DE3361470D1 - Process for producing alpha-l-aspartyl-l-phenylalanine methyl ester or its hydrochloride - Google Patents
Process for producing alpha-l-aspartyl-l-phenylalanine methyl ester or its hydrochlorideInfo
- Publication number
- DE3361470D1 DE3361470D1 DE8383302061T DE3361470T DE3361470D1 DE 3361470 D1 DE3361470 D1 DE 3361470D1 DE 8383302061 T DE8383302061 T DE 8383302061T DE 3361470 T DE3361470 T DE 3361470T DE 3361470 D1 DE3361470 D1 DE 3361470D1
- Authority
- DE
- Germany
- Prior art keywords
- aspartyl
- hydrochloride
- methyl ester
- phenylalanine methyl
- producing alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP57067687A JPS58185545A (ja) | 1982-04-22 | 1982-04-22 | α−L−アスパルチル−L−フエニルアラニンメチルエステルまたはその塩酸塩の製法 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3361470D1 true DE3361470D1 (en) | 1986-01-23 |
Family
ID=13352144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8383302061T Expired DE3361470D1 (en) | 1982-04-22 | 1983-04-13 | Process for producing alpha-l-aspartyl-l-phenylalanine methyl ester or its hydrochloride |
Country Status (6)
Country | Link |
---|---|
US (1) | US4684745A (de) |
EP (1) | EP0092933B1 (de) |
JP (1) | JPS58185545A (de) |
CA (1) | CA1250089A (de) |
DE (1) | DE3361470D1 (de) |
IE (1) | IE54796B1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE810577L (en) * | 1983-05-31 | 1982-09-16 | Prendergast Angela | Apparatus for fermentation |
GB8321802D0 (en) * | 1983-08-12 | 1983-09-14 | Erba Farmitalia | Aspartame synthesis |
JPS60174799A (ja) * | 1984-02-21 | 1985-09-09 | Ajinomoto Co Inc | α−L−アスパルチル−L−フエニルアラニンメチルエステルの製造法 |
JPH07636B2 (ja) * | 1984-12-17 | 1995-01-11 | 三井東圧化学株式会社 | N−ホルミル−α−アスパルチルフエニルアラニンの製造法 |
ES8703487A1 (es) * | 1984-12-27 | 1987-03-01 | Mitsui Toatsu Chemicals | Procedimiento para la preparacion de a-l-aspartil-l-fenila- lanina metil ester |
AU561384B2 (en) * | 1985-03-26 | 1987-05-07 | Mitsui Toatsu Chemicals Inc. | Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof |
AU586669B2 (en) * | 1985-03-29 | 1989-07-20 | Mitsui Toatsu Chemicals Inc. | Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof |
JPH0657719B2 (ja) * | 1986-06-03 | 1994-08-03 | 味の素株式会社 | α−L−アスパルチル−L−フエニルアラニンメチルエステルの回収方法 |
DE3780585T2 (de) * | 1986-12-05 | 1993-03-18 | Mitsui Toatsu Chemicals | Herstellung von alpha-l-aspartyl-l-phenylalanin-methylester oder deren hydrohalide. |
JPH0832719B2 (ja) * | 1986-12-19 | 1996-03-29 | 三井東圧化学株式会社 | 吸湿性の小さいα−L−アスパルチル−L−フエニルアラニンメチルエステルの製造法 |
US4892820A (en) * | 1987-06-10 | 1990-01-09 | The Nutrasweet Company | Solvent system for enzymatic coupling process |
AU628257B2 (en) * | 1990-03-15 | 1992-09-10 | Nutrasweet Company, The | Process for manufacturing aspartame from a diketopiperazine and novel intermediates and derivatives therefor |
JP2946853B2 (ja) * | 1991-05-09 | 1999-09-06 | 味の素株式会社 | アスパルテームの晶析法 |
JP2979761B2 (ja) * | 1991-05-23 | 1999-11-15 | 味の素株式会社 | α−L−アスパルチル−L−フェニルアラニンメチルエステル塩酸塩の製造法 |
JP3178092B2 (ja) * | 1992-06-29 | 2001-06-18 | 味の素株式会社 | α−L−アスパルチル−L−フェニルアラニンメチルエステル塩酸塩の製造方法 |
JP3239452B2 (ja) * | 1992-08-05 | 2001-12-17 | 味の素株式会社 | α−L−アスパルチル−L−フェニルアラニンメチルエステル塩酸塩の製造法 |
IT1270852B (it) * | 1992-08-27 | 1997-05-13 | Miwon Co Ltd | Procedimento per la produzione dell'estere metilico di alfa-l-aspartil-l-fenilalanina. |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3786039A (en) * | 1969-04-30 | 1974-01-15 | Ajinomoto Kk | Method of producing alpha-l-aspartyl-l-phenylalanine lower alkyl esters |
JPS4941425B1 (de) * | 1970-10-26 | 1974-11-08 | ||
BE791544A (fr) * | 1971-11-19 | 1973-05-17 | Stamicarbon | Preparation d'esters alkyliques de dipeptide |
US3933781A (en) * | 1973-11-05 | 1976-01-20 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters |
JPS5223001A (en) * | 1975-08-14 | 1977-02-21 | Ajinomoto Co Inc | Process for elimination of formyl group |
US4173562A (en) * | 1976-12-27 | 1979-11-06 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester |
US4111925A (en) * | 1977-10-14 | 1978-09-05 | Monsanto Company | Hydrolysis of esters of α-L-aspartyl-L-phenylalanine |
US4348317A (en) * | 1980-12-29 | 1982-09-07 | Monsanto Company | Recovery of L-phenylalanine and L-aspartic acid during preparation of α-L-aspartyl-L-phenylalanine methyl ester |
JPS57131746A (en) * | 1981-02-10 | 1982-08-14 | Ajinomoto Co Inc | Removal of n-formyl group |
-
1982
- 1982-04-22 JP JP57067687A patent/JPS58185545A/ja active Granted
-
1983
- 1983-04-13 DE DE8383302061T patent/DE3361470D1/de not_active Expired
- 1983-04-13 EP EP83302061A patent/EP0092933B1/de not_active Expired
- 1983-04-13 US US06/484,506 patent/US4684745A/en not_active Expired - Lifetime
- 1983-04-14 IE IE852/83A patent/IE54796B1/en not_active IP Right Cessation
- 1983-04-21 CA CA000426430A patent/CA1250089A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CA1250089A (en) | 1989-02-14 |
JPH0372640B2 (de) | 1991-11-19 |
IE54796B1 (en) | 1990-02-14 |
JPS58185545A (ja) | 1983-10-29 |
EP0092933B1 (de) | 1985-12-11 |
US4684745A (en) | 1987-08-04 |
EP0092933A1 (de) | 1983-11-02 |
IE830852L (en) | 1983-10-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |