GB2057433B - 3,4,5-trimethoxy cinnamoyl piperazine derivatives processes for preparing the same and their use in therapeutics - Google Patents

3,4,5-trimethoxy cinnamoyl piperazine derivatives processes for preparing the same and their use in therapeutics

Info

Publication number
GB2057433B
GB2057433B GB8025200A GB8025200A GB2057433B GB 2057433 B GB2057433 B GB 2057433B GB 8025200 A GB8025200 A GB 8025200A GB 8025200 A GB8025200 A GB 8025200A GB 2057433 B GB2057433 B GB 2057433B
Authority
GB
United Kingdom
Prior art keywords
therapeutics
preparing
same
piperazine derivatives
trimethoxy cinnamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8025200A
Other versions
GB2057433A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Publication of GB2057433A publication Critical patent/GB2057433A/en
Application granted granted Critical
Publication of GB2057433B publication Critical patent/GB2057433B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
GB8025200A 1979-08-03 1980-08-01 3,4,5-trimethoxy cinnamoyl piperazine derivatives processes for preparing the same and their use in therapeutics Expired GB2057433B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7919990A FR2462432A2 (en) 1979-08-03 1979-08-03 NOVEL DERIVATIVES OF 3,4,5 TRIMETHOXY CINNAMOYL PIPERAZINE, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC USE THEREOF

Publications (2)

Publication Number Publication Date
GB2057433A GB2057433A (en) 1981-04-01
GB2057433B true GB2057433B (en) 1983-08-10

Family

ID=9228620

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8025200A Expired GB2057433B (en) 1979-08-03 1980-08-01 3,4,5-trimethoxy cinnamoyl piperazine derivatives processes for preparing the same and their use in therapeutics

Country Status (14)

Country Link
JP (1) JPS5626885A (en)
AU (1) AU6100380A (en)
BE (1) BE884602R (en)
CA (1) CA1155121A (en)
CH (1) CH646694A5 (en)
DE (1) DE3028912A1 (en)
ES (2) ES8107195A1 (en)
FR (1) FR2462432A2 (en)
GB (1) GB2057433B (en)
GR (1) GR68073B (en)
LU (1) LU82677A1 (en)
NL (1) NL8004434A (en)
SE (1) SE8005300L (en)
ZA (1) ZA804709B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2507604A2 (en) * 1977-04-19 1982-12-17 Delalande Sa Tri:methoxy cinnamoyl piperazine(s) - for treatment of cardiovascular disorders
US4499100A (en) * 1983-05-18 1985-02-12 Syntex (U.S.A.) Inc. Benzodioxanyl-hydroxyethyleneamino-piperidinyl acetanilides, ketones, esters and carbamates which effect immunity and calcium entry and β-blockade
US4567264A (en) * 1983-05-18 1986-01-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
US4558129A (en) * 1983-05-18 1985-12-10 Syntex (U.S.A.) Inc. Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade
US4997836A (en) * 1988-11-11 1991-03-05 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use
US6514996B2 (en) 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
CA2272327A1 (en) * 1996-11-19 1998-05-28 Kyowa Hakko Kogyo Co., Ltd. Oxygen-containing heterocyclic compounds
US8614233B2 (en) 2007-05-29 2013-12-24 Universite De Montreal Cinnamoyl inhibitors of transglutaminase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387971A1 (en) * 1977-04-19 1978-11-17 Delalande Sa NEW TRIMETHOXY CINNAMOYLES PIPERAZINES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number Publication date
ZA804709B (en) 1981-10-28
FR2462432A2 (en) 1981-02-13
ES499814A0 (en) 1982-12-16
ES493931A0 (en) 1981-10-01
NL8004434A (en) 1981-02-05
ES8301944A1 (en) 1982-12-16
GR68073B (en) 1981-10-29
CH646694A5 (en) 1984-12-14
LU82677A1 (en) 1982-05-10
JPS634827B2 (en) 1988-02-01
DE3028912A1 (en) 1981-09-24
CA1155121A (en) 1983-10-11
AU6100380A (en) 1981-02-05
FR2462432B2 (en) 1983-05-27
SE8005300L (en) 1981-02-04
ES8107195A1 (en) 1981-10-01
GB2057433A (en) 1981-04-01
JPS5626885A (en) 1981-03-16
BE884602R (en) 1981-02-02

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930801