DE3273952D1 - Pharmaceutical composition comprising phenyl acetyl glutamine,a combination of this compound with phenylacetic acid or 3-(phenylacetylamino)piperidine-2,6-dione,a process for isolating the latter from urine and a process for the synthesis of 3-(phenylacetylamino)piperidine-2,6-dione - Google Patents

Pharmaceutical composition comprising phenyl acetyl glutamine,a combination of this compound with phenylacetic acid or 3-(phenylacetylamino)piperidine-2,6-dione,a process for isolating the latter from urine and a process for the synthesis of 3-(phenylacetylamino)piperidine-2,6-dione

Info

Publication number
DE3273952D1
DE3273952D1 DE8282104867T DE3273952T DE3273952D1 DE 3273952 D1 DE3273952 D1 DE 3273952D1 DE 8282104867 T DE8282104867 T DE 8282104867T DE 3273952 T DE3273952 T DE 3273952T DE 3273952 D1 DE3273952 D1 DE 3273952D1
Authority
DE
Germany
Prior art keywords
phenylacetylamino
dione
piperidine
urine
isolating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282104867T
Other languages
English (en)
Inventor
Stanislaw R Burzynski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE3273952D1 publication Critical patent/DE3273952D1/de
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • C07K4/12—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/834—Urine; urinary system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8282104867T 1981-07-02 1982-06-03 Pharmaceutical composition comprising phenyl acetyl glutamine,a combination of this compound with phenylacetic acid or 3-(phenylacetylamino)piperidine-2,6-dione,a process for isolating the latter from urine and a process for the synthesis of 3-(phenylacetylamino)piperidine-2,6-dione Expired DE3273952D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27972881A 1981-07-02 1981-07-02
US06/330,383 US4470970A (en) 1981-07-02 1981-12-15 Purified antineoplaston fractions and methods of treating neoplastic disease

Publications (1)

Publication Number Publication Date
DE3273952D1 true DE3273952D1 (en) 1986-12-04

Family

ID=26959856

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282104867T Expired DE3273952D1 (en) 1981-07-02 1982-06-03 Pharmaceutical composition comprising phenyl acetyl glutamine,a combination of this compound with phenylacetic acid or 3-(phenylacetylamino)piperidine-2,6-dione,a process for isolating the latter from urine and a process for the synthesis of 3-(phenylacetylamino)piperidine-2,6-dione

Country Status (14)

Country Link
US (1) US4470970A (de)
EP (1) EP0069232B1 (de)
JP (3) JPH0729925B2 (de)
AU (1) AU551109B2 (de)
CA (1) CA1188218A (de)
DE (1) DE3273952D1 (de)
DK (2) DK162813C (de)
ES (1) ES512894A0 (de)
HK (1) HK30289A (de)
IL (1) IL65960A (de)
MY (1) MY102918A (de)
NO (1) NO163595C (de)
NZ (1) NZ200805A (de)
SG (1) SG4489G (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559325A (en) * 1981-12-15 1985-12-17 Burzynski Stanislaw R Purified antineoplaston fractions and methods of treating neoplastic disease
US4593038A (en) * 1985-04-03 1986-06-03 Burzynski Stanislaw R Topical use of 3-phenylacetylamino-2,6-piperidinedione for treatment of skin wrinkles and hyperpigmentation
US4705796A (en) * 1986-08-25 1987-11-10 Stereochemical Genetics, Inc. Use of 3-N-phenylacetylamino-2,6-piperidinedione for treatment of neuropsychiatric disorders
US5238947A (en) * 1990-04-12 1993-08-24 University Of Georgia Research Foundation, Inc. Synthetic piperidinediones with cytostatic activity
AU7742491A (en) * 1990-04-12 1991-11-11 Stereo-Chemical Genetics, Inc. Synthetic piperidinediones with cytostatic activity
US5089508A (en) * 1990-09-04 1992-02-18 Burzynski Stanislaw R Methods for treating aids
US5116622A (en) * 1990-09-12 1992-05-26 Burzynski Stanislaw R Methods for treating parkinson's disease
US5605930A (en) * 1991-10-21 1997-02-25 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for treating and preventing pathologies including cancer
US5635532A (en) * 1991-10-21 1997-06-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia
US6037376A (en) * 1991-10-21 2000-03-14 The United States Of America As Represented By The Department Of Health And Human Services Methods for therapy of cancer
EP0567613B1 (de) * 1991-10-21 2002-02-20 The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services Zusammensetzungen zur behandlung und vorbeugung von krebs
IT1257184B (it) * 1992-12-22 1996-01-10 Applied Research Systems Preparato ad attivita' antinfiammatoria, anticoagulante e antitumorale
US5783605A (en) * 1995-02-27 1998-07-21 Kuo; Sheng-Chu Helper inducers for differentiation therapy and chemoprevention of cancer
US6013278A (en) * 1996-05-14 2000-01-11 Burzynski Research Institute Liposomal antineoplaston therapies with markedly improved antineoplastic activity
EP2298350A3 (de) * 1996-07-26 2011-06-08 Susan P. Perrine Zusammensetzung enthaltend einen induzierenden wikstoff und einen antiviralen wirkstoff zur behandlung von viralen störungen
US6258849B1 (en) 1998-07-23 2001-07-10 Stanislaw R. Burzynski Treatment regimen for administration of phenylacetylglutamine, phenylacetylisoglutamine, and/or phenylacetate
US6127419A (en) * 1998-11-23 2000-10-03 Burzynski; Stanislaw R. Phenylacetic acid compositions for treating or preventing atherosclerosis and restenosis
AU1553799A (en) * 1998-12-18 2000-07-12 Chang, Ming-Lieh Pharmaceutical composition inducing cancer cell differentiation and the use for treatment and prevention of cancer thereof
US6987131B1 (en) * 2000-06-26 2006-01-17 Burzynski Stanislaw R Phenylacetic acid compositions for treating or preventing hypercholesterolemia
CN1802152A (zh) * 2002-08-01 2006-07-12 艾斯根公司 用谷氨酰胺改善癌症的治疗
US20060246016A1 (en) * 2003-05-28 2006-11-02 Burzynski Stanislaw R Toothpaste containing anticancer agents
US7087219B2 (en) * 2003-05-28 2006-08-08 Stanislaw R. Burzynski Toothpaste containing anticancer agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE463549A (de) *
GB2003887A (en) * 1977-09-06 1979-03-21 Nyegaard & Co As Isolation of peptides from urine
JPS57115330A (en) * 1981-01-08 1982-07-17 Toshiba Mach Co Ltd Forming process for thick plastic products and its metal mold
JP2897285B2 (ja) * 1989-10-19 1999-05-31 東洋紡績株式会社 熱可塑性樹脂フィルム積層物

Also Published As

Publication number Publication date
NO822218L (no) 1983-01-03
DK162813C (da) 1992-05-04
DK143491A (da) 1991-08-06
EP0069232A2 (de) 1983-01-12
US4470970A (en) 1984-09-11
ES8502417A1 (es) 1985-01-01
SG4489G (en) 1989-05-26
DK162813B (da) 1991-12-16
CA1262907C (de) 1989-11-14
AU8423982A (en) 1983-01-06
JPH0558886A (ja) 1993-03-09
IL65960A0 (en) 1982-09-30
DK143491D0 (da) 1991-08-06
EP0069232B1 (de) 1986-10-29
CA1188218A (en) 1985-06-04
NZ200805A (en) 1986-08-08
AU551109B2 (en) 1986-04-17
IL65960A (en) 1985-11-29
JPH0780764B2 (ja) 1995-08-30
DK242082A (da) 1983-01-03
JPH0729925B2 (ja) 1995-04-05
HK30289A (en) 1989-04-21
JPH0739390B2 (ja) 1995-05-01
EP0069232A3 (en) 1984-07-04
NO163595C (no) 1990-06-27
MY102918A (en) 1993-03-31
ES512894A0 (es) 1985-01-01
NO163595B (no) 1990-03-19
JPS5810521A (ja) 1983-01-21
JPH0532548A (ja) 1993-02-09

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