DE3226552C2 - - Google Patents
Info
- Publication number
- DE3226552C2 DE3226552C2 DE3226552A DE3226552A DE3226552C2 DE 3226552 C2 DE3226552 C2 DE 3226552C2 DE 3226552 A DE3226552 A DE 3226552A DE 3226552 A DE3226552 A DE 3226552A DE 3226552 C2 DE3226552 C2 DE 3226552C2
- Authority
- DE
- Germany
- Prior art keywords
- electrode
- electrochemical cell
- cell according
- reaction chamber
- measuring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000006243 chemical reaction Methods 0.000 claims description 39
- 238000005259 measurement Methods 0.000 claims description 26
- 239000000126 substance Substances 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 12
- 150000002500 ions Chemical class 0.000 claims description 11
- 239000007789 gas Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 3
- 108010093096 Immobilized Enzymes Proteins 0.000 claims 1
- 239000004020 conductor Substances 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 238000012883 sequential measurement Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 description 20
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 10
- 239000008103 glucose Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 5
- 239000004202 carbamide Substances 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 102000003914 Cholinesterases Human genes 0.000 description 1
- 108090000322 Cholinesterases Proteins 0.000 description 1
- 102000005548 Hexokinase Human genes 0.000 description 1
- 108700040460 Hexokinases Proteins 0.000 description 1
- -1 NH4+ ion Chemical class 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- XKMRRTOUMJRJIA-UHFFFAOYSA-N ammonia nh3 Chemical compound N.N XKMRRTOUMJRJIA-UHFFFAOYSA-N 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229940048961 cholinesterase Drugs 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000005351 kimble Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000012723 sample buffer Substances 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22887/81A IT1167468B (it) | 1981-07-13 | 1981-07-13 | Cella elettrochimica dotata di elettrodi selettivi ed almeno un reattore chimico, atta alla misura indiretta di parametri chimico-clinici, e metodo di misura impiegante tale cella |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3226552A1 DE3226552A1 (de) | 1983-02-17 |
| DE3226552C2 true DE3226552C2 (US07922777-20110412-C00004.png) | 1992-04-23 |
Family
ID=11201552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19823226552 Granted DE3226552A1 (de) | 1981-07-13 | 1982-07-13 | Elektrochemische zelle zum messen klinisch-chemischer parameter |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4490235A (US07922777-20110412-C00004.png) |
| DE (1) | DE3226552A1 (US07922777-20110412-C00004.png) |
| GB (1) | GB2102962B (US07922777-20110412-C00004.png) |
| IT (1) | IT1167468B (US07922777-20110412-C00004.png) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946651A (en) * | 1985-11-15 | 1990-08-07 | Smithkline Diagnostics, Inc. | Sample holder for a body fluid analyzer |
| US4935106A (en) * | 1985-11-15 | 1990-06-19 | Smithkline Diagnostics, Inc. | Ion selective/enzymatic electrode medical analyzer device and method of use |
| DE3624075A1 (de) * | 1986-07-17 | 1988-06-16 | Henning Hans Georg | Anordnung und verfahren zur erfassung von schadstoffen in gasen, fluessigkeiten und festen stoffen |
| FI80800C (fi) * | 1986-10-03 | 1990-07-10 | Kone Oy | Foerfarande foer bestaemning av den totala karbonathalten speciellt i en biologisk vaetska. |
| DE3639797C1 (en) * | 1986-11-21 | 1988-02-25 | Fresenius Ag | Method and device for monitoring the correct composition of dialysis solution, in particular for bicarbonate dialysis |
| US4891104A (en) * | 1987-04-24 | 1990-01-02 | Smithkline Diagnostics, Inc. | Enzymatic electrode and electrode module and method of use |
| US4997627A (en) * | 1987-07-17 | 1991-03-05 | Fisher Scientific Company | Sample analysis |
| US5158868A (en) * | 1987-07-17 | 1992-10-27 | Iniziative Marittime 1991, S.R.L. | Method of sample analysis |
| US5206145A (en) * | 1988-05-19 | 1993-04-27 | Thorn Emi Plc | Method of measuring the concentration of a substance in a sample solution |
| US5037737A (en) * | 1988-06-29 | 1991-08-06 | Apec, Inc. | Analysis by sensor placement in recprocating flow |
| IT1226234B (it) * | 1988-07-08 | 1990-12-27 | Instrumentation Lab Spa | Cella elettrochimica per misurare l'attivita' ionica in una soluzionee metodo per il suo impiego |
| US5133937A (en) * | 1989-06-01 | 1992-07-28 | Iniziative Marittime, 1991 S.R.L. | Analysis system having a removable reaction cartridge and temperature control |
| DE4029746A1 (de) * | 1990-09-20 | 1992-04-02 | Joachim Hermann Dr Med Lehner | Vorrichtung und verfahren zur gleichzeitigen messung verschiedener physikalischer und chemischer parameter einer fluessigkeit |
| DE4328689A1 (de) * | 1993-08-26 | 1995-03-02 | Beiersdorf Ag | Verfahren zur Detektion und Zählung von Mikroorganismen |
| ATE315225T1 (de) * | 1996-03-29 | 2006-02-15 | Byk Gulden Italia Spa | Automatische diagnosevorrichtung |
| GB2312750A (en) * | 1996-05-02 | 1997-11-05 | Univ Degli Studi Milano | Differential pH measurement apparatus |
| US9297797B2 (en) * | 2009-07-01 | 2016-03-29 | Beckman Coulter, Inc. | Ion selective electrode module for clinical diagnostics |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3151052A (en) * | 1962-05-17 | 1964-09-29 | Beckman Instruments Inc | Electrochemical flow cell |
| US3306837A (en) * | 1963-05-09 | 1967-02-28 | Corning Glass Works | Glass electrode apparatus and process for making same |
| US3479255A (en) * | 1964-01-27 | 1969-11-18 | Beckman Instruments Inc | Electrochemical transducer |
| US3408269A (en) * | 1965-04-30 | 1968-10-29 | Beckman Instruments Inc | Analysis of organic materials |
| US3707455A (en) * | 1968-07-15 | 1972-12-26 | Ibm | Measuring system |
| US3620931A (en) * | 1968-11-12 | 1971-11-16 | Westinghouse Electric Corp | Gas analysis method |
| US3865708A (en) * | 1969-12-22 | 1975-02-11 | Foxboro Co | Apparatus for measuring ionic concentration |
| US3896008A (en) * | 1971-10-28 | 1975-07-22 | Owens Illinois Inc | Electrochemical potentiometric method for selectively determining alkaline phosphatase content in aqueous fluids |
| US3846257A (en) * | 1972-01-19 | 1974-11-05 | Orion Research | Electrochemical monitoring |
| CA1096940A (en) * | 1977-12-05 | 1981-03-03 | The Babcock & Wilcox Company | High temperature reference electrode |
-
1981
- 1981-07-13 IT IT22887/81A patent/IT1167468B/it active
-
1982
- 1982-07-07 US US06/396,090 patent/US4490235A/en not_active Expired - Fee Related
- 1982-07-12 GB GB08220213A patent/GB2102962B/en not_active Expired
- 1982-07-13 DE DE19823226552 patent/DE3226552A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE3226552A1 (de) | 1983-02-17 |
| GB2102962A (en) | 1983-02-09 |
| GB2102962B (en) | 1985-09-25 |
| US4490235A (en) | 1984-12-25 |
| IT8122887A0 (it) | 1981-07-13 |
| IT1167468B (it) | 1987-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8125 | Change of the main classification |
Ipc: G01N 27/46 |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |