FR2382695A1 - Reactif pour la mise en oeuvre de procedes d'analyse immunochimiques en presence d'un liquide aqueux et son application - Google Patents

Reactif pour la mise en oeuvre de procedes d'analyse immunochimiques en presence d'un liquide aqueux et son application

Info

Publication number
FR2382695A1
FR2382695A1 FR7806163A FR7806163A FR2382695A1 FR 2382695 A1 FR2382695 A1 FR 2382695A1 FR 7806163 A FR7806163 A FR 7806163A FR 7806163 A FR7806163 A FR 7806163A FR 2382695 A1 FR2382695 A1 FR 2382695A1
Authority
FR
France
Prior art keywords
application
reagent
aqueous liquid
analysis methods
implementation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7806163A
Other languages
English (en)
Other versions
FR2382695B1 (fr
Inventor
Jan Per Erik Carlsson
Rolf Erik Axel Verner Axen
Hakan Nils Yngve Drevin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phadia AB
Original Assignee
Pharmacia Diagnostics AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Diagnostics AB filed Critical Pharmacia Diagnostics AB
Publication of FR2382695A1 publication Critical patent/FR2382695A1/fr
Application granted granted Critical
Publication of FR2382695B1 publication Critical patent/FR2382695B1/fr
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/964—Chemistry: molecular biology and microbiology including enzyme-ligand conjugate production, e.g. reducing rate of nonproductive linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Réactif pour la mise en oeuvre de procédés d'analyse immunochimiques en présence d'un liquide aqueux et son application. Ce réactif est constitué par un produit conjugué ou composé d'addition d'une ou plusieurs molécules d'immunoglobuline et d'une ou plusieurs entités d'un groupement marqueur, lesquelles molécules et entités sont liées les unes aux autres par des ponts renfermant le groupement disulfure -S-S-, ce produit conjugué étant soluble dans ledit liquide aqueux. Application à l'analyse quantitative de la gamma -globuline humaine.
FR7806163A 1977-03-04 1978-03-03 Reactif pour la mise en oeuvre de procedes d'analyse immunochimiques en presence d'un liquide aqueux et son application Granted FR2382695A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7702464A SE427505B (sv) 1977-03-04 1977-03-04 Reagens till anvendning vid immunkemiska bestemningsmetoder

Publications (2)

Publication Number Publication Date
FR2382695A1 true FR2382695A1 (fr) 1978-09-29
FR2382695B1 FR2382695B1 (fr) 1984-07-13

Family

ID=20330625

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7806163A Granted FR2382695A1 (fr) 1977-03-04 1978-03-03 Reactif pour la mise en oeuvre de procedes d'analyse immunochimiques en presence d'un liquide aqueux et son application

Country Status (7)

Country Link
US (1) US4232119A (fr)
JP (1) JPS53130423A (fr)
DE (1) DE2808476C2 (fr)
FR (1) FR2382695A1 (fr)
GB (1) GB1597754A (fr)
NL (1) NL188544C (fr)
SE (1) SE427505B (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007879A1 (fr) * 1978-08-02 1980-02-06 Institut National De La Sante Et De La Recherche Medicale (Inserm) Delta-5,3-céto stéroide isomérase et son application dans les dosages immunoenzymatiques
EP0040365A1 (fr) * 1980-05-19 1981-11-25 Pharmacia Diagnostics Ab Méthode d'essai comportant des réactions d'affinité biospécifique
EP0065320A1 (fr) * 1979-11-28 1982-11-24 Institut Pasteur Procédé de couplage d'un médicament avec un composé polypeptidique thiolé provenant d'un fragment de la toxine tétanique et ses applications
EP0117693A2 (fr) * 1983-02-25 1984-09-05 The Upjohn Company Essai immunologique à enzyme lié, trousses à réactifs et agents de couplage
FR2586813A1 (fr) * 1985-08-30 1987-03-06 Inst Nat Sante Rech Med Supports proteiques modifies aptes a immobiliser de facon reversible des anticorps ou des substances immunologiquement actives, et leurs applications au dosage et a la purification d'antigenes ou similaires.
EP0214995A1 (fr) * 1985-03-04 1987-03-25 Dana Farber Cancer Inst Inc Immunotoxine et procede de production.
WO1988007200A1 (fr) * 1987-03-19 1988-09-22 Perry, Robert, Edward Conjugaison d'anticorps monoclonaux
US4888415A (en) * 1985-03-04 1989-12-19 Dana-Farber Cancer Institute, Inc. Gelonin immunotoxin

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55136261A (en) * 1979-04-12 1980-10-23 Toyo Jozo Co Ltd Novel compound and kit comprising it
US4318981A (en) * 1980-04-24 1982-03-09 Miles Laboratories, Inc. Homogeneous specific binding assay employing an intramolecularly modulated photogenic enzyme substrate label
US4486540A (en) * 1980-07-18 1984-12-04 Science Research Center, Inc. Identification of reagins in the blood serum of allergen sensitized vertebrates
US4696907A (en) * 1980-07-18 1987-09-29 Science Research Center, Inc. Identification of reagins in the blood serum of allergen sensitized vertebrates
SE8102194L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna
SE8102193L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och dess anvendning
US4481298A (en) * 1981-04-13 1984-11-06 Amf Incorporated Pre-precipitated double antibody immunoassay method
NL8102178A (nl) * 1981-05-02 1982-12-01 Stichting Centraal Lab Werkwijze voor het aantonen van tegen bepaalde antigenen gerichte antistoffen, alsmede inrichting en reagentia voor het uitvoeren van deze werkwijze.
FR2523445A1 (fr) * 1982-03-17 1983-09-23 Sanofi Sa Nouveaux conjugues associant, par liaison covalente, une enzyme et un anticorps, et associations medicamenteuses utilisant lesdits conjugues
SE8302758L (sv) * 1983-05-17 1984-11-18 Pharmacia Ab Sett for uppspjelkning av disulfidbindningar och derigenom erhallen forening
US4687732A (en) * 1983-06-10 1987-08-18 Yale University Visualization polymers and their application to diagnostic medicine
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
US4665022A (en) * 1984-02-17 1987-05-12 The Regents Of The University Of California Bioluminescent assay reagent and method
US4863875A (en) * 1985-08-26 1989-09-05 Gia Research Company, L.P. Dye labelled antibodies as reagents for use in immunoassay systems
US4780421A (en) * 1986-04-03 1988-10-25 Sclavo Inc. Cleavable labels for use in binding assays
US4975532A (en) * 1986-11-28 1990-12-04 Sclavo, Inc. Method to derivatize dextran
US4959306A (en) * 1986-11-28 1990-09-25 Sclavo, Inc. Labeling design for a binding assay reagent
US5171563A (en) * 1988-09-30 1992-12-15 Neorx Corporation Cleavable linkers for the reduction of non-target organ retention of immunoconjugates
GB8927365D0 (en) * 1989-12-04 1990-01-31 Ici Plc Reagent
US5324650A (en) * 1990-03-20 1994-06-28 E. I. Du Pont De Nemours And Company Situ process for production of conjugates
US6274325B1 (en) * 1990-06-25 2001-08-14 Boehringer Mannheim Gmbh Method for carrying out a homogeneous-immunoassay based on agglutination
US5191066A (en) * 1990-12-07 1993-03-02 Abbott Laboratories Site-specific conjugation of immunoglobulins and detectable labels
US5470997A (en) * 1992-04-06 1995-11-28 Biosite Diagnostics Incorporated Amphetamine derivatives and protein and polypeptide amphetamine derivative conjugates and labels
EP0635019B1 (fr) * 1992-04-06 1999-05-26 Biosite Diagnostics Inc. Derives opiaces et etiquettes et conjugues de derives opiaces polypeptidiques et proteiques
US5331109A (en) * 1992-04-06 1994-07-19 Biosite Diagnostics Incorporated Phencyclidine derivatives and protein and polypeptide phencyclidine derivative conjugates and labels
US6037455A (en) * 1992-11-09 2000-03-14 Biosite Diagnostics Incorporated Propoxyphene derivatives and protein and polypeptide propoxyphene derivative conjugates and labels
US5536820A (en) * 1993-02-26 1996-07-16 E. I. Du Pont De Nemours And Company Avidin-binding azo reagents
US5736624A (en) * 1994-12-02 1998-04-07 Abbott Laboratories Phosphatase activated crosslinking, conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating agents
US5795784A (en) 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
US5856194A (en) 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
US20040241688A1 (en) * 2001-07-19 2004-12-02 Cuneyt Bukusoglu Human tissue specific drug screening procedure
US7695752B2 (en) 2003-01-24 2010-04-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target activated microtransfer
CA2513646C (fr) * 2003-01-24 2013-09-17 Michael R. Emmert-Buck Microtransfert active d'un element cible
US20050176108A1 (en) * 2003-03-13 2005-08-11 Young-Min Kim Physiologically active polypeptide conjugate having prolonged in vivo half-life
US20040180054A1 (en) * 2003-03-13 2004-09-16 Hanmi Pharm. Co., Ltd. Physiologically active polypeptide conjugate having prolonged in vivo half-life
EP1877101B1 (fr) 2005-04-28 2016-11-16 Ventana Medical Systems, Inc. Enzymes conjuguées à des anticorps par un lieur peg hétérobifonctionnel
EP1893241A2 (fr) * 2005-04-28 2008-03-05 Ventana Medical Systems, Inc. Nanoparticules flourescentes conjuguées á des anticorps via un linker peg
US7957466B2 (en) * 2005-09-16 2011-06-07 Sony Corporation Adaptive area of influence filter for moving object boundaries
JP5199880B2 (ja) * 2005-11-23 2013-05-15 ベンタナ・メデイカル・システムズ・インコーポレーテツド 分子コンジュゲート
US8492098B2 (en) 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
ES2556627T3 (es) 2007-08-30 2016-01-19 Trustees Of Tufts College Métodos para determinar la concentración de un analito en solución
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US9910040B2 (en) * 2012-07-09 2018-03-06 Sevident, Inc. Molecular nets comprising capture agents and linking agents
US9733242B2 (en) * 2012-10-07 2017-08-15 Sevident, Inc. Devices for capturing analyte
WO2011066449A1 (fr) * 2009-11-24 2011-06-03 Sevident Dispositifs de détection de composés à analyser
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
WO2011109379A1 (fr) 2010-03-01 2011-09-09 Quanterix Corporation Procédés et systèmes pour étendre la plage dynamique dans des dosages pour la détection de molécules ou de particules
US9347946B2 (en) * 2010-09-23 2016-05-24 Biocept, Inc. Methods and reagents for signal amplification
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
WO2012142301A2 (fr) 2011-04-12 2012-10-18 Quanterix Corporation Procédé de détermination d'un protocole de traitement et/ou d'un pronostic de rétablissement d'un patient à la suite d'un traumatisme cérébral
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4004979A (en) * 1968-03-29 1977-01-25 Agence Nationale De Valorisation De La Recherche (Anvar) Preparation of active proteins cross-linked to inactive proteins
US3652761A (en) * 1969-09-04 1972-03-28 Corning Glass Works Immunochemical composites and antigen or antibody purification therewith
SE420733B (sv) * 1974-05-30 1981-10-26 Exploaterings Ab Tbf Gelprodukt, innehallande tiosulfatgrupper samt sett for framstellning derav
US4002532A (en) * 1974-10-21 1977-01-11 Weltman Joel K Enzyme conjugates

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007879A1 (fr) * 1978-08-02 1980-02-06 Institut National De La Sante Et De La Recherche Medicale (Inserm) Delta-5,3-céto stéroide isomérase et son application dans les dosages immunoenzymatiques
FR2432713A1 (fr) * 1978-08-02 1980-02-29 Inst Nat Sante Rech Med Application de la d5,3-ceto steroide isomerase dans les dosages immunoenzymatiques
EP0065320A1 (fr) * 1979-11-28 1982-11-24 Institut Pasteur Procédé de couplage d'un médicament avec un composé polypeptidique thiolé provenant d'un fragment de la toxine tétanique et ses applications
EP0040365A1 (fr) * 1980-05-19 1981-11-25 Pharmacia Diagnostics Ab Méthode d'essai comportant des réactions d'affinité biospécifique
EP0117693A2 (fr) * 1983-02-25 1984-09-05 The Upjohn Company Essai immunologique à enzyme lié, trousses à réactifs et agents de couplage
EP0117693A3 (fr) * 1983-02-25 1986-10-08 The Upjohn Company Essai immunologique à enzyme lié, trousses à réactifs et agents de couplage
EP0214995A1 (fr) * 1985-03-04 1987-03-25 Dana Farber Cancer Inst Inc Immunotoxine et procede de production.
EP0214995A4 (fr) * 1985-03-04 1987-07-22 Dana Farber Cancer Inst Inc Immunotoxine et procede de production.
US4888415A (en) * 1985-03-04 1989-12-19 Dana-Farber Cancer Institute, Inc. Gelonin immunotoxin
FR2586813A1 (fr) * 1985-08-30 1987-03-06 Inst Nat Sante Rech Med Supports proteiques modifies aptes a immobiliser de facon reversible des anticorps ou des substances immunologiquement actives, et leurs applications au dosage et a la purification d'antigenes ou similaires.
EP0214053A1 (fr) * 1985-08-30 1987-03-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Supports protéiques modifiés aptes à immobiliser de façon covalente ou réversible des anticorps ou des substances immunologiquement actives, et leurs applications au dosage et à la purification d'antigènes ou similaires
WO1988007200A1 (fr) * 1987-03-19 1988-09-22 Perry, Robert, Edward Conjugaison d'anticorps monoclonaux

Also Published As

Publication number Publication date
JPS53130423A (en) 1978-11-14
NL7802451A (nl) 1978-09-06
GB1597754A (en) 1981-09-09
NL188544B (nl) 1992-02-17
SE7702464L (sv) 1978-09-05
DE2808476A1 (de) 1978-09-07
JPS6145775B2 (fr) 1986-10-09
US4232119A (en) 1980-11-04
FR2382695B1 (fr) 1984-07-13
DE2808476C2 (de) 1986-11-06
SE427505B (sv) 1983-04-11
NL188544C (nl) 1993-09-16

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