DE3061229D1 - Ortho-tolyl ester of an alpha-carboxy penicillin, process for its preparation and pharmaceutical compositions comprising the penicillin - Google Patents
Ortho-tolyl ester of an alpha-carboxy penicillin, process for its preparation and pharmaceutical compositions comprising the penicillinInfo
- Publication number
- DE3061229D1 DE3061229D1 DE8080303378T DE3061229T DE3061229D1 DE 3061229 D1 DE3061229 D1 DE 3061229D1 DE 8080303378 T DE8080303378 T DE 8080303378T DE 3061229 T DE3061229 T DE 3061229T DE 3061229 D1 DE3061229 D1 DE 3061229D1
- Authority
- DE
- Germany
- Prior art keywords
- penicillin
- ortho
- alpha
- preparation
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182555 Penicillin Natural products 0.000 title 2
- 229940049954 penicillin Drugs 0.000 title 2
- -1 Ortho-tolyl ester Chemical class 0.000 title 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/72—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by carbon atoms having three bonds to hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/76—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with hetero rings directly attached to the carboxamido radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7934062 | 1979-10-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3061229D1 true DE3061229D1 (en) | 1983-01-05 |
Family
ID=10508217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8080303378T Expired DE3061229D1 (en) | 1979-10-02 | 1980-09-26 | Ortho-tolyl ester of an alpha-carboxy penicillin, process for its preparation and pharmaceutical compositions comprising the penicillin |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4385060A (enExample) |
| EP (1) | EP0026644B1 (enExample) |
| JP (1) | JPS5659781A (enExample) |
| KR (1) | KR850000474B1 (enExample) |
| AR (1) | AR227953A1 (enExample) |
| AU (1) | AU534572B2 (enExample) |
| CA (1) | CA1148941A (enExample) |
| DE (1) | DE3061229D1 (enExample) |
| DK (1) | DK415780A (enExample) |
| ES (1) | ES8106733A1 (enExample) |
| FI (1) | FI803015A7 (enExample) |
| GR (1) | GR70283B (enExample) |
| HK (1) | HK786A (enExample) |
| HU (1) | HU182676B (enExample) |
| IE (1) | IE50508B1 (enExample) |
| IL (1) | IL61031A0 (enExample) |
| MY (1) | MY8600395A (enExample) |
| NO (1) | NO802910L (enExample) |
| NZ (1) | NZ194912A (enExample) |
| PH (1) | PH17119A (enExample) |
| PL (3) | PL129141B1 (enExample) |
| PT (1) | PT71856B (enExample) |
| SG (1) | SG72685G (enExample) |
| YU (2) | YU249080A (enExample) |
| ZA (1) | ZA805665B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL67672A0 (en) * | 1982-01-22 | 1983-05-15 | Beecham Group Plc | Penicillin derivatives,their preparation and pharmaceutical compositions containing them |
| CZ303537B6 (cs) | 2000-03-09 | 2012-11-21 | Gw Pharma Limited | Použití konopí pri príprave farmaceutické formulace a pumpickové sprejové zarízení |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3853849A (en) * | 1969-05-29 | 1974-12-10 | Beecham Group Ltd | Alpha(aryloxycarbonyl)-and alpha(alkoxy-carbonyl)-aralkyl penicillins |
| GB1229670A (enExample) | 1968-09-03 | 1971-04-28 | ||
| BE759795A (fr) | 1969-12-11 | 1971-06-03 | Pfizer | Synthese de penicillines par l'intermediaire d'anhydrides mixtes de l'acide sulfurique |
| US4171303A (en) * | 1974-07-30 | 1979-10-16 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Process for the preparation of reactive penicillanic acid and cephalosporanic acid derivatives |
| GB1455529A (enExample) | 1975-02-27 | 1976-11-10 | ||
| JO984B1 (en) | 1977-10-11 | 1979-12-01 | بيتشام غروب ليمتد | A dry pharmaceutical compound with a suitable dosage unit for oral administration |
-
1980
- 1980-09-10 GR GR62854A patent/GR70283B/el unknown
- 1980-09-10 NZ NZ194912A patent/NZ194912A/xx unknown
- 1980-09-12 ZA ZA00805665A patent/ZA805665B/xx unknown
- 1980-09-14 IL IL61031A patent/IL61031A0/xx unknown
- 1980-09-22 US US06/189,622 patent/US4385060A/en not_active Expired - Lifetime
- 1980-09-25 FI FI803015A patent/FI803015A7/fi not_active Application Discontinuation
- 1980-09-26 EP EP80303378A patent/EP0026644B1/en not_active Expired
- 1980-09-26 DE DE8080303378T patent/DE3061229D1/de not_active Expired
- 1980-09-30 AU AU62830/80A patent/AU534572B2/en not_active Ceased
- 1980-09-30 KR KR1019800003787A patent/KR850000474B1/ko not_active Expired
- 1980-09-30 PT PT71856A patent/PT71856B/pt unknown
- 1980-09-30 YU YU02490/80A patent/YU249080A/xx unknown
- 1980-10-01 PL PL1980232295A patent/PL129141B1/pl unknown
- 1980-10-01 DK DK415780A patent/DK415780A/da unknown
- 1980-10-01 PL PL1980227022A patent/PL129153B1/pl unknown
- 1980-10-01 HU HU802394A patent/HU182676B/hu unknown
- 1980-10-01 CA CA000361314A patent/CA1148941A/en not_active Expired
- 1980-10-01 PL PL23229480A patent/PL232294A1/xx unknown
- 1980-10-01 ES ES495554A patent/ES8106733A1/es not_active Expired
- 1980-10-01 NO NO802910A patent/NO802910L/no unknown
- 1980-10-01 IE IE2045/80A patent/IE50508B1/en unknown
- 1980-10-02 JP JP13823280A patent/JPS5659781A/ja active Pending
- 1980-10-02 PH PH24658A patent/PH17119A/en unknown
-
1981
- 1981-12-21 AR AR287880A patent/AR227953A1/es active
-
1983
- 1983-02-25 YU YU00458/83A patent/YU45883A/xx unknown
-
1985
- 1985-10-05 SG SG726/85A patent/SG72685G/en unknown
-
1986
- 1986-01-02 HK HK7/86A patent/HK786A/xx unknown
- 1986-12-30 MY MY395/86A patent/MY8600395A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL232294A1 (enExample) | 1982-03-29 |
| JPS5659781A (en) | 1981-05-23 |
| HK786A (en) | 1986-01-10 |
| KR850000474B1 (ko) | 1985-04-08 |
| AR227953A1 (es) | 1982-12-30 |
| PL232295A1 (enExample) | 1982-03-29 |
| NZ194912A (en) | 1983-05-31 |
| EP0026644A1 (en) | 1981-04-08 |
| PH17119A (en) | 1984-06-01 |
| EP0026644B1 (en) | 1982-12-01 |
| CA1148941A (en) | 1983-06-28 |
| PT71856B (en) | 1981-07-09 |
| YU249080A (en) | 1983-06-30 |
| KR830003498A (ko) | 1983-06-21 |
| GR70283B (enExample) | 1982-09-03 |
| MY8600395A (en) | 1986-12-31 |
| ZA805665B (en) | 1981-09-30 |
| PT71856A (en) | 1980-10-01 |
| YU45883A (en) | 1983-12-31 |
| IE50508B1 (en) | 1986-04-30 |
| ES495554A0 (es) | 1981-09-01 |
| NO802910L (no) | 1981-04-03 |
| IL61031A0 (en) | 1980-11-30 |
| FI803015A7 (fi) | 1981-01-01 |
| PL129153B1 (en) | 1984-04-30 |
| SG72685G (en) | 1986-05-02 |
| IE802045L (en) | 1981-04-02 |
| AU534572B2 (en) | 1984-02-09 |
| DK415780A (da) | 1981-04-03 |
| ES8106733A1 (es) | 1981-09-01 |
| AU6283080A (en) | 1981-04-09 |
| US4385060A (en) | 1983-05-24 |
| PL227022A1 (enExample) | 1981-12-11 |
| HU182676B (en) | 1984-02-28 |
| PL129141B1 (en) | 1984-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8328 | Change in the person/name/address of the agent |
Free format text: JUNG, E., DIPL.-CHEM. DR.PHIL. SCHIRDEWAHN, J., DIPL.-PHYS. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN |
|
| 8339 | Ceased/non-payment of the annual fee |