DE3460841D1 - Mercaptoacetic acid and 3-mercaptopropionic acid amide derivatives for use in treatment of a human or animal body, some new derivatives and pharmaceutical compositions containing them - Google Patents
Mercaptoacetic acid and 3-mercaptopropionic acid amide derivatives for use in treatment of a human or animal body, some new derivatives and pharmaceutical compositions containing themInfo
- Publication number
- DE3460841D1 DE3460841D1 DE8484400217T DE3460841T DE3460841D1 DE 3460841 D1 DE3460841 D1 DE 3460841D1 DE 8484400217 T DE8484400217 T DE 8484400217T DE 3460841 T DE3460841 T DE 3460841T DE 3460841 D1 DE3460841 D1 DE 3460841D1
- Authority
- DE
- Germany
- Prior art keywords
- derivatives
- group
- human
- treatment
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 241001465754 Metazoa Species 0.000 title abstract 2
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 title 2
- JLSJEUQOXVVCPN-UHFFFAOYSA-N 3-sulfanylpropanamide Chemical class NC(=O)CCS JLSJEUQOXVVCPN-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000003729 Neprilysin Human genes 0.000 abstract 3
- 108090000028 Neprilysin Proteins 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 m-trifluoromethylphenyl Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8301863A FR2540498B1 (fr) | 1983-02-07 | 1983-02-07 | Nouveaux medicaments derives d'amides d'acide mercaptoacetique et de l'acide 3-mercaptopropionique et les compositions pharmaceutiques les renfermant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3460841D1 true DE3460841D1 (en) | 1986-11-06 |
Family
ID=9285652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8484400217T Expired DE3460841D1 (en) | 1983-02-07 | 1984-02-01 | Mercaptoacetic acid and 3-mercaptopropionic acid amide derivatives for use in treatment of a human or animal body, some new derivatives and pharmaceutical compositions containing them |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4567198A (enExample) |
| EP (1) | EP0117183B1 (enExample) |
| JP (1) | JPS59152368A (enExample) |
| KR (1) | KR910008183B1 (enExample) |
| AT (1) | ATE22555T1 (enExample) |
| AU (1) | AU569487B2 (enExample) |
| CA (1) | CA1215648A (enExample) |
| DE (1) | DE3460841D1 (enExample) |
| DK (1) | DK169254B1 (enExample) |
| ES (1) | ES8500899A1 (enExample) |
| FR (1) | FR2540498B1 (enExample) |
| GR (1) | GR81411B (enExample) |
| HU (1) | HU191991B (enExample) |
| NZ (1) | NZ207057A (enExample) |
| PT (1) | PT78071B (enExample) |
| ZA (1) | ZA84571B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4611002A (en) * | 1977-07-14 | 1986-09-09 | E. R. Squibb And Sons, Inc. | Carboxymethyl esters of mercaptopropanoic acids as enkephalinase inhibitors |
| FR2540495B1 (fr) * | 1983-02-07 | 1986-02-14 | Roussel Uclaf | Nouveaux derives de o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus |
| US4868310A (en) * | 1986-08-04 | 1989-09-19 | Rohm And Haas Company | Process for preparing isothiazolones |
| DE3639322A1 (de) * | 1986-11-17 | 1988-05-26 | Henkel Kgaa | Verfahren zur reinigung und desinfektion von endoskopen und mittel zur durchfuehrung des verfahrens |
| CA2698928A1 (en) * | 2007-09-28 | 2009-04-09 | Absolute Science, Inc. | Compounds and methods for treating zinc matrix metalloprotease dependent diseases |
| WO2010033360A1 (en) * | 2008-09-19 | 2010-03-25 | 1/3 Absolute Science, Inc. | Methods of treating a botulinum toxin related condition in a subject |
| JP5546947B2 (ja) * | 2010-05-13 | 2014-07-09 | 高砂香料工業株式会社 | 含硫カルボン酸エステル類の製造方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2709706A (en) * | 1950-05-06 | 1955-05-31 | Goodrich Co B F | Preparation of beta-dithiocarbamyl and beta-mercapto carboxylic acid amides and the corresponding hydrazides |
| FR1193289A (fr) * | 1958-03-14 | 1959-11-02 | Oreal | Procédé pour la mise en plis permanentée de cheveux au moyen de nouveaux composés tensio-actifs et procédé pour préparer ces composés |
| US3878248A (en) * | 1971-05-03 | 1975-04-15 | Monsanto Co | Substituted alpha, alpha-dichloro-methane-sulfenyl chlorides |
| US3770824A (en) * | 1971-05-03 | 1973-11-06 | Monsanto Co | Substituted alpha,alpha-dichloromethane-sulfenyl chlorides and their manufacture |
| AU4091178A (en) * | 1977-10-25 | 1980-04-24 | Merck & Co Inc | Substituted mercapto acid amides |
| US4329495A (en) * | 1981-05-18 | 1982-05-11 | Pfizer Inc. | Enkephalinase enzyme inhibiting compounds |
| FR2540495B1 (fr) * | 1983-02-07 | 1986-02-14 | Roussel Uclaf | Nouveaux derives de o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus |
-
1983
- 1983-02-07 FR FR8301863A patent/FR2540498B1/fr not_active Expired
-
1984
- 1984-01-10 ES ES528765A patent/ES8500899A1/es not_active Expired
- 1984-01-25 ZA ZA84571A patent/ZA84571B/xx unknown
- 1984-02-01 DE DE8484400217T patent/DE3460841D1/de not_active Expired
- 1984-02-01 AT AT84400217T patent/ATE22555T1/de not_active IP Right Cessation
- 1984-02-01 EP EP84400217A patent/EP0117183B1/fr not_active Expired
- 1984-02-06 DK DK051484A patent/DK169254B1/da not_active IP Right Cessation
- 1984-02-06 US US06/577,032 patent/US4567198A/en not_active Expired - Fee Related
- 1984-02-06 CA CA000446814A patent/CA1215648A/fr not_active Expired
- 1984-02-06 GR GR73712A patent/GR81411B/el unknown
- 1984-02-06 AU AU24202/84A patent/AU569487B2/en not_active Ceased
- 1984-02-06 PT PT78071A patent/PT78071B/pt not_active IP Right Cessation
- 1984-02-06 HU HU84481A patent/HU191991B/hu not_active IP Right Cessation
- 1984-02-06 JP JP59018511A patent/JPS59152368A/ja active Granted
- 1984-02-07 KR KR1019840000560A patent/KR910008183B1/ko not_active Expired
- 1984-02-07 NZ NZ207057A patent/NZ207057A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK51484D0 (da) | 1984-02-06 |
| FR2540498A1 (fr) | 1984-08-10 |
| PT78071B (fr) | 1986-06-11 |
| NZ207057A (en) | 1987-07-31 |
| EP0117183B1 (fr) | 1986-10-01 |
| ES528765A0 (es) | 1984-11-01 |
| KR910008183B1 (ko) | 1991-10-10 |
| DK169254B1 (da) | 1994-09-26 |
| DK51484A (da) | 1984-08-08 |
| ZA84571B (en) | 1985-02-27 |
| ATE22555T1 (de) | 1986-10-15 |
| HU191991B (en) | 1987-04-28 |
| JPS59152368A (ja) | 1984-08-31 |
| KR850001163A (ko) | 1985-03-16 |
| FR2540498B1 (fr) | 1986-02-14 |
| CA1215648A (fr) | 1986-12-23 |
| JPH0455188B2 (enExample) | 1992-09-02 |
| AU569487B2 (en) | 1988-02-04 |
| ES8500899A1 (es) | 1984-11-01 |
| PT78071A (fr) | 1984-03-01 |
| AU2420284A (en) | 1984-08-16 |
| GR81411B (enExample) | 1984-12-11 |
| US4567198A (en) | 1986-01-28 |
| EP0117183A1 (fr) | 1984-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |