DE3373676D1 - A process for the preparation of chymosin - Google Patents

A process for the preparation of chymosin

Info

Publication number
DE3373676D1
DE3373676D1 DE8383901829T DE3373676T DE3373676D1 DE 3373676 D1 DE3373676 D1 DE 3373676D1 DE 8383901829 T DE8383901829 T DE 8383901829T DE 3373676 T DE3373676 T DE 3373676T DE 3373676 D1 DE3373676 D1 DE 3373676D1
Authority
DE
Germany
Prior art keywords
chymosin
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383901829T
Other languages
German (de)
English (en)
Inventor
Norman Henry Carey
Michael Terence Doel
Timothy John Roy Harris
John Spencer Emtage
Peter Anthony Lowe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chr Hansen AS
Original Assignee
Celltech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25669713&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3373676(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB838308234A external-priority patent/GB8308234D0/en
Application filed by Celltech Ltd filed Critical Celltech Ltd
Application granted granted Critical
Publication of DE3373676D1 publication Critical patent/DE3373676D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE8383901829T 1982-06-07 1983-06-07 A process for the preparation of chymosin Expired DE3373676D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA404600 1982-06-07
GB838308234A GB8308234D0 (en) 1983-03-25 1983-03-25 Recovery of products produced by host organisms
PCT/GB1983/000152 WO1983004418A1 (en) 1982-06-07 1983-06-07 A process for the preparation of chymosin

Publications (1)

Publication Number Publication Date
DE3373676D1 true DE3373676D1 (en) 1987-10-22

Family

ID=25669713

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383901829T Expired DE3373676D1 (en) 1982-06-07 1983-06-07 A process for the preparation of chymosin

Country Status (10)

Country Link
EP (1) EP0112849B1 (enExample)
JP (1) JPS59500996A (enExample)
AU (1) AU553017B2 (enExample)
DE (1) DE3373676D1 (enExample)
DK (1) DK49984A (enExample)
FI (1) FI78318C (enExample)
GB (1) GB2129810B (enExample)
IE (1) IE55163B1 (enExample)
NZ (1) NZ204477A (enExample)
WO (1) WO1983004418A1 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663285A (en) * 1981-01-06 1987-05-05 The Public Health Laboratory Service Board Chimeric plasmids
IE56372B1 (en) * 1982-12-22 1991-07-03 Genentech Inc Microbially produced rennet methods for its production and plasmids used for its production
US4961938A (en) * 1982-12-22 1990-10-09 Genentech, Inc. Preparation of cheese with rennin from recombinant microbial cells
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
JPS59162879A (ja) * 1982-12-22 1984-09-13 ジエネンテツク・インコ−ポレイテツド 微生物により産生されるレンネツト、その産生及び再活性化方法並びにそれを使用するチ−ズの製造方法
US4518526A (en) * 1982-12-22 1985-05-21 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4599197A (en) * 1982-12-22 1986-07-08 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US5340926A (en) * 1983-03-25 1994-08-23 Celltech, Limited Process for the recovery of recombinantly produced protein from insoluble aggregate
EP0122080B1 (en) * 1983-03-25 1989-09-13 Celltech Limited A process for the production of a protein
EP0268743B1 (en) 1983-03-25 1994-06-15 Celltech Limited A process for the production of a protein
US4935354A (en) * 1983-07-14 1990-06-19 Genentech, Inc. Rennin from recombinant microbial cells for preparation of cheese
BG49718A3 (bg) * 1983-07-15 1992-01-15 Bio- Technology General Corp Метод за получаване на полипептид със супероксиддисмутазна активност
US4721673A (en) * 1983-09-01 1988-01-26 Genex Corporation Recovery and activation process for microbially produced calf prochymosin
IL74094A0 (en) * 1984-01-23 1985-04-30 Takeda Chemical Industries Ltd Highly solubilised protein and production thereof
US5082775A (en) * 1984-05-11 1992-01-21 Berlex Laboratories, Inc. Efficient process for isolating insoluble heterologous protein using non-ionic detergents
GB8414354D0 (en) * 1984-06-05 1984-07-11 Biogen Nv Purifying protein
ES8800957A1 (es) * 1985-02-22 1987-12-01 Monsanto Co Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina
US4766205A (en) * 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
DE3611817A1 (de) * 1986-04-08 1987-10-15 Boehringer Mannheim Gmbh Verfahren zur renaturierung von proteinen
US4705848A (en) * 1986-06-02 1987-11-10 International Minerals & Chemical Corp. Isolation of bioactive, monomeric growth hormone
ATE78809T1 (de) 1987-05-15 1992-08-15 Univ Texas Keramische zusammensetzungen und verfahren zu ihrer anwendung.
EP0301835A1 (en) * 1987-07-29 1989-02-01 Schering Biotech Corporation Purification of human interleukin-4 expressed in Escherichia Coli
US5637566A (en) * 1988-08-24 1997-06-10 Southern Cross Biotech Pty. Ltd. Method of improving carcass quality by administering growth hormone
US5064943A (en) * 1988-12-16 1991-11-12 American Cyanamid Company Method for solubilization and naturation of somatotropin
AUPO005496A0 (en) * 1996-05-24 1996-06-13 Bresagen Limited An interleukin-5 antagonist
US6465616B1 (en) 1994-04-08 2002-10-15 Bresagen Limited Interleukin-5 antagonist
AU723413B2 (en) * 1996-05-24 2000-08-24 Bresagen Limited An interleukin-5 antagonist
US6316240B1 (en) 1999-01-25 2001-11-13 Novozymes A/S Recovery of a glycosidase or peptidase from a culture broth at high pH
DE10309691B4 (de) 2003-02-28 2018-10-04 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Gewinnung von löslichen Proteinen aus der Biomasse rekombinanter Mikroorganismen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350764A (en) * 1980-03-10 1982-09-21 The Regents Of The University Of California Microbiological synthesis of beta endorphin
IE53517B1 (en) * 1981-06-17 1988-12-07 Celltech Ltd Process for the production of a polypeptide

Also Published As

Publication number Publication date
DK49984D0 (da) 1984-02-03
FI78318B (fi) 1989-03-31
IE831341L (en) 1983-12-07
NZ204477A (en) 1986-09-10
JPH0472508B2 (enExample) 1992-11-18
EP0112849B1 (en) 1987-09-16
FI840468A0 (fi) 1984-02-06
DK49984A (da) 1984-02-03
GB2129810B (en) 1985-09-18
AU1607383A (en) 1983-12-30
AU553017B2 (en) 1986-06-26
JPS59500996A (ja) 1984-06-07
FI78318C (fi) 1989-07-10
FI840468A7 (fi) 1984-02-06
EP0112849A1 (en) 1984-07-11
WO1983004418A1 (en) 1983-12-22
GB2129810A (en) 1984-05-23
GB8401585D0 (en) 1984-02-22
IE55163B1 (en) 1990-06-20

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: PFIZER INC., NEW YORK, N.Y., US

8328 Change in the person/name/address of the agent

Free format text: LEDERER, KELLER & RIEDERER, 80538 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: CHR. HANSEN A/S, HORSHOLM, DK

8339 Ceased/non-payment of the annual fee