DE3426331A1 - Asymmetrische mikroporoese hohlfaser fuer die haemodialyse sowie verfahren zu ihrer herstellung - Google Patents
Asymmetrische mikroporoese hohlfaser fuer die haemodialyse sowie verfahren zu ihrer herstellungInfo
- Publication number
- DE3426331A1 DE3426331A1 DE3426331A DE3426331A DE3426331A1 DE 3426331 A1 DE3426331 A1 DE 3426331A1 DE 3426331 A DE3426331 A DE 3426331A DE 3426331 A DE3426331 A DE 3426331A DE 3426331 A1 DE3426331 A1 DE 3426331A1
- Authority
- DE
- Germany
- Prior art keywords
- polymer
- hollow fiber
- weight
- solvent
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000012510 hollow fiber Substances 0.000 title claims description 52
- 238000000034 method Methods 0.000 title claims description 31
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- 238000001631 haemodialysis Methods 0.000 title abstract description 13
- 229920000642 polymer Polymers 0.000 claims abstract description 65
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000002904 solvent Substances 0.000 claims abstract description 23
- 239000011148 porous material Substances 0.000 claims abstract description 18
- 229920001600 hydrophobic polymer Polymers 0.000 claims abstract description 5
- 238000005406 washing Methods 0.000 claims abstract description 3
- 239000012528 membrane Substances 0.000 claims description 53
- 238000001556 precipitation Methods 0.000 claims description 31
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 14
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 14
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 14
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000000010 aprotic solvent Substances 0.000 claims description 11
- 229920002492 poly(sulfone) Polymers 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 9
- 210000004369 blood Anatomy 0.000 claims description 9
- 239000008280 blood Substances 0.000 claims description 9
- 238000009987 spinning Methods 0.000 claims description 8
- 230000002209 hydrophobic effect Effects 0.000 claims description 7
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 6
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 229920001577 copolymer Polymers 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 229920000136 polysorbate Polymers 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 229920006393 polyether sulfone Polymers 0.000 claims description 5
- 229940068965 polysorbates Drugs 0.000 claims description 4
- 239000004952 Polyamide Substances 0.000 claims description 3
- 239000004695 Polyether sulfone Substances 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 229920002647 polyamide Polymers 0.000 claims description 3
- 239000004417 polycarbonate Substances 0.000 claims description 3
- 229920000515 polycarbonate Polymers 0.000 claims description 3
- 229920000570 polyether Polymers 0.000 claims description 3
- 229920000151 polyglycol Polymers 0.000 claims description 3
- 239000010695 polyglycol Substances 0.000 claims description 3
- 229920001451 polypropylene glycol Polymers 0.000 claims description 3
- 229920002635 polyurethane Polymers 0.000 claims description 3
- 239000004814 polyurethane Substances 0.000 claims description 3
- 239000004800 polyvinyl chloride Substances 0.000 claims description 3
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical class OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims 2
- 238000002386 leaching Methods 0.000 claims 1
- 239000000835 fiber Substances 0.000 abstract description 45
- 230000000322 hemodialysis Effects 0.000 abstract description 12
- 230000001376 precipitating effect Effects 0.000 abstract description 10
- 239000000470 constituent Substances 0.000 abstract description 3
- 229920001477 hydrophilic polymer Polymers 0.000 abstract description 3
- 230000003019 stabilising effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 19
- 230000035699 permeability Effects 0.000 description 13
- 230000004888 barrier function Effects 0.000 description 11
- 239000000706 filtrate Substances 0.000 description 11
- 239000007788 liquid Substances 0.000 description 11
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 10
- 238000000926 separation method Methods 0.000 description 10
- 230000008569 process Effects 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 238000000108 ultra-filtration Methods 0.000 description 6
- 229920001202 Inulin Polymers 0.000 description 5
- 229910019142 PO4 Inorganic materials 0.000 description 5
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 5
- 239000004202 carbamide Substances 0.000 description 5
- 229940109239 creatinine Drugs 0.000 description 5
- 229940029339 inulin Drugs 0.000 description 5
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
- 239000010452 phosphate Substances 0.000 description 5
- 238000007873 sieving Methods 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000000502 dialysis Methods 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 238000005534 hematocrit Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000008030 elimination Effects 0.000 description 3
- 238000003379 elimination reaction Methods 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000001223 reverse osmosis Methods 0.000 description 3
- 229920001059 synthetic polymer Polymers 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- 229920004482 WACKER® Polymers 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000001601 blood-air barrier Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 201000002364 leukopenia Diseases 0.000 description 2
- 231100001022 leukopenia Toxicity 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000004627 regenerated cellulose Substances 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 229920004142 LEXAN™ Polymers 0.000 description 1
- 239000004418 Lexan Substances 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 102000036675 Myoglobin Human genes 0.000 description 1
- 108010062374 Myoglobin Proteins 0.000 description 1
- 229920000784 Nomex Polymers 0.000 description 1
- 229920002302 Nylon 6,6 Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 150000001253 acrylic acids Chemical class 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000004154 complement system Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000002615 hemofiltration Methods 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000012982 microporous membrane Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000004763 nomex Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003058 plasma substitute Substances 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 238000004382 potting Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 238000002166 wet spinning Methods 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/08—Addition of substances to the spinning solution or to the melt for forming hollow filaments
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0002—Organic membrane manufacture
- B01D67/0023—Organic membrane manufacture by inducing porosity into non porous precursor membranes
- B01D67/003—Organic membrane manufacture by inducing porosity into non porous precursor membranes by selective elimination of components, e.g. by leaching
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/08—Hollow fibre membranes
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/24—Formation of filaments, threads, or the like with a hollow structure; Spinnerette packs therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/06—Specific viscosities of materials involved
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/12—Specific ratios of components used
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/02—Details relating to pores or porosity of the membranes
- B01D2325/022—Asymmetric membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/36—Hydrophilic membranes
Landscapes
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing & Machinery (AREA)
- Textile Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Artificial Filaments (AREA)
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
- External Artificial Organs (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3426331A DE3426331A1 (de) | 1984-07-17 | 1984-07-17 | Asymmetrische mikroporoese hohlfaser fuer die haemodialyse sowie verfahren zu ihrer herstellung |
| DE3587850T DE3587850D1 (de) | 1984-07-17 | 1985-07-11 | Asymmetrische mikroporöse Hohlfaser für die Hämodialyse sowie Verfahren zu ihrer Herstellung. |
| EP85108676A EP0168783B1 (de) | 1984-07-17 | 1985-07-11 | Asymmetrische mikroporöse Hohlfaser für die Hämodialyse sowie Verfahren zu ihrer Herstellung |
| AT85108676T ATE107189T1 (de) | 1984-07-17 | 1985-07-11 | Asymmetrische mikroporöse hohlfaser für die hämodialyse sowie verfahren zu ihrer herstellung. |
| YU116885A YU46155B (sh) | 1984-07-17 | 1985-07-16 | Postupak za dobijanje asimetričnog mikroporoznog šupljeg vlakna |
| BR8503391A BR8503391A (pt) | 1984-07-17 | 1985-07-16 | Fibra oca assimetrica e microporosa bem como processo para a sua producao |
| CA000486874A CA1294745C (en) | 1984-07-17 | 1985-07-16 | Asymmetrical microporous hollow fiber for hemodialysis and a process for manufacturing such fibers |
| JP60157958A JPS6193801A (ja) | 1984-07-17 | 1985-07-17 | 非対称微孔性中空繊維の製造方法 |
| ES545300A ES8605686A1 (es) | 1984-07-17 | 1985-07-17 | Estructura de fibra hueca, microporosa y asimetrica para la hemodialisis y su procedimiento de fabricacion |
| HR920394A HRP920394B1 (en) | 1984-07-17 | 1992-09-21 | Asymetric microporous hollow fibre, especially for hemodialysis, and process for making it |
| JP7000370A JP2782583B2 (ja) | 1984-07-17 | 1995-01-05 | 非対称微孔性中空繊維 |
| JP9242108A JP2916446B2 (ja) | 1984-07-17 | 1997-08-21 | 非対称微孔性中空繊維の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3426331A DE3426331A1 (de) | 1984-07-17 | 1984-07-17 | Asymmetrische mikroporoese hohlfaser fuer die haemodialyse sowie verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3426331A1 true DE3426331A1 (de) | 1986-01-30 |
Family
ID=6240870
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3426331A Withdrawn DE3426331A1 (de) | 1984-07-17 | 1984-07-17 | Asymmetrische mikroporoese hohlfaser fuer die haemodialyse sowie verfahren zu ihrer herstellung |
| DE3587850T Expired - Lifetime DE3587850D1 (de) | 1984-07-17 | 1985-07-11 | Asymmetrische mikroporöse Hohlfaser für die Hämodialyse sowie Verfahren zu ihrer Herstellung. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3587850T Expired - Lifetime DE3587850D1 (de) | 1984-07-17 | 1985-07-11 | Asymmetrische mikroporöse Hohlfaser für die Hämodialyse sowie Verfahren zu ihrer Herstellung. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0168783B1 (enExample) |
| JP (3) | JPS6193801A (enExample) |
| AT (1) | ATE107189T1 (enExample) |
| BR (1) | BR8503391A (enExample) |
| CA (1) | CA1294745C (enExample) |
| DE (2) | DE3426331A1 (enExample) |
| ES (1) | ES8605686A1 (enExample) |
| YU (1) | YU46155B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4320198C1 (de) * | 1993-06-18 | 1994-07-14 | Fresenius Ag | Vorrichtung zum Gasaustausch, insbesondere zum Oxygenieren von Blut |
| DE4007383C2 (de) * | 1990-03-08 | 1998-10-29 | Seitz Filter Werke | Herstellung von hydrophilen Mikrofiltrationsmembranen aus Polysulfonen |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62258707A (ja) * | 1985-12-23 | 1987-11-11 | ジエルマン サイエンシス インコ−ポレ−テツド | 濾過膜およびその製法 |
| JP2505428B2 (ja) * | 1986-10-15 | 1996-06-12 | 東レ株式会社 | 低温溶解型原液およびその製造法 |
| JPS6397205A (ja) * | 1986-10-15 | 1988-04-27 | Toray Ind Inc | ポリスルホン系樹脂半透膜の処理方法 |
| JPH0613048B2 (ja) * | 1987-07-01 | 1994-02-23 | 帝人株式会社 | 選択透過性中空糸 |
| SE460521B (sv) * | 1987-08-31 | 1989-10-23 | Gambro Dialysatoren | Permselektiv asymmetriskt membran samt foerfarande foer dess framstaellning |
| JPH0714468B2 (ja) * | 1987-10-20 | 1995-02-22 | ダイセル化学工業株式会社 | 超純水製造用中空糸膜の製造方法 |
| JPH0759764B2 (ja) * | 1987-11-10 | 1995-06-28 | 三菱レイヨン株式会社 | 耐アルカリ性及び保液性に優れたバッテリーセパレータ用合成繊維 |
| US4919811A (en) * | 1988-01-14 | 1990-04-24 | The Standard Oil Company | Affinity membranes having pendant hydroxy groups and processes for the preparation and use thereof |
| US4970034A (en) * | 1988-09-23 | 1990-11-13 | W. R. Grace & Co.-Conn. | Process for preparing isotropic microporous polysulfone membranes |
| DE3903098A1 (de) * | 1989-02-02 | 1990-08-16 | Hoechst Ag | Semipermeable membran aus einer homogen mischbaren polymerlegierung |
| US5641450A (en) * | 1991-03-28 | 1997-06-24 | Toray Industries, Inc. | Process of making a module including a polysulphonic hollow fiber membrane |
| EP0550798A1 (de) * | 1991-10-04 | 1993-07-14 | Kawasumi Laboratories, Inc. | Hohlfasermembran auf Basis von Polysulfon |
| JP3232117B2 (ja) * | 1991-11-19 | 2001-11-26 | 鐘淵化学工業株式会社 | ポリスルホン多孔質中空糸 |
| US5340480A (en) * | 1992-04-29 | 1994-08-23 | Kuraray Co., Ltd. | Polysulfone-based hollow fiber membrane and process for manufacturing the same |
| US5232601A (en) * | 1992-05-29 | 1993-08-03 | W. R. Grace & Co.-Conn. | High flux hollow fiber membrane |
| JP3714686B2 (ja) * | 1994-04-27 | 2005-11-09 | 旭化成メディカル株式会社 | ポリスルホン系中空糸膜及びその製造方法 |
| CA2165221C (en) | 1994-12-16 | 2003-09-23 | Kazuhisa Shibata | Module for blood purification, blood purification membrane and its production |
| JP2812890B2 (ja) * | 1995-03-20 | 1998-10-22 | 帝人株式会社 | 血液浄化器 |
| EP0824960A4 (en) * | 1995-05-09 | 1998-11-11 | Teijin Ltd | HOLLOW FIBER MEMBRANE BASED ON POLYSULFONE POLYMER AND PROCESS FOR PRODUCING THE SAME |
| DE69634352T2 (de) * | 1995-06-30 | 2006-01-12 | Toray Industries, Inc. | Methode zur Herstellung einer teildurchlässigen Hohlfasermembran aus Polysulfon |
| EP0750936B2 (en) * | 1995-06-30 | 2019-09-11 | Toray Industries, Inc. | Permselective membranes and methods for their production |
| US6355730B1 (en) | 1995-06-30 | 2002-03-12 | Toray Industries, Inc. | Permselective membranes and methods for their production |
| WO1998052683A1 (en) | 1997-05-19 | 1998-11-26 | Asahi Medical Co., Ltd. | Polysulfone-base hollow-fiber hemocathartic membrane and processes for the production thereof |
| ES2307312T3 (es) | 1997-12-17 | 2008-11-16 | Asahi Kasei Kuraray Medical Co., Ltd. | Metodo para la fabricacion de un organo artificial, membrana de fibr as huecas y dializador del tipo de membrana de fibras huecas. |
| KR100289413B1 (ko) * | 1997-12-30 | 2001-05-02 | 구광시 | 폴리설폰계 중공사 막 및 그의 제조 방법 |
| GB9808689D0 (en) * | 1998-04-23 | 1998-06-24 | Kalsep Ltd | Improved membrane |
| US6908553B1 (en) * | 1998-07-08 | 2005-06-21 | Baxter International Inc. | Composite membrane with particulate matter substantially immobilized therein |
| WO2000012154A1 (en) | 1998-08-27 | 2000-03-09 | Toray Industries, Inc. | Blood processing device |
| KR100804330B1 (ko) * | 1998-11-09 | 2008-02-15 | 아사히 카세이 쿠라레 메디칼 가부시키가이샤 | 혈액 정화기 |
| DE10007327A1 (de) * | 2000-02-17 | 2001-08-30 | Fresenius Medical Care De Gmbh | Filtervorrichtung, vorzugsweise Hohlfaserdialysator mit gelockten Hohlfasern |
| DE10034098C2 (de) * | 2000-07-13 | 2002-11-21 | Fresenius Medical Care De Gmbh | Hydrophobe mikroporöse Hohlfasermembran und Verfahren zur Herstellung dieser Membran sowie deren Verwendung in der Membranoxygenierung |
| DE10217440A1 (de) | 2002-04-18 | 2003-11-06 | Basf Ag | Verwendung hydrophob modifizierter Copolymere auf Basis von N-Vinylmonomeren zur Herstellung von Membranen |
| WO2004024216A1 (ja) | 2002-09-12 | 2004-03-25 | Asahi Medical Co., Ltd. | 血漿浄化膜及び血漿浄化システム |
| SE0203855L (sv) | 2002-12-20 | 2004-06-21 | Gambro Lundia Ab | Permselektivt membran |
| SE0203857L (sv) | 2002-12-20 | 2004-06-21 | Gambro Lundia Ab | Permselektivt membran och förfarande för tillverkning därav |
| JP3551971B1 (ja) | 2003-11-26 | 2004-08-11 | 東洋紡績株式会社 | ポリスルホン系選択透過性中空糸膜 |
| JP3580314B1 (ja) | 2003-12-09 | 2004-10-20 | 東洋紡績株式会社 | ポリスルホン系選択透過性中空糸膜束およびその製造方法 |
| DE102004008220B4 (de) | 2004-02-19 | 2006-01-12 | Membrana Gmbh | High-Flux Dialysemembran mit verbessertem Trennverhalten |
| DE102004008221B4 (de) | 2004-02-19 | 2006-01-26 | Membrana Gmbh | Dialysemembran mit verbesserter Mittelmolekülentfernung |
| DE102004008219B3 (de) * | 2004-02-19 | 2005-10-27 | Membrana Gmbh | Integral asymmetrische Membran, Verfahren zu ihrer Herstellung und ihre Verwendung |
| JP4288602B2 (ja) * | 2004-06-09 | 2009-07-01 | 東洋紡績株式会社 | ポリスルホン系選択透過性中空糸膜 |
| CN100515548C (zh) | 2004-08-10 | 2009-07-22 | 尼普洛株式会社 | 聚砜系选择渗透性中空纤维膜组件及其制造方法 |
| DE102005011544A1 (de) * | 2005-03-10 | 2006-09-14 | Gkss-Forschungszentrum Geesthacht Gmbh | Verfahren zur Herstellung einer Polymermembran sowie Polymermembran |
| WO2008047760A1 (fr) | 2006-10-17 | 2008-04-24 | Tokai University Educational System | Tubule rénal bioartificiel |
| EP2383031B1 (en) | 2006-10-18 | 2016-05-25 | Gambro Lundia AB | Use of a hollow fibre membrane in microdialysis |
| JP5121470B2 (ja) | 2007-01-26 | 2013-01-16 | 株式会社日本触媒 | ポリビニルピロリドン粉体組成物 |
| DE102008000220A1 (de) | 2008-02-01 | 2009-08-13 | ASCALON Gesellschaft für Innovation in der Medizintechnik m.b.H. | Hohlfaser-Separationsmembranen und Verfahren zu ihrer Herstellung |
| KR100978931B1 (ko) * | 2008-02-18 | 2010-08-31 | 웅진케미칼 주식회사 | 고강도를 지니는 고흡수성 섬유 및 이의 제조방법 |
| ES2422162T3 (es) | 2008-04-30 | 2013-09-09 | Gambro Lundia Ab | Membrana de fibra hueca para hemodiálisis con permeabilidad y selectividad mejoradas |
| EP2156881A1 (en) | 2008-08-22 | 2010-02-24 | Gambro Lundia AB | Cap for a diffusion and/or filtration device |
| JP2012520761A (ja) | 2009-03-19 | 2012-09-10 | イー・エム・デイー・ミリポア・コーポレイシヨン | ナノ繊維濾過媒体を用いる、流体資料からの微生物の除去 |
| EP2253368B1 (en) | 2009-05-20 | 2011-11-02 | Gambro Lundia AB | Membranes having improved performance |
| EP2253369B1 (en) | 2009-05-20 | 2011-11-09 | Gambro Lundia AB | Membranes having improved performance |
| ITBO20090705A1 (it) * | 2009-10-29 | 2011-04-29 | Medica S R L | Procedimento per la preparazione di una membrana cava per lo scambio di materia tra una fase liquida e una fase gassosa |
| EP2412426A1 (de) | 2010-07-30 | 2012-02-01 | Schaefer Kalk GmbH & Co. KG | Poröse Hohlfaser |
| SG190002A1 (en) | 2010-10-25 | 2013-06-28 | Agency Science Tech & Res | Tubular fiber membrane with nanoporous skin |
| SG10201605328WA (en) | 2011-04-01 | 2016-08-30 | Emd Millipore Corp | Nanofiber containing composite structures |
| WO2015046411A1 (ja) * | 2013-09-30 | 2015-04-02 | 東レ株式会社 | 多孔質膜、多孔質膜を内蔵する血液浄化用モジュールおよび多孔質膜の製造方法 |
| EP3102314B1 (en) | 2014-02-06 | 2018-09-19 | Gambro Lundia AB | Membrane for blood purification |
| KR102316246B1 (ko) | 2014-02-06 | 2021-10-25 | 감브로 룬디아 아베 | 혈액 정화를 위한 혈액 투석기 |
| SG10201911354UA (en) | 2014-06-26 | 2020-02-27 | Emd Millipore Corp | Filter structure with enhanced dirt holding capacity |
| KR102206959B1 (ko) | 2015-04-17 | 2021-01-25 | 이엠디 밀리포어 코포레이션 | 접선방향 유동 여과 모드에서 작동되는 나노섬유 한외여과막을 사용하여 샘플에서 목적하는 생물학적 물질을 정제하는 방법 |
| DE102016224627A1 (de) | 2016-12-09 | 2018-06-14 | Fresenius Medical Care Deutschland Gmbh | Hohlfasermembran mit verbesserter Trennleistung und Herstellung einer Hohlfasermembran mit verbesserter Trennleistung |
| DE102017201630A1 (de) | 2017-02-01 | 2018-08-02 | Fresenius Medical Care Deutschland Gmbh | Hohlfasermembran mit verbesserter Biokompatibilität |
| JP7159308B2 (ja) | 2017-07-21 | 2022-10-24 | メルク・ミリポア・リミテッド | ラテラルフローデバイスおよびこれを用いる試料中の検体を検出する方法 |
| CN114206483A (zh) * | 2019-06-24 | 2022-03-18 | 路博润先进材料公司 | 中空纤维膜 |
| DE102021108842A1 (de) | 2021-04-09 | 2022-10-13 | Fresenius Medical Care Deutschland Gmbh | Dialysator |
| DE102023133783A1 (de) | 2023-12-04 | 2025-06-05 | Fresenius Medical Care Deutschland Gmbh | Hohlfasermembran mit hoher Biokompatibilität und geringem Albuminverlust |
| CN119951344B (zh) * | 2025-04-11 | 2025-07-04 | 开源环境科技集团有限公司 | 一种处理印染废水的中空纤维膜及其制备方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3615024A (en) * | 1968-08-26 | 1971-10-26 | Amicon Corp | High flow membrane |
| US3691068A (en) * | 1971-01-08 | 1972-09-12 | Amicon Corp | Dialysis membrane and its use |
| US4051300A (en) * | 1973-09-03 | 1977-09-27 | Gulf South Research Institute | Hollow synthetic fibers |
| DE2917357A1 (de) * | 1978-05-02 | 1979-11-08 | Asahi Chemical Ind | Semipermeable membran und verfahren zu ihrer herstellung |
| DE3149976A1 (de) * | 1981-12-17 | 1983-06-30 | Hoechst Ag, 6230 Frankfurt | Makroporoese asymmetrische hydrophile membran aus synthetischem polymerisat |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55106243A (en) * | 1979-02-07 | 1980-08-14 | Nitto Electric Ind Co Ltd | Preparation of microporous polymer membrane |
| JPS58156018A (ja) * | 1982-01-29 | 1983-09-16 | Asahi Chem Ind Co Ltd | ポリスルホン系樹脂中空糸 |
| DE3138525A1 (de) * | 1981-09-28 | 1983-04-14 | Akzo Gmbh, 5600 Wuppertal | Verfahren zur herstellung einer asymmetrischen hohlfadenmembran aus polyamid |
| JPS58132112A (ja) * | 1982-02-02 | 1983-08-06 | Nok Corp | 中空糸の製造方法 |
-
1984
- 1984-07-17 DE DE3426331A patent/DE3426331A1/de not_active Withdrawn
-
1985
- 1985-07-11 EP EP85108676A patent/EP0168783B1/de not_active Expired - Lifetime
- 1985-07-11 AT AT85108676T patent/ATE107189T1/de not_active IP Right Cessation
- 1985-07-11 DE DE3587850T patent/DE3587850D1/de not_active Expired - Lifetime
- 1985-07-16 YU YU116885A patent/YU46155B/sh unknown
- 1985-07-16 CA CA000486874A patent/CA1294745C/en not_active Expired - Lifetime
- 1985-07-16 BR BR8503391A patent/BR8503391A/pt not_active IP Right Cessation
- 1985-07-17 ES ES545300A patent/ES8605686A1/es not_active Expired
- 1985-07-17 JP JP60157958A patent/JPS6193801A/ja active Granted
-
1995
- 1995-01-05 JP JP7000370A patent/JP2782583B2/ja not_active Expired - Fee Related
-
1997
- 1997-08-21 JP JP9242108A patent/JP2916446B2/ja not_active Expired - Lifetime
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3615024A (en) * | 1968-08-26 | 1971-10-26 | Amicon Corp | High flow membrane |
| US3691068A (en) * | 1971-01-08 | 1972-09-12 | Amicon Corp | Dialysis membrane and its use |
| US4051300A (en) * | 1973-09-03 | 1977-09-27 | Gulf South Research Institute | Hollow synthetic fibers |
| DE2917357A1 (de) * | 1978-05-02 | 1979-11-08 | Asahi Chemical Ind | Semipermeable membran und verfahren zu ihrer herstellung |
| DE3149976A1 (de) * | 1981-12-17 | 1983-06-30 | Hoechst Ag, 6230 Frankfurt | Makroporoese asymmetrische hydrophile membran aus synthetischem polymerisat |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4007383C2 (de) * | 1990-03-08 | 1998-10-29 | Seitz Filter Werke | Herstellung von hydrophilen Mikrofiltrationsmembranen aus Polysulfonen |
| DE4320198C1 (de) * | 1993-06-18 | 1994-07-14 | Fresenius Ag | Vorrichtung zum Gasaustausch, insbesondere zum Oxygenieren von Blut |
Also Published As
| Publication number | Publication date |
|---|---|
| YU46155B (sh) | 1993-05-28 |
| DE3587850D1 (de) | 1994-07-21 |
| JP2782583B2 (ja) | 1998-08-06 |
| ATE107189T1 (de) | 1994-07-15 |
| CA1294745C (en) | 1992-01-28 |
| JP2916446B2 (ja) | 1999-07-05 |
| YU116885A (en) | 1988-10-31 |
| ES8605686A1 (es) | 1986-02-01 |
| BR8503391A (pt) | 1986-04-08 |
| JPH07278948A (ja) | 1995-10-24 |
| JPH0554373B2 (enExample) | 1993-08-12 |
| JPH10121324A (ja) | 1998-05-12 |
| JPS6193801A (ja) | 1986-05-12 |
| ES545300A0 (es) | 1986-02-01 |
| EP0168783B1 (de) | 1994-06-15 |
| EP0168783A1 (de) | 1986-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0168783B1 (de) | Asymmetrische mikroporöse Hohlfaser für die Hämodialyse sowie Verfahren zu ihrer Herstellung | |
| DE69305567T2 (de) | Hohlfasermembran auf Polysulfonbasis und Verfahren zu ihrer Herstellung | |
| DE102004008220B4 (de) | High-Flux Dialysemembran mit verbessertem Trennverhalten | |
| DE60034416T2 (de) | Dialysatoren zur Blutbehandlung sowie ihr Herstellungsverfahren | |
| DE3851572T2 (de) | Polysulfon-Hohlfasermembran und Verfahren zu ihrer Herstellung. | |
| DE2917357C2 (enExample) | ||
| DE69634352T2 (de) | Methode zur Herstellung einer teildurchlässigen Hohlfasermembran aus Polysulfon | |
| DE3875203T3 (de) | Verfahren zur Herstellung einer permselektiven, asymmetrischen Membrane, verwendbar in der Hämodialyse und die so hergestellten Membrane. | |
| DE69232823T2 (de) | Poröse Hohlfaser aus Polysulfon | |
| DE69304796T2 (de) | Hohlfasermembran mit hohem spezifischen Durchsatz | |
| US4906375A (en) | Asymmetrical microporous hollow fiber for hemodialysis | |
| DE2935097C2 (enExample) | ||
| DE102004008221B4 (de) | Dialysemembran mit verbesserter Mittelmolekülentfernung | |
| DE20321776U1 (de) | Hohlfasermembran zur Entfernung toxischer Mediatoren aus Blut | |
| WO2007128488A1 (de) | Ultrafiltrationsmembran | |
| EP0828553A1 (de) | Synthetische trennmembran | |
| DE3934267A1 (de) | Hohlfasermembran und verfahren zu ihrer herstellung | |
| EP1718399B1 (de) | Integral asymmetrische membran, verfahren zu ihrer herstellung und ihre verwendung | |
| DE69623196T3 (de) | Permselektive Membranen und Verfahren zu ihrer Herstellung | |
| DE69320000T2 (de) | Hohe Durchflussrate aufweisende Hohlfasermembran mit erhöhter Transportmöglichkeit und Verfahren zu deren Herstellung | |
| DE3042110C2 (enExample) | ||
| DE60111791T2 (de) | Hohlfaser-Membrane und ihre Herstellung | |
| DE68909307T2 (de) | Halbdurchlässige Membran und Verfahren zu ihrer Herstellung. | |
| CH629515A5 (en) | Polycarbonate membrane for use in haemodialysis | |
| DE3006880C2 (de) | Plasmaphoresemembran |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8125 | Change of the main classification |
Ipc: B01D 69/02 |
|
| 8130 | Withdrawal |