DE3262536D1 - N-dihydrothiazolyl-3-quinoleine carboxyamide derivatives, their salts, their preparation and use as pharmaceutical preparations, and pharmaceutical preparations containing them - Google Patents

N-dihydrothiazolyl-3-quinoleine carboxyamide derivatives, their salts, their preparation and use as pharmaceutical preparations, and pharmaceutical preparations containing them

Info

Publication number
DE3262536D1
DE3262536D1 DE8282401062T DE3262536T DE3262536D1 DE 3262536 D1 DE3262536 D1 DE 3262536D1 DE 8282401062 T DE8282401062 T DE 8282401062T DE 3262536 T DE3262536 T DE 3262536T DE 3262536 D1 DE3262536 D1 DE 3262536D1
Authority
DE
Germany
Prior art keywords
pharmaceutical preparations
quinoleine
dihydrothiazolyl
salts
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282401062T
Other languages
German (de)
English (en)
Inventor
Francois Clemence
Peter Francis Hunt
Martret Odile Le
Daniel Humbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8111607A external-priority patent/FR2507602A1/fr
Priority claimed from FR8204331A external-priority patent/FR2523130A1/fr
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of DE3262536D1 publication Critical patent/DE3262536D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE8282401062T 1981-06-12 1982-06-11 N-dihydrothiazolyl-3-quinoleine carboxyamide derivatives, their salts, their preparation and use as pharmaceutical preparations, and pharmaceutical preparations containing them Expired DE3262536D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8111607A FR2507602A1 (fr) 1981-06-12 1981-06-12 Nouveau derive dihydrothiazole de la quinoleine, ses sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR8204331A FR2523130A1 (fr) 1982-03-15 1982-03-15 Nouveaux derives de la n-dihydrothiazolyl-3-quinoleine carboxamide, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant

Publications (1)

Publication Number Publication Date
DE3262536D1 true DE3262536D1 (en) 1985-04-18

Family

ID=26222434

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282401062T Expired DE3262536D1 (en) 1981-06-12 1982-06-11 N-dihydrothiazolyl-3-quinoleine carboxyamide derivatives, their salts, their preparation and use as pharmaceutical preparations, and pharmaceutical preparations containing them

Country Status (16)

Country Link
US (1) US4450166A (ko)
EP (1) EP0067772B1 (ko)
KR (1) KR880000808B1 (ko)
AU (1) AU552029B2 (ko)
CA (1) CA1216795A (ko)
DE (1) DE3262536D1 (ko)
DK (1) DK150070C (ko)
ES (1) ES8304567A1 (ko)
FI (1) FI78087C (ko)
GR (1) GR77201B (ko)
HU (1) HU190796B (ko)
IE (1) IE53520B1 (ko)
IL (1) IL65943A (ko)
MA (1) MA19488A1 (ko)
NZ (1) NZ200931A (ko)
PT (1) PT75023B (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2557570B1 (fr) * 1984-01-04 1986-04-18 Adir Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
US4602014A (en) * 1984-07-09 1986-07-22 Ciba-Geigy Corporation Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodiazepine receptor modulators
US4560692A (en) * 1984-07-18 1985-12-24 Hoffmann-La Roche Inc. 4-Piperidino-2-phenylquinolines
US4786644A (en) * 1987-11-27 1988-11-22 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-quinolinecarboxamide
DE69925462T2 (de) * 1998-02-26 2006-02-02 Neurogen Corp., Branford Substituierte cycloalkyl-4-oxonicotinische karboxamide; gaba gehirn-rezeptorligande
EP1177177B1 (en) * 1999-05-06 2005-02-23 Neurogen Corporation Substituted 4-oxo-quinoline-3-carboxamides: gaba brain receptor ligands
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
EP2489659B1 (en) 2004-06-24 2017-12-13 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
JP2009521468A (ja) * 2005-12-24 2009-06-04 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｂｃ輸送体の調節因子としてのキノリン−４−オン誘導体
ES2790700T3 (es) 2005-12-28 2020-10-28 Vertex Pharma Composiciones farmacéuticas de la forma amorfa de N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida
BRPI1011506B8 (pt) 2009-03-20 2021-05-25 Vertex Pharma processo para a fabricação de moduladores de regulador de condutância de transmembrana de fibrose cística
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
CN104470518A (zh) 2012-02-27 2015-03-25 沃泰克斯药物股份有限公司 药物组合物及其施用
WO2016057730A1 (en) 2014-10-07 2016-04-14 Strohmeier Mark Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1364605A (fr) * 1962-03-01 1964-06-26 Procédé de préparation d'amides des acides carboxyliques
FR2281761A1 (fr) * 1974-08-13 1976-03-12 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2324304A2 (fr) * 1975-09-22 1977-04-15 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2340735A1 (fr) * 1976-02-11 1977-09-09 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2377400A2 (fr) * 1977-01-18 1978-08-11 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2443467A1 (fr) * 1978-12-08 1980-07-04 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2482596A1 (fr) * 1980-05-19 1981-11-20 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament

Also Published As

Publication number Publication date
GR77201B (ko) 1984-09-11
ES512852A0 (es) 1983-03-01
FI822067A0 (fi) 1982-06-10
ES8304567A1 (es) 1983-03-01
US4450166A (en) 1984-05-22
KR880000808B1 (ko) 1988-05-11
DK150070B (da) 1986-12-01
AU552029B2 (en) 1986-05-22
IL65943A (en) 1985-12-31
FI78087B (fi) 1989-02-28
DK262782A (da) 1982-12-13
FI78087C (fi) 1989-06-12
AU8482782A (en) 1982-12-16
PT75023A (fr) 1982-07-01
EP0067772A1 (fr) 1982-12-22
IL65943A0 (en) 1982-09-30
NZ200931A (en) 1984-12-14
IE821394L (en) 1982-12-12
EP0067772B1 (fr) 1985-03-13
PT75023B (fr) 1985-05-17
MA19488A1 (fr) 1982-12-31
HU190796B (en) 1986-11-28
KR840000541A (ko) 1984-02-25
IE53520B1 (en) 1988-12-07
DK150070C (da) 1987-11-09
CA1216795A (fr) 1987-01-20

Similar Documents

Publication Publication Date Title
IL65257A0 (en) Arylcyclo-butanealkylamine derivatives,their preparation and pharmaceutical compositions containing them
IL65963A0 (en) Bis-triazole derivative and salts thereof,their preparation and pharmaceutical compositions containing them
DE3262516D1 (en) Omega-cyano-1, omega-diphenyl azalcane derivatives, their preparation and pharmaceutical preparations containing them
IL78605A0 (en) Xanthine derivatives,their preparation and pharmaceutical compositions containing them
IL65803A (en) Cyclobutene-dione derivatives,their preparation and pharmaceutical compositions containing them
ZA83403B (en) Phenylethylene derivatives,their preparation and their use as drugs
IL64777A0 (en) 3-aminopropoxyaryl derivatives,their preparation and pharmaceutical compositions containing them
IL66408A (en) 3-amino-pyridazine derivatives,their preparation and pharmaceutical compositions containing them
DE3262536D1 (en) N-dihydrothiazolyl-3-quinoleine carboxyamide derivatives, their salts, their preparation and use as pharmaceutical preparations, and pharmaceutical preparations containing them
IL67180A0 (en) Morphinate derivatives,their preparation and pharmaceutical compositions containing them
DE3266442D1 (en) Phenylethylene derivatives, their preparation and use as medicines
ZA821957B (en) Acylquinolinone derivatives, processes for their manufacture, pharmaceutical preparations containing them and their use
IL66424A (en) 3-amino-pyridazine derivatives,their preparation and pharmaceutical compositions containing them
ZA844563B (en) 13alpha-alkylgonanes,their preparation and pharmaceutical preparations containing them
IL66227A0 (en) Amidobenzamides and their salts,their preparation and pharmaceutical compositions containing them
IL66238A0 (en) Benzothiazolesulfonamide derivatives,their preparation and pharmaceutical compositions containing them
IL65422A0 (en) 2-piperazino-pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
IL65216A (en) Guanidinoheteroaromatic amide derivatives,their preparation and pharmaceutical preparations containing them
DE3168978D1 (en) Thiazoline derivatives, their preparation and use and pharmaceutical preparations containing them
DE3267528D1 (en) Aminocyclitol derivatives, their preparation and pharmaceutical preparations containing them
DE3375783D1 (en) Phenyl-acetic-acid derivatives, their preparation and pharmaceutical compostions containing them
IL72480A0 (en) Benzamidine derivatives,their preparation and pharmaceutical compositions containing them
IL65541A0 (en) Alkylamino-2-propanols,process for their preparation and pharmaceutical preparations containing same
DE3260949D1 (en) Benzoyl-phenyl-piperidine derivatives, their preparation and medicinal use
IL65965A0 (en) 4-amino-benzylamine derivatives,their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee