DE3590578T - - Google Patents

Info

Publication number
DE3590578T
DE3590578T DE19853590578 DE3590578T DE3590578T DE 3590578 T DE3590578 T DE 3590578T DE 19853590578 DE19853590578 DE 19853590578 DE 3590578 T DE3590578 T DE 3590578T DE 3590578 T DE3590578 T DE 3590578T
Authority
DE
Germany
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19853590578
Other versions
DE3590578C2 (de
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of DE3590578T publication Critical patent/DE3590578T/de
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
DE19853590578 1984-11-13 1985-11-12 Pending DE3590578T (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/671,106 US4687659A (en) 1984-11-13 1984-11-13 Diamide-DTPA-paramagnetic contrast agents for MR imaging

Publications (1)

Publication Number Publication Date
DE3590578T true DE3590578T (de) 1987-01-29

Family

ID=24693155

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19853590578 Pending DE3590578T (de) 1984-11-13 1985-11-12
DE3590578A Expired - Lifetime DE3590578C2 (de) 1984-11-13 1985-11-12 Paramagnetische Diamid-DTPA-Kontrastmittel für MR-Tomographie

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3590578A Expired - Lifetime DE3590578C2 (de) 1984-11-13 1985-11-12 Paramagnetische Diamid-DTPA-Kontrastmittel für MR-Tomographie

Country Status (6)

Country Link
US (1) US4687659A (de)
EP (1) EP0203962B1 (de)
JP (1) JPH0645632B2 (de)
DE (2) DE3590578T (de)
GB (1) GB2181428B (de)
WO (1) WO1986002841A1 (de)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735796A (en) * 1983-12-08 1988-04-05 Gordon Robert T Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
EP0330801A1 (de) * 1983-02-08 1989-09-06 Schering Aktiengesellschaft Ferromagnetische, diamagnetische oder paramagnetische Partikel, die in der Diagnose und Behandlung von Krankheiten nützlich sind
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
US4859451A (en) * 1984-10-04 1989-08-22 Salutar, Inc. Paramagnetic contrast agents for MR imaging
US4826673A (en) * 1985-01-09 1989-05-02 Mallinckrodt, Inc. Methods and compositions for enhancing magnetic resonance imaging
DE3614142C2 (de) * 1985-04-26 1996-03-28 Toshiba Kawasaki Kk Verwendung eines Materials für die Diagnose durch Kernresonanz-Spektroskopie
US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
US5422096A (en) * 1985-05-08 1995-06-06 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
US5219552A (en) * 1986-04-07 1993-06-15 Francois Dietlin Compositions intended for use in tomo densitometry
US4951675A (en) * 1986-07-03 1990-08-28 Advanced Magnetics, Incorporated Biodegradable superparamagnetic metal oxides as contrast agents for MR imaging
AU608759B2 (en) * 1986-08-04 1991-04-18 Amersham Health Salutar Inc NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes
US4785245A (en) * 1986-09-12 1988-11-15 Engineering Measurement Company Rapid pulse NMR cut meter
IL83966A (en) * 1986-09-26 1992-03-29 Schering Ag Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them
JPH01500274A (ja) * 1987-02-12 1989-02-02 ゼネラル・エレクトリック・カンパニイ ポリエーテルイミド―ポリアミド組成物
DE3710730A1 (de) * 1987-03-31 1988-10-20 Schering Ag Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US4863716A (en) * 1987-05-08 1989-09-05 Salutar, Inc. Determination of fallopian tubal patency by magnetic resonance imaging
US5399340A (en) * 1987-09-24 1995-03-21 Schering Aktiengesellschaft Use of amide complex compounds
DE3927444A1 (de) * 1989-08-16 1991-02-28 Schering Ag Verwendung von amid-komplexverbindungen
GB8801646D0 (en) * 1988-01-26 1988-02-24 Nycomed As Chemical compounds
US5137711A (en) * 1988-07-19 1992-08-11 Mallickrodt Medical, Inc. Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents
US5130120A (en) * 1988-07-19 1992-07-14 Mallinckrodt Medical, Inc. Paramagnetic DTPA and EDTA alkoxyalkylamide complexes as MRI agents
US5314681A (en) * 1988-12-23 1994-05-24 Nycomed Innovation Ab Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
US5702683A (en) * 1989-01-24 1997-12-30 The United States Of America As Represented By The United States Department Of Energy Nuclear magnetic resonance contrast agents
US5011925A (en) * 1989-03-09 1991-04-30 Mallinckrodt, Inc. Morpholinoamido EDTA derivatives
US5384108A (en) * 1989-04-24 1995-01-24 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
WO1990013256A1 (en) * 1989-05-04 1990-11-15 Wisconsin Alumni Research Foundation Method for localization and treatment of tumors and complexes therefor
US5230883A (en) * 1989-05-04 1993-07-27 Wisconsin Alumni Research Foundation Method for localization and treatment of tumors using polylysine complexes
US5494655A (en) * 1990-03-09 1996-02-27 The Regents Of The University Of California Methods for detecting blood perfusion variations by magnetic resonance imaging
US6994841B1 (en) * 1990-03-09 2006-02-07 Kucharczyk And Moseley Partners Relating to magnetic resonance imaging
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
US5242681A (en) * 1990-03-12 1993-09-07 Research Corporation Technologies, Inc. Lipophilic contrast agents for diagnostic image analysis
US5154914A (en) * 1990-03-12 1992-10-13 Research Corporation Technologies, Inc. Methods of diagnostic image analysis using lipophilic contrast agents
GB9006606D0 (en) * 1990-03-23 1990-05-23 Allied Colloids Ltd Chelate compositions and their production
WO1992017215A1 (en) 1990-03-28 1992-10-15 Nycomed Salutar, Inc. Contrast media
DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
US5843399A (en) * 1990-04-06 1998-12-01 Schering Aktiengesellschaft DTPA monoamides for MRI
US5077037A (en) * 1990-08-03 1991-12-31 Mallinckrodt Medical, Inc. Novel compositions for magnetic resonance imaging
US5162109A (en) * 1990-09-13 1992-11-10 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
US5217706A (en) * 1990-11-21 1993-06-08 Mallinckrodt Medical, Inc. Complexes and compositions for magnetic resonance imaging
US5141740A (en) * 1990-11-21 1992-08-25 Mallinckrodt Medical, Inc. Complexes and compositions for magnetic resonance imaging and usage methods
GB9027922D0 (en) * 1990-12-21 1991-02-13 Nycomed As Compounds
US5463030A (en) * 1991-05-03 1995-10-31 Research Foundation Of The State Of New York Metal chelating agents for medical application
AU660033B2 (en) * 1991-05-23 1995-06-08 Imarx Pharmaceutical Corp. Liposoluble compounds for magnetic resonance imaging
US5208375A (en) * 1991-07-02 1993-05-04 Mallinckrodt Medical, Inc. Compositions for magnetic resonance imaging
US5138040A (en) * 1991-07-02 1992-08-11 Mallinckrodt Medical, Inc. Composition for magnetic resonance imaging
US6875864B2 (en) * 1991-08-01 2005-04-05 Bracco International B.V. Aminocarboxylate ligands having substituted aromatic amide moieties
US5562894A (en) * 1991-08-09 1996-10-08 Regents Of The University Of California Amino-acyl-type and catecholamine-type contrast agents for MRI
WO1993003045A1 (en) * 1991-08-09 1993-02-18 The Regents Of The University Of California Process for purer organic metal ion chelate complexes
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
GB9208908D0 (en) * 1992-04-24 1992-06-10 Nycomed As Contrast agents
US5439913A (en) 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
US5508388A (en) * 1992-07-16 1996-04-16 Mallinckrodt Medical, Inc. Process for manufacturing DTPA-bis amide magnetic resonance imaging
WO1994008630A1 (en) * 1992-10-13 1994-04-28 Mallinckrodt Medical, Inc. Novel compositions for magnetic resonance imaging
US5817292A (en) * 1992-10-14 1998-10-06 Nycomed Imaging As MR imaging compositions and methods
EP0664713B1 (de) * 1992-10-14 2000-01-19 Nycomed Imaging As Therapeutische und diagnostische bilderzeugungzusammensetzung und verfahren zur herstellung
AU5323794A (en) * 1992-10-14 1994-05-09 Sterling Winthrop Inc. Chelating polymers
US5330743A (en) * 1992-11-12 1994-07-19 Magnetic Research, Inc. Aminosaccharide contrast agents for magnetic resonance images
GB9321595D0 (en) * 1993-10-20 1993-12-08 Nycomed Imaging As Contrast agents
WO1995027705A1 (en) * 1994-04-08 1995-10-19 Bracco International B.V. Aromatic amide compounds and metal chelates thereof
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
GB9501560D0 (en) * 1995-01-26 1995-03-15 Nycomed Imaging As Contrast agents
US6117412A (en) * 1995-01-26 2000-09-12 Nycomed Imaging As Non-cluster type bismuth compounds
TW319763B (de) 1995-02-01 1997-11-11 Epix Medical Inc
DE19507820A1 (de) * 1995-02-21 1996-08-22 Schering Ag Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19507819A1 (de) * 1995-02-21 1996-08-22 Schering Ag DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
US5804164A (en) * 1996-03-13 1998-09-08 Research Corporation Technologies, Inc. Water-soluble lipophilic contrast agents
DE19641197C2 (de) * 1996-09-24 1999-02-18 Schering Ag Ionenpaare und ihre Verwendung als Kontrastmittel
US5861138A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Ligands for MRI contrast agent
US5861140A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Tripodal paramagnetic contrast agents for MR imaging
US5824288A (en) * 1997-08-21 1998-10-20 Hoechst Celanese Corporation Thio-substituted pyridines as MRI ligand precursors
US5858329A (en) * 1997-08-21 1999-01-12 Hoechst Celanese Corporation MRI diagnostic procedures using tripodal pyridinyl metal complexes
US5820851A (en) * 1997-08-21 1998-10-13 Hoechst Celanese Corporation Tripodal pyridine ligands as MRI contrast agents
US5869025A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corporation Tripodal aromatic heterocycle carboxamide MRI contrast agents
US5869026A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corp. Tripodal carboxamide ligands for MRI contrast agents
US6190923B1 (en) 1997-09-05 2001-02-20 David K. Johnson Diethylenetriamine-N,N′,N″-triacetic acid derivatives
WO1999033823A1 (en) * 1997-12-23 1999-07-08 Nycomed Imaging As Nitric oxide releasing chelating agents and their therapeutic use
EP1463751B1 (de) 2001-12-21 2013-05-22 Human Genome Sciences, Inc. Albuminfusionsproteine
US7563882B2 (en) * 2002-06-10 2009-07-21 University Of Rochester Polynucleotides encoding antibodies that bind to the C35 polypeptide
CN1774267A (zh) * 2003-01-22 2006-05-17 综合医院有限公司 与淀粉样物质结合的金属螯合剂
US20040265235A1 (en) * 2003-06-26 2004-12-30 Uzgiris Egidijus Edward Magnetic resonance contrast-enhancing agents and method for detecting and imaging artherosclerotic plaque
EP1708751B1 (de) * 2003-12-04 2011-09-28 Vaccinex, Inc. Verfahren zum abtöten von tumorzellen mittels targeting von auf apoptotischen tumorzellen exponierten internen antigenen
EP1729823B1 (de) 2004-03-04 2009-11-04 GE Healthcare AS Konjugate von angiotensin-peptid analoga und chelatbildner für diagnose und therapie
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
US8182790B2 (en) 2004-11-22 2012-05-22 Ge Healthcare As Contrast agents
US8669236B2 (en) * 2005-05-12 2014-03-11 The General Hospital Corporation Biotinylated compositions
WO2007088051A2 (en) 2006-01-31 2007-08-09 Bayer Schering Pharma Aktiengesellschaft Modulation of mdl-1 activity for treatment of inflammatory disease
WO2007142804A2 (en) * 2006-06-01 2007-12-13 Mallinckrodt Inc. Preparation of complexing agents and metal ion complexes in aqueous media
KR100829175B1 (ko) * 2006-11-21 2008-05-13 동국정밀화학(주) 가도디아미드의 제조방법
US8030358B2 (en) 2007-10-29 2011-10-04 University Of Kentucky Research Foundation Methods and pharmaceutical compositions for decorporation of radioactive compounds
EP2072060A1 (de) 2007-12-18 2009-06-24 Institut Curie Verfahren und Zusammensetzungen zur Herstellung und Verwendung von Toxinkonjugaten
AU2008341050B2 (en) * 2007-12-26 2013-10-24 Vaccinex, Inc. Anti-C35 antibody combination therapies and methods
WO2010116209A1 (en) 2009-04-10 2010-10-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Fucoidans as ligands for the diagnosis of degenerative pathologies
JP5712504B2 (ja) 2010-04-27 2015-05-07 住友化学株式会社 有害生物防除組成物およびその用途
WO2012072819A1 (en) 2010-12-03 2012-06-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Agents for the molecular imaging of serine-protease in human pathologies
WO2013153138A1 (en) 2012-04-11 2013-10-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof
AU2013308519A1 (en) 2012-08-31 2015-04-09 The General Hospital Corporation Biotin complexes for treatment and diagnosis of Alzheimer's disease
ES2890650T3 (es) 2012-11-26 2022-01-21 Univ North Carolina Chapel Hill Esteres de di-etilo de DTPA, composiciones de los mismos, y métodos para utilizar los mismos
US10670679B2 (en) * 2016-07-01 2020-06-02 Canon Medical Systems Corporation Magnetic resonance imaging apparatus and image processing apparatus

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3859337A (en) * 1969-06-11 1975-01-07 Stauffer Chemical Co Ethylenediaminetetraacetic acid anhydride derivatives
DE3129906C3 (de) 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze

Also Published As

Publication number Publication date
WO1986002841A1 (en) 1986-05-22
DE3590578C2 (de) 1993-10-21
EP0203962B1 (de) 1991-05-02
GB2181428A (en) 1987-04-23
EP0203962A1 (de) 1986-12-10
GB8614549D0 (en) 1986-07-23
EP0203962A4 (de) 1988-11-14
JPH0645632B2 (ja) 1994-06-15
GB2181428B (en) 1989-01-05
JPS62501412A (ja) 1987-06-11
US4687659A (en) 1987-08-18

Similar Documents

Publication Publication Date Title
DE3590578T (de)
DE3437195C2 (de)
AT379850B (de)
DE3426328C2 (de)
DE3439590C2 (de)
DE8435809U1 (de)
DE3428603C2 (de)
DE8422092U1 (de)
AU2219783A (de)
AU2557584A (de)
GR76576B (de)
GR79622B (de)
GR73339B (de)
BG44749A1 (de)
BG45080A1 (de)
BG45042A3 (de)
BG45025A1 (de)
BG44935A1 (de)
BG45054A1 (de)
BG44917A1 (de)
BG44848A1 (de)
BG44830A1 (de)
BG44829A1 (de)
BG44806A1 (de)
BG45060A1 (de)