DE3279900D1 - Stabilizing & selecting cells - Google Patents

Stabilizing & selecting cells

Info

Publication number
DE3279900D1
DE3279900D1 DE8282306207T DE3279900T DE3279900D1 DE 3279900 D1 DE3279900 D1 DE 3279900D1 DE 8282306207 T DE8282306207 T DE 8282306207T DE 3279900 T DE3279900 T DE 3279900T DE 3279900 D1 DE3279900 D1 DE 3279900D1
Authority
DE
Germany
Prior art keywords
stabilizing
selecting cells
cells
selecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282306207T
Other languages
English (en)
Inventor
Charles Lee Hershberger
Paul Robert Rosteck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE3279900D1 publication Critical patent/DE3279900D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/18—Thymus derived hormone or factor; related peptides
DE8282306207T 1981-11-27 1982-11-22 Stabilizing & selecting cells Expired DE3279900D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/325,511 US4436815A (en) 1981-11-27 1981-11-27 Method for stabilizing and selecting recombinant DNA containing host cells

Publications (1)

Publication Number Publication Date
DE3279900D1 true DE3279900D1 (en) 1989-09-28

Family

ID=23268189

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282306207T Expired DE3279900D1 (en) 1981-11-27 1982-11-22 Stabilizing & selecting cells

Country Status (13)

Country Link
US (1) US4436815A (de)
EP (1) EP0080848B1 (de)
JP (1) JPH0665305B2 (de)
AU (1) AU555637B2 (de)
CA (1) CA1190490A (de)
DD (2) DD212532A5 (de)
DE (1) DE3279900D1 (de)
DK (1) DK527482A (de)
GB (1) GB2110694B (de)
GR (1) GR77798B (de)
HU (1) HU197043B (de)
IE (1) IE54267B1 (de)
IL (1) IL67176A0 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650761A (en) * 1981-11-27 1987-03-17 Eli Lilly And Company Method for stabilizing and selecting recombinant DNA containing host cell
US5112755A (en) * 1982-04-15 1992-05-12 Genentech, Inc. Preparation of functional human urokinase proteins
US4530904A (en) * 1982-09-03 1985-07-23 Eli Lilly And Company Method for conferring bacteriophage resistance to bacteria
US5702916A (en) * 1982-09-16 1997-12-30 Gx Biosystems A/S Biological Containment
WO1987005932A1 (en) * 1986-03-26 1987-10-08 Genexpress Aps Biological containment
US4634678A (en) * 1982-12-13 1987-01-06 Molecular Genetics Research And Development Limited Partnership Plasmid cloning and expression vectors for use in microorganisms
US4673641A (en) * 1982-12-16 1987-06-16 Molecular Genetics Research And Development Limited Partnership Co-aggregate purification of proteins
US4559300A (en) * 1983-01-18 1985-12-17 Eli Lilly And Company Method for using an homologous bacillus promoter and associated natural or modified ribosome binding site-containing DNA sequence in streptomyces
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty
SE455704B (sv) * 1983-10-24 1988-08-01 Ac Biotechnics Ab Bakteriecell innehallande plasmid med stabiliserad nedervning, plasmid samt forfarande for framstellning av bakteriecellen
IL71555A (en) * 1984-04-15 1992-06-21 State Of Israel Israel Inst Fo Bovine interferon
US4774182A (en) * 1984-06-29 1988-09-27 Wisconsin Alumni Research Foundation Partially defective foreign gene for conferring immunity on a biological host
US5759816A (en) * 1984-08-27 1998-06-02 Bio-Technology General Corp. Expression vectors containing λPL promoter and T1 T2 rRNA termination sequence plasmids containing the vectors hosts containing the plasmids and related methods
US5059529A (en) * 1984-08-27 1991-10-22 Bio-Technology General Corp. Stabilized expression vectors containing λPL promoter and the gene for the cI434 repressor, plasmids containing the vectors, hosts containing the plasmids and related methods
US4766066A (en) * 1984-09-27 1988-08-23 Eli Lilly And Company Method of using bacteriophage lambda p1 promoter to produce a functional polypeptide in streptomyces
DK594084A (da) * 1984-12-12 1986-06-13 Novo Industri As Fremgangsmaade til stabilisering af extra-chromosomale elementer i bakterier under dyrkning
FI90990C (fi) * 1984-12-18 1994-04-25 Boehringer Ingelheim Int Rekombinantti-DNA-molekyyli, transformoitu isäntäorganismi ja menetelmä interferonin valmistamiseksi
US4743546A (en) * 1985-02-13 1988-05-10 Biotechnica International, Inc. Controlled gene excision
DK275685D0 (da) * 1985-06-18 1985-06-18 Benzon As Alfred Stabilisering af biologiske systemer
US4874703A (en) * 1985-08-26 1989-10-17 Eli Lilly And Company Expression vectors for use in E. coli
US4960707A (en) * 1987-08-17 1990-10-02 Associated Universities, Inc. Recombinant plasmids for encoding restriction enzymes DpnI and DpnII of streptococcus pneumontae
AU623698B2 (en) 1988-09-02 1992-05-21 Chiron Corporation Macrophage-derived inflammatory mediator (mip-2)
US5198346A (en) * 1989-01-06 1993-03-30 Protein Engineering Corp. Generation and selection of novel DNA-binding proteins and polypeptides
US5096815A (en) * 1989-01-06 1992-03-17 Protein Engineering Corporation Generation and selection of novel dna-binding proteins and polypeptides
IL97312A (en) 1990-02-23 1999-01-26 Lilly Co Eli A method of generating a polypeptide in an eukaryotic vector AND recombinant surrogate cell containing an enhanced transcriptional control unit based on the primary late adenovirus coefficient
AU3929793A (en) * 1992-03-31 1993-11-08 Albert Einstein College Of Medicine Of Yeshiva University Prokaryotes including DNA encoding bacteriophage immunity
ATE312934T1 (de) * 1995-06-07 2005-12-15 Univ Washington Rekombinant bakterielle system mit umweltbeschränkte lebensfähigkeit
US6087128A (en) 1998-02-12 2000-07-11 Ndsu Research Foundation DNA encoding an avian E. coli iss
US7094873B1 (en) 1999-05-17 2006-08-22 Board Of Regents, The University Of Texas System Polypeptide that interacts with heat shock proteins
US20020177212A1 (en) * 1999-05-17 2002-11-28 Board Of Regents, The University Of Texas System Polypeptide that interacts with heat shock proteins
WO2004062767A1 (ja) * 2003-01-16 2004-07-29 Nissei Bio Co., Ltd. 二本鎖ｄｎａを用いた有害物質の濃縮除去方法､並びにそのための吸着体および装置

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356270A (en) 1977-11-08 1982-10-26 Genentech, Inc. Recombinant DNA cloning vehicle
US4366246A (en) 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
DE2963374D1 (en) 1978-10-10 1982-09-09 Univ Leland Stanford Junior Recombinant dna, method for preparing it and production of foreign proteins by unicellular hosts containing it
JPS55156591A (en) 1979-05-23 1980-12-05 Ajinomoto Co Inc Method for stabilizing property of bacteria containing plasmid
US4296482A (en) * 1980-03-24 1981-10-20 Sperry Corporation Parametric array Doppler sonar apparatus
US4506013A (en) * 1980-10-03 1985-03-19 Eli Lilly And Company Stabilizing and selecting recombinant DNA host cells
JPS5878589A (ja) * 1981-11-06 1983-05-12 Kanegafuchi Chem Ind Co Ltd プラスミド含有微生物の培養法

Also Published As

Publication number Publication date
EP0080848A2 (de) 1983-06-08
AU555637B2 (en) 1986-10-02
US4436815A (en) 1984-03-13
IE54267B1 (en) 1989-08-02
HU197043B (en) 1989-02-28
GB2110694B (en) 1985-02-27
JPH0665305B2 (ja) 1994-08-24
DD212532A5 (de) 1984-08-15
IE822817L (en) 1983-05-27
GR77798B (de) 1984-09-25
EP0080848B1 (de) 1989-08-23
IL67176A0 (en) 1983-03-31
CA1190490A (en) 1985-07-16
EP0080848A3 (en) 1985-01-16
GB2110694A (en) 1983-06-22
AU9013082A (en) 1983-06-02
DD216044A5 (de) 1984-11-28
JPS58107184A (ja) 1983-06-25
DK527482A (da) 1983-05-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: SPOTT, G., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN

8339 Ceased/non-payment of the annual fee