DE3045153A1 - Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x - Google Patents

Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x

Info

Publication number
DE3045153A1
DE3045153A1 DE19803045153 DE3045153A DE3045153A1 DE 3045153 A1 DE3045153 A1 DE 3045153A1 DE 19803045153 DE19803045153 DE 19803045153 DE 3045153 A DE3045153 A DE 3045153A DE 3045153 A1 DE3045153 A1 DE 3045153A1
Authority
DE
Germany
Prior art keywords
factor
mol
factors
calcium
hepatitis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19803045153
Other languages
German (de)
English (en)
Inventor
Norbert Prof. Dipl.-Biol. 3550 Marburg Heimburger
Gerhardt 3552 Wetter Kumpe
Horst Dipl.-Chem. Dr. Schwinn
Wilfried 3575 Kirchhain Wormsbächer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Priority to DE19803045153 priority Critical patent/DE3045153A1/de
Priority to EP81109825A priority patent/EP0053338B1/de
Priority to AT81109825T priority patent/ATE11640T1/de
Priority to DE8181109825T priority patent/DE3168834D1/de
Priority to ES507400A priority patent/ES507400A0/es
Priority to US06/324,872 priority patent/US4405603A/en
Priority to JP56189354A priority patent/JPS57120524A/ja
Priority to CA000391129A priority patent/CA1182047A/en
Priority to AU77950/81A priority patent/AU544157B2/en
Priority to MX819785U priority patent/MX6947E/es
Priority to IL64396A priority patent/IL64396A/xx
Publication of DE3045153A1 publication Critical patent/DE3045153A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE19803045153 1980-11-29 1980-11-29 Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x Withdrawn DE3045153A1 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE19803045153 DE3045153A1 (de) 1980-11-29 1980-11-29 Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x
EP81109825A EP0053338B1 (de) 1980-11-29 1981-11-21 Verfahren zur Herstellung von Blutgerinnungsfaktoren
AT81109825T ATE11640T1 (de) 1980-11-29 1981-11-21 Verfahren zur herstellung von blutgerinnungsfaktoren.
DE8181109825T DE3168834D1 (en) 1980-11-29 1981-11-21 Process for the preparation of blood coagulation factors
ES507400A ES507400A0 (es) 1980-11-29 1981-11-24 Procedimiento para la produccion de un preparado, practica- mente seguro frente a hepatitis,de los factores de coagula- cion de sange ix y-o x.
US06/324,872 US4405603A (en) 1980-11-29 1981-11-25 Method for rendering factors IX and X hepatitis-safe with calcium ions
JP56189354A JPS57120524A (en) 1980-11-29 1981-11-27 Manufacture of blood coagulation factor medicine
CA000391129A CA1182047A (en) 1980-11-29 1981-11-27 Process for the production of blood-clotting factors and preparation of factors ix and x, prepared by this process
AU77950/81A AU544157B2 (en) 1980-11-29 1981-11-27 Production of stable blood clotting factors ix + x by warming with calcium ions
MX819785U MX6947E (es) 1980-11-29 1981-11-27 Procedimiento para la preparacion de un concentrado de los factores de coagulacion ix y x de la sangre
IL64396A IL64396A (en) 1980-11-29 1981-11-27 Process for the production of hepatitis-safe blood clotting factors ix and x

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803045153 DE3045153A1 (de) 1980-11-29 1980-11-29 Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x

Publications (1)

Publication Number Publication Date
DE3045153A1 true DE3045153A1 (de) 1982-07-08

Family

ID=6117972

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19803045153 Withdrawn DE3045153A1 (de) 1980-11-29 1980-11-29 Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x
DE8181109825T Expired DE3168834D1 (en) 1980-11-29 1981-11-21 Process for the preparation of blood coagulation factors

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8181109825T Expired DE3168834D1 (en) 1980-11-29 1981-11-21 Process for the preparation of blood coagulation factors

Country Status (10)

Country Link
US (1) US4405603A (cg-RX-API-DMAC7.html)
EP (1) EP0053338B1 (cg-RX-API-DMAC7.html)
JP (1) JPS57120524A (cg-RX-API-DMAC7.html)
AT (1) ATE11640T1 (cg-RX-API-DMAC7.html)
AU (1) AU544157B2 (cg-RX-API-DMAC7.html)
CA (1) CA1182047A (cg-RX-API-DMAC7.html)
DE (2) DE3045153A1 (cg-RX-API-DMAC7.html)
ES (1) ES507400A0 (cg-RX-API-DMAC7.html)
IL (1) IL64396A (cg-RX-API-DMAC7.html)
MX (1) MX6947E (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4001451A1 (de) * 1990-01-19 1991-08-01 Octapharma Ag Stabile injizierbare loesungen von faktor viii und faktor ix

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456590B2 (en) * 1981-11-02 1989-05-30 Heat treatment of lyphilized blood clotting factor viii concentrate
DE3230849A1 (de) * 1982-08-19 1984-02-23 Behringwerke Ag, 3550 Marburg Pasteurisiertes human-fibrinogen (hf) und verfahren zu dessen herstellung
DE3237512A1 (de) * 1982-10-09 1984-04-12 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von antihaemophilem kryopraezipitat (ahk) und danach hergestelltes antihaemophiles kryopraezipitat
ATE36457T1 (de) * 1983-05-02 1988-09-15 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen krankheitserregern.
US4764369A (en) * 1983-07-14 1988-08-16 New York Blood Center Inc. Undenatured virus-free biologically active protein derivatives
US4820805A (en) * 1983-07-14 1989-04-11 New York Blood Center, Inc. Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives
DE3330770A1 (de) * 1983-08-26 1985-03-14 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von humanplasma
US4615886A (en) * 1983-08-31 1986-10-07 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Utilizing a halohydrocarbon containing dissolved water to inactivate a lipid virus
DE3336631A1 (de) * 1983-10-08 1985-04-18 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von plasma oder von konzentraten der blutgerinnungsfaktoren ii, vii, ix und x
JPS6094917A (ja) * 1983-10-28 1985-05-28 Green Cross Corp:The Ｂ型肝炎感染予防用ワクチンの製造方法
US4490361A (en) * 1983-12-02 1984-12-25 Alpha Therapeutic Corporation Virus inactivating heat treatment of plasma fractions
AT389815B (de) * 1984-03-09 1990-02-12 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten
US5171569A (en) * 1985-03-15 1992-12-15 National Research Development Corporation Factor IX preparations uncontaminated by plasma components or pox virus
AT390560B (de) * 1986-05-30 1990-05-25 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
IL86417A (en) * 1987-05-22 1992-09-06 Armour Pharma Process for the inactivation of pathogens in biological or pharmaceutical material by mixing with aqueous solution containing a sugar(alcohol)and neutral salts as stabilizers
WO1989005652A1 (en) * 1987-12-21 1989-06-29 American National Red Cross Pure factor ix product
FR2664165B1 (fr) * 1990-07-03 1992-10-16 Lille Transfusion Sanguine Composition pour stabiliser le plasma sanguin en cours de pasteurisation.
WO1992015324A1 (en) * 1991-03-01 1992-09-17 Rhone-Poulenc Rorer International (Holdings) Inc. Preparation of factor ix
AT402891B (de) * 1991-06-20 1997-09-25 Immuno Ag Verfahren zur herstellung eines inaktivierten blutproduktes
FR2687317B1 (fr) * 1992-02-13 1995-06-23 Aetsrn Composition pour stabiliser le plasma sanguin en cour de pasteurisation et solution plasmatique pasteurisee a usage therapeutique.
AT399818B (de) * 1992-04-24 1995-07-25 Immuno Ag Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation
WO1994013329A1 (de) * 1992-12-16 1994-06-23 Immuno Aktiengesellschaft Verfahren zur herstellung eines virussicheren biologischen präparates
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
DE4342132C1 (de) 1993-12-10 1994-11-03 Octapharma Ag Verfahren zur Herstellung virusinaktivierte Vitamin K abhängige Plasmakomponenten sowie Protein C und Protein S enthaltender Mittel durch Membran-Chromatographie
US6372716B1 (en) * 1994-04-26 2002-04-16 Genetics Institute, Inc. Formulations for factor IX
US5770700A (en) * 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
EP1010852A1 (en) 1998-12-15 2000-06-21 Schlegel BVBA Sealing gasket and method of making and inserting the same
GB0521139D0 (en) 2005-10-18 2005-11-23 Univ Sheffield Therapeutic agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4081432A (en) * 1977-07-25 1978-03-28 Monsanto Company Method of separating a Factor IX preparation from plasma using ethylene-maleic anhydride polymers
DE2916711A1 (de) * 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
JPS56135418A (en) * 1980-03-27 1981-10-22 Green Cross Corp:The Heat treatment of aqueous solution containing 8 factor of coagulation of blood derived from human

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4001451A1 (de) * 1990-01-19 1991-08-01 Octapharma Ag Stabile injizierbare loesungen von faktor viii und faktor ix

Also Published As

Publication number Publication date
EP0053338B1 (de) 1985-02-06
EP0053338A2 (de) 1982-06-09
US4405603A (en) 1983-09-20
ATE11640T1 (de) 1985-02-15
EP0053338A3 (en) 1982-08-04
MX6947E (es) 1986-12-19
IL64396A0 (en) 1982-02-28
JPS57120524A (en) 1982-07-27
CA1182047A (en) 1985-02-05
ES8206975A1 (es) 1982-09-01
AU544157B2 (en) 1985-05-16
IL64396A (en) 1985-02-28
JPH0348171B2 (cg-RX-API-DMAC7.html) 1991-07-23
DE3168834D1 (en) 1985-03-21
ES507400A0 (es) 1982-09-01
AU7795081A (en) 1982-06-10

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