DE69132055T2 - Ortsgenaue konjugatbildung zwischen immunglobulinen und nachweisbaren markierungsstoffen - Google Patents

Ortsgenaue konjugatbildung zwischen immunglobulinen und nachweisbaren markierungsstoffen

Info

Publication number
DE69132055T2
DE69132055T2 DE69132055T DE69132055T DE69132055T2 DE 69132055 T2 DE69132055 T2 DE 69132055T2 DE 69132055 T DE69132055 T DE 69132055T DE 69132055 T DE69132055 T DE 69132055T DE 69132055 T2 DE69132055 T2 DE 69132055T2
Authority
DE
Germany
Prior art keywords
immunoglobulin
immunoglobulines
locally
derivatized
conjugate formation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69132055T
Other languages
English (en)
Other versions
DE69132055D1 (de
Inventor
Christopher Bieniarz
Mazhar Husain
E Bond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE69132055D1 publication Critical patent/DE69132055D1/de
Application granted granted Critical
Publication of DE69132055T2 publication Critical patent/DE69132055T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69132055T 1990-12-07 1991-12-02 Ortsgenaue konjugatbildung zwischen immunglobulinen und nachweisbaren markierungsstoffen Expired - Fee Related DE69132055T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/624,169 US5191066A (en) 1990-12-07 1990-12-07 Site-specific conjugation of immunoglobulins and detectable labels
PCT/US1991/008971 WO1992010507A1 (en) 1990-12-07 1991-12-02 Site-specific conjugation of immunoglobulins and detectable labels

Publications (2)

Publication Number Publication Date
DE69132055D1 DE69132055D1 (de) 2000-04-20
DE69132055T2 true DE69132055T2 (de) 2000-10-26

Family

ID=24500943

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69132055T Expired - Fee Related DE69132055T2 (de) 1990-12-07 1991-12-02 Ortsgenaue konjugatbildung zwischen immunglobulinen und nachweisbaren markierungsstoffen

Country Status (12)

Country Link
US (1) US5191066A (de)
EP (1) EP0560912B1 (de)
JP (1) JP3390430B2 (de)
KR (1) KR930703347A (de)
AT (1) ATE190624T1 (de)
AU (1) AU659427B2 (de)
CA (1) CA2097920C (de)
DE (1) DE69132055T2 (de)
DK (1) DK0560912T3 (de)
ES (1) ES2146209T3 (de)
GR (1) GR3033553T3 (de)
WO (1) WO1992010507A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
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US5547833A (en) * 1994-01-04 1996-08-20 Intracel Corporation Radial flow assay, delivering member, test kit, and methods
US5561045A (en) * 1994-01-04 1996-10-01 Intracel Corporation Detection reagent, article, and immunoassay method
US5596081A (en) * 1994-03-11 1997-01-21 University Of Kentucky Research Foundation Nucleotide or nucleoside photoaffinity compound modified antibodies, methods for their manufacture and use thereof as diagnostics and therapeutics
WO1996010585A1 (en) * 1994-09-30 1996-04-11 Inex Pharmaceuticals Corp. Glycosylated protein-liposome conjugates and methods for their preparation
US5736624A (en) * 1994-12-02 1998-04-07 Abbott Laboratories Phosphatase activated crosslinking, conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating agents
DK0752102T3 (da) * 1995-01-23 2001-01-08 Pasteur Sanofi Diagnostics Immunoenzymatisk konjugat, fremgangsmåde til fremstilling af konjugatet og anvendelse af dette.
EP1378525A3 (de) * 1996-06-07 2004-01-14 Neorx Corporation Humanisierte Antikörper die and das gleiche Antigen wie Antikörper NR-LU-13 binden und deren Verwendung in "Pretargeting" Verfahren
US20050033033A1 (en) * 1998-05-04 2005-02-10 Heinz Kohler Trans-membrane-antibody induced inhibition of apoptosis
US20040185039A1 (en) * 2002-08-30 2004-09-23 Heinz Kohler Therapeutic applications of noncovalent dimerizing antibodies
US7569674B2 (en) * 1998-05-04 2009-08-04 Innexus Biotechnology International Limited Autophilic antibodies
US6218160B1 (en) * 1997-10-31 2001-04-17 Roche Diagnostics Corporation Site-specific conjugation of glycoproteins
EP1087791B1 (de) * 1998-04-15 2005-09-21 Mayo Foundation for Medical Education and Research Hemmung xenoreaktiver antikörper
US20090208418A1 (en) * 2005-04-29 2009-08-20 Innexus Biotechnology Internaltional Ltd. Superantibody synthesis and use in detection, prevention and treatment of disease
US6335155B1 (en) * 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
EP1131430B1 (de) * 1998-11-10 2007-01-17 Emory University Mitogene regulatoren
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
US8110665B2 (en) 2003-11-13 2012-02-07 Hanmi Holdings Co., Ltd. Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
CN103212084B (zh) 2003-11-13 2018-07-13 韩美科学株式会社 含有免疫球蛋白fc区作为载体的药物组合物
CA2609702C (en) 2005-04-28 2013-05-28 Ventana Medical Systems, Inc. Antibody conjugates via heterobifunctional peg linkers
CA2606018A1 (en) * 2005-04-28 2006-11-02 Ventana Medical Systems, Inc. Nanoparticle conjugates
DK2963011T3 (en) * 2005-11-23 2018-08-06 Ventana Med Syst Inc MOLECULAR CONJUGATE
US20080108147A1 (en) * 2006-11-03 2008-05-08 Tie Wei Reduction of non-specific binding in immunoassays
WO2013016449A2 (en) 2011-07-26 2013-01-31 Indicator Systems International, Inc. Assays for the detection of microbes
WO2014127211A1 (en) 2013-02-15 2014-08-21 Research Development Foundation Deimmunized gelonin molecules and therapies
CN105848671B (zh) 2013-08-28 2019-12-13 艾伯维施特姆森特克斯有限责任公司 位点特异性抗体缀合方法和组合物
PE20160870A1 (es) 2013-11-06 2016-09-09 Abbvie Stemcentrx Llc Anticuerpos anti-claudina novedosos y metodos de uso
CN106104273A (zh) 2013-12-12 2016-11-09 施特姆森特克斯股份有限公司 新型抗dpep3抗体和使用方法
MX2016010677A (es) 2014-02-21 2017-04-10 Abbvie Stemcentrx Llc Conjugados de anticuerpos anti-drosophila similar a delta 3 (anti-dll3) y medicamentos para usarse en el tratamiento contra melanoma.
TW201617368A (zh) 2014-09-05 2016-05-16 史坦森特瑞斯公司 新穎抗ｍｆｉ２抗體及使用方法
JP7126665B2 (ja) * 2020-05-22 2022-08-29 学校法人麻布獣医学園 アレルゲン不活化剤の評価方法及びアレルゲン不活化剤の評価キット
CN112067826B (zh) * 2020-09-15 2024-02-06 济南国科医工科技发展有限公司 基于高比活力碱性磷酸酶构建的NT-proBNP检测试剂盒及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140679A (en) * 1976-10-12 1979-02-20 Research Corporation Antigen-protein complex for blocking allergic reactions
SE427505B (sv) * 1977-03-04 1983-04-11 Pharmacia Diagnostics Ab Reagens till anvendning vid immunkemiska bestemningsmetoder
FR2437213A1 (fr) * 1978-09-28 1980-04-25 Cm Ind Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation
US4699784A (en) * 1986-02-25 1987-10-13 Center For Molecular Medicine & Immunology Tumoricidal methotrexate-antibody conjugate
FR2601679B1 (fr) * 1986-07-15 1990-05-25 Sanofi Sa Immunotoxines, procede de preparation et compositions pharmaceutiques en contenant
US4994385A (en) * 1987-10-30 1991-02-19 Abbott Laboratories Heterobifunctional coupling agents

Also Published As

Publication number Publication date
ES2146209T3 (es) 2000-08-01
US5191066A (en) 1993-03-02
AU659427B2 (en) 1995-05-18
EP0560912B1 (de) 2000-03-15
WO1992010507A1 (en) 1992-06-25
EP0560912A1 (de) 1993-09-22
JP3390430B2 (ja) 2003-03-24
EP0560912A4 (en) 1996-08-28
CA2097920C (en) 2003-11-04
ATE190624T1 (de) 2000-04-15
GR3033553T3 (en) 2000-09-29
DK0560912T3 (da) 2000-07-24
KR930703347A (ko) 1993-11-29
CA2097920A1 (en) 1992-06-08
JPH06504776A (ja) 1994-06-02
AU9145291A (en) 1992-07-08
DE69132055D1 (de) 2000-04-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee