DE3361812D1 - Antiinflammatory and/or analgesic 2,3-diaryl-5-halo thiophenes - Google Patents

Antiinflammatory and/or analgesic 2,3-diaryl-5-halo thiophenes

Info

Publication number
DE3361812D1
DE3361812D1 DE8383101247T DE3361812T DE3361812D1 DE 3361812 D1 DE3361812 D1 DE 3361812D1 DE 8383101247 T DE8383101247 T DE 8383101247T DE 3361812 T DE3361812 T DE 3361812T DE 3361812 D1 DE3361812 D1 DE 3361812D1
Authority
DE
Germany
Prior art keywords
diaryl
antiinflammatory
analgesic
thiophenes
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383101247T
Other languages
German (de)
English (en)
Inventor
Stephen Barry Haber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Application granted granted Critical
Publication of DE3361812D1 publication Critical patent/DE3361812D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Container, Conveyance, Adherence, Positioning, Of Wafer (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Measuring Volume Flow (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
DE8383101247T 1982-03-03 1983-02-10 Antiinflammatory and/or analgesic 2,3-diaryl-5-halo thiophenes Expired DE3361812D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35430082A 1982-03-03 1982-03-03

Publications (1)

Publication Number Publication Date
DE3361812D1 true DE3361812D1 (en) 1986-02-27

Family

ID=23392697

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383101247T Expired DE3361812D1 (en) 1982-03-03 1983-02-10 Antiinflammatory and/or analgesic 2,3-diaryl-5-halo thiophenes

Country Status (18)

Country Link
EP (1) EP0087629B1 (enExample)
JP (1) JPS58159489A (enExample)
AT (1) ATE17480T1 (enExample)
AU (1) AU553269B2 (enExample)
CA (1) CA1242725A (enExample)
DE (1) DE3361812D1 (enExample)
DK (1) DK161320C (enExample)
ES (1) ES520218A0 (enExample)
FI (1) FI79308C (enExample)
GR (1) GR78135B (enExample)
IE (1) IE54816B1 (enExample)
IL (1) IL67940A (enExample)
NO (1) NO155198B (enExample)
NZ (1) NZ203317A (enExample)
PH (1) PH18061A (enExample)
PT (1) PT76247B (enExample)
SU (1) SU1250172A3 (enExample)
ZA (1) ZA831046B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346175A1 (de) * 1983-12-21 1985-07-11 Merck Patent Gmbh, 6100 Darmstadt Pyridylthiophene
NZ211146A (en) * 1984-02-29 1987-10-30 Merck & Co Inc 2,5-diaryl-tetrahydrothiophene derivatives and pharmaceutical compositions
US5571810A (en) * 1990-06-11 1996-11-05 Fujisawa Pharmaceutical Co., Ltd. Thiophene derivatives
GB9012936D0 (en) * 1990-06-11 1990-08-01 Fujisawa Pharmaceutical Co Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
US6492413B2 (en) 1993-01-15 2002-12-10 G.D. Searle & Co. 3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
CA2152792C (en) * 1993-01-15 2000-02-15 Stephen R. Bertenshaw Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
GB9420616D0 (en) * 1994-10-12 1994-11-30 Merck Sharp & Dohme Method, compositions and use
AU6718494A (en) * 1993-05-13 1994-12-12 Merck Frosst Canada Inc. 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase
US5840746A (en) * 1993-06-24 1998-11-24 Merck Frosst Canada, Inc. Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
DE10001166A1 (de) 2000-01-13 2001-07-19 Merckle Gmbh Anellierte Pyrrolverbindungen, diese enthaltende pharmazeutische Mittel und deren Verwendung
AUPR283801A0 (en) * 2001-02-01 2001-03-01 Australian National University, The Chemical compounds and methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6028837B2 (ja) * 1979-08-09 1985-07-06 イ−・アイ・デユポン・ド・ネモア−ス・アンド・コンパニ− ジアリ−ルチオフエン化合物、その製造法およびそれを含有する抗炎症剤
US4302461A (en) * 1979-08-09 1981-11-24 E. I. Du Pont De Nemours And Company Antiinflammatory 5-substituted-2,3-diarylthiophenes
US4381311A (en) * 1980-12-29 1983-04-26 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-α-(polyhalomethyl)-2-thiophenemethanols

Also Published As

Publication number Publication date
PT76247A (en) 1983-03-01
GR78135B (enExample) 1984-09-26
FI830523L (fi) 1983-09-04
PH18061A (en) 1985-03-18
DK67683D0 (da) 1983-02-16
EP0087629A2 (en) 1983-09-07
AU1146083A (en) 1983-09-08
NO155198B (no) 1986-11-17
ATE17480T1 (de) 1986-02-15
FI79308B (fi) 1989-08-31
DK67683A (da) 1983-09-04
ES8403884A1 (es) 1984-04-01
DK161320C (da) 1991-12-09
FI79308C (fi) 1989-12-11
CA1242725A (en) 1988-10-04
EP0087629A3 (en) 1983-10-19
JPS58159489A (ja) 1983-09-21
ES520218A0 (es) 1984-04-01
ZA831046B (en) 1984-09-26
IL67940A0 (en) 1983-06-15
NZ203317A (en) 1985-07-12
DK161320B (da) 1991-06-24
SU1250172A3 (ru) 1986-08-07
EP0087629B1 (en) 1986-01-15
IE830331L (en) 1983-09-03
JPH0314312B2 (enExample) 1991-02-26
AU553269B2 (en) 1986-07-10
IE54816B1 (en) 1990-02-14
NO830527L (no) 1983-09-05
FI830523A0 (fi) 1983-02-16
PT76247B (en) 1986-02-04
IL67940A (en) 1986-02-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: THE DU PONT MERCK PHARMACEUTICAL CO., WILMINGTON,

8328 Change in the person/name/address of the agent

Free format text: VON KREISLER, A., DIPL.-CHEM. SELTING, G., DIPL.-ING. WERNER, H., DIPL.-CHEM. DR.RER.NAT. FUES, J., DIPL.-CHEM. DR.RER.NAT. BOECKMANN GEN. DALLMEYER, G., DIPL.-ING. HILLERINGMANN, J., DIPL.-ING. JOENSSON, H., DIPL.-CHEM. DR.RER.NAT. MEYERS, H., DIPL.-CHEM. DR.RER.NAT., PAT.-ANWAELTE, 5000 KOELN

8327 Change in the person/name/address of the patent owner

Owner name: DU PONT PHARMACEUTICALS CO., WILMINGTON, DEL., US

8339 Ceased/non-payment of the annual fee