AU544157B2 - Production of stable blood clotting factors ix + x by warming with calcium ions - Google Patents
Production of stable blood clotting factors ix + x by warming with calcium ionsInfo
- Publication number
- AU544157B2 AU544157B2 AU77950/81A AU7795081A AU544157B2 AU 544157 B2 AU544157 B2 AU 544157B2 AU 77950/81 A AU77950/81 A AU 77950/81A AU 7795081 A AU7795081 A AU 7795081A AU 544157 B2 AU544157 B2 AU 544157B2
- Authority
- AU
- Australia
- Prior art keywords
- warming
- calcium ions
- blood clotting
- clotting factors
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003114 blood coagulation factor Substances 0.000 title abstract 2
- 229910001424 calcium ion Inorganic materials 0.000 title abstract 2
- 238000010792 warming Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000005846 sugar alcohols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
What is disclosed is a method for making a preparation containing blood clotting Factors IX and/or X virtually hepatitis-safe by warming said peparation in the presence of calcium ions and in the further presence of an amino acid and/or a saccharide or sugar alcohol.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803045153 DE3045153A1 (en) | 1980-11-29 | 1980-11-29 | METHOD FOR THE PRODUCTION OF BLOOD COagulation FACTORS AND THE PREPARATION OF FACTORS IX AND X THEREFORE PRODUCED |
DE30451537 | 1980-11-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
AU7795081A AU7795081A (en) | 1982-06-10 |
AU544157B2 true AU544157B2 (en) | 1985-05-16 |
Family
ID=6117972
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU77950/81A Expired AU544157B2 (en) | 1980-11-29 | 1981-11-27 | Production of stable blood clotting factors ix + x by warming with calcium ions |
Country Status (10)
Country | Link |
---|---|
US (1) | US4405603A (en) |
EP (1) | EP0053338B1 (en) |
JP (1) | JPS57120524A (en) |
AT (1) | ATE11640T1 (en) |
AU (1) | AU544157B2 (en) |
CA (1) | CA1182047A (en) |
DE (2) | DE3045153A1 (en) |
ES (1) | ES507400A0 (en) |
IL (1) | IL64396A (en) |
MX (1) | MX6947E (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU587365B2 (en) * | 1982-08-19 | 1989-08-17 | Aventis Behring Gmbh | Pasteurized human fibrinogen (HF), a process for its preparation and its use |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4456590B2 (en) * | 1981-11-02 | 1989-05-30 | Heat treatment of lyphilized blood clotting factor viii concentrate | |
DE3237512A1 (en) * | 1982-10-09 | 1984-04-12 | Behringwerke Ag, 3550 Marburg | METHOD FOR PASTEURIZING ANTIHAEMOPHILIC CRYOPRAEZIPITATE (AHK) AND ANTIHAEMOPHILE CRYOPRAECIPITATE PRODUCED THEREOF |
ATE36457T1 (en) * | 1983-05-02 | 1988-09-15 | Immuno Ag | METHOD OF INACTIVATING REPRODUCTIVE pathogens. |
US4764369A (en) * | 1983-07-14 | 1988-08-16 | New York Blood Center Inc. | Undenatured virus-free biologically active protein derivatives |
US4820805A (en) * | 1983-07-14 | 1989-04-11 | New York Blood Center, Inc. | Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives |
DE3330770A1 (en) * | 1983-08-26 | 1985-03-14 | Behringwerke Ag, 3550 Marburg | METHOD FOR PASTEURIZING HUMAN PLASMA |
US4615886A (en) * | 1983-08-31 | 1986-10-07 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Utilizing a halohydrocarbon containing dissolved water to inactivate a lipid virus |
DE3336631A1 (en) * | 1983-10-08 | 1985-04-18 | Behringwerke Ag, 3550 Marburg | METHOD FOR THE PASTEURIZATION OF PLASMA OR CONCENTRATES OF THE BLOOD COAGINING FACTORS II, VII, IX AND X |
JPS6094917A (en) * | 1983-10-28 | 1985-05-28 | Green Cross Corp:The | Production of vaccine for preventing infection to hepatitis b |
US4490361A (en) * | 1983-12-02 | 1984-12-25 | Alpha Therapeutic Corporation | Virus inactivating heat treatment of plasma fractions |
AT389815B (en) * | 1984-03-09 | 1990-02-12 | Immuno Ag | METHOD FOR INACTIVATING VARIABLE FILTERABLE DISEASERS IN BLOOD PRODUCTS |
US5171569A (en) * | 1985-03-15 | 1992-12-15 | National Research Development Corporation | Factor IX preparations uncontaminated by plasma components or pox virus |
AT390560B (en) * | 1986-05-30 | 1990-05-25 | Immuno Ag | METHOD FOR INACTIVATING VARIABLE FILTERABLE DISEASES |
IL86417A (en) * | 1987-05-22 | 1992-09-06 | Armour Pharma | Process for the inactivation of pathogens in biological or pharmaceutical material by mixing with aqueous solution containing a sugar(alcohol)and neutral salts as stabilizers |
US4876241A (en) * | 1987-05-22 | 1989-10-24 | Armour Pharmaceutical Company | Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants |
WO1989005652A1 (en) * | 1987-12-21 | 1989-06-29 | American National Red Cross | Pure factor ix product |
DE4001451A1 (en) * | 1990-01-19 | 1991-08-01 | Octapharma Ag | STABLE INJECTABLE SOLUTIONS OF FACTOR VIII AND FACTOR IX |
FR2664165B1 (en) * | 1990-07-03 | 1992-10-16 | Lille Transfusion Sanguine | COMPOSITION FOR STABILIZING BLOOD PLASMA DURING PASTEURIZATION. |
DK0573605T3 (en) * | 1991-03-01 | 2001-01-02 | Rhone Poulenc Rorer Int | Preparation of Factor IX |
AT402891B (en) * | 1991-06-20 | 1997-09-25 | Immuno Ag | METHOD FOR PRODUCING AN INACTIVATED BLOOD PRODUCT |
FR2687317B1 (en) * | 1992-02-13 | 1995-06-23 | Aetsrn | COMPOSITION FOR STABILIZING BLOOD PLASMA DURING PASTEURIZATION AND PASTEURIZED PLASMATIC SOLUTION FOR THERAPEUTIC USE. |
AT399818B (en) * | 1992-04-24 | 1995-07-25 | Immuno Ag | METHOD FOR PRODUCING A HIGH PURIFIED VIRUS-SAFE FACTOR VIII PREPARATION |
JP3133338B2 (en) * | 1992-12-16 | 2001-02-05 | イムノ・アクチエンゲゼルシャフト | Methods for preparing virally safe biological compositions |
DE4320294A1 (en) * | 1993-06-18 | 1994-12-22 | Immuno Ag | Use of human protein C to prevent and treat platelet deposits |
DE4342132C1 (en) * | 1993-12-10 | 1994-11-03 | Octapharma Ag | Process for the preparation of virus-inactivated vitamin K-dependent plasma components, and protein C and protein S-containing compositions by membrane chromatography |
US6372716B1 (en) * | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
US5770700A (en) * | 1996-01-25 | 1998-06-23 | Genetics Institute, Inc. | Liquid factor IX formulations |
EP1010852A1 (en) | 1998-12-15 | 2000-06-21 | Schlegel BVBA | Sealing gasket and method of making and inserting the same |
GB0521139D0 (en) | 2005-10-18 | 2005-11-23 | Univ Sheffield | Therapeutic agent |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4081432A (en) * | 1977-07-25 | 1978-03-28 | Monsanto Company | Method of separating a Factor IX preparation from plasma using ethylene-maleic anhydride polymers |
DE2916711A1 (en) * | 1979-04-25 | 1980-11-06 | Behringwerke Ag | Blood coagulation factors and process for their manufacture |
JPS56135418A (en) * | 1980-03-27 | 1981-10-22 | Green Cross Corp:The | Heat treatment of aqueous solution containing 8 factor of coagulation of blood derived from human |
-
1980
- 1980-11-29 DE DE19803045153 patent/DE3045153A1/en not_active Withdrawn
-
1981
- 1981-11-21 EP EP81109825A patent/EP0053338B1/en not_active Expired
- 1981-11-21 DE DE8181109825T patent/DE3168834D1/en not_active Expired
- 1981-11-21 AT AT81109825T patent/ATE11640T1/en not_active IP Right Cessation
- 1981-11-24 ES ES507400A patent/ES507400A0/en active Granted
- 1981-11-25 US US06/324,872 patent/US4405603A/en not_active Expired - Lifetime
- 1981-11-27 AU AU77950/81A patent/AU544157B2/en not_active Expired
- 1981-11-27 IL IL64396A patent/IL64396A/en not_active IP Right Cessation
- 1981-11-27 CA CA000391129A patent/CA1182047A/en not_active Expired
- 1981-11-27 MX MX819785U patent/MX6947E/en unknown
- 1981-11-27 JP JP56189354A patent/JPS57120524A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU587365B2 (en) * | 1982-08-19 | 1989-08-17 | Aventis Behring Gmbh | Pasteurized human fibrinogen (HF), a process for its preparation and its use |
Also Published As
Publication number | Publication date |
---|---|
DE3168834D1 (en) | 1985-03-21 |
JPH0348171B2 (en) | 1991-07-23 |
US4405603A (en) | 1983-09-20 |
JPS57120524A (en) | 1982-07-27 |
CA1182047A (en) | 1985-02-05 |
ES8206975A1 (en) | 1982-09-01 |
EP0053338A2 (en) | 1982-06-09 |
DE3045153A1 (en) | 1982-07-08 |
IL64396A (en) | 1985-02-28 |
AU7795081A (en) | 1982-06-10 |
MX6947E (en) | 1986-12-19 |
IL64396A0 (en) | 1982-02-28 |
EP0053338A3 (en) | 1982-08-04 |
ATE11640T1 (en) | 1985-02-15 |
ES507400A0 (en) | 1982-09-01 |
EP0053338B1 (en) | 1985-02-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HB | Alteration of name in register |
Owner name: AVENTIS BEHRING GMBH Free format text: FORMER NAME WAS: CENTEON PHARMA GMBH |
|
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |