DE3578608D1 - Substituierte azabicycloheptane, ihre verwendung, pharmazeutische praeparate, welche diese verbindungen enthalten, und verfahren zur herstellung dieser verbindungen. - Google Patents
Substituierte azabicycloheptane, ihre verwendung, pharmazeutische praeparate, welche diese verbindungen enthalten, und verfahren zur herstellung dieser verbindungen.Info
- Publication number
- DE3578608D1 DE3578608D1 DE8585810275T DE3578608T DE3578608D1 DE 3578608 D1 DE3578608 D1 DE 3578608D1 DE 8585810275 T DE8585810275 T DE 8585810275T DE 3578608 T DE3578608 T DE 3578608T DE 3578608 D1 DE3578608 D1 DE 3578608D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- represents hydrogen
- lower alkyl
- contain
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- UUAVYXKRUSVCDJ-UHFFFAOYSA-N 1-cycloheptylazepane Chemical class C1CCCCCC1N1CCCCCC1 UUAVYXKRUSVCDJ-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- MRPSJNZPBSDZOW-UHFFFAOYSA-N 5-phenyl-3-azabicyclo[3.1.1]heptane-2,4-dione Chemical class C1C(C2)C(=O)NC(=O)C21C1=CC=CC=C1 MRPSJNZPBSDZOW-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 239000003886 aromatase inhibitor Substances 0.000 abstract 1
- 229940046844 aromatase inhibitors Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 201000008275 breast carcinoma Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Chemical group 0.000 abstract 1
- -1 sulpho Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH298784 | 1984-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3578608D1 true DE3578608D1 (de) | 1990-08-16 |
Family
ID=4246108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8585810275T Expired - Lifetime DE3578608D1 (de) | 1984-06-20 | 1985-06-14 | Substituierte azabicycloheptane, ihre verwendung, pharmazeutische praeparate, welche diese verbindungen enthalten, und verfahren zur herstellung dieser verbindungen. |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US4677129A (enExample) |
| EP (1) | EP0166692B1 (enExample) |
| JP (1) | JPH0625127B2 (enExample) |
| KR (1) | KR920005494B1 (enExample) |
| AT (1) | ATE54446T1 (enExample) |
| AU (1) | AU584098B2 (enExample) |
| DD (2) | DD245871A5 (enExample) |
| DE (1) | DE3578608D1 (enExample) |
| DK (1) | DK164052C (enExample) |
| ES (4) | ES8801261A1 (enExample) |
| FI (1) | FI83214C (enExample) |
| GR (1) | GR851498B (enExample) |
| HU (2) | HU192231B (enExample) |
| IE (1) | IE58069B1 (enExample) |
| IL (1) | IL75545A0 (enExample) |
| NO (1) | NO166444C (enExample) |
| NZ (1) | NZ212482A (enExample) |
| PH (1) | PH21957A (enExample) |
| PT (1) | PT80659B (enExample) |
| ZA (1) | ZA854613B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0114033B1 (de) * | 1982-12-21 | 1988-10-12 | Ciba-Geigy Ag | Substituierte Azabicycloalkane, ihre Verwendung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verfahren zur Herstellung dieser Verbindungen |
| ATE54446T1 (de) * | 1984-06-20 | 1990-07-15 | Ciba Geigy Ag | Substituierte azabicycloheptane, ihre verwendung, pharmazeutische praeparate, welche diese verbindungen enthalten, und verfahren zur herstellung dieser verbindungen. |
| US4883877A (en) * | 1987-11-13 | 1989-11-28 | Ciba-Geigy Corporation | Azabicycloheptanes and process for their preparation |
| DE3843481A1 (de) * | 1988-12-23 | 1990-06-28 | Boehringer Ingelheim Kg | Substituierte 3-azabicyclo/3.1.1/heptane, ihre herstellung und ihre verwendung |
| CH683151A5 (de) * | 1991-04-24 | 1994-01-31 | Ciba Geigy Ag | Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus. |
| DE69233409T2 (de) | 1991-05-14 | 2005-03-03 | Seiko Epson Corp. | Bilderzeugungsgerät |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE548074A (enExample) * | ||||
| US2673205A (en) * | 1951-02-13 | 1954-03-23 | Ciba Pharm Prod Inc | 3-disubstituted dioxopiperidines and the manufacture thereof |
| DE1088957B (de) * | 1955-07-18 | 1960-09-15 | Ciba Geigy | Verfahren zur Herstellung von ª‡-(p-Amino-phenyl)-ª‡-alkyl-glutarimiden |
| US2848455A (en) * | 1955-07-18 | 1958-08-19 | Ciba Pharm Prod Inc | Alpha-(p-amino-phenyl)-alpha-lower alkyl glutarimides |
| GB1015618A (en) * | 1962-04-10 | 1966-01-05 | Aspro Nicholas Ltd | Glutarimide therapeutic compositions |
| DE1299617B (de) * | 1965-01-13 | 1969-07-24 | Degussa | Verfahren zur Herstellung von feinverteiltem gefaelltem Siliciumdioxid |
| US4231935A (en) * | 1975-07-31 | 1980-11-04 | American Cyanamid Company | 1-Phenyl-3-azabicyclo[3.1.0]hexanes |
| US4131611A (en) * | 1975-07-31 | 1978-12-26 | American Cyanamid Company | Azabicyclohexanes |
| US4435419A (en) * | 1981-07-01 | 1984-03-06 | American Cyanamid Company | Method of treating depression using azabicyclohexanes |
| EP0114033B1 (de) * | 1982-12-21 | 1988-10-12 | Ciba-Geigy Ag | Substituierte Azabicycloalkane, ihre Verwendung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verfahren zur Herstellung dieser Verbindungen |
| ATE54446T1 (de) * | 1984-06-20 | 1990-07-15 | Ciba Geigy Ag | Substituierte azabicycloheptane, ihre verwendung, pharmazeutische praeparate, welche diese verbindungen enthalten, und verfahren zur herstellung dieser verbindungen. |
-
1985
- 1985-06-14 AT AT85810275T patent/ATE54446T1/de not_active IP Right Cessation
- 1985-06-14 DE DE8585810275T patent/DE3578608D1/de not_active Expired - Lifetime
- 1985-06-14 EP EP85810275A patent/EP0166692B1/de not_active Expired - Lifetime
- 1985-06-18 ES ES544319A patent/ES8801261A1/es not_active Expired
- 1985-06-18 IL IL75545A patent/IL75545A0/xx not_active IP Right Cessation
- 1985-06-18 PH PH32419A patent/PH21957A/en unknown
- 1985-06-18 DD DD85290286A patent/DD245871A5/de not_active IP Right Cessation
- 1985-06-18 DD DD85277494A patent/DD234419A5/de not_active IP Right Cessation
- 1985-06-18 PT PT80659A patent/PT80659B/pt not_active IP Right Cessation
- 1985-06-19 JP JP60132121A patent/JPH0625127B2/ja not_active Expired - Lifetime
- 1985-06-19 HU HU852418A patent/HU192231B/hu not_active IP Right Cessation
- 1985-06-19 KR KR1019850004322A patent/KR920005494B1/ko not_active Expired
- 1985-06-19 HU HU864193A patent/HU194180B/hu not_active IP Right Cessation
- 1985-06-19 GR GR851498A patent/GR851498B/el unknown
- 1985-06-19 DK DK277485A patent/DK164052C/da not_active IP Right Cessation
- 1985-06-19 AU AU43858/85A patent/AU584098B2/en not_active Ceased
- 1985-06-19 FI FI852429A patent/FI83214C/fi not_active IP Right Cessation
- 1985-06-19 NZ NZ212482A patent/NZ212482A/xx unknown
- 1985-06-19 IE IE151985A patent/IE58069B1/en not_active IP Right Cessation
- 1985-06-19 NO NO852478A patent/NO166444C/no unknown
- 1985-06-19 ZA ZA854613A patent/ZA854613B/xx unknown
- 1985-06-20 US US06/746,814 patent/US4677129A/en not_active Expired - Fee Related
-
1986
- 1986-10-01 ES ES557121A patent/ES8801214A1/es not_active Expired
- 1986-10-01 ES ES557122A patent/ES8802388A1/es not_active Expired
- 1986-10-01 ES ES557123A patent/ES8801278A1/es not_active Expired
-
1987
- 1987-04-01 US US07/032,656 patent/US4764640A/en not_active Expired - Lifetime
-
1988
- 1988-04-22 US US07/185,205 patent/US4857660A/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |