DE3150916C2 - - Google Patents

Info

Publication number
DE3150916C2
DE3150916C2 DE3150916A DE3150916A DE3150916C2 DE 3150916 C2 DE3150916 C2 DE 3150916C2 DE 3150916 A DE3150916 A DE 3150916A DE 3150916 A DE3150916 A DE 3150916A DE 3150916 C2 DE3150916 C2 DE 3150916C2
Authority
DE
Germany
Prior art keywords
diamide
hydroxyethyl
acid bis
general formula
trihydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3150916A
Other languages
German (de)
English (en)
Other versions
DE3150916A1 (de
Inventor
Heinrich Dr. Pfeiffer
Wolfgang Dr. Muetzel
Ulrich Dr. 1000 Berlin De Speck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE19813150916 priority Critical patent/DE3150916A1/de
Priority to DK544682A priority patent/DK544682A/da
Priority to ES518180A priority patent/ES518180A0/es
Priority to IL67468A priority patent/IL67468A0/xx
Priority to GR70102A priority patent/GR78422B/el
Priority to EP82730146A priority patent/EP0082803A1/de
Priority to JP57219354A priority patent/JPS58110551A/ja
Priority to NO824252A priority patent/NO824252L/no
Priority to CA000418020A priority patent/CA1189533A/en
Priority to US06/451,374 priority patent/US4547357A/en
Priority to AU91654/82A priority patent/AU9165482A/en
Publication of DE3150916A1 publication Critical patent/DE3150916A1/de
Application granted granted Critical
Publication of DE3150916C2 publication Critical patent/DE3150916C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE19813150916 1981-12-18 1981-12-18 N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel" Granted DE3150916A1 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE19813150916 DE3150916A1 (de) 1981-12-18 1981-12-18 N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
DK544682A DK544682A (da) 1981-12-18 1982-12-08 N-hydroxyethylerede 2,4,6-trijodaminoisophthalsyre-bis-trihydroxybutylamider, deres fremstilling og roentgenkontrastmidler indeholdende dem
IL67468A IL67468A0 (en) 1981-12-18 1982-12-14 N-hydroxyethylated 2,4,6-triiodoaminoisophthalic acid bis-trihydroxybutylamides,x-ray contrast preparations containing the same and methods for the preparation thereof
ES518180A ES518180A0 (es) 1981-12-18 1982-12-14 Procedimiento para la preparacion de bis-trihidroxibutil-amidas de acidos 2,4,6-triyodoaminoisoftalicos, hidroxietiladas en n.
EP82730146A EP0082803A1 (de) 1981-12-18 1982-12-16 N-Hydroxyäthylierte 2,4,6-trijodaminoisophthalsäure-bis-trihydroxybutylamide, deren Herstellung und diese enthaltende Röntgenkontrastmittel
JP57219354A JPS58110551A (ja) 1981-12-18 1982-12-16 Ｎ−ヒドロキシエチル化２，４，６−トリヨ−ドアミノイソフタル酸−ビス−トリヒドロキシブチルアミド、その製法及び該化合物からなるレントゲン造影剤
GR70102A GR78422B (en, 2012) 1981-12-18 1982-12-16
NO824252A NO824252L (no) 1981-12-18 1982-12-17 N-hydroxyethylerte 2,4,6-trijodisofthalsyre-bis-trihydroxybutylamider, fremstilling av disse og roentgenkontrastmidler inneholdende disse
CA000418020A CA1189533A (en) 1981-12-18 1982-12-17 N-hydroxyethylated 2,4,6-triiodo-aminoisophthalic acid bis-trihydroxybutylamides, their manufacture and their use as x-ray contrast agents
US06/451,374 US4547357A (en) 1981-12-18 1982-12-20 N-Hydroxyethylated 2,4,6-triiodoaminoisophthalic acid bistrihydroxybutylamides, their preparation and x-ray contrast media containing them
AU91654/82A AU9165482A (en) 1981-12-18 1982-12-20 X-ray contrast agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813150916 DE3150916A1 (de) 1981-12-18 1981-12-18 N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"

Publications (2)

Publication Number Publication Date
DE3150916A1 DE3150916A1 (de) 1983-06-30
DE3150916C2 true DE3150916C2 (en, 2012) 1990-11-22

Family

ID=6149449

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19813150916 Granted DE3150916A1 (de) 1981-12-18 1981-12-18 N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"

Country Status (10)

Country Link
US (1) US4547357A (en, 2012)
EP (1) EP0082803A1 (en, 2012)
JP (1) JPS58110551A (en, 2012)
AU (1) AU9165482A (en, 2012)
CA (1) CA1189533A (en, 2012)
DE (1) DE3150916A1 (en, 2012)
DK (1) DK544682A (en, 2012)
ES (1) ES518180A0 (en, 2012)
GR (1) GR78422B (en, 2012)
NO (1) NO824252L (en, 2012)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
US4584401A (en) * 1983-10-20 1986-04-22 Biophysica Foundation Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
US4954348A (en) * 1985-08-09 1990-09-04 Cook Imaging Corporation Non-ionic polyol contrast media from ionic contrast media
US5035877A (en) * 1985-08-09 1991-07-30 Cook Imaging Corporation Non-ionic contrast media from ionic contrast media
DE3689330T2 (de) * 1985-08-09 1994-05-19 Cook Imaging Corp Nichtionische polyolkontrastmittel aus ionischen kontrastmitteln.
JPH0420687Y2 (en, 2012) * 1986-10-21 1992-05-12
NZ224743A (en) * 1987-05-22 1991-07-26 Bracco Ind Chimica Spa 5-acylamino-2,4,6-tribromo- or triiodo-benzoic acid derivatives and intermediate compounds used in their preparation
IL94718A (en) * 1989-07-05 1994-10-21 Schering Ag Non-ionic carboxamide contrast agent and method of preparation
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
US5614638A (en) * 1989-11-29 1997-03-25 Bracco International B.V. Nonionic radiographic contrast agents
IL96324A (en) * 1989-11-29 1995-01-24 Squibb & Sons Inc 5-Amino-2, 4, 6-triiodo-1, 3-benzenecarboxylic acid derivatives, processes for their preparation, and methods utilizing them as contrast agents
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4109169A1 (de) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung
US5318770A (en) * 1991-10-25 1994-06-07 Mallinckrodt Medical, Inc. Trifluoromethyl analogs of X-ray contrast media for magnetic resonance imaging
FR2687669B1 (fr) * 1992-02-24 1997-12-19 Guerbet Sa Composes utilisables dans des produits de contraste pour la radiographie.
US5278311A (en) * 1992-06-05 1994-01-11 E. R. Squibb & Sons, Inc. Nonionic radiographic contrast agents
IT1256162B (it) * 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
IL110391A (en) * 1993-07-30 1998-12-06 Zambon Spa Process for the crystallization of iopamidol
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
IL265536B (en) 2016-09-27 2022-07-01 Bayer Pharma AG Method for producing the crystalline form of modification a of calcobutrol
WO2018104228A1 (en) * 2016-12-05 2018-06-14 Bracco Imaging Spa Mechanochemical synthesis of radiographic agents intermediates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021481A (en) * 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
IE34927B1 (en) * 1969-06-27 1975-10-01 Nyegaard & Co As Non-ionic iodinated x-ray contrast agents
GB1495679A (en) * 1974-06-17 1977-12-21 Mallinckrodt Inc Substituted isophthalamic acids
CH608189A5 (en, 2012) * 1974-12-13 1978-12-29 Savac Ag
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
CA1132901A (en) * 1978-07-04 1982-10-05 Fridtjov B. Rakli Aniline x-ray agent and buffer whose ph decreases with temperature
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
US4341756A (en) * 1980-01-31 1982-07-27 The Regents Of The University Of California Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent

Also Published As

Publication number Publication date
JPH039900B2 (en, 2012) 1991-02-12
CA1189533A (en) 1985-06-25
DE3150916A1 (de) 1983-06-30
US4547357A (en) 1985-10-15
NO824252L (no) 1983-06-20
ES8308535A1 (es) 1983-10-01
GR78422B (en, 2012) 1984-09-27
ES518180A0 (es) 1983-10-01
DK544682A (da) 1983-06-19
JPS58110551A (ja) 1983-07-01
AU9165482A (en) 1983-06-23
EP0082803A1 (de) 1983-06-29

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SCHERING AG, 13353 BERLIN, DE

8330 Complete renunciation