GB2149399B - A process for the preparation of 2-hydroxy-5-1-hydroxy-2-(4phenyl-2-bukyl)-amine-ethyl-benzamide - Google Patents

A process for the preparation of 2-hydroxy-5-1-hydroxy-2-(4phenyl-2-bukyl)-amine-ethyl-benzamide

Info

Publication number
GB2149399B
GB2149399B GB08424100A GB8424100A GB2149399B GB 2149399 B GB2149399 B GB 2149399B GB 08424100 A GB08424100 A GB 08424100A GB 8424100 A GB8424100 A GB 8424100A GB 2149399 B GB2149399 B GB 2149399B
Authority
GB
United Kingdom
Prior art keywords
hydroxy
bukyl
4phenyl
benzamide
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08424100A
Other versions
GB8424100D0 (en
GB2149399A (en
Inventor
Angelo Marai
Giuseppe Cerri
Mario Paini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SCHARPER SpA
Original Assignee
SCHARPER SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SCHARPER SpA filed Critical SCHARPER SpA
Publication of GB8424100D0 publication Critical patent/GB8424100D0/en
Publication of GB2149399A publication Critical patent/GB2149399A/en
Application granted granted Critical
Publication of GB2149399B publication Critical patent/GB2149399B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
GB08424100A 1983-09-27 1984-09-24 A process for the preparation of 2-hydroxy-5-1-hydroxy-2-(4phenyl-2-bukyl)-amine-ethyl-benzamide Expired GB2149399B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23005/83A IT1194406B (en) 1983-09-27 1983-09-27 PROCEDURE FOR THE PREPARATION OF 2-HYDROXY-5-01-HYDROXY-2 - ((4-FENYL-2-BUTYL) AMINO) ETHYL BENZAMIDE

Publications (3)

Publication Number Publication Date
GB8424100D0 GB8424100D0 (en) 1984-10-31
GB2149399A GB2149399A (en) 1985-06-12
GB2149399B true GB2149399B (en) 1987-05-13

Family

ID=11202777

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08424100A Expired GB2149399B (en) 1983-09-27 1984-09-24 A process for the preparation of 2-hydroxy-5-1-hydroxy-2-(4phenyl-2-bukyl)-amine-ethyl-benzamide

Country Status (7)

Country Link
JP (1) JPS60105651A (en)
BE (1) BE900663A (en)
CH (1) CH661923A5 (en)
DE (1) DE3435349A1 (en)
FR (1) FR2552427B1 (en)
GB (1) GB2149399B (en)
IT (1) IT1194406B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017098520A1 (en) * 2015-12-09 2017-06-15 prscDAVALURI RAMAMOHAN RAO Process for the preparation of labetalol hydrochloride
CN112225674B (en) * 2020-10-28 2021-12-03 天津大学 Labetalol hydrochloride crystal form compound and preparation method and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1266058A (en) * 1969-07-08 1972-03-08
JPS4843341A (en) * 1971-10-02 1973-06-22
ZA794872B (en) * 1978-09-20 1980-11-26 Schering Corp A phenylalkylaminoethylsalicylamide,its preparation and pharmaceutical compositions containing it

Also Published As

Publication number Publication date
IT8323005A1 (en) 1985-03-27
DE3435349C2 (en) 1989-09-21
DE3435349A1 (en) 1985-04-18
GB8424100D0 (en) 1984-10-31
BE900663A (en) 1985-01-16
FR2552427B1 (en) 1988-03-25
FR2552427A1 (en) 1985-03-29
JPS60105651A (en) 1985-06-11
CH661923A5 (en) 1987-08-31
IT1194406B (en) 1988-09-22
IT8323005A0 (en) 1983-09-27
GB2149399A (en) 1985-06-12

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930924