DE3586801D1 - Synthetische hepatitis-b-virus-vakzine die t-zellen- und b-zellenbestimmer enthalten. - Google Patents

Synthetische hepatitis-b-virus-vakzine die t-zellen- und b-zellenbestimmer enthalten.

Info

Publication number
DE3586801D1
DE3586801D1 DE8585301588T DE3586801T DE3586801D1 DE 3586801 D1 DE3586801 D1 DE 3586801D1 DE 8585301588 T DE8585301588 T DE 8585301588T DE 3586801 T DE3586801 T DE 3586801T DE 3586801 D1 DE3586801 D1 DE 3586801D1
Authority
DE
Germany
Prior art keywords
cell
determiners
hepatitis
virus vaccine
vaccine containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585301588T
Other languages
English (en)
Inventor
David R Milich
Frank V Chisari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Clinic and Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/588,122 external-priority patent/US4599230A/en
Priority claimed from US06/587,983 external-priority patent/US4599231A/en
Application filed by Scripps Clinic and Research Foundation filed Critical Scripps Clinic and Research Foundation
Application granted granted Critical
Publication of DE3586801D1 publication Critical patent/DE3586801D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Air Bags (AREA)
  • Selective Calling Equipment (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE8585301588T 1984-03-09 1985-03-07 Synthetische hepatitis-b-virus-vakzine die t-zellen- und b-zellenbestimmer enthalten. Expired - Lifetime DE3586801D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/588,122 US4599230A (en) 1984-03-09 1984-03-09 Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US06/587,983 US4599231A (en) 1984-03-09 1984-03-09 Synthetic hepatitis B virus vaccine including both T cell and B cell determinants

Publications (1)

Publication Number Publication Date
DE3586801D1 true DE3586801D1 (de) 1992-12-17

Family

ID=27080174

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585301588T Expired - Lifetime DE3586801D1 (de) 1984-03-09 1985-03-07 Synthetische hepatitis-b-virus-vakzine die t-zellen- und b-zellenbestimmer enthalten.

Country Status (11)

Country Link
EP (1) EP0155146B1 (de)
AT (1) ATE82135T1 (de)
AU (2) AU579148B2 (de)
CA (1) CA1253069A (de)
DE (1) DE3586801D1 (de)
DK (1) DK516385A (de)
FI (1) FI84558C (de)
IL (3) IL74545A (de)
NO (1) NO167359C (de)
NZ (2) NZ227731A (de)
WO (1) WO1985004103A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2560890B1 (fr) * 1984-03-07 1987-10-16 Grp Genie Genetique Composition utile pour la fabrication de vaccins contenant des particules portant l'antigene de surface du virus de l'hepatite b et le recepteur de l'albumine serique humaine polymerisee, cellules animales capables de produire de telles particules et procede pour leur obtention
AU617292B2 (en) * 1986-06-20 1991-11-28 Scripps Clinic And Research Foundation T and b cell epitopes of the pre-s region of hepatitis b virus surface antigen
US6222020B1 (en) * 1987-01-07 2001-04-24 Imperial Cancer Research Technology Limited Antigens derived from the core protein of the human mammary epithelial mucin
EP0293201A3 (de) * 1987-05-26 1990-02-28 The Wistar Institute Methode zur Impfung gegen Hepatitis-B-Virus
WO1988010300A1 (en) * 1987-06-22 1988-12-29 Medico Labs Ag Heterologous viral peptide particle immunogens
WO1989001943A1 (en) * 1987-09-04 1989-03-09 Whitehead Institute For Biomedical Research Peptide complexes having enhanced stability
EP0491077A1 (de) * 1990-12-19 1992-06-24 Medeva Holdings B.V. Zusammensetzung verwendbar als therapeutisches Mittel gegen chronische virale Leberkrankheiten
GB9325772D0 (en) * 1993-12-16 1994-02-16 Smithkline Beecham Biolog Novel compounds
JP2000514643A (ja) * 1996-04-18 2000-11-07 アボツト・ラボラトリーズ Ｂ型肝炎表面抗原のａ―決定基の抗原エピトープ及びその利用法
WO1998012332A1 (en) 1996-09-17 1998-03-26 Chiron Corporation Compositions and methods for treating intracellular diseases
WO1998029442A1 (en) * 1996-12-30 1998-07-09 Innogenetics N.V. ANNEXIN V-BINDING POLYPEPTIDES DERIVED FROM HBsAg AND THEIR USES
US6881723B1 (en) 1998-11-05 2005-04-19 Powderject Vaccines, Inc. Nucleic acid constructs
ES2330904B1 (es) 2005-09-21 2010-09-23 Fundacio Centre De Recerca En Sanitat Animal Polinucleotidos de haemophilus parasuis y su uso.
CA2926004A1 (en) 2006-08-11 2008-02-14 Life Sciences Research Partners Vzw Immunogenic peptides and their use in allergic and autoimmune disorders
WO2009101205A2 (en) 2008-02-14 2009-08-20 Life Sciences Research Partners Vzw Immunogenic control of tumours and tumour cells
ES2637812T3 (es) 2008-02-14 2017-10-17 Life Sciences Research Partners Vzw Inmunoterapia dirigida a patógenos intracelulares
EP3763729B1 (de) 2010-11-25 2022-07-06 Imcyse SA Immunogene peptide zur verwendung in der vorbeugung und/oder behandlung von infektionskrankheiten, autoimmunerkrankungen, immunreaktionen auf allofaktoren, allergischen erkrankungen, tumoren, transplantatabstossungen und immunreaktionen auf virale vektoren für gentherapie oder genimpfung
GB201201511D0 (en) 2012-01-30 2012-03-14 Univ Leuven Kath Modified epitopes for boosting CD4+ T-cell responses
EP2860188B1 (de) * 2012-06-11 2020-10-21 Xiamen University Polypeptide und antikörper zur behandlung von hbv-infektionen und verwandten erkrankungen
GB201309469D0 (en) 2013-05-28 2013-07-10 Imcyse Sa Detection of CD4+ T lymphocytes
US10729791B2 (en) 2015-05-18 2020-08-04 Imcyse Sa Animal models for evaluating pharmaceutical compounds
EP3352782B1 (de) 2015-09-25 2021-03-31 ImCyse SA Verbesserte verfahren und verbindungen zur beseitigung von immunreaktionen auf therapeutische mittel
KR20220132023A (ko) 2016-04-19 2022-09-29 임시스 에스에이 신규 면역원성 CD1d 결합 펩티드
CN108456686B (zh) 2017-02-17 2021-03-05 厦门大学 一种用于展示目的多肽的多肽载体及其用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA792485B (en) * 1978-06-07 1980-06-25 New York Blood Center Inc Vaccine for active immunization containing hepatitis b surface and/or e-antigens
FR2480779B2 (fr) * 1979-08-30 1986-07-18 Anvar Vecteur contenant une sequence nucleotidique de l'antigene de surface du virus de l'hepatite b et procede de fabrication d'une molecule immunogene mettant en oeuvre ce vecteur
JP2530801B2 (ja) * 1978-12-22 1996-09-04 バイオゲン インコーポレイテッド 組換えｄｎａ分子
US4415491A (en) * 1980-01-14 1983-11-15 The Regents Of The University Of California Synthetic vaccine peptide epitomes of hepatitis B surface antigen
IL63224A (en) * 1980-07-17 1985-05-31 Scripps Clinic Res Synthetic peptide specific antigenic determinant and method of manufacturing antigenic materials therefrom
IL61904A (en) * 1981-01-13 1985-07-31 Yeda Res & Dev Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same
DE3275998D1 (en) * 1981-12-22 1987-05-14 Baylor College Medicine Immunological composition and method for hepatitis b virus
US4483793A (en) * 1982-10-04 1984-11-20 The Regents Of The University Of California Dimeric oligopeptides as heptenic epitopic sites for hepatitis
JPS5974985A (ja) * 1982-10-19 1984-04-27 Takeda Chem Ind Ltd 新規ｄｎａ
NZ207394A (en) * 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids

Also Published As

Publication number Publication date
AU4115985A (en) 1985-10-11
ATE82135T1 (de) 1992-11-15
IL90035A0 (en) 1989-12-15
AU2682388A (en) 1989-05-25
AU579148B2 (en) 1988-11-17
FI854396A (fi) 1985-11-07
EP0155146A3 (en) 1988-01-20
FI854396A0 (fi) 1985-11-07
IL90035A (en) 1990-11-05
NO167359B (no) 1991-07-22
IL74545A (en) 1990-11-05
NO854460L (no) 1986-01-08
DK516385D0 (da) 1985-11-08
FI84558C (fi) 1991-12-27
NO167359C (no) 1991-10-30
CA1253069A (en) 1989-04-25
FI84558B (fi) 1991-09-13
DK516385A (da) 1985-11-08
NZ227731A (en) 1990-07-26
EP0155146B1 (de) 1992-11-11
WO1985004103A1 (en) 1985-09-26
AU623106B2 (en) 1992-05-07
IL74545A0 (en) 1985-06-30
EP0155146A2 (de) 1985-09-18
NZ211356A (en) 1990-07-26

Similar Documents

Publication Publication Date Title
ATE82135T1 (de) Synthetische hepatitis-b-virus-vakzine die tzellen- und b-zellenbestimmer enthalten.
IL86832A0 (en) Recombinant dna molecules,host cells containing the same,immunogenic particles,pharmaceutical compositions containing the same and processes for the preparation thereof
LU91498I2 (fr) Etanercept et ses dérivés pharmaceutiquement acceptables.
OA07233A (fr) Interféron immunitaire humain.
IE873314L (en) T cell epitopes of the hepatitis b virus nucleocapsid¹protein
DE3650540D1 (de) Antigene Proteine und diese enthaltende Impfstoffe zur Verhütung von Kokzidiose
ATE173275T1 (de) Von einem retrovirus aus der hiv-gruppe abgeleitete peptide und deren verwendung
FI863041A (fi) Fusionsprotein, foerfarande foer deras framstaellning och deras anvaendning.
ES555124A0 (es) Procedimiento de preparar particulas que contienen secuencias de aminoacidos y que tienen propiedades inmunogenas
DK0666914T3 (da) Hidtil ukendt P-selectin-ligandprotein
FI19992546A (fi) Hepatiitti B:n S- ja PreS2-proteiinien ilmentäminen metylotrofisissa hiivoissa
ATE128728T1 (de) Interferon-gamma bindende proteine.
FI923020A0 (fi) Inte a inte b-sekvenser.
EP0485347A3 (en) Recombinant hepatitis delta antigen, process for the purification and use thereof
EP0248642A3 (en) Interleukin-2 induced antineoplastic peptide
IS3511A7 (is) Fjölpeptíð framleidd með aðferðum líftækninnar, kjarnsýrur sem samsvara þeim, og notkun fjölpeptíðanna sem bóluefnis gegn VHS veiru í fiski
ES8801958A1 (es) Un procedimiento para la determinacion de virus de sida
SU1380209A1 (ru) РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК PUR 291-HAV 22, КОДИРУЮЩАЯ СИНТЕЗ ГИБРИДНОГО ПОЛИПЕПТИДА АНТИГЕННЫХ ДЕТЕРМИНАНТ ВИРУСА ГЕПАТИТА А С β -ГАЛАКТОЗИДАЗОЙ
KR890002399A (ko) 하이브리드 인터페론 및 재조합 dna기술을 이용한 그의 제조방법
TH2972EX (th) แอนติเจนผิวหน้าของเฮพาไททิส บี ไวรัส และการผลิต

Legal Events

Date Code Title Description
8332 No legal effect for de