DE2936388A1 - Verfahren und vorrichtung zur verbesserung der mischguete fluessiger, insbesondere zaeher medien - Google Patents
Verfahren und vorrichtung zur verbesserung der mischguete fluessiger, insbesondere zaeher medienInfo
- Publication number
- DE2936388A1 DE2936388A1 DE19792936388 DE2936388A DE2936388A1 DE 2936388 A1 DE2936388 A1 DE 2936388A1 DE 19792936388 DE19792936388 DE 19792936388 DE 2936388 A DE2936388 A DE 2936388A DE 2936388 A1 DE2936388 A1 DE 2936388A1
- Authority
- DE
- Germany
- Prior art keywords
- reactor
- elements
- baffles
- flow
- stirrer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims abstract description 12
- 239000007788 liquid Substances 0.000 title claims abstract description 10
- 238000000855 fermentation Methods 0.000 claims abstract description 22
- 230000004151 fermentation Effects 0.000 claims abstract description 22
- 238000002156 mixing Methods 0.000 claims abstract description 12
- 230000033001 locomotion Effects 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 8
- 235000010633 broth Nutrition 0.000 claims description 3
- 238000009423 ventilation Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 abstract description 13
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 239000003651 drinking water Substances 0.000 description 4
- 235000020188 drinking water Nutrition 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229930182555 Penicillin Natural products 0.000 description 3
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 229940049954 penicillin Drugs 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- 235000012424 soybean oil Nutrition 0.000 description 3
- 239000003549 soybean oil Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 239000004098 Tetracycline Substances 0.000 description 2
- 238000005273 aeration Methods 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 2
- LCPDWSOZIOUXRV-UHFFFAOYSA-N phenoxyacetic acid Chemical compound OC(=O)COC1=CC=CC=C1 LCPDWSOZIOUXRV-UHFFFAOYSA-N 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 229960002180 tetracycline Drugs 0.000 description 2
- 229930101283 tetracycline Natural products 0.000 description 2
- 235000019364 tetracycline Nutrition 0.000 description 2
- 150000003522 tetracyclines Chemical class 0.000 description 2
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 235000021551 crystal sugar Nutrition 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000010699 lard oil Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000006241 metabolic reaction Methods 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000012495 reaction gas Substances 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/86—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis co-operating with deflectors or baffles fixed to the receptacle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
- C12M27/08—Stirrer or mobile mixing elements with different stirrer shapes in one shaft or axis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/18—Flow directing inserts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
- C12M41/22—Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls
Landscapes
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Sustainable Development (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792936388 DE2936388A1 (de) | 1979-09-08 | 1979-09-08 | Verfahren und vorrichtung zur verbesserung der mischguete fluessiger, insbesondere zaeher medien |
| AT80105314T ATE7308T1 (de) | 1979-09-08 | 1980-09-05 | Verfahren und vorrichtung zur verbesserung der mischguete fluessiger, insbesondere zaeher medien. |
| JP50206380A JPS56501549A (https=) | 1979-09-08 | 1980-09-05 | |
| DE8080105314T DE3067696D1 (en) | 1979-09-08 | 1980-09-05 | Process and apparatus for improving the mixing capability of liquid, especially viscous media |
| PCT/EP1980/000093 WO1981000722A1 (fr) | 1979-09-08 | 1980-09-05 | Procede et dispositif pour l'amelioration de materiaux melanges, de substances liquides, en particulier de substances visqueuses |
| US06/261,195 US4378436A (en) | 1979-09-08 | 1980-09-05 | Process and device for improving the quality of mixing of liquid especially viscous media |
| EP80105314A EP0025571B1 (de) | 1979-09-08 | 1980-09-05 | Verfahren und Vorrichtung zur Verbesserung der Mischgüte flüssiger, insbesondere zäher Medien |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792936388 DE2936388A1 (de) | 1979-09-08 | 1979-09-08 | Verfahren und vorrichtung zur verbesserung der mischguete fluessiger, insbesondere zaeher medien |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2936388A1 true DE2936388A1 (de) | 1981-04-02 |
Family
ID=6080406
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19792936388 Withdrawn DE2936388A1 (de) | 1979-09-08 | 1979-09-08 | Verfahren und vorrichtung zur verbesserung der mischguete fluessiger, insbesondere zaeher medien |
| DE8080105314T Expired DE3067696D1 (en) | 1979-09-08 | 1980-09-05 | Process and apparatus for improving the mixing capability of liquid, especially viscous media |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8080105314T Expired DE3067696D1 (en) | 1979-09-08 | 1980-09-05 | Process and apparatus for improving the mixing capability of liquid, especially viscous media |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4378436A (https=) |
| EP (1) | EP0025571B1 (https=) |
| JP (1) | JPS56501549A (https=) |
| AT (1) | ATE7308T1 (https=) |
| DE (2) | DE2936388A1 (https=) |
| WO (1) | WO1981000722A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2662616B1 (fr) * | 1990-05-31 | 1994-07-08 | Anjou Rech | Installation pour le traitement de flux liquides a contacteur monophasique, et dispositif recirculateur-degazeur pour une telle installation. |
| FR2672230B1 (fr) * | 1991-02-04 | 1993-04-16 | Anjou Rech | Installation de melange de deux phases fluides par agitation mecanique, notamment pour le traitement des eaux par transfert de gaz oxydant, et utilisation d'une telle installation. |
| FI95664C (fi) * | 1994-05-20 | 1999-01-19 | Outokumpu Eng Contract | Tapa ja laite hallittujen sekoituspyörteiden aikaansaamiseksi ja kaasun kierrättämiseksi |
| CN1044334C (zh) * | 1994-12-28 | 1999-07-28 | 黄为民 | 搅拌釜 |
| US5972661A (en) * | 1998-09-28 | 1999-10-26 | Penn State Research Foundation | Mixing systems |
| US9101898B2 (en) | 2006-03-29 | 2015-08-11 | Robert M. Zubrin | Portable gas generating device |
| JP2009072133A (ja) * | 2007-09-21 | 2009-04-09 | Hitachi Plant Technologies Ltd | 培養槽装置、細胞培養方法及び物質生産方法 |
| EP2216395A1 (en) | 2009-02-09 | 2010-08-11 | Lonza Biologics plc. | Bioreactor for the cultivation of mammalian cells |
| DE102014016297A1 (de) * | 2014-11-06 | 2016-05-12 | Xylem Ip Management S.À.R.L. | Temperiervorrichtung |
| EP3093336A1 (de) * | 2015-05-11 | 2016-11-16 | Wintershall Holding GmbH | Fermenter zur herstellung eines strukturviskosen mediums |
| CA3163799A1 (en) * | 2020-01-13 | 2021-07-22 | Cassandra Schoessow | Slurry phase reactor with internal vapor-liquid separator |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1585169A (en) * | 1923-10-26 | 1926-05-18 | Perkins Glue Co | Mixing kettle |
| US2085947A (en) * | 1936-03-30 | 1937-07-06 | Galigher Company | Aerating machine |
| GB478354A (en) * | 1936-06-16 | 1938-01-17 | Pfaudler Co Inc | Fluid processing apparatus and method |
| DE743984C (de) * | 1938-09-16 | 1944-01-06 | Eugen Stich | Verfahren und Vorrichtung zum Belueften von Gaerfluessigkeiten |
| US2453592A (en) * | 1944-12-08 | 1948-11-09 | Stratford Dev Corp | Contacting apparatus for catalytic processes |
| US2530814A (en) * | 1945-10-12 | 1950-11-21 | Schenley Ind Inc | Apparatus for aerating liquids |
| US2767965A (en) * | 1950-11-03 | 1956-10-23 | Mining Process & Patent Co | Dual pumping agitation |
| AT175862B (de) * | 1952-04-15 | 1953-08-25 | Wilhelm Vogelbusch | Verfahren und Vorrichtung zur Belüftung bzw. Begasung von Flüssigkeiten, insbesondere für Feinstbelüftungen in Gärbottichen |
| US2973095A (en) * | 1957-07-09 | 1961-02-28 | Galigher Company | Impeller-stator combination for aeration machines |
| US3092678A (en) * | 1958-04-29 | 1963-06-04 | Vogelbusch Gmbh | Apparatus for gasifying liquids |
| US3378141A (en) * | 1963-03-28 | 1968-04-16 | Res & Dev Pty Ltd | Froth flotation apparatus |
| DE1557021B2 (de) | 1966-05-21 | 1970-09-24 | Basf Ag | Stromstoerer fuer einen stehenden zylindrischen Ruehrbehaelter |
| FR1523664A (fr) * | 1966-05-21 | 1968-05-03 | Basf Ag | Modificateur d'écoulement |
| DE1557185A1 (de) * | 1966-07-04 | 1971-02-25 | Process Engineering Co | Verfahren zur Herstellung und Aufrechterhaltung einer Feinstdurchmischung gasfoermiger und fluessiger Stoffe untereinander |
| FR1546174A (fr) * | 1966-12-01 | 1968-11-15 | Lonza Ag | Perfectionnements apportés aux agitateurs mécaniques |
| CH456760A (de) | 1967-05-17 | 1968-07-31 | Bbc Brown Boveri & Cie | Elektrische Energieübertragungsanordnung mit mindestens einem MHD-Generator als Gleichspannungserzeuger |
| GB1223418A (en) * | 1967-06-19 | 1971-02-24 | British Petroleum Co | Improvements in or relating to a fermenter and to a process in which said fermenter is employed |
| CH471892A (de) * | 1968-04-04 | 1969-04-30 | Mueller Hans | Verfahren und Anordnung zur Steuerung des Substratflusses zu und aus Fermentationsbehältern mit eingebauten rotierenden Werkzeugen für Mischung und Schaumabscheidung |
| FR1571522A (https=) * | 1968-05-10 | 1969-06-20 | ||
| FR2041779A1 (fr) * | 1969-05-27 | 1971-02-05 | Vergne Claude Jean | Ameliorations apportees aux melangeurs a action rotative pour fluides ou poudres |
| DE2043077C3 (de) * | 1970-08-31 | 1975-05-28 | Hoechst Ag, 6000 Frankfurt | Vorrichtung zur biologischen Reinigung von hochbelasteten Abwässern |
| US3882016A (en) * | 1974-01-02 | 1975-05-06 | Charles A Green | Flotation machine and impeller therefor |
| CH587915A5 (https=) * | 1974-05-28 | 1977-05-13 | Nestle Societe D Assistance Te | |
| US4019962A (en) * | 1975-08-11 | 1977-04-26 | Standard Oil Company (Indiana) | Apparatus for aerobic fermentation |
| HU175206B (hu) * | 1976-12-01 | 1980-06-28 | Biogal Gyogyszergyar | Ispravlennyjj fermentor |
-
1979
- 1979-09-08 DE DE19792936388 patent/DE2936388A1/de not_active Withdrawn
-
1980
- 1980-09-05 JP JP50206380A patent/JPS56501549A/ja active Pending
- 1980-09-05 US US06/261,195 patent/US4378436A/en not_active Expired - Fee Related
- 1980-09-05 AT AT80105314T patent/ATE7308T1/de not_active IP Right Cessation
- 1980-09-05 WO PCT/EP1980/000093 patent/WO1981000722A1/de not_active Ceased
- 1980-09-05 EP EP80105314A patent/EP0025571B1/de not_active Expired
- 1980-09-05 DE DE8080105314T patent/DE3067696D1/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ATE7308T1 (de) | 1984-05-15 |
| EP0025571A1 (de) | 1981-03-25 |
| US4378436A (en) | 1983-03-29 |
| WO1981000722A1 (fr) | 1981-03-19 |
| DE3067696D1 (en) | 1984-06-07 |
| JPS56501549A (https=) | 1981-10-29 |
| EP0025571B1 (de) | 1984-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8130 | Withdrawal |