DE3587468T2 - Adhesin-antigene, antikörper und dns-fragmente die das antigen kodieren, verfahren und mittel zur diagnose und immunisierung, usw. - Google Patents

Adhesin-antigene, antikörper und dns-fragmente die das antigen kodieren, verfahren und mittel zur diagnose und immunisierung, usw.

Info

Publication number
DE3587468T2
DE3587468T2 DE85902487T DE3587468T DE3587468T2 DE 3587468 T2 DE3587468 T2 DE 3587468T2 DE 85902487 T DE85902487 T DE 85902487T DE 3587468 T DE3587468 T DE 3587468T DE 3587468 T2 DE3587468 T2 DE 3587468T2
Authority
DE
Germany
Prior art keywords
antigens
antibodies
adhesine
immunization
diagnosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE85902487T
Other languages
English (en)
Other versions
DE3587468D1 (de
Inventor
Frederik Lindberg
Bjoern Lund
Britt Monika Baga
Mari Norgren
Mikael Goeransson
Bernt Uhlin
Jan Normark
David Lark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Symbicom AB
Original Assignee
Symbicom AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symbicom AB filed Critical Symbicom AB
Application granted granted Critical
Publication of DE3587468D1 publication Critical patent/DE3587468D1/de
Publication of DE3587468T2 publication Critical patent/DE3587468T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/82—Subcellular parts of microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria
DE85902487T 1984-05-02 1985-05-02 Adhesin-antigene, antikörper und dns-fragmente die das antigen kodieren, verfahren und mittel zur diagnose und immunisierung, usw. Expired - Lifetime DE3587468T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK2190/84A DK219084D0 (da) 1984-05-02 1984-05-02 Antigen

Publications (2)

Publication Number Publication Date
DE3587468D1 DE3587468D1 (de) 1993-08-26
DE3587468T2 true DE3587468T2 (de) 1993-12-02

Family

ID=8110676

Family Applications (1)

Application Number Title Priority Date Filing Date
DE85902487T Expired - Lifetime DE3587468T2 (de) 1984-05-02 1985-05-02 Adhesin-antigene, antikörper und dns-fragmente die das antigen kodieren, verfahren und mittel zur diagnose und immunisierung, usw.

Country Status (13)

Country Link
US (3) US4795803A (de)
EP (1) EP0179887B1 (de)
JP (2) JP2974028B2 (de)
KR (1) KR950000688B1 (de)
AT (1) ATE91629T1 (de)
AU (1) AU593770B2 (de)
CA (1) CA1340847C (de)
DE (1) DE3587468T2 (de)
DK (2) DK219084D0 (de)
FI (1) FI93310C (de)
IE (1) IE59826B1 (de)
RU (1) RU1787165C (de)
WO (1) WO1985005037A1 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4736017A (en) * 1984-04-30 1988-04-05 The Board Of Trustees Of The Leland Stanford Junior University Chemically defined vaccine against urinary infections
US4584195A (en) * 1984-06-21 1986-04-22 The Board Of Trustees Of The Leland Stanford Junior University Broad spectrum vaccine against gonorrhea
US4740585A (en) * 1984-07-30 1988-04-26 The Board Of Trustees Of The Leland Stanford Junior University Synthetic vaccine against urinary infections
AU590230B2 (en) * 1984-10-31 1989-11-02 Commonwealth Scientific And Industrial Research Organisation Improved antigenic preparation
US5288617A (en) * 1984-10-31 1994-02-22 Commonwealth Scientific And Industrial Research Organization Method of producing an antigenic preparation
IL78775A (en) * 1985-05-15 1992-06-21 Biotech Australia Pty Ltd Oral vaccines
DE3689713T2 (de) * 1985-08-01 1994-07-07 Miles Inc Schützende Antikörper gegen serotypische Determinanten von flagellären Antigenen.
US4900659A (en) * 1986-01-30 1990-02-13 Enzo Biochem, Inc. Nucleotide sequence composition and method for detection of Neisseria gonorrhoeae and method for screening for a nucleotide sequence that is specific for a genetically distinct group
US4801690A (en) * 1986-03-24 1989-01-31 Bactex, Inc. Novel lectins derived from bacterial pili
SE8601940D0 (sv) * 1986-04-25 1986-04-25 Kabigen Ab Preparation of fused proteins, antibodies and processes therefor
US4786592A (en) * 1986-06-18 1988-11-22 Scripps Clinic And Research Foundation Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic marker and means for producing this lectin
US7138516B1 (en) 1986-11-24 2006-11-21 Gen-Probe Incorporated Oligonucleotide probes for the detection and/or quantitation of non-viral organisms
US7087742B1 (en) 1986-11-24 2006-08-08 Gen-Probe Incorporated Oligonucleotide probes for the detection and/or quantitation of non-viral organisms
US5036003A (en) * 1987-08-21 1991-07-30 Monsanto Company Antibodies to VPF
AU601510B2 (en) * 1987-11-06 1990-09-13 Immunomed Corporation Preparation of bacterium pili subunits and vaccines containing pili subunits
SE8801894D0 (sv) * 1988-05-20 1988-05-20 Alfa Laval Agri Int Fibronektinbindande protein
US5055455A (en) 1988-09-28 1991-10-08 Brigham And Women's Hospital Capsular polysaccharide adhesin antigen, preparation, purification and use
US7172863B1 (en) 1988-12-09 2007-02-06 Gen-Probe Incorporated Nucleic acid probes and methods for detecting Neisseria gonorrhoeae
CA1340530C (en) * 1989-04-28 1999-05-04 Kok Kheong Lee Synthetic pseudomonas aeruginosa pilin peptide and related vaccines and diagnostics
SE8901687D0 (sv) * 1989-05-11 1989-05-11 Alfa Laval Agri Int Fibronectin binding protein as well as its preparation
US5202113A (en) * 1990-04-30 1993-04-13 The United States Of America As Represented By The Department Of Health And Human Services Plaque-inhibiting protein from bacteroides loeschei and methods for using the same
EP0553113B1 (de) * 1990-08-02 1998-11-25 Antex Biologics, Inc. Adhäsionsrezeptoren für pathogene oder opportunistische mikroorganismen
US5440014A (en) * 1990-08-10 1995-08-08 H+E,Uml/Oo/ K; Magnus Fibronectin binding peptide
US5843463A (en) * 1990-12-21 1998-12-01 Antexbiologics, Inc. Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae
JPH06504670A (ja) * 1990-12-21 1994-06-02 マイクロカーブ　インコーポレイティド 微生物に関する脂質レセプター及び対応の付着因子、付着因子をコードするｄｎａ配列、並びにそれらの利用方法
US5834591A (en) * 1991-01-31 1998-11-10 Washington University Polypeptides and antibodies useful for the diagnosis and treatment of pathogenic neisseria and other microorganisms having type 4 pilin
US5980908A (en) * 1991-12-05 1999-11-09 Alfa Laval Ab Bacterial cell surface protein with fibronectin, fibrinogen, collagen and laminin binding ability, process for the manufacture of the protein and prophylactic treatment
AU662783B2 (en) * 1992-01-08 1995-09-14 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur Whooping cough vaccine
PT699076E (pt) * 1993-05-18 2003-03-31 Univ Ohio State Res Found Vacina contra a otite media
US5648240A (en) * 1994-05-24 1997-07-15 Texas A&M University MHC II analog from Staphylococcus aureus
US5798260A (en) * 1994-06-24 1998-08-25 Children's Hospital And Medical Center Escherichia coli O157:H7 epithelial adhesin
DE19534579C2 (de) * 1995-09-18 2000-06-08 Max Planck Gesellschaft Nucleinsäure-Moleküle codierend Proteine, die die Adhäsion von Neisseria-Zellen an humane Zellen vermitteln
US6872398B2 (en) * 1995-12-22 2005-03-29 The United States Of America As Represented By The Secretary Of The Army Conjugate vaccine against gram-negative bacterial infections
CA2257826C (en) * 1996-06-10 2011-11-22 Thomas Boren Helicobacter pylori adhesin binding group antigen
PT1047784E (pt) * 1998-01-14 2009-12-21 Novartis Vaccines & Diagnostic Antigénios de neisseria meningitidis
US7252828B2 (en) 1998-07-15 2007-08-07 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for staphylococcal infections
US6692739B1 (en) 1998-08-31 2004-02-17 Inhibitex, Inc. Staphylococcal immunotherapeutics via donor selection and donor stimulation
EP1121149A4 (de) * 1998-08-31 2002-03-20 Inhibitex Inc Immunotherapeutika gegen staphylokokkus mittels donor selektion und donor stimulation
US20040001863A1 (en) * 1998-12-03 2004-01-01 Shau-Chi Chi Immortal cell line derived from grouper Epinephelus coioides and its applications therein
GB9924351D0 (en) 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
JP2003518073A (ja) * 1999-12-21 2003-06-03 メリアル クリプトスポリジウムパルヴァムと他の腸内病原体の抗原を含む組成物およびワクチン
IL154853A0 (en) * 2000-10-27 2003-10-31 Chiron Spa Nucleic acids and proteins from streptococcus groups a & b
EP1377314B1 (de) 2001-01-26 2011-09-14 Inhibitex, Inc. Monoklonale antikörper gegen das clfa-protein und verfahren zur verwendung bei der behandlung bzw. pr vention von infektionen
US7396822B2 (en) 2001-05-24 2008-07-08 Vaxiion Therapeutics, Inc. Immunogenic minicells and methods of use
US20030194798A1 (en) 2001-05-24 2003-10-16 Surber Mark W. Minicell compositions and methods
US7132101B2 (en) * 2002-02-27 2006-11-07 Duquesne University Of The Holy Ghost Compositions and methods for eliciting an immune response to gram-negative bacterial infections
AU2003256329A1 (en) * 2002-06-27 2004-01-19 University Of Washington Use of adhesion molecules as bond stress-enhanced nanoscale binding switches
US7723087B2 (en) * 2002-11-12 2010-05-25 The Brigham And Women's Hospital, Inc. Nucleic acid molecules for enhanced production of a bacterial polysaccharide and methods of use thereof
CN100351260C (zh) 2002-11-12 2007-11-28 布赖汉姆妇女医院 葡萄球菌感染的多糖疫苗
WO2006055024A2 (en) * 2004-04-05 2006-05-26 Vaxiion Therapeutics, Inc. Minicells as vaccines
AU2005236068C1 (en) * 2004-04-21 2012-08-30 Beth Israel Deaconess Medical Center, Inc. Poly-N-acetyl glucosamine (PNAG/DPNAG)-binding peptides and methods of use thereof
US7585236B2 (en) * 2006-08-02 2009-09-08 Wilson Sporting Goods Co. Game ball having optimally positioned grooves and/or ridges
US8251846B2 (en) * 2006-08-02 2012-08-28 Wilson Sporting Goods Co. Game ball having optimally positioned grooves
US7686713B2 (en) * 2007-04-11 2010-03-30 Wilson Sporting Goods Co. Racquet stringing machine
CA2685308A1 (en) * 2007-04-27 2009-01-29 Dow Global Technologies Inc. Improved production and in vivo assembly of soluble recombinant icosahedral virus-like particles
RU2532911C2 (ru) * 2008-07-21 2014-11-20 Дзе Брихэм Энд Уимен'З Хоспитал, Инк. Способы и композиции, относящиеся к синтетическим бета-1,6-глюкозаминолигосахаридам
JP6199746B2 (ja) 2011-02-15 2017-09-20 バキシオン セラピューティクス，リミテッド ライアビリティ カンパニー 抗体およびＦｃ含有標的化分子に基づく生理活性分子の標的送達のための細菌ミニ細胞による治療用組成物および方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1332108B (en) 1908-12-21 1909-11-30 Improvements in means for transporting merchandise and other material in connection with the loading and unloading of vehicles
AU853813B (en) 1913-03-31 1914-04-11 George Reid Angus Improvements in the manufacture of filter frames for beer and other liquids
GB1472624A (en) * 1974-09-02 1977-05-04 Canadian Patents Dev Enteric disease vaccine
US4461838A (en) * 1975-04-25 1984-07-24 Bactex, Inc. Gonococcal Pili processes for the preparation thereof and the use thereof for the detection of and prevention of infections caused by Neisseria gonorrhoeae
GB1549345A (en) * 1975-04-25 1979-08-08 Bactex Inc Gonococcal pili processes for the preparation thereof and the use thereof
US4136167A (en) * 1975-06-12 1979-01-23 Internationale Octrooi Maatschappij "Octropa" B.V. Process for reducing the incidence of neonatal diarrhoea in pigs
GB1553664A (en) * 1975-06-12 1979-09-26 Unilever Ltd Antigenic compositions
US4237115A (en) * 1977-11-23 1980-12-02 Bactex, Inc. Method of immunization against enterotoxogenic infection by Escherichia coli
US4336336A (en) * 1979-01-12 1982-06-22 President And Fellows Of Harvard College Fused gene and method of making and using same
FR2466251B1 (fr) * 1979-10-03 1983-03-18 Agronomique Inst Nat Rech Vaccin animal anticolibacillaire, obtention et application
US4311797A (en) * 1979-09-18 1982-01-19 University Of Saskatchewan Anucleated live E. coli vaccine
SE8001748L (sv) * 1980-03-05 1981-09-06 Kaellenius Gunilla Kompositioner for terapeutisk eller diagnostisk anvendning jemte forfarande for terapeutik
US4454117A (en) * 1980-09-15 1984-06-12 Bactex, Inc. Immunization against infection by Escherichia coli
GB2094314A (en) * 1981-02-05 1982-09-15 Wellcome Found Recombinant DNA
WO1982003088A1 (en) * 1981-03-09 1982-09-16 Corp Cetus Vaccines
US4443431A (en) * 1981-05-27 1984-04-17 The United States Of America As Represented By The Department Of Health And Human Services Neisseria gonorrhoeae vaccine
US4443549A (en) * 1981-10-19 1984-04-17 Molecular Genetics, Inc. Production of monoclonal antibodies against bacterial adhesins
NZ202203A (en) * 1981-10-19 1986-05-09 Molecular Genetics Inc Producing anti-adhesin antibodies
FR2516385A1 (fr) * 1981-11-19 1983-05-20 Merieux Inst Vaccin anti-aphteux et anti-colibacillaire et son procede de preparation
JPS58502181A (ja) * 1982-01-18 1983-12-22 サンド・アクチエンゲゼルシヤフト 新規プラスミドと細菌株並びにその製造法
EP0089940A1 (de) * 1982-03-23 1983-09-28 BioCarp AB Oligosaccharide umfassende Zusammensetzung für therapeutische oder diagnostische Verwendung
US4597967A (en) * 1982-07-27 1986-07-01 The University Of Tennessee Research Corp. Synthetic polypeptide fragments
US4521334A (en) * 1982-07-27 1985-06-04 The University Of Tennesse Research Corporation Synthetic polypeptide fragments
NZ205392A (en) * 1982-09-02 1987-03-06 Unilever Plc Preparation of immunoglobulins against e.coli pili
US4652448A (en) * 1982-10-07 1987-03-24 Molecular Genetics, Inc. Use of monoclonal antibodies against bacterial adhesins
US4736017A (en) * 1984-04-30 1988-04-05 The Board Of Trustees Of The Leland Stanford Junior University Chemically defined vaccine against urinary infections
US4801690A (en) * 1986-03-24 1989-01-31 Bactex, Inc. Novel lectins derived from bacterial pili
US4786592A (en) * 1986-06-18 1988-11-22 Scripps Clinic And Research Foundation Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic marker and means for producing this lectin

Also Published As

Publication number Publication date
EP0179887A1 (de) 1986-05-07
FI860015A0 (fi) 1986-01-02
US5804198A (en) 1998-09-08
US4795803A (en) 1989-01-03
JP2974028B2 (ja) 1999-11-08
DK219084D0 (da) 1984-05-02
WO1985005037A1 (en) 1985-11-21
CA1340847C (en) 1999-12-14
IE851102L (en) 1985-11-02
KR860700090A (ko) 1986-03-31
JPH09183791A (ja) 1997-07-15
FI860015A (fi) 1986-01-02
JPS62501355A (ja) 1987-06-04
FI93310B (fi) 1994-12-15
AU593770B2 (en) 1990-02-22
KR950000688B1 (ko) 1995-01-27
AU4299485A (en) 1985-11-28
EP0179887B1 (de) 1993-07-21
IE59826B1 (en) 1994-04-06
ATE91629T1 (de) 1993-08-15
RU1787165C (ru) 1993-01-07
DK171258B1 (da) 1996-08-12
DK609985A (da) 1985-12-30
FI93310C (fi) 1995-03-27
DE3587468D1 (de) 1993-08-26
US6291649B1 (en) 2001-09-18
DK609985D0 (da) 1985-12-30

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