DE3028912A1 - Neue derivate des 3,45-trimethoxycinnamoyl-piperazins, verfahren zu ihrer herstellung und solche derivate - Google Patents

Neue derivate des 3,45-trimethoxycinnamoyl-piperazins, verfahren zu ihrer herstellung und solche derivate

Info

Publication number
DE3028912A1
DE3028912A1 DE19803028912 DE3028912A DE3028912A1 DE 3028912 A1 DE3028912 A1 DE 3028912A1 DE 19803028912 DE19803028912 DE 19803028912 DE 3028912 A DE3028912 A DE 3028912A DE 3028912 A1 DE3028912 A1 DE 3028912A1
Authority
DE
Germany
Prior art keywords
formula
deep
group
compound
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19803028912
Other languages
German (de)
English (en)
Inventor
Guy Colombes Bourgery
Alain La Varenne Lacour
Gerard Orsay Moinet
Bernard Meudon La Foret Pourrias
Anne-Marie Paris Ruch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Publication of DE3028912A1 publication Critical patent/DE3028912A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
DE19803028912 1979-08-03 1980-07-30 Neue derivate des 3,45-trimethoxycinnamoyl-piperazins, verfahren zu ihrer herstellung und solche derivate Ceased DE3028912A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7919990A FR2462432A2 (fr) 1979-08-03 1979-08-03 Nouveaux derives de la 3,4,5 trimethoxy cinnamoyle piperazine, leur procede de preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
DE3028912A1 true DE3028912A1 (de) 1981-09-24

Family

ID=9228620

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19803028912 Ceased DE3028912A1 (de) 1979-08-03 1980-07-30 Neue derivate des 3,45-trimethoxycinnamoyl-piperazins, verfahren zu ihrer herstellung und solche derivate

Country Status (14)

Country Link
JP (1) JPS5626885A (enExample)
AU (1) AU6100380A (enExample)
BE (1) BE884602R (enExample)
CA (1) CA1155121A (enExample)
CH (1) CH646694A5 (enExample)
DE (1) DE3028912A1 (enExample)
ES (2) ES8107195A1 (enExample)
FR (1) FR2462432A2 (enExample)
GB (1) GB2057433B (enExample)
GR (1) GR68073B (enExample)
LU (1) LU82677A1 (enExample)
NL (1) NL8004434A (enExample)
SE (1) SE8005300L (enExample)
ZA (1) ZA804709B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0368670A1 (en) * 1988-11-11 1990-05-16 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2507604A2 (fr) * 1977-04-19 1982-12-17 Delalande Sa Nouvelles trimethoxy-3,4,5 cinnamoyle piperazines, leur procede de preparation et leur application en therapeutique
US4567264A (en) * 1983-05-18 1986-01-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
US4558129A (en) * 1983-05-18 1985-12-10 Syntex (U.S.A.) Inc. Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade
US4499100A (en) * 1983-05-18 1985-02-12 Syntex (U.S.A.) Inc. Benzodioxanyl-hydroxyethyleneamino-piperidinyl acetanilides, ketones, esters and carbamates which effect immunity and calcium entry and β-blockade
US6514996B2 (en) 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
AU4967697A (en) * 1996-11-19 1998-06-10 Kyowa Hakko Kogyo Co. Ltd. Oxygenic heterocyclic compounds
WO2008144933A1 (en) * 2007-05-29 2008-12-04 Université de Montréal Cinnamoyl inhibitors of transglutaminase

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE865990A (fr) 1977-04-19 1978-10-16 Delalande Sa Nouvelles cinnamoyles piperazines et homopiperazines, leur procede de preparation et leur application en therapeutique

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE865990A (fr) 1977-04-19 1978-10-16 Delalande Sa Nouvelles cinnamoyles piperazines et homopiperazines, leur procede de preparation et leur application en therapeutique

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. Org. Chem. 42, 1006 (1977)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0368670A1 (en) * 1988-11-11 1990-05-16 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use

Also Published As

Publication number Publication date
FR2462432A2 (fr) 1981-02-13
GR68073B (enExample) 1981-10-29
ZA804709B (en) 1981-10-28
JPS5626885A (en) 1981-03-16
AU6100380A (en) 1981-02-05
GB2057433A (en) 1981-04-01
SE8005300L (sv) 1981-02-04
FR2462432B2 (enExample) 1983-05-27
ES8301944A1 (es) 1982-12-16
JPS634827B2 (enExample) 1988-02-01
BE884602R (fr) 1981-02-02
CA1155121A (en) 1983-10-11
ES493931A0 (es) 1981-10-01
CH646694A5 (fr) 1984-12-14
GB2057433B (en) 1983-08-10
ES8107195A1 (es) 1981-10-01
LU82677A1 (fr) 1982-05-10
ES499814A0 (es) 1982-12-16
NL8004434A (nl) 1981-02-05

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8125 Change of the main classification
8126 Change of the secondary classification
8131 Rejection