DE3071053D1 - Vibrio cholerae mutants, vaccine comprising them, method for preparing a subunit therefrom and composition comprising it - Google Patents

Vibrio cholerae mutants, vaccine comprising them, method for preparing a subunit therefrom and composition comprising it

Info

Publication number
DE3071053D1
DE3071053D1 DE8080301116T DE3071053T DE3071053D1 DE 3071053 D1 DE3071053 D1 DE 3071053D1 DE 8080301116 T DE8080301116 T DE 8080301116T DE 3071053 T DE3071053 T DE 3071053T DE 3071053 D1 DE3071053 D1 DE 3071053D1
Authority
DE
Germany
Prior art keywords
vaccine
preparing
composition
vibrio cholerae
mutants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080301116T
Other languages
English (en)
Inventor
Takeshi Honda
Richard A Finkelstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Application granted granted Critical
Publication of DE3071053D1 publication Critical patent/DE3071053D1/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/107—Vibrio
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/63—Vibrio
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/909—Vibrio

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE8080301116T 1979-04-11 1980-04-08 Vibrio cholerae mutants, vaccine comprising them, method for preparing a subunit therefrom and composition comprising it Expired DE3071053D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/029,092 US4328209A (en) 1979-04-11 1979-04-11 Cholera vaccine

Publications (1)

Publication Number Publication Date
DE3071053D1 true DE3071053D1 (en) 1985-10-10

Family

ID=21847167

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080301116T Expired DE3071053D1 (en) 1979-04-11 1980-04-08 Vibrio cholerae mutants, vaccine comprising them, method for preparing a subunit therefrom and composition comprising it

Country Status (4)

Country Link
US (1) US4328209A (de)
EP (1) EP0018154B1 (de)
JP (2) JPS5612319A (de)
DE (1) DE3071053D1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681762A (en) * 1979-05-23 1987-07-21 Research Corporation Genetically attenuated bacterial vaccines with multiple mutations of the same phenotype
EP0076636B1 (de) * 1981-09-30 1988-02-24 National Research Development Corporation Zusammenstellungen mit verzögerter Abgabe
US4666837A (en) * 1982-05-24 1987-05-19 Smithkline-Rit DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits
DE3245411A1 (de) * 1982-12-08 1984-07-05 Gerhard Collardin GmbH, 5000 Köln Verfahren zur phosphatierung elektrolytisch verzinkter metallwaren
US5882653A (en) * 1983-03-04 1999-03-16 The University Of Maryland System Vibrio cholerae 01 (CVD111) and non-01 (CVD112 and CVD112RM) serogroup vaccine strains, methods of making same and products thereof
US4935364A (en) * 1983-03-04 1990-06-19 Swiss Serum And Vaccine Institute Berne Method of isolating restriction fragment deletions in vibrio cholerae and products thereof
US5135862A (en) * 1983-03-04 1992-08-04 University Of Maryland Method of isolating restriction fragment deletions in vibrio cholerae, products thereof
US5399494A (en) * 1983-03-04 1995-03-21 The University Of Maryland System Vibrio cholerae strain CVD103Hgr, method of making same, and vaccines derived therefrom
US5470729A (en) * 1983-03-04 1995-11-28 University Of Maryland At Baltimore Method of isolating restriction fragment deletions in Vibrio cholerae, and products thereof
US4882278A (en) * 1983-04-29 1989-11-21 President And Fellows Of Harvard College Non-toxinogenic vibrio cholerae mutants
GB8333131D0 (en) * 1983-12-12 1984-01-18 Glaxo Group Ltd Microbiological process
IT1217303B (it) * 1984-02-01 1990-03-22 Enterovax Res Pty Ltd Ceppi batterici particolarmente utili per la produzione di vaccini per il trattamenmto di malattie intestinali e simili e metodo di ingegneria gentica per la produzione dei detti vaccini
CA1340372C (en) * 1984-07-09 1999-02-02 John D. Clements Production of e. coli lt-b enterotoxin subunit
JPH02115129A (ja) * 1988-10-21 1990-04-27 Kokuritsu Yobou Eisei Kenkyusho 抗ウィルス剤
IL101715A (en) * 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs
GB9513371D0 (en) * 1995-06-30 1995-09-06 Biocine Spa Immunogenic detoxified mutant toxins
GB9326174D0 (en) * 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
US6818222B1 (en) 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
US7063852B2 (en) 2000-05-19 2006-06-20 The Administrators Of The Tulane Educational Fund Hybrid LT-A/CT-B holotoxin for use as an adjuvant
CA2416156A1 (en) * 2000-07-28 2002-02-07 University Of Maryland, Baltimore Accessory cholera enterotoxin and analogs thereof as activators of calcium dependent chloride channel
CA2512812A1 (en) * 2003-01-09 2004-07-29 The Trustees Of The University Of Pennsylvania Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector
KR100512433B1 (ko) * 2003-04-25 2005-09-05 전남대학교산학협력단 비브리오 패혈증균의 독력인자 발현을 조절하는범독력인자 발현 조절인자인 ｃＡＭＰ 수용체 단백질 및아데닐레이트 사이클라아제
JP2009163818A (ja) * 2008-01-07 2009-07-23 Nidec Sankyo Corp 磁気ヘッド

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145144A (en) * 1951-08-09 1964-08-18 Takeda Pharmacentical Ind Ltd Process for manufacturing chromium treated vaccines
US3329573A (en) * 1963-08-26 1967-07-04 Univ Colorado State Res Found Bovine vibriosis vaccine and method of administering same
US3328253A (en) * 1965-04-15 1967-06-27 Watanabe Yoshikazu Process for the production and purification of ogawa lipopolysaccharide cholera antigen
DE1792256C3 (de) * 1968-08-10 1979-07-05 Kali-Chemie Pharma Gmbh, 3000 Hannover Oral applizierbare, polyvalente Impfstoffe gegen lokale Darminfektionen
GB1452648A (en) * 1973-11-21 1976-10-13 American Home Prod Cholera toxoid
DE2364317C3 (de) * 1973-12-22 1979-10-11 Behringwerke Ag, 3550 Marburg Verfahren zur Isolierung von Choleragen
US4125492A (en) * 1974-05-31 1978-11-14 Pedro Cuatrecasas Affinity chromatography of vibrio cholerae enterotoxin-ganglioside polysaccharide and the biological effects of ganglioside-containing soluble polymers
DE2825619A1 (de) * 1977-06-22 1979-01-11 Sandoz Ag Vakzinen gegen ferkel-colibacillose und verfahren zu ihrer herstellung
US4264737A (en) * 1978-09-21 1981-04-28 President And Fellows Of Harvard College Method of making genetically stable mutants of vibrio cholerae

Also Published As

Publication number Publication date
EP0018154A2 (de) 1980-10-29
JPS5612319A (en) 1981-02-06
JPS6257305B2 (de) 1987-11-30
EP0018154A3 (en) 1981-05-27
JPS5877821A (ja) 1983-05-11
US4328209A (en) 1982-05-04
EP0018154B1 (de) 1985-09-04

Similar Documents

Publication Publication Date Title
DE3071053D1 (en) Vibrio cholerae mutants, vaccine comprising them, method for preparing a subunit therefrom and composition comprising it
DE3266201D1 (en) Infectious-bronchitis vaccines for poultry, combined infectious-bronchitis vaccines, process for preparing such vaccines and infectious-bronchitis virus strain
PT71436B (en) Process for preparing pharmaceutical compositions
PT76013B (en) Process for preparing interferon formulations
MY8500052A (en) 2-penem compounds, a method for their preparation and pharmaceutical compositions comprising them
YU316980A (en) Process for preparing 4,1',6'-trichloro-4,1',6'-trideoxy-galactosaccharose
DK159882A (da) Fremgangsmaade til fremstilling af omega-cyan-1,omega-diphenyl-azaalkanderivater
GB2058094B (en) Process for preparing terpolymers
PL232259A1 (en) Process for preparing pharmaceutical preparation
MW5688A1 (en) Process for preparing explosive
DE2862086D1 (en) Antigenic, immunogenic herpes virus subunit and process for preparing it
EG13435A (en) High molecular weight meningococal group c.vaccine and method for preparation thereof
EP0004793A3 (en) Process for preparing 2-aminopyrimidones, intermediate 2-nitroaminopyrimidones and a process for their preparation
YU87579A (en) Process for preparing n,n,n,n-tetraacetyl-ethylene diamine
ZA781876B (en) Pharmaceutical compositions,alkenyl xanthines contained therein and process for preparing them
GB2108999B (en) Cyclopentadiene derivatives, method for preparing, and use thereof
PT69207A (en) Process for preparing pharmaceutical formulations
DE2962306D1 (en) Stabilized ethylene-tetrafluoroethylene-type copolymers, process for preparing them and their use
IL60588A (en) Halovincamone derivatives,a process for the preparation thereof and vasodilating pharmaceutical compositions containing them
DE3071707D1 (en) 7-n-heterocyclyl cephalosporins, a process for preparing and a pharmaceutical composition comprising the same
EP0030255A3 (en) 2-hydroxyaclacinomycin a, pharmaceutical composition containing it; 2-hydroxyaclavinone and fermentative process for preparing same
DE3173289D1 (en) Xanthine derivatives, pharmaceutical compositions containing them and a process for their preparation
BG36934A3 (en) Method for preparing sulphuric- containing isoquinolinic derivatives
EP0164049A3 (en) Process for preparing hmg-coa reductase inhibtors with a 3,5-dihydroxypentanoate subunit
EP0300323A3 (en) Process for the preparation of aliphatic n,n-dialkyl substituted aminoalcohols

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee