ja) * 1998-10-22 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体
US6121253A (en) * 1998-11-20 2000-09-19 Merck Frosst Canada & Co. Prostaglandin conjugates for treating or preventing bone disease
AU2486800A (en) * 1998-12-31 2000-07-31 General Hospital Corporation, The Pth functional domain conjugate peptides, derivatives thereof and novel tetheredligand-receptor molecules
US7057012B1 (en) * 1998-12-31 2006-06-06 The General Hospital Corporation PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules
US7534605B2 (en) 1999-06-08 2009-05-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases
US7022815B1 (en) 1999-09-29 2006-04-04 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
ATE412670T1 (de) 1999-09-29 2008-11-15 Gen Hospital Corp Parathyroid hormon (pth) polypeptidderivate
WO2001023521A2 (en) * 1999-09-29 2001-04-05 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
FR2801218B1 (fr) * 1999-11-23 2001-12-28 Hoechst Marion Roussel Inc Compositions pharmaceutiques comprenant de la trimegestone, leurs procedes de preparation ainsi que le conditionnement primaire les renfermant
US6978894B2 (en) 1999-12-20 2005-12-27 Merck & Co., Inc. Blister package for pharmaceutical treatment card
US6677320B2 (en) 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
AU2001269803A1 (en) * 2000-06-20 2002-01-02 The Trustees Of The University Of Pennsylvania Compositions and methods for modulating muscle cell and tissue contractility
EP1296689B3 (de) * 2000-06-20 2013-02-13 Novartis AG Methode zur verabreichung von biphosphonaten
US20050147602A1 (en) * 2000-10-19 2005-07-07 Maine Medical Center Research Institute Compositions, methods and kits relating to CTHRC1, a novel modulator of collagen matrix
US6630325B1 (en) * 2000-10-19 2003-10-07 Maine Medical Center Research Institute Compositions, methods and kits relating to remodel
WO2003009804A2 (en) * 2001-07-23 2003-02-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
US20030119771A1 (en) * 2001-08-22 2003-06-26 Rompaey Luc Van Modulators of bone homeostasis identified in a high-throughput screen
US20080057059A1 (en) * 2001-11-09 2008-03-06 Novo Nordisk Healthcare A/G Pharmaceutical Composition Comprising Factor VII Polypeptides and Protein S Inhibitors
US20030124118A1 (en) * 2001-11-27 2003-07-03 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and protein S inhibitors
US20050070504A1 (en) * 2001-12-21 2005-03-31 The Procter & Gamble Co. Risedronate compositions and their methods of use
TWI349553B (en) * 2001-12-21 2011-10-01 Procter & Gamble Kit and use of bisphosphonate for treating high bone turnover
WO2003061566A2 (en) * 2002-01-24 2003-07-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Anti-cancer combination and use thereof
US20050176685A1 (en) * 2002-04-05 2005-08-11 Daifotis Anastasia G. Method for inhibiting bone resorption with an alendronate and vitamin d formulation
MXPA04009586A (es) * 2002-05-10 2005-01-11 Hoffmann La Roche Acidos bisfosfonicos para el tratamiento y prevencion de la osteoporosis.
WO2003103664A1 (en) * 2002-06-06 2003-12-18 Merck Frosst Canada & Co. 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
FR2841472B1 (fr) 2002-06-28 2006-02-24 Agronomique Inst Nat Rech Composition nutritionnelle ou therapeutique contenant le compose hesperidine ou l'un de ses derives
US20050031610A1 (en) * 2002-07-19 2005-02-10 Tae-Wan Kim CD44-related fragments, compositions and methods
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
BE1015150A3 (nl) * 2002-10-21 2004-10-05 Sonitron Nv Verbeterde transducent
SI1596870T2 (sl) * 2002-12-20 2011-07-29 Hoffmann La Roche Formulacija z visokim odmerkom ibandronata
AU2003217243A1 (en) * 2003-01-24 2004-08-23 Thomas J. Gardella Conformationally constrained parathyroid hormone (pth) analogs with lactam bridges
WO2004093902A1 (en) * 2003-03-19 2004-11-04 The General Hospital Corporation CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH α-HELIX STABILIZERS
FR2853549B1 (fr) 2003-04-11 2007-11-09 Agronomique Inst Nat Rech Composition nutritionnelle ou therapeutique contenant le compose oleuropeine ou l'un de ses derives
WO2005009358A2 (en) 2003-07-17 2005-02-03 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
US20050043359A1 (en) * 2003-08-20 2005-02-24 The Procter & Gamble Company Kit for treatment of upper gastrointestinal tract conditions
WO2005019161A1 (en) 2003-08-21 2005-03-03 Merck Frosst Canada Ltd. Cathepsin cysteine protease inhibitors
MXPA06003063A (es) * 2003-09-19 2006-05-31 Pfizer Prod Inc Composiciones farmaceuticas y metodos que comprenden combinaciones de derivados de 2-alquiliden-19-nor-vitamina- d y un bisfosfonato.
US20050261250A1 (en) * 2004-05-19 2005-11-24 Merck & Co., Inc., Compositions and methods for inhibiting bone resorption
ES2349584T3 (es) 2004-05-24 2011-01-05 Warner Chilcott Company, Llc Forma de dosificación sólida entérica para administración oral de un bifosfonato que contiene un agente quelante.
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
CA2599572A1 (en) 2005-03-02 2007-04-26 Merck & Co., Inc. Composition for inhibition of cathepsin k
CN101198316A (zh) * 2005-03-17 2008-06-11 伊兰制药国际有限公司 纳米微粒双膦酸盐组合物
CN101212954A (zh) * 2005-05-10 2008-07-02 伊兰制药国际有限公司 纳米粒氯吡格雷制剂
WO2006130839A1 (en) * 2005-06-02 2006-12-07 U.S. Borax Inc. Prevention and treatment of osteochondrosis in animals and humans
US20080293677A1 (en) * 2005-06-06 2008-11-27 Brookler Kenneth H Use of Alternating Amine and Non-Amine Bisphosphonate Combinations For Treating Osteoporosis
WO2008019062A2 (en) 2006-08-04 2008-02-14 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
US7781418B2 (en) 2006-12-14 2010-08-24 Isis Innovation Ltd. Composition for treating bone disorders
US8568737B2 (en) 2007-08-01 2013-10-29 The General Hospital Corporation Screening methods using G-protein coupled receptors and related compositions
US8354446B2 (en) * 2007-12-21 2013-01-15 Ligand Pharmaceuticals Incorporated Selective androgen receptor modulators (SARMs) and uses thereof
US20100068211A1 (en) * 2008-02-08 2010-03-18 Bateman Ted A Use of antiresorptive compounds to prevent ionizing radiation-induced activation of osteoclasts and resulting bone loss
US20120100206A1 (en) 2009-06-11 2012-04-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Targeted liposomes comprising n-containing bisphosphonates and uses thereof
US8882740B2 (en) * 2009-12-23 2014-11-11 Stryker Trauma Gmbh Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone
JP5941040B2 (ja) 2010-05-13 2016-06-29 ザ ジェネラル ホスピタル コーポレイション 副甲状腺ホルモン類似体およびその使用
CN102372773B (zh) * 2010-08-11 2013-06-05 中国科学院生物物理研究所 人膀胱癌肿瘤标志物及其抗体和应用
WO2012112363A1 (en) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
US9327013B2 (en) * 2011-03-11 2016-05-03 Tokyo University Of Science Foundation Activity enhancer for anticancer agent
SI2731591T1 (sl) 2011-07-13 2021-02-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Liposomi ko-inkapsulirajoči bifosfonat in amfipatično sredstvo
FR3005419B1 (fr) 2013-05-13 2015-09-04 Agronomique Inst Nat Rech Utilisation d'une association de deux composes pour le traitement et/ou la prevention de troubles osseux
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015054089A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015120580A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
PL407922A1 (pl) 2014-04-16 2015-10-26 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Nowe bisfosfoniany i ich zastosowanie
WO2015181676A1 (en) 2014-05-30 2015-12-03 Pfizer Inc. Carbonitrile derivatives as selective androgen receptor modulators
ES2799404T3 (es) 2014-07-15 2020-12-17 Yissum Research And Development Company Of The Hebrew Univ Of Jerusalem Ltd Polipéptidos de CD44 aislados y usos de los mismos
FR3066919B1 (fr) 2017-06-06 2019-08-02 Institut National De La Recherche Agronomique (Inra) Composition de phycocyanine pour son utilisation pour inhiber la resorption osseuse.
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
US4230700A (en) * 1977-12-07 1980-10-28 The Procter & Gamble Company Methods for inhibiting mobilization of calcium phosphate in animal tissue
US4330537A (en) * 1977-12-07 1982-05-18 The Procter & Gamble Company Compositions for inhibiting mobilization of calcium phosphate in animal tissue
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
IT1195993B (it) * 1984-01-12 1988-11-03 Gentili Ist Spa Forme farmaceutiche a base di difosfonati
DE3583887D1 (de) * 1984-04-30 1991-10-02 Procter & Gamble Ausruestung fuer die behandlung der osteoporose.

Also Published As

Publication number Publication date
EP0210728A3 (en) 1989-06-07
DE3650403D1 (de) 1995-11-02
US4761406A (en) 1988-08-02
DK174584B1 (da) 2003-07-07
EP0210728A2 (de) 1987-02-04
DK268486A (da) 1986-12-07
FI862407A0 (fi) 1986-06-05
GB2177001A (en) 1987-01-14
EP0210728B1 (de) 1995-09-27
EP0210728B2 (de) 2005-08-17
JPS6248627A (ja) 1987-03-03
JP2509185B2 (ja) 1996-06-19
CA1282702C (en) 1991-04-09
PH23686A (en) 1989-09-27
ZA864149B (en) 1988-11-30
AU603766B2 (en) 1990-11-29
AU5836986A (en) 1986-12-11
FI862407A (fi) 1986-12-07
ATE128356T1 (de) 1995-10-15
DK268486D0 (da) 1986-06-06
GB8613585D0 (en) 1986-07-09
GB2177001B (en) 1989-12-28
DE3650403T2 (de) 1996-03-28
CA1338376E (en) 1996-06-18
HK104292A (en) 1992-12-31

Similar Documents

Publication Publication Date Title
DE3650403T3 (de) Polyphosphonat enthaltende Packung zur Behandlung von Osteoporose.
GEP20084347B (en) New derivatives of diphosphonic acid, method for their preparation and medicamentous form containing them
DE3650696D1 (de) Paralleles prozessorsystem und zugehöriges verfahren zur behandlung von natürlichen nebenläufigkeiten
DE3484933D1 (de) Implantat zur befestigung von zahnprothesen.
AT388096B (de) Implantat zur befestigung von zahnprothesen
DE3853546D1 (de) Vorrichtung zum Positionieren von Gliedmassen von Patienten und torischer chirurgischer Schild.
EP0203580A3 (en) Gamma-ifn as an agent for the inhibition (hindering) of the decay process of bones
DE58900119D1 (de) Chirurgisches instrument zum einsetzen von hueftpfannen-prothesen.
DE69316013D1 (de) Verwendung von phosphinate zur behandlung der osteoporose
DE3763286D1 (de) T-geschiebe zur loesbaren befestigung von zahnprothesen.
AT379507B (de) Vorrichtung zum prophylaktischen behandeln von zahnkaries
DE3666826D1 (en) Human natural inhibitor of collagenases
DE3778158D1 (de) Inhibitoren von esterase produzierenden mikroorganismen zur hauptverwendung in deodorants.
ATE75610T1 (de) Pharmazeutische zubereitung zur behandlung des bluthochdrucks.
ATE136463T1 (de) Verwendung von 1,2,3,4-tetrahydroacridinen zur behandlung von aids, sowie verbindungen
NO972558L (no) Sett for osteoporose-behandlingssyklus
DE68918449D1 (de) Siliziumverbindungen zur behandlung von knochen.
ATE72397T1 (de) Pharmazeutische zusammensetzungen zur behandlung von hyperproliferativer hautkrankheit.
DE3683330D1 (de) Verwendung von imidazolinylaminoisoindolen und verwandten verbindungen zur behandlung von hyperglykaemie.
KR880016579U (ko) 가습기의 경도제거 및 살균장치
ATE84435T1 (de) Einrichtung zur behandlung von gasen.
ATE101795T1 (de) Behandlung von osteoporosis.
DK8587D0 (da) Apparat til afgasning af det i et tandklinisk behandlingsapparaturs vandsteriliseringsapparat steriliserede vand
ATE44481T1 (de) Vorrichtung zur behandlung von werkstuecken.
ATE79529T1 (de) Vorrichtung zur stimulation von gliedversteifungen.

Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings
8310 Action for declaration of annulment
8312 Partial invalidation
8310 Action for declaration of annulment
8313 Request for invalidation rejected/withdrawn