DE3504421A1 - Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate - Google Patents
Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparateInfo
- Publication number
- DE3504421A1 DE3504421A1 DE19853504421 DE3504421A DE3504421A1 DE 3504421 A1 DE3504421 A1 DE 3504421A1 DE 19853504421 DE19853504421 DE 19853504421 DE 3504421 A DE3504421 A DE 3504421A DE 3504421 A1 DE3504421 A1 DE 3504421A1
- Authority
- DE
- Germany
- Prior art keywords
- hydroxy
- methyl
- estradien
- alkyl
- propynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
- C07J21/003—Lactones at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19853504421 DE3504421A1 (de) | 1985-02-07 | 1985-02-07 | Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate |
AU52913/86A AU580843B2 (en) | 1985-02-07 | 1986-01-31 | 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them |
NZ214998A NZ214998A (en) | 1985-02-07 | 1986-01-31 | 13-(methyl or ethyl)-11-beta-phenyl-gonane derivatives; preparatory processes and pharmaceutical compositions |
IL77762A IL77762A (en) | 1985-02-07 | 1986-02-02 | 11beta-phenyl gonane derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
CN86100994A CN1033753C (zh) | 1985-02-07 | 1986-02-03 | 11β-苯基-甾烷的制备方法 |
ES551625A ES8701778A1 (es) | 1985-02-07 | 1986-02-04 | Procedimiento para la preparacion de 13-alquil-ll b -fenil-gonamos |
PT81969A PT81969B (pt) | 1985-02-07 | 1986-02-05 | Processo para preparacao de 11 beta-fenil-esteroides e de composicoes farmaceuticas que os contem |
GR860342A GR860342B (en) | 1985-02-07 | 1986-02-05 | 11b- phenyl-gonane their preparation and pharmaceutical preparations containing them |
DK056086A DK161709C (da) | 1985-02-07 | 1986-02-05 | 13-alkyl-11beta-phenylgonaner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater indeholdende dem samt deres anvendelse til fremstilling af laegemidler |
NO860425A NO171994C (no) | 1985-02-07 | 1986-02-06 | Fremgangsmaate for fremstilling av dihydroxylerte 11beta-(4-acetylfenyl)-17beta-hydroxy-17alfa-(1-propynyl)-4,9-estradien-3-oner |
CA000501252A CA1310630C (en) | 1985-02-07 | 1986-02-06 | 11.beta.-PHENYL-GONANES, THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
AT86101548T ATE45956T1 (de) | 1985-02-07 | 1986-02-06 | 11 beta-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate. |
IE33486A IE58149B1 (en) | 1985-02-07 | 1986-02-06 | 11 beta-phenyl-gonanes,their manufacture and pharmaceutical preparations containing them |
DE8686101548T DE3665307D1 (en) | 1985-02-07 | 1986-02-06 | 11-beta phenyl gonanes, their preparation and pharmaceutical compositions containing them |
DD86286860A DD261166A5 (de) | 1985-02-07 | 1986-02-06 | Verfahren zur herstellung von 11beta-phenyl-genanen |
HU86499A HU194904B (en) | 1985-02-07 | 1986-02-06 | Process for producing 11-beta-phenyl-gonanes and pharmaceutical compositions containing them |
EP86101548A EP0190759B1 (de) | 1985-02-07 | 1986-02-06 | 11 Beta-Phenyl-Gonane, deren Herstellung und diese enthaltende pharmazeutische Präparate |
US06/827,050 US5089635A (en) | 1985-02-07 | 1986-02-07 | 11 β-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them |
FI860559A FI85377C (fi) | 1985-02-07 | 1986-02-07 | Foerfarande foer framstaellning av terapeutiskt aktiva 13-alkyl-11 -fenylgonaner. |
ZA86936A ZA86936B (en) | 1985-02-07 | 1986-02-07 | 11beta-phenyl-gonanes,their manufacture and pharmaceutical preparations containing them |
JP61024260A JPS61183296A (ja) | 1985-02-07 | 1986-02-07 | 11β―フェニル―ゴナン及びその製法 |
NO864209A NO170285C (no) | 1985-02-07 | 1986-10-21 | 13-alkyl-llbeta-fenyl-gonaner, og antikonsepsjonsmiddel inneholdende disse |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19853504421 DE3504421A1 (de) | 1985-02-07 | 1985-02-07 | Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3504421A1 true DE3504421A1 (de) | 1986-08-07 |
Family
ID=6262067
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19853504421 Withdrawn DE3504421A1 (de) | 1985-02-07 | 1985-02-07 | Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS61183296A (ja) |
DD (1) | DD261166A5 (ja) |
DE (1) | DE3504421A1 (ja) |
ZA (1) | ZA86936B (ja) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4332284A1 (de) * | 1993-09-20 | 1995-03-23 | Jenapharm Gmbh | Neue 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
WO2001044267A1 (de) * | 1999-12-15 | 2001-06-21 | Jenapharm Gmbh & Co. Kg | 11-β-PHENYLESTRADIEN-DERIVATE MIT FLUORALKYLGRUPPEN IN DER AROMATISCHEN SEITENKETTE, DEREN HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN |
WO2004014935A1 (de) * | 2002-08-02 | 2004-02-19 | Schering Aktiengesellschaft | Progesteronrezeptormodulatoren mit erhöhter antigonadotroper aktivität für die weibliche fertilitätskontrolle und hormonersatztherapie |
BG64735B1 (bg) * | 1998-03-03 | 2006-01-31 | Jenapharm Gmbh & Co. Kg | S-заместени тиолови естери на 11бета-бензалдоксим-естра-4,9-диен-въглеродна киселина, метод за тяхното получаване и фармацевтични препарати, съдържащи тези съединения |
DE102006018869A1 (de) * | 2006-04-13 | 2007-10-18 | Bayer Schering Pharma Ag | 17alpha-substituierte 4-(3-Oxoestra-4,9-dien-11beta-yl)-benzoesäure, deren Derivate und Verfahren zu ihrer Herstellung |
US7550451B2 (en) | 2002-08-02 | 2009-06-23 | Bayer Schering Pharma Ag | Progesterone receptor modulators with increased antigonadotropic activity for female birth control and hormone replacement therapy |
US7759330B2 (en) | 1996-05-01 | 2010-07-20 | The United States Of America As Represented By The Department Of Health And Human Services | 21-substituted progesterone derivatives as new antiprogestational agents |
CN102471366A (zh) * | 2009-07-20 | 2012-05-23 | 拜耳医药股份有限公司 | 17-羟基-17-五氟乙基雌-4,9(10)-二烯11-苯亚甲基衍生物、其制备方法及其用于治疗疾病的用途 |
US8569276B2 (en) * | 1996-05-01 | 2013-10-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1265911T3 (da) * | 2000-03-17 | 2008-09-29 | Us Gov Health & Human Serv | 17-alfa-substitueret-11-beta-substitueret-4-aryl og 21-substitueret 19-norpregnadiendion som antiprogestationelle midler |
DE102009034525A1 (de) * | 2009-07-21 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034526A1 (de) * | 2009-07-21 | 2011-02-10 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2377418A1 (fr) * | 1977-01-13 | 1978-08-11 | Roussel Uclaf | Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments |
ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
DE3231827A1 (de) * | 1982-08-24 | 1984-03-01 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11ss-aryl-17(alpha)-alkinyl-17ss-hydroxy-4,9(10)- estradien-3-on-derivate, deren herstellung und diese enthaltende pharmazeutische praeparate |
-
1985
- 1985-02-07 DE DE19853504421 patent/DE3504421A1/de not_active Withdrawn
-
1986
- 1986-02-06 DD DD86286860A patent/DD261166A5/de not_active IP Right Cessation
- 1986-02-07 JP JP61024260A patent/JPS61183296A/ja active Granted
- 1986-02-07 ZA ZA86936A patent/ZA86936B/xx unknown
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4332284A1 (de) * | 1993-09-20 | 1995-03-23 | Jenapharm Gmbh | Neue 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
US7759330B2 (en) | 1996-05-01 | 2010-07-20 | The United States Of America As Represented By The Department Of Health And Human Services | 21-substituted progesterone derivatives as new antiprogestational agents |
US8003629B2 (en) | 1996-05-01 | 2011-08-23 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | 21-substituted progesterone derivatives as new antiprogestational agents |
US8569276B2 (en) * | 1996-05-01 | 2013-10-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
BG64735B1 (bg) * | 1998-03-03 | 2006-01-31 | Jenapharm Gmbh & Co. Kg | S-заместени тиолови естери на 11бета-бензалдоксим-естра-4,9-диен-въглеродна киселина, метод за тяхното получаване и фармацевтични препарати, съдържащи тези съединения |
WO2001044267A1 (de) * | 1999-12-15 | 2001-06-21 | Jenapharm Gmbh & Co. Kg | 11-β-PHENYLESTRADIEN-DERIVATE MIT FLUORALKYLGRUPPEN IN DER AROMATISCHEN SEITENKETTE, DEREN HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN |
WO2004014935A1 (de) * | 2002-08-02 | 2004-02-19 | Schering Aktiengesellschaft | Progesteronrezeptormodulatoren mit erhöhter antigonadotroper aktivität für die weibliche fertilitätskontrolle und hormonersatztherapie |
US7550451B2 (en) | 2002-08-02 | 2009-06-23 | Bayer Schering Pharma Ag | Progesterone receptor modulators with increased antigonadotropic activity for female birth control and hormone replacement therapy |
DE102006018869A1 (de) * | 2006-04-13 | 2007-10-18 | Bayer Schering Pharma Ag | 17alpha-substituierte 4-(3-Oxoestra-4,9-dien-11beta-yl)-benzoesäure, deren Derivate und Verfahren zu ihrer Herstellung |
CN102471366A (zh) * | 2009-07-20 | 2012-05-23 | 拜耳医药股份有限公司 | 17-羟基-17-五氟乙基雌-4,9(10)-二烯11-苯亚甲基衍生物、其制备方法及其用于治疗疾病的用途 |
CN102471366B (zh) * | 2009-07-20 | 2015-12-16 | 拜耳知识产权有限责任公司 | 17-羟基-17-五氟乙基雌-4,9(10)-二烯11-苯亚甲基衍生物、其制备方法及其用于治疗疾病的用途 |
Also Published As
Publication number | Publication date |
---|---|
JPS61183296A (ja) | 1986-08-15 |
DD261166A5 (de) | 1988-10-19 |
JPH0437080B2 (ja) | 1992-06-18 |
ZA86936B (en) | 1986-09-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8130 | Withdrawal |