DE3071409D1 - Furyl intermediates of cardenolides, their synthesis and production of cardenolides and their isomers therefrom - Google Patents

Furyl intermediates of cardenolides, their synthesis and production of cardenolides and their isomers therefrom

Info

Publication number
DE3071409D1
DE3071409D1 DE8080303433T DE3071409T DE3071409D1 DE 3071409 D1 DE3071409 D1 DE 3071409D1 DE 8080303433 T DE8080303433 T DE 8080303433T DE 3071409 T DE3071409 T DE 3071409T DE 3071409 D1 DE3071409 D1 DE 3071409D1
Authority
DE
Germany
Prior art keywords
cardenolides
furyl
intermediates
synthesis
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080303433T
Other languages
German (de)
English (en)
Inventor
Karel Wiesner
Thomas Y R C O University Tsai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Advance Biofactures Corp
Original Assignee
Advance Biofactures Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advance Biofactures Corp filed Critical Advance Biofactures Corp
Application granted granted Critical
Publication of DE3071409D1 publication Critical patent/DE3071409D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8080303433T 1979-09-28 1980-09-29 Furyl intermediates of cardenolides, their synthesis and production of cardenolides and their isomers therefrom Expired DE3071409D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/080,004 US4259240A (en) 1979-09-28 1979-09-28 Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom

Publications (1)

Publication Number Publication Date
DE3071409D1 true DE3071409D1 (en) 1986-03-20

Family

ID=22154308

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080303433T Expired DE3071409D1 (en) 1979-09-28 1980-09-29 Furyl intermediates of cardenolides, their synthesis and production of cardenolides and their isomers therefrom

Country Status (6)

Country Link
US (1) US4259240A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0027023B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JPS5657800A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE17856T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1159050A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3071409D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4380624A (en) * 1981-07-31 1983-04-19 Advance Biofactures Corp. Novel isomers of bufalin and resibufogenin and their preparation
CA1241324A (en) * 1984-03-08 1988-08-30 Paul A. Aristoff Interphenylene carbacyclin derivatives
GB8606105D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Chemical compounds
DE4221636C1 (de) * 1992-07-01 1994-03-31 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate
DE4221635C1 (de) * 1992-07-01 1994-05-05 Sigma Tau Ind Farmaceuti 3beta-Digitoxigenin- und 3beta-Dihydrodigitoxigenin-Derivate
DE4221538C1 (de) * 1992-07-01 1994-03-31 Sigma Tau Ind Farmaceuti 14-Desoxy-14alpha-cardenolid-3beta-thioderivate
JPH09511214A (ja) * 1993-10-27 1997-11-11 メレルファーマス−ティカルズ インコーポレイテッド ステロイドｃ▲下１７−２０▼リアーゼ阻害剤として有用なδ▲上１６▼不飽和ｃ▲下１７▼複素環ステロイド類
CN102964417A (zh) * 2012-11-30 2013-03-13 华中药业股份有限公司 17-羟基四氢吡喃醚甾族化合物的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3398138A (en) * 1966-05-24 1968-08-20 American Home Prod Novel cardenolides and derivatives
GB1553222A (en) * 1975-05-07 1979-09-26 Steele Chemical Co Ltd 14 - hydroxy 3- eoxycardenolides
DE2744255A1 (de) * 1976-10-05 1978-04-06 Ciba Geigy Ag Verfahren zur herstellung neuer steroidverbindungen mit 19-staendiger sauerstoffunktion

Also Published As

Publication number Publication date
US4259240A (en) 1981-03-31
JPH0372240B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-11-18
EP0027023A1 (en) 1981-04-15
JPH0210840B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-03-09
CA1159050A (en) 1983-12-20
EP0027023B1 (en) 1986-02-05
JPH0276897A (ja) 1990-03-16
JPS5657800A (en) 1981-05-20
ATE17856T1 (de) 1986-02-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee