DE2808476C2 - Reagens zur Verwendung in immunochemischen Untersuchungsmethoden - Google Patents

Reagens zur Verwendung in immunochemischen Untersuchungsmethoden

Info

Publication number
DE2808476C2
DE2808476C2 DE2808476A DE2808476A DE2808476C2 DE 2808476 C2 DE2808476 C2 DE 2808476C2 DE 2808476 A DE2808476 A DE 2808476A DE 2808476 A DE2808476 A DE 2808476A DE 2808476 C2 DE2808476 C2 DE 2808476C2
Authority
DE
Germany
Prior art keywords
conjugate
disulfide
immunoglobulin
reaction
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2808476A
Other languages
German (de)
English (en)
Other versions
DE2808476A1 (de
Inventor
Rolf Erik Axel Verner Bälinge Axen
Jan Per Erik Uppsala Carlsson
Haakan Nils Yngve Brunna Drevin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phadia AB
Original Assignee
Pharmacia Diagnostics AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Diagnostics AB filed Critical Pharmacia Diagnostics AB
Publication of DE2808476A1 publication Critical patent/DE2808476A1/de
Application granted granted Critical
Publication of DE2808476C2 publication Critical patent/DE2808476C2/de
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/964—Chemistry: molecular biology and microbiology including enzyme-ligand conjugate production, e.g. reducing rate of nonproductive linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DE2808476A 1977-03-04 1978-02-28 Reagens zur Verwendung in immunochemischen Untersuchungsmethoden Expired DE2808476C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7702464A SE427505B (sv) 1977-03-04 1977-03-04 Reagens till anvendning vid immunkemiska bestemningsmetoder

Publications (2)

Publication Number Publication Date
DE2808476A1 DE2808476A1 (de) 1978-09-07
DE2808476C2 true DE2808476C2 (de) 1986-11-06

Family

ID=20330625

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2808476A Expired DE2808476C2 (de) 1977-03-04 1978-02-28 Reagens zur Verwendung in immunochemischen Untersuchungsmethoden

Country Status (7)

Country Link
US (1) US4232119A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS53130423A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2808476C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2382695A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1597754A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL188544C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE427505B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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JPS55136261A (en) * 1979-04-12 1980-10-23 Toyo Jozo Co Ltd Novel compound and kit comprising it
FR2470773B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1979-11-28 1983-01-28 Pasteur Institut
US4318981A (en) * 1980-04-24 1982-03-09 Miles Laboratories, Inc. Homogeneous specific binding assay employing an intramolecularly modulated photogenic enzyme substrate label
SE8003732L (sv) * 1980-05-19 1981-11-20 Pharmacia Diagnostics Ab Sett vid bestemningsmetoder involverande biospecifika affinitetsreaktioner
US4486540A (en) * 1980-07-18 1984-12-04 Science Research Center, Inc. Identification of reagins in the blood serum of allergen sensitized vertebrates
US4696907A (en) * 1980-07-18 1987-09-29 Science Research Center, Inc. Identification of reagins in the blood serum of allergen sensitized vertebrates
SE8102194L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna
SE8102193L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och dess anvendning
US4481298A (en) * 1981-04-13 1984-11-06 Amf Incorporated Pre-precipitated double antibody immunoassay method
NL8102178A (nl) * 1981-05-02 1982-12-01 Stichting Centraal Lab Werkwijze voor het aantonen van tegen bepaalde antigenen gerichte antistoffen, alsmede inrichting en reagentia voor het uitvoeren van deze werkwijze.
FR2523445A1 (fr) * 1982-03-17 1983-09-23 Sanofi Sa Nouveaux conjugues associant, par liaison covalente, une enzyme et un anticorps, et associations medicamenteuses utilisant lesdits conjugues
US4614712A (en) * 1983-02-25 1986-09-30 The Upjohn Company Immunoassays with luciferase labeled ligands or receptors
SE8302758L (sv) * 1983-05-17 1984-11-18 Pharmacia Ab Sett for uppspjelkning av disulfidbindningar och derigenom erhallen forening
US4687732A (en) * 1983-06-10 1987-08-18 Yale University Visualization polymers and their application to diagnostic medicine
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
US4665022A (en) * 1984-02-17 1987-05-12 The Regents Of The University Of California Bioluminescent assay reagent and method
US4888415A (en) * 1985-03-04 1989-12-19 Dana-Farber Cancer Institute, Inc. Gelonin immunotoxin
EP0214995B1 (en) * 1985-03-04 1990-12-27 Dana Farber Cancer Institute Immunotoxin and method of making
US4863875A (en) * 1985-08-26 1989-09-05 Gia Research Company, L.P. Dye labelled antibodies as reagents for use in immunoassay systems
FR2586813B1 (fr) * 1985-08-30 1989-05-12 Inst Nat Sante Rech Med Supports proteiques modifies aptes a immobiliser de facon reversible des anticorps ou des substances immunologiquement actives, et leurs applications au dosage et a la purification d'antigenes ou similaires.
US4780421A (en) * 1986-04-03 1988-10-25 Sclavo Inc. Cleavable labels for use in binding assays
US4959306A (en) * 1986-11-28 1990-09-25 Sclavo, Inc. Labeling design for a binding assay reagent
US4975532A (en) * 1986-11-28 1990-12-04 Sclavo, Inc. Method to derivatize dextran
WO1988007200A1 (en) * 1987-03-19 1988-09-22 Perry, Robert, Edward Monoclonal antibody conjugation
US5171563A (en) * 1988-09-30 1992-12-15 Neorx Corporation Cleavable linkers for the reduction of non-target organ retention of immunoconjugates
GB8927365D0 (en) * 1989-12-04 1990-01-31 Ici Plc Reagent
US5324650A (en) * 1990-03-20 1994-06-28 E. I. Du Pont De Nemours And Company Situ process for production of conjugates
US6274325B1 (en) * 1990-06-25 2001-08-14 Boehringer Mannheim Gmbh Method for carrying out a homogeneous-immunoassay based on agglutination
US5191066A (en) * 1990-12-07 1993-03-02 Abbott Laboratories Site-specific conjugation of immunoglobulins and detectable labels
US5331109A (en) * 1992-04-06 1994-07-19 Biosite Diagnostics Incorporated Phencyclidine derivatives and protein and polypeptide phencyclidine derivative conjugates and labels
CA2132342A1 (en) * 1992-04-06 1993-10-14 Kenneth F. Buechler Novel opiate derivatives and protein and polypeptide opiate derivative conjugates and labels
US5470997A (en) * 1992-04-06 1995-11-28 Biosite Diagnostics Incorporated Amphetamine derivatives and protein and polypeptide amphetamine derivative conjugates and labels
US6037455A (en) * 1992-11-09 2000-03-14 Biosite Diagnostics Incorporated Propoxyphene derivatives and protein and polypeptide propoxyphene derivative conjugates and labels
US5536820A (en) * 1993-02-26 1996-07-16 E. I. Du Pont De Nemours And Company Avidin-binding azo reagents
US5736624A (en) * 1994-12-02 1998-04-07 Abbott Laboratories Phosphatase activated crosslinking, conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating agents
US5856194A (en) 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
US5795784A (en) 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
US20040241688A1 (en) * 2001-07-19 2004-12-02 Cuneyt Bukusoglu Human tissue specific drug screening procedure
CA2513646C (en) * 2003-01-24 2013-09-17 Michael R. Emmert-Buck Target activated microtransfer
US7695752B2 (en) * 2003-01-24 2010-04-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target activated microtransfer
US20040180054A1 (en) * 2003-03-13 2004-09-16 Hanmi Pharm. Co., Ltd. Physiologically active polypeptide conjugate having prolonged in vivo half-life
US20050176108A1 (en) * 2003-03-13 2005-08-11 Young-Min Kim Physiologically active polypeptide conjugate having prolonged in vivo half-life
WO2006116742A2 (en) * 2005-04-28 2006-11-02 Ventana Medical Systems, Inc. Fluorescent nanoparticles conjugated to antibodies via a peg linker
AU2006239315B2 (en) 2005-04-28 2012-03-01 Ventana Medical Systems, Inc. Enzymes conjugated to antiobodies via a PEG heterobifuctional linker
US7957466B2 (en) * 2005-09-16 2011-06-07 Sony Corporation Adaptive area of influence filter for moving object boundaries
EP3095467B1 (en) * 2005-11-23 2020-05-06 Ventana Medical Systems, Inc. Antibody-enzyme conjugate
US8460879B2 (en) * 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
ES2556627T3 (es) * 2007-08-30 2016-01-19 Trustees Of Tufts College Métodos para determinar la concentración de un analito en solución
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US9910040B2 (en) * 2012-07-09 2018-03-06 Sevident, Inc. Molecular nets comprising capture agents and linking agents
US9733242B2 (en) * 2012-10-07 2017-08-15 Sevident, Inc. Devices for capturing analyte
EP2504702A4 (en) * 2009-11-24 2014-12-17 Argos Inc DEVICES FOR DETECTION OF COMPOUNDS FOR ANALYZING
CA2791655C (en) 2010-03-01 2014-11-04 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
CA2812291C (en) * 2010-09-23 2020-06-16 Biocept, Inc. Methods and reagents for signal amplification
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques

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Publication number Priority date Publication date Assignee Title
US4004979A (en) * 1968-03-29 1977-01-25 Agence Nationale De Valorisation De La Recherche (Anvar) Preparation of active proteins cross-linked to inactive proteins
US3652761A (en) * 1969-09-04 1972-03-28 Corning Glass Works Immunochemical composites and antigen or antibody purification therewith
SE420733B (sv) * 1974-05-30 1981-10-26 Exploaterings Ab Tbf Gelprodukt, innehallande tiosulfatgrupper samt sett for framstellning derav
US4002532A (en) * 1974-10-21 1977-01-11 Weltman Joel K Enzyme conjugates

Also Published As

Publication number Publication date
US4232119A (en) 1980-11-04
FR2382695B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-07-13
NL188544C (nl) 1993-09-16
NL7802451A (nl) 1978-09-06
NL188544B (nl) 1992-02-17
SE7702464L (sv) 1978-09-05
DE2808476A1 (de) 1978-09-07
FR2382695A1 (fr) 1978-09-29
SE427505B (sv) 1983-04-11
GB1597754A (en) 1981-09-09
JPS53130423A (en) 1978-11-14
JPS6145775B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1986-10-09

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee