DE3324593C2 - Stabilisierte Lösung einer radioaktiv markierten Verbindung und Verfahren zu ihrer Herstellung - Google Patents

Stabilisierte Lösung einer radioaktiv markierten Verbindung und Verfahren zu ihrer Herstellung

Info

Publication number
DE3324593C2
DE3324593C2 DE3324593A DE3324593A DE3324593C2 DE 3324593 C2 DE3324593 C2 DE 3324593C2 DE 3324593 A DE3324593 A DE 3324593A DE 3324593 A DE3324593 A DE 3324593A DE 3324593 C2 DE3324593 C2 DE 3324593C2
Authority
DE
Germany
Prior art keywords
methyl
compounds
diethylenetriamine
thiocarbonylated
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3324593A
Other languages
German (de)
English (en)
Other versions
DE3324593A1 (de
Inventor
Nathan R. Marshfield Mass. Tzodikov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Revvity Health Sciences Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of DE3324593A1 publication Critical patent/DE3324593A1/de
Application granted granted Critical
Publication of DE3324593C2 publication Critical patent/DE3324593C2/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121—Solutions, i.e. homogeneous liquid formulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE3324593A 1982-07-12 1983-07-07 Stabilisierte Lösung einer radioaktiv markierten Verbindung und Verfahren zu ihrer Herstellung Expired DE3324593C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/397,501 US4411881A (en) 1982-07-12 1982-07-12 Composition and method for stabilizing radiolabeled compounds using thiocarbonylated diethylenetriamines

Publications (2)

Publication Number Publication Date
DE3324593A1 DE3324593A1 (de) 1984-02-02
DE3324593C2 true DE3324593C2 (de) 1986-10-23

Family

ID=23571454

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3324593A Expired DE3324593C2 (de) 1982-07-12 1983-07-07 Stabilisierte Lösung einer radioaktiv markierten Verbindung und Verfahren zu ihrer Herstellung

Country Status (7)

Country Link
US (1) US4411881A (enExample)
JP (1) JPS5924257A (enExample)
CA (1) CA1205070A (enExample)
CH (1) CH655853A5 (enExample)
DE (1) DE3324593C2 (enExample)
FR (1) FR2536998B1 (enExample)
GB (1) GB2123412B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3331159A1 (de) * 1983-08-30 1985-03-14 Hoechst Ag, 6230 Frankfurt N-(4-aminobenzoyl)-aminodicarbonsaeuren zur stabilisierung von technetium-99m-praeparaten, stabilisierte injektionspraeparate und verfahren zu ihrer herstellung
US4656280A (en) * 1984-03-07 1987-04-07 E. I. Du Pont De Nemours And Company Radioiodinated dopamine receptor ligand
GB8510726D0 (en) * 1985-04-26 1985-06-26 Amersham Int Plc Stabilised radio-labelled compounds
JPH0317229U (enExample) * 1989-06-30 1991-02-20
MC2260A1 (fr) * 1990-06-18 1993-04-26 Dow Chemical Co Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
AU9172191A (en) * 1990-12-12 1992-07-08 Mallinckrodt Medical, Inc. Method of radioactive labelling of blood cells and kit therefor
WO1993002652A2 (en) * 1991-08-01 1993-02-18 Hybritech Incorporated Modified haptens useful as imaging and therapeutic agents
US5686058A (en) * 1992-04-30 1997-11-11 Amersham International Plc Radiolabelled nucleotide formulations stored in an unfrozen state
CA2105402C (en) * 1992-04-30 2000-04-04 Roger M. Price Radiolabelled compound formulations
US5342926A (en) * 1993-06-08 1994-08-30 The Regents Of The University Of California Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport
RU2104035C1 (ru) * 1995-02-27 1998-02-10 Физико-энергетический институт Препарат, содержащий органическое соединение, меченное бета-радионуклидом
WO1997001520A1 (en) * 1995-06-28 1997-01-16 E.I. Du Pont De Nemours And Company Composition and method for stabilizing radiolabeled organic compounds
ATE314097T1 (de) 1996-10-28 2006-01-15 Amersham Health As Kontrastmittel
US5961955A (en) 1997-06-03 1999-10-05 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope
HUP0101921A2 (hu) * 2001-05-10 2004-01-28 Izotóp Intézet Kft Radioaktívan jelzett nukleotido/ka/t tartalmazó preparátumok és eljárás azok előállítására
JP5139678B2 (ja) * 2003-07-24 2013-02-06 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 安定な放射性医薬品組成物およびその製法
US11474106B2 (en) 2015-07-08 2022-10-18 Lawrence Livermore National Security, Llc Methods for cytotoxic chemotherapy-based predictive assays
WO2018132766A1 (en) * 2017-01-12 2018-07-19 The Regents Of The University Of California Cytotoxic chemotherapy-based predictive assays for acute myeloid leukemia

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919095A (en) * 1973-07-30 1975-11-11 Mobil Oil Corp Organic compositions containing antioxidant and antiwear additives
US3876550A (en) * 1974-04-15 1975-04-08 Lubrizol Corp Lubricant compositions
US4358434A (en) * 1979-12-19 1982-11-09 New England Nuclear Corporation Method, composition and kit for stabilizing radiolabeled compounds
US4390517A (en) * 1979-12-19 1983-06-28 New England Nuclear Corporation Method, composition and kit for stabilizing radiolabeled compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS-ERMITTELT

Also Published As

Publication number Publication date
US4411881A (en) 1983-10-25
JPH0211105B2 (enExample) 1990-03-12
FR2536998B1 (fr) 1988-01-22
GB2123412A (en) 1984-02-01
GB8316714D0 (en) 1983-07-20
CH655853A5 (de) 1986-05-30
DE3324593A1 (de) 1984-02-02
CA1205070A (en) 1986-05-27
JPS5924257A (ja) 1984-02-07
FR2536998A1 (fr) 1984-06-08
GB2123412B (en) 1986-03-05

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8127 New person/name/address of the applicant

Owner name: E.I. DUPONT DE NEMOURS AND CO., WILMINGTON, DEL.,

8125 Change of the main classification

Ipc: A61K 43/00

8125 Change of the main classification

Ipc: C07B 63/04

D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NEN LIFE SCIENCE PRODUCTS, INC., BOSTON, MASS., US

8328 Change in the person/name/address of the agent

Free format text: SCHWABE, SANDMAIR, MARX, 81677 MUENCHEN